-
1
-
-
0142166332
-
Targeting HIF-1 for cancer therapy
-
Semenza G.L. Targeting HIF-1 for cancer therapy. Nat. Rev. Cancer 2003, 3:721-732.
-
(2003)
Nat. Rev. Cancer
, vol.3
, pp. 721-732
-
-
Semenza, G.L.1
-
3
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando D., Peet D.J., Gorman J.J., Whelan D.A., Whitelaw M.L., Bruick R.K. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 2002, 16:1466-1471.
-
(2002)
Genes Dev.
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
4
-
-
18544386401
-
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
-
Hewitson K.S., et al. Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J. Biol. Chem. 2002, 277:26351-26355.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 26351-26355
-
-
Hewitson, K.S.1
-
5
-
-
63049120802
-
Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins
-
Cockman M.E., Webb J.D., Kramer H.B., Kessler B.M., Ratcliffe P.J. Proteomics-based identification of novel factor inhibiting hypoxia-inducible factor (FIH) substrates indicates widespread asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. Mol. Cell. Proteomics 2009, 8:535-546.
-
(2009)
Mol. Cell. Proteomics
, vol.8
, pp. 535-546
-
-
Cockman, M.E.1
Webb, J.D.2
Kramer, H.B.3
Kessler, B.M.4
Ratcliffe, P.J.5
-
6
-
-
42149117769
-
Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways
-
Zheng X., et al. Interaction with factor inhibiting HIF-1 defines an additional mode of cross-coupling between the Notch and hypoxia signaling pathways. Proc. Natl. Acad. Sci. USA 2008, 105:3368-3373.
-
(2008)
Proc. Natl. Acad. Sci. USA
, vol.105
, pp. 3368-3373
-
-
Zheng, X.1
-
7
-
-
34548239264
-
Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor
-
Coleman M.L., et al. Asparaginyl hydroxylation of the Notch ankyrin repeat domain by factor inhibiting hypoxia-inducible factor. J. Biol. Chem. 2007, 282:24027-24038.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 24027-24038
-
-
Coleman, M.L.1
-
8
-
-
70350389957
-
FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins
-
Cockman M.E., Webb J.D., Ratcliffe P.J. FIH-dependent asparaginyl hydroxylation of ankyrin repeat domain-containing proteins. Ann. NY Acad. Sci. 2009, 1177:9-18.
-
(2009)
Ann. NY Acad. Sci.
, vol.1177
, pp. 9-18
-
-
Cockman, M.E.1
Webb, J.D.2
Ratcliffe, P.J.3
-
9
-
-
34548794831
-
ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism
-
Ferguson J.E., Wu Y., Smith K., Charles P., Powers K., Wang H., Patterson C. ASB4 is a hydroxylation substrate of FIH and promotes vascular differentiation via an oxygen-dependent mechanism. Mol. Cell. Biol. 2007, 27:6407-6419.
-
(2007)
Mol. Cell. Biol.
, vol.27
, pp. 6407-6419
-
-
Ferguson, J.E.1
Wu, Y.2
Smith, K.3
Charles, P.4
Powers, K.5
Wang, H.6
Patterson, C.7
-
10
-
-
33749518516
-
Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH)
-
Cockman M.E., et al. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc. Natl. Acad. Sci. USA 2006, 103:14767-14772.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 14767-14772
-
-
Cockman, M.E.1
-
12
-
-
2442706456
-
The ankyrin repeat as molecular architecture for protein recognition
-
Mosavi L.K., Cammett T.J., Desrosiers D.C., Peng Z.Y. The ankyrin repeat as molecular architecture for protein recognition. Protein Sci. 2004, 13:1435-1448.
-
(2004)
Protein Sci.
, vol.13
, pp. 1435-1448
-
-
Mosavi, L.K.1
Cammett, T.J.2
Desrosiers, D.C.3
Peng, Z.Y.4
-
13
-
-
34248997836
-
A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity
-
O'Dea E.L., Barken D., Peralta R.Q., Tran K.T., Werner S.L., Kearns J.D., Levchenko A., Hoffmann A. A homeostatic model of IkappaB metabolism to control constitutive NF-kappaB activity. Mol. Syst. Biol. 2007, 3:111.
-
(2007)
Mol. Syst. Biol.
