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Volumn 20, Issue 2, 2008, Pages 186-193

Cell regulation by the Apc protein. Apc as master regulator of epithelia

Author keywords

[No Author keywords available]

Indexed keywords

APC PROTEIN; BETA CATENIN; CYCLIC AMP DEPENDENT PROTEIN KINASE; GLYCOGEN SYNTHASE KINASE 3; WNT PROTEIN;

EID: 41549117418     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ceb.2008.02.001     Document Type: Review
Times cited : (122)

References (62)
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    • This paper demonstrates immediate defects in cell cycle machinery, including the spindle checkpoint, after the loss of Apc in cells and tissue.
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    • This is the first demonstration that Apc can bind to microtubules.
    • Munemitsu S., Souza B., Müller O., Albert I., Rubinfeld B., and Polakis P. The APC gene product associates with microtubules in vivo and promotes their assembly in vitro. Cancer Res 54 (1994) 3676-3681. This is the first demonstration that Apc can bind to microtubules.
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    • Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3b phosphorylation
    • This paper shows the direct effect of Apc on microtubule stability in vitro and in cells and provides evidence that this function can be regulated by the phosphorylation with GSK3b.
    • Zumbrunn J., Inoshita K., Hyman A.A., and Näthke I.S. Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3b phosphorylation. Curr Biol 11 (2001) 44-49. This paper shows the direct effect of Apc on microtubule stability in vitro and in cells and provides evidence that this function can be regulated by the phosphorylation with GSK3b.
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    • Zumbrunn, J.1    Inoshita, K.2    Hyman, A.A.3    Näthke, I.S.4
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    • APC on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1
    • This paper demonstrates direct link between endogenous Apc protein and microtubule dynamics in cells.
    • Kita K., Wittmann T., Näthke I.S., and Waterman-Storer C.M. APC on microtubule plus ends in cell extensions can promote microtubule net growth with or without EB1. Mol Biol Cell 17 (2006) 2331-2345. This paper demonstrates direct link between endogenous Apc protein and microtubule dynamics in cells.
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    • Kita, K.1    Wittmann, T.2    Näthke, I.S.3    Waterman-Storer, C.M.4
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    • APC binds to the novel protein EB1
    • This paper identifies EB1 as an Apc binding partner and thus brings Apc closer to the microtubule cytoskeleton.
    • Su L.-K., Burrell M., Hill D.E., Gyuris J., Brent R., Wiltshire R., Trent J., Vogelstein B., and Kinzler K.W. APC binds to the novel protein EB1. Cancer Res 55 (1995) 2972-2977. This paper identifies EB1 as an Apc binding partner and thus brings Apc closer to the microtubule cytoskeleton.
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    • Su, L.-K.1    Burrell, M.2    Hill, D.E.3    Gyuris, J.4    Brent, R.5    Wiltshire, R.6    Trent, J.7    Vogelstein, B.8    Kinzler, K.W.9
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    • 0034682888 scopus 로고    scopus 로고
    • Asef, a link between the tumor suppressor APC and G-protein signaling
    • Identifies Apc as a regulator for the activity of an exchange factor for small GTP-ases thus establishing a functional link between Apc and actin.
    • Kawasaki Y., Senda T., Ishidate T., Koyama R., Morishita T., Iwayama Y., Higuchi O., and Akiyama T. Asef, a link between the tumor suppressor APC and G-protein signaling. Science 289 (2000) 1194-1197. Identifies Apc as a regulator for the activity of an exchange factor for small GTP-ases thus establishing a functional link between Apc and actin.
    • (2000) Science , vol.289 , pp. 1194-1197
    • Kawasaki, Y.1    Senda, T.2    Ishidate, T.3    Koyama, R.4    Morishita, T.5    Iwayama, Y.6    Higuchi, O.7    Akiyama, T.8
  • 50
    • 2942668475 scopus 로고    scopus 로고
    • Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration
    • Shows that conditionally inactivating Apc in the gut immediately leads to changes that underlie tumourigenesis.
    • Sansom O.J., Reed K.R., Hayes A.J., Ireland H., Brinkmann H., Newton I.P., Batlle E., Simon-Assmann P., Clevers H., Näthke I.S., et al. Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migration. Genes Dev 18 (2004) 1385-1390. Shows that conditionally inactivating Apc in the gut immediately leads to changes that underlie tumourigenesis.
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    • Sansom, O.J.1    Reed, K.R.2    Hayes, A.J.3    Ireland, H.4    Brinkmann, H.5    Newton, I.P.6    Batlle, E.7    Simon-Assmann, P.8    Clevers, H.9    Näthke, I.S.10
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    • Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells
