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Volumn 35, Issue 5, 2014, Pages 1067-1077

Inhibition of hypoxia-inducible factors limits tumor progression in a mouse model of colorectal cancer

Author keywords

[No Author keywords available]

Indexed keywords

ACRIFLAVINE; HYPOXIA INDUCIBLE FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; VASCULOTROPIN;

EID: 84901997518     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgu004     Document Type: Article
Times cited : (57)

References (59)
  • 1
    • 5444250952 scopus 로고
    • Aetologie der neoplastichen Geshwulste. Pathogenie der neoplastischen Geschwustle
    • Virchow, R. (1863) Aetologie der neoplastichen Geshwulste. Pathogenie der neoplastischen Geschwustle. Die Krankhafter Geschwulste, 1, 57-101.
    • (1863) Die Krankhafter Geschwulste , vol.1 , pp. 57-101
    • Virchow, R.1
  • 2
    • 77953479589 scopus 로고    scopus 로고
    • Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer
    • Danese, S. et al. (2010) Inflammatory bowel disease and intestinal cancer: a paradigm of the Yin-Yang interplay between inflammation and cancer. Oncogene, 29, 3313-3323.
    • (2010) Oncogene , vol.29 , pp. 3313-3323
    • Danese, S.1
  • 3
    • 3543102542 scopus 로고    scopus 로고
    • Inflammation and necrosis promote tumour growth
    • Vakkila, J. et al. (2004) Inflammation and necrosis promote tumour growth. Nat. Rev. Immunol., 4, 641-648.
    • (2004) Nat. Rev. Immunol. , vol.4 , pp. 641-648
    • Vakkila, J.1
  • 4
    • 0035901090 scopus 로고    scopus 로고
    • Inflammation and cancer: back to Virchow?
    • Balkwill, F. et al. (2001) Inflammation and cancer: back to Virchow? Lancet, 357, 539-545.
    • (2001) Lancet , vol.357 , pp. 539-545
    • Balkwill, F.1
  • 5
    • 0036138686 scopus 로고    scopus 로고
    • Inflammation and colorectal cancer: IBDassociated and sporadic cancer compared
    • Rhodes, J.M. et al. (2002) Inflammation and colorectal cancer: IBDassociated and sporadic cancer compared. Trends Mol. Med., 8, 10-16.
    • (2002) Trends Mol. Med. , vol.8 , pp. 10-16
    • Rhodes, J.M.1
  • 6
    • 0035080617 scopus 로고    scopus 로고
    • The risk of colorectal cancer in ulcerative colitis: a meta-analysis
    • Eaden, J.A. et al. (2001) The risk of colorectal cancer in ulcerative colitis: a meta-analysis. Gut, 48, 526-535.
    • (2001) Gut , vol.48 , pp. 526-535
    • Eaden, J.A.1
  • 7
    • 77955279767 scopus 로고    scopus 로고
    • Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease
    • O'Connor, P.M. et al. (2010) Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease. Inflamm. Bowel Dis., 16, 1411-1420.
    • (2010) Inflamm. Bowel Dis. , vol.16 , pp. 1411-1420
    • O'Connor, P.M.1
  • 8
    • 57149142495 scopus 로고    scopus 로고
    • The impact of O2 availability on human cancer
    • Bertout, J.A. et al. (2008) The impact of O2 availability on human cancer. Nat. Rev. Cancer, 8, 967-975.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 967-975
    • Bertout, J.A.1
  • 9
    • 68049105076 scopus 로고    scopus 로고
    • Role of hypoxia in the hallmarks of human cancer
    • Ruan, K. et al. (2009) Role of hypoxia in the hallmarks of human cancer. J. Cell. Biochem., 107, 1053-1062.
    • (2009) J. Cell. Biochem. , vol.107 , pp. 1053-1062
    • Ruan, K.1
  • 10
    • 4944244259 scopus 로고    scopus 로고
    • Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues
    • Murdoch, C. et al. (2004) Mechanisms regulating the recruitment of macrophages into hypoxic areas of tumors and other ischemic tissues. Blood, 104, 2224-2234.