, vol.3
, pp. 111
-
-
O'Dea, E.L.1
Barken, D.2
Peralta, R.Q.3
Tran, K.T.4
Werner, S.L.5
Kearns, J.D.6
Levchenko, A.7
Hoffmann, A.8
-
14
-
-
77749298990
-
Molecular mechanisms of system control of NF-kappaB signaling by IkappaBalpha
-
Ferreiro D.U., Komives E.A. Molecular mechanisms of system control of NF-kappaB signaling by IkappaBalpha. Biochemistry 2010, 49:1560-1567.
-
(2010)
Biochemistry
, vol.49
, pp. 1560-1567
-
-
Ferreiro, D.U.1
Komives, E.A.2
-
15
-
-
3042628330
-
Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution
-
Croy C.H., Bergqvist S., Huxford T., Ghosh G., Komives E.A. Biophysical characterization of the free IkappaBalpha ankyrin repeat domain in solution. Protein Sci. 2004, 13:176777.
-
(2004)
Protein Sci.
, vol.13
, pp. 176777
-
-
Croy, C.H.1
Bergqvist, S.2
Huxford, T.3
Ghosh, G.4
Komives, E.A.5
-
16
-
-
34447628760
-
Regions of IkappaBalpha that are critical for its inhibition of NF-kappaB. DNA interaction fold upon binding to NF-kappaB
-
Truhlar S.M., Torpey J.W., Komives E.A. Regions of IkappaBalpha that are critical for its inhibition of NF-kappaB. DNA interaction fold upon binding to NF-kappaB. Proc. Natl. Acad. Sci. USA 2006, 103:18951-18956.
-
(2006)
Proc. Natl. Acad. Sci. USA
, vol.103
, pp. 18951-18956
-
-
Truhlar, S.M.1
Torpey, J.W.2
Komives, E.A.3
-
17
-
-
44649146416
-
Pre-folding IkappaBalpha alters control of NF-kappaB signaling
-
Truhlar S.M.E., Mathes E., Cervantes C.F., Ghosh G., Komives E.A. Pre-folding IkappaBalpha alters control of NF-kappaB signaling. J. Mol. Biol. 2008, 380:67-82.
-
(2008)
J. Mol. Biol.
, vol.380
, pp. 67-82
-
-
Truhlar, S.M.E.1
Mathes, E.2
Cervantes, C.F.3
Ghosh, G.4
Komives, E.A.5
-
18
-
-
69749089963
-
Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function
-
Hardy A.P., Prokes I., Kelly L., Campbell I.D., Schofield C.J. Asparaginyl beta-hydroxylation of proteins containing ankyrin repeat domains influences their stability and function. J. Mol. Biol. 2009, 392:994-1006.
-
(2009)
J. Mol. Biol.
, vol.392
, pp. 994-1006
-
-
Hardy, A.P.1
Prokes, I.2
Kelly, L.3
Campbell, I.D.4
Schofield, C.J.5
-
19
-
-
33745276259
-
Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex
-
Bergqvist S., Croy C.H., Kjaergaard M., Huxford T., Ghosh G., Komives E.A. Thermodynamics reveal that helix four in the NLS of NF-kappaB p65 anchors IkappaBalpha, forming a very stable complex. J. Mol. Biol. 2006, 360:421-434.
-
(2006)
J. Mol. Biol.
, vol.360
, pp. 421-434
-
-
Bergqvist, S.1
Croy, C.H.2
Kjaergaard, M.3
Huxford, T.4
Ghosh, G.5
Komives, E.A.6
-
20
-
-
39749190672
-
Characterization of ankyrin repeat-containing proteins as substrates of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible transcription factor
-
Linke S., Hampton-Smith R.J., Peet D.J. Characterization of ankyrin repeat-containing proteins as substrates of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible transcription factor. Methods Enzymol. 2007, 435:61-85.
-
(2007)
Methods Enzymol.
, vol.435
, pp. 61-85
-
-
Linke, S.1
Hampton-Smith, R.J.2
Peet, D.J.3
-
22
-
-
0022555885
-
Determination and analysis of urea and guanidine hydrochloride denaturation curves
-
Pace C.N. Determination and analysis of urea and guanidine hydrochloride denaturation curves. Methods Enzymol. 1986, 131:266-280.