    • Draviam V.M., Shapiro I., Aldridge B., and Sorger P.K. Misorientation and reduced stretching of aligned sister kinetochores promote chromosome missegregation in EB1- or APC-depleted cells. EMBO J 25 (2006) 2814-2827
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    • Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC
    • This paper demonstrates a dominant effect of N-terminal Apc fragments in mitosis.
    • Green R.A., and Kaplan K.B. Chromosome instability in colorectal tumor cells is associated with defects in microtubule plus-end attachments caused by a dominant mutation in APC. J Cell Biol 163 (2003) 949-961. This paper demonstrates a dominant effect of N-terminal Apc fragments in mitosis.
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    • Green, R.A.1    Kaplan, K.B.2
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    • APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice
    • Caldwell C.M., Green R.A., and Kaplan K.B. APC mutations lead to cytokinetic failures in vitro and tetraploid genotypes in Min mice. J Cell Biol 178 (2007) 1109-1120
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    • 2-terminal fragments are the most stable part of the adenomatous polyposis coli protein and can be regulated by interactions with COOH-terminal domains
    • 2-terminal fragments are the most stable part of the adenomatous polyposis coli protein and can be regulated by interactions with COOH-terminal domains. Cancer Res 65 (2005) 5195-5204
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    • Li, Z.1    Näthke, I.S.2
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    • APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment
    • Green R.A., Wollman R., and Kaplan K.B. APC and EB1 function together in mitosis to regulate spindle dynamics and chromosome alignment. Mol Biol Cell 16 (2005) 4609-4622
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    • Green, R.A.1    Wollman, R.2    Kaplan, K.B.3
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    • The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain
    • Berrueta L., Tirnauer J.S., Schuyler S.C., Pellman D., and Bierer B.E. The APC-associated protein EB1 associates with components of the dynactin complex and cytoplasmic dynein intermediate chain. Curr Biol 9 (1999) 425-428
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    • Interaction between EB1 and p150glued is required for anaphase astral microtubule elongation and stimulation of cytokinesis
    • Strickland L.I., Wen Y., Gundersen G.G., and Burgess D.R. Interaction between EB1 and p150glued is required for anaphase astral microtubule elongation and stimulation of cytokinesis. Curr Biol 15 (2005) 2249-2255
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  • 60
    • 34247231997 scopus 로고    scopus 로고
    • A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer
    • This paper introduces a novel rat model for Apc-mediated tumourigenesis that mimics the human disease more accurately.
    • Amos-Landgraf J.M., Kwong L.N., Kendziorski C.M., Reichelderfer M., Torrealba J., Weichert J., Haag J.D., Chen K.S., Waller J.L., Gould M.N., et al. A target-selected Apc-mutant rat kindred enhances the modeling of familial human colon cancer. Proc Natl Acad Sci U S A 104 (2007) 4036-4041. This paper introduces a novel rat model for Apc-mediated tumourigenesis that mimics the human disease more accurately.
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    • Amos-Landgraf, J.M.1    Kwong, L.N.2    Kendziorski, C.M.3    Reichelderfer, M.4    Torrealba, J.5    Weichert, J.6    Haag, J.D.7    Chen, K.S.8    Waller, J.L.9    Gould, M.N.10
  • 61
    • 34247187543 scopus 로고    scopus 로고
    • Myc deletion rescues Apc deficiency in the small intestine
    • This paper demonstrates that Myc is absolutely required for Apc-deficient cells to survive in intestinal tissue and form tumours and that de-regulated, nuclear β-catenin is not sufficient.
    • Sansom O.J., Meniel V.S., Muncan V., Phesse T.J., Wilkins J.A., Reed K.R., Vass J.K., Athineos D., Clevers H., and Clarke A.R. Myc deletion rescues Apc deficiency in the small intestine. Nature 446 (2007) 676-679. This paper demonstrates that Myc is absolutely required for Apc-deficient cells to survive in intestinal tissue and form tumours and that de-regulated, nuclear β-catenin is not sufficient.
    • (2007) Nature , vol.446 , pp. 676-679
    • Sansom, O.J.1    Meniel, V.S.2    Muncan, V.3    Phesse, T.J.4    Wilkins, J.A.5    Reed, K.R.6    Vass, J.K.7    Athineos, D.8    Clevers, H.9    Clarke, A.R.10
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    • Downregulation of ß-catenin by human axin and its association with the APC tumor suppressor, ß-catenin and GSK3ß
    • Hart M.J., de los Santos R., Albert I., Rubinfeld B., and Polakis P. Downregulation of ß-catenin by human axin and its association with the APC tumor suppressor, ß-catenin and GSK3ß. Curr Biol 8 (1998) 573-581
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    • Hart, M.J.1    de los Santos, R.2    Albert, I.3    Rubinfeld, B.4    Polakis, P.5


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