    • (2004) Blood , vol.104 , pp. 2224-2234
    • Murdoch, C.1
  • 11
    • 78650624793 scopus 로고    scopus 로고
    • Innate immune mechanisms of colitis and colitisassociated colorectal cancer
    • Saleh, M. et al. (2011) Innate immune mechanisms of colitis and colitisassociated colorectal cancer. Nat. Rev. Immunol., 11, 9-20.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 9-20
    • Saleh, M.1
  • 12
    • 70350728931 scopus 로고    scopus 로고
    • Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation
    • Solinas, G. et al. (2009) Tumor-associated macrophages (TAM) as major players of the cancer-related inflammation. J. Leukoc. Biol., 86, 1065-1073.
    • (2009) J. Leukoc. Biol. , vol.86 , pp. 1065-1073
    • Solinas, G.1
  • 13
    • 0021637875 scopus 로고
    • Macrophage activation, chronic inflammation and gastrointestinal disease
    • Tanner, A.R. et al. (1984) Macrophage activation, chronic inflammation and gastrointestinal disease. Gut, 25, 760-783.
    • (1984) Gut , vol.25 , pp. 760-783
    • Tanner, A.R.1
  • 14
    • 68249140395 scopus 로고    scopus 로고
    • Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia
    • Fang, H.Y. et al. (2009) Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia. Blood, 114, 844-859.
    • (2009) Blood , vol.114 , pp. 844-859
    • Fang, H.Y.1
  • 15
    • 0034787977 scopus 로고    scopus 로고
    • Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors
    • Crowther, M. et al. (2001) Microenvironmental influence on macrophage regulation of angiogenesis in wounds and malignant tumors. J. Leukoc. Biol., 70, 478-490.
    • (2001) J. Leukoc. Biol. , vol.70 , pp. 478-490
    • Crowther, M.1
  • 16
    • 77951497951 scopus 로고    scopus 로고
    • The molecular therapy of colorectal cancer
    • Waldner, M.J. et al. (2010) The molecular therapy of colorectal cancer. Mol. Aspects Med., 31, 171-178.
    • (2010) Mol. Aspects Med. , vol.31 , pp. 171-178
    • Waldner, M.J.1
  • 17
    • 0036187615 scopus 로고    scopus 로고
    • The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies
    • Bingle, L. et al. (2002) The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies. J. Pathol., 196, 254-265.
    • (2002) J. Pathol. , vol.196 , pp. 254-265
    • Bingle, L.1
  • 18
    • 35148888161 scopus 로고    scopus 로고
    • Life with oxygen
    • Semenza, G.L. (2007) Life with oxygen. Science, 318, 62-64.
    • (2007) Science , vol.318 , pp. 62-64
    • Semenza, G.L.1
  • 19
    • 78649364332 scopus 로고    scopus 로고
    • Hypoxia-inducible factors and the response to hypoxic stress
    • Majmundar, A.J. et al. (2010) Hypoxia-inducible factors and the response to hypoxic stress. Mol. Cell, 40, 294-309.
    • (2010) Mol. Cell , vol.40 , pp. 294-309
    • Majmundar, A.J.1
  • 20
    • 0034682783 scopus 로고    scopus 로고
    • Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
    • Cockman, M.E. et al. (2000) Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem., 275, 25733-25741.
    • (2000) J. Biol. Chem. , vol.275 , pp. 25733-25741
    • Cockman, M.E.1
  • 21
    • 0035917808 scopus 로고    scopus 로고
    • Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation
    • Jaakkola, P. et al. (2001) Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science, 292, 468-472.
    • (2001) Science , vol.292 , pp. 468-472
    • Jaakkola, P.1
  • 22
    • 77955295091 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation
    • Imtiyaz, H.Z. et al. (2010) Hypoxia-inducible factor 2alpha regulates macrophage function in mouse models of acute and tumor inflammation. J. Clin. Invest., 120, 2699-2714.
    • (2010) J. Clin. Invest. , vol.120 , pp. 2699-2714
    • Imtiyaz, H.Z.1
  • 23
    • 0033870281 scopus 로고    scopus 로고
    • The expression and distribution of the hypoxiainducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages
    • Talks, K.L. et al. (2000) The expression and distribution of the hypoxiainducible factors HIF-1alpha and HIF-2alpha in normal human tissues, cancers, and tumor-associated macrophages. Am. J. Pathol., 157, 411-421.
    • (2000) Am. J. Pathol. , vol.157 , pp. 411-421
    • Talks, K.L.1
  • 24
    • 0345118952 scopus 로고    scopus 로고
    • Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis
    • White, J.R. et al. (2004) Genetic amplification of the transcriptional response to hypoxia as a novel means of identifying regulators of angiogenesis. Genomics, 83, 1-8.
