-
1
-
-
22144493866
-
Negative and positive regulation of HIF-1: A complex network
-
Bardos, J. I. and Ashcroft, M. (2005) Negative and positive regulation of HIF-