-
(1986)
Methods Enzymol.
, vol.131
, pp. 266-280
-
-
Pace, C.N.1
-
23
-
-
33845731817
-
Stabilizing IkappaBalpha by "consensus" design
-
Ferreiro D.U., Cervantes C.F., Truhlar S.M., Cho S.S., Wolynes P.G., Komives E.A. Stabilizing IkappaBalpha by "consensus" design. J. Mol. Biol. 2007, 365:1201-1216.
-
(2007)
J. Mol. Biol.
, vol.365
, pp. 1201-1216
-
-
Ferreiro, D.U.1
Cervantes, C.F.2
Truhlar, S.M.3
Cho, S.S.4
Wolynes, P.G.5
Komives, E.A.6
-
24
-
-
0032186122
-
Measurement of amide hydrogen exchange by MALDI-TOF mass spectrometry
-
Mandell J.G., Falick A.M., Komives E.A. Measurement of amide hydrogen exchange by MALDI-TOF mass spectrometry. Anal. Chem. 1998, 70:3987-3995.
-
(1998)
Anal. Chem.
, vol.70
, pp. 3987-3995
-
-
Mandell, J.G.1
Falick, A.M.2
Komives, E.A.3
-
25
-
-
43249110701
-
NF-kappaB dictates the degradation pathway of IkappaBalpha
-
Mathes E., O'Dea E.L., Hoffmann A., Ghosh G. NF-kappaB dictates the degradation pathway of IkappaBalpha. EMBO J. 2008, 27:1357-1367.
-
(2008)
EMBO J.
, vol.27
, pp. 1357-1367
-
-
Mathes, E.1
O'Dea, E.L.2
Hoffmann, A.3
Ghosh, G.4
-
26
-
-
0037044575
-
The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation
-
Hoffmann A., Levchenko A., Scott M.L., Baltimore D. The IkappaB-NF-kappaB signaling module: temporal control and selective gene activation. Science 2002, 298:1241-1245.
-
(2002)
Science
, vol.298
, pp. 1241-1245
-
-
Hoffmann, A.1
Levchenko, A.2
Scott, M.L.3
Baltimore, D.4
-
27
-
-
0031034814
-
Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells
-
Schmedtje J.F., Ji Y.S., Liu W.L., DuBois R.N., Runge M.S. Hypoxia induces cyclooxygenase-2 via the NF-kappaB p65 transcription factor in human vascular endothelial cells. J. Biol. Chem. 1997, 272:601-608.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 601-608
-
-
Schmedtje, J.F.1
Ji, Y.S.2
Liu, W.L.3
DuBois, R.N.4
Runge, M.S.5
-
28
-
-
9444252869
-
Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-kappaB: the prominent role of p42/ p44 and PI3 kinase pathways
-
Zampetaki A., Mitsialis S.A., Pfeilschifter J., Kourembanas S. Hypoxia induces macrophage inflammatory protein-2 (MIP-2) gene expression in murine macrophages via NF-kappaB: the prominent role of p42/ p44 and PI3 kinase pathways. FASEB J. 2004, 18:1090-1092.
-
(2004)
FASEB J.
, vol.18
, pp. 1090-1092
-
-
Zampetaki, A.1
Mitsialis, S.A.2
Pfeilschifter, J.3
Kourembanas, S.4
-
29
-
-
70350380469
-
From polyps to people: a highly familiar response to hypoxia
-
Hampton-Smith R.J., Peet D.J. From polyps to people: a highly familiar response to hypoxia. Ann. NY Acad. Sci. 2009, 1177:19-29.
-
(2009)
Ann. NY Acad. Sci.
, vol.1177
, pp. 19-29
-
-
Hampton-Smith, R.J.1
Peet, D.J.2
-
30
-
-
77955284188
-
The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism
-
Zhang N., et al. The asparaginyl hydroxylase factor inhibiting HIF-1alpha is an essential regulator of metabolism. Cell Metab. 2010, 11:364-378.
-
(2010)
Cell Metab.
, vol.11
, pp. 364-378
-
-
Zhang, N.1
-
31
-
-
0037066706
-
Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia
-
Dinchuk J.E., et al. Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia. J. Biol. Chem. 2002, 277:12970-12977.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 12970-12977
-
-
Dinchuk, J.E.1
|