    • (2004) Genomics , vol.83 , pp. 1-8
    • White, J.R.1
  • 25
    • 35048875691 scopus 로고    scopus 로고
    • Evaluation of HIF-1 inhibitors as anticancer agents
    • Semenza, G.L. (2007) Evaluation of HIF-1 inhibitors as anticancer agents. Drug Discov. Today, 12, 853-859.
    • (2007) Drug Discov. Today , vol.12 , pp. 853-859
    • Semenza, G.L.1
  • 26
    • 84655161946 scopus 로고    scopus 로고
    • HIF1a and HIF2a: sibling rivalry in hypoxic tumour growth and progression
    • Keith, B. et al. (2012) HIF1a and HIF2a: sibling rivalry in hypoxic tumour growth and progression. Nat. Rev. Cancer, 12, 9-22.
    • (2012) Nat. Rev. Cancer , vol.12 , pp. 9-22
    • Keith, B.1
  • 27
    • 34247527730 scopus 로고    scopus 로고
    • Hypoxia-inducible factors, stem cells, and cancer
    • Keith, B. et al. (2007) Hypoxia-inducible factors, stem cells, and cancer. Cell, 129, 465-472.
    • (2007) Cell , vol.129 , pp. 465-472
    • Keith, B.1
  • 28
    • 0037315337 scopus 로고    scopus 로고
    • Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs
    • Wiesener, M.S. et al. (2003) Widespread hypoxia-inducible expression of HIF-2alpha in distinct cell populations of different organs. FASEB J., 17, 271-273.
    • (2003) FASEB J. , vol.17 , pp. 271-273
    • Wiesener, M.S.1
  • 29
    • 84862877433 scopus 로고    scopus 로고
    • Effects of hypoxia and HIFs on cancer metabolism
    • Mucaj, V. et al. (2012) Effects of hypoxia and HIFs on cancer metabolism. Int. J. Hematol., 95, 464-470.
    • (2012) Int. J. Hematol. , vol.95 , pp. 464-470
    • Mucaj, V.1
  • 30
    • 0141425768 scopus 로고    scopus 로고
    • Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy
    • Burke, B. et al. (2003) Hypoxia-induced gene expression in human macrophages: implications for ischemic tissues and hypoxia-regulated gene therapy. Am. J. Pathol., 163, 1233-1243.
    • (2003) Am. J. Pathol. , vol.163 , pp. 1233-1243
    • Burke, B.1
  • 31
    • 0036007293 scopus 로고    scopus 로고
    • Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy
    • Burke, B. et al. (2002) Expression of HIF-1alpha by human macrophages: implications for the use of macrophages in hypoxia-regulated cancer gene therapy. J. Pathol., 196, 204-212.
    • (2002) J. Pathol. , vol.196 , pp. 204-212
    • Burke, B.1
  • 32
    • 0033405817 scopus 로고    scopus 로고
    • Macrophage responses to hypoxia: relevance to disease mechanisms
    • Lewis, J.S. et al. (1999) Macrophage responses to hypoxia: relevance to disease mechanisms. J. Leukoc. Biol., 66, 889-900.
    • (1999) J. Leukoc. Biol. , vol.66 , pp. 889-900
    • Lewis, J.S.1
  • 33
    • 27744472334 scopus 로고    scopus 로고
    • Macrophage migration and gene expression in response to tumor hypoxia
    • Murdoch, C. et al. (2005) Macrophage migration and gene expression in response to tumor hypoxia. Int. J. Cancer, 117, 701-708.
    • (2005) Int. J. Cancer , vol.117 , pp. 701-708
    • Murdoch, C.1
  • 34
    • 77649177217 scopus 로고    scopus 로고
    • Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis
    • Takeda, N. et al. (2010) Differential activation and antagonistic function of HIF-{alpha} isoforms in macrophages are essential for NO homeostasis. Genes Dev., 24, 491-501.
    • (2010) Genes Dev. , vol.24 , pp. 491-501
    • Takeda, N.1
  • 35
    • 0037423948 scopus 로고    scopus 로고
    • HIF-1alpha is essential for myeloid cell-mediated inflammation
    • Cramer, T. et al. (2003) HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell, 112, 645-657.
    • (2003) Cell , vol.112 , pp. 645-657
    • Cramer, T.1
  • 36
    • 84861960811 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: crosstalk between inflammation and metabolism
    • Shay, J.E. et al. (2012) Hypoxia-inducible factors: crosstalk between inflammation and metabolism. Semin. Cell Dev. Biol., 23, 389-394.
    • (2012) Semin. Cell Dev. Biol. , vol.23 , pp. 389-394
    • Shay, J.E.1
  • 37
    • 33645786505 scopus 로고    scopus 로고
    • Development of novel therapeutic strategies that target HIF-1
    • Semenza, G.L. (2006) Development of novel therapeutic strategies that target HIF-1. Expert Opin. Ther. Targets, 10, 267-280.
    • (2006) Expert Opin. Ther. Targets , vol.10 , pp. 267-280
    • Semenza, G.L.1
  • 38
    • 84859445000 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
    • Semenza, G.L. (2012) Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol. Sci., 33, 207-214.
    • (2012) Trends Pharmacol. Sci. , vol.33 , pp. 207-214
    • Semenza, G.L.1
  • 39
    • 84856739946 scopus 로고    scopus 로고
    • Hypoxia-inducible factors in physiology and medicine
    • Semenza, G.L. (2012) Hypoxia-inducible factors in physiology and medicine. Cell, 148, 399-408.
    • (2012) Cell , vol.148 , pp. 399-408
    • Semenza, G.L.1
  • 40
    • 70449580319 scopus 로고    scopus 로고
    • Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization
    • Lee, K. et al. (2009) Acriflavine inhibits HIF-1 dimerization, tumor growth, and vascularization. Proc. Natl. Acad. Sci. USA, 106, 17910-17915.
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 17910-17915
    • Lee, K.1
  • 41
    • 84865149277 scopus 로고    scopus 로고
    • Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis
    • Wong, C.C. et al. (2012) Inhibitors of hypoxia-inducible factor 1 block breast cancer metastatic niche formation and lung metastasis. J. Mol. Med. (Berl)., 90, 803-815.
    • (2012) J. Mol. Med. (Berl). , vol.90 , pp. 803-815
    • Wong, C.C.1
  • 42
    • 0035177432 scopus 로고    scopus 로고
    • Acridine-a neglected antibacterial chromophore
    • Wainwright, M. (2001) Acridine-a neglected antibacterial chromophore. J. Antimicrob. Chemother., 47, 1-13.
    • (2001) J. Antimicrob. Chemother. , vol.47 , pp. 1-13
    • Wainwright, M.1
  • 43
    • 13444267759 scopus 로고    scopus 로고
    • Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing
    • Stadtfeld, M. et al. (2005) Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing. Development, 132, 203-213.
    • (2005) Development , vol.132 , pp. 203-213
    • Stadtfeld, M.1
  • 44
    • 0033777202 scopus 로고    scopus 로고
    • Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha
    • Tomita, S. et al. (2000) Conditional disruption of the aryl hydrocarbon receptor nuclear translocator (Arnt) gene leads to loss of target gene induction by the aryl hydrocarbon receptor and hypoxia-inducible factor 1alpha. Mol. Endocrinol., 14, 1674-1681.
    • (2000) Mol. Endocrinol. , vol.14 , pp. 1674-1681
    • Tomita, S.1
  • 45
    • 3042779529 scopus 로고    scopus 로고
    • p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment
    • Pan, Y. et al. (2004) p53 cannot be induced by hypoxia alone but responds to the hypoxic microenvironment. Oncogene, 23, 4975-4983.
    • (2004) Oncogene , vol.23 , pp. 4975-4983
    • Pan, Y.1
  • 46
    • 0025181580 scopus 로고
    • A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice
    • Okayasu, I. et al. (1990) A novel method in the induction of reliable experimental acute and chronic ulcerative colitis in mice. Gastroenterology, 98, 694-702.
    • (1990) Gastroenterology , vol.98 , pp. 694-702
    • Okayasu, I.1
  • 47
    • 0029942998 scopus 로고    scopus 로고
    • Promotion of colorectal neoplasia in experimental murine ulcerative colitis
    • Okayasu, I. et al. (1996) Promotion of colorectal neoplasia in experimental murine ulcerative colitis. Gut, 39, 87-92.
    • (1996) Gut , vol.39 , pp. 87-92
    • Okayasu, I.1
  • 48
    • 0036051423 scopus 로고    scopus 로고
    • Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model
    • Okayasu, I. et al. (2002) Dysplasia and carcinoma development in a repeated dextran sulfate sodium-induced colitis model. J. Gastroenterol. Hepatol., 17, 1078-1083.
    • (2002) J. Gastroenterol. Hepatol. , vol.17 , pp. 1078-1083
    • Okayasu, I.1
  • 49
    • 33745396463 scopus 로고    scopus 로고
    • Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility
    • Hogan, S.P. et al. (2006) Resistin-like molecule beta regulates innate colonic function: barrier integrity and inflammation susceptibility. J. Allergy Clin. Immunol., 118, 257-268.
    • (2006) J. Allergy Clin. Immunol. , vol.118 , pp. 257-268
    • Hogan, S.P.1
  • 50
    • 0037340434 scopus 로고    scopus 로고
    • Angiogenins: a new class of microbicidal proteins involved in innate immunity
    • Hooper, L.V. et al. (2003) Angiogenins: a new class of microbicidal proteins involved in innate immunity. Nat. Immunol., 4, 269-273.
    • (2003) Nat. Immunol. , vol.4 , pp. 269-273
    • Hooper, L.V.1
  • 51
    • 0034025425 scopus 로고    scopus 로고
    • The role of the resident intestinal flora in acute and chronic dextran sulfate sodium-induced colitis in mice
    • Hans, W. et al. (2000) The role of the resident intestinal flora in acute and chronic dextran sulfate sodium-induced colitis in mice. Eur. J. Gastroenterol. Hepatol., 12, 267-273.
    • (2000) Eur. J. Gastroenterol. Hepatol. , vol.12 , pp. 267-273
    • Hans, W.1
  • 52
    • 79955564023 scopus 로고    scopus 로고
    • Intestinal inflammation and cancer
    • Ullman, T.A. et al. (2011) Intestinal inflammation and cancer. Gastroenterology, 140, 1807-1816.
    • (2011) Gastroenterology , vol.140 , pp. 1807-1816
    • Ullman, T.A.1
  • 53
    • 0030615201 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases
    • Barnes, P.J. et al. (1997) Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med., 336, 1066-1071.
    • (1997) N. Engl. J. Med. , vol.336 , pp. 1066-1071
    • Barnes, P.J.1
  • 54
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl, H.L. (1999) Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene, 18, 6853-6866.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 55
    • 33845466231 scopus 로고    scopus 로고
    • Monocyte/macrophage infiltration in tumors: modulators of angiogenesis
    • Dirkx, A.E. et al. (2006) Monocyte/macrophage infiltration in tumors: modulators of angiogenesis. J. Leukoc. Biol., 80, 1183-1196.
    • (2006) J. Leukoc. Biol. , vol.80 , pp. 1183-1196
    • Dirkx, A.E.1
  • 56
    • 47949090079 scopus 로고    scopus 로고
    • The role of myeloid cells in the promotion of tumour angiogenesis
    • Murdoch, C. et al. (2008) The role of myeloid cells in the promotion of tumour angiogenesis. Nat. Rev. Cancer, 8, 618-631.
    • (2008) Nat. Rev. Cancer , vol.8 , pp. 618-631
    • Murdoch, C.1
  • 57
    • 72849115544 scopus 로고    scopus 로고
    • Development of HIF-1 inhibitors for cancer therapy
    • Onnis, B. et al. (2009) Development of HIF-1 inhibitors for cancer therapy. J. Cell. Mol. Med., 13, 2780-2786.
    • (2009) J. Cell. Mol. Med. , vol.13 , pp. 2780-2786
    • Onnis, B.1
  • 58
    • 81855183258 scopus 로고    scopus 로고
    • Novel activity of acriflavine against colorectal cancer tumor cells
    • Hassan, S. et al. (2011) Novel activity of acriflavine against colorectal cancer tumor cells. Cancer Sci., 102, 2206-2213.
    • (2011) Cancer Sci. , vol.102 , pp. 2206-2213
    • Hassan, S.1
  • 59
    • 84861452422 scopus 로고    scopus 로고
    • Acriflavine enhances radiosensitivity of colon cancer cells through endoplasmic reticulum stress-mediated apoptosis
    • Lim, M.J. et al. (2012) Acriflavine enhances radiosensitivity of colon cancer cells through endoplasmic reticulum stress-mediated apoptosis. Int. J. Biochem. Cell Biol., 44, 1214-1222.
    • (2012) Int. J. Biochem. Cell Biol. , vol.44 , pp. 1214-1222
    • Lim, M.J.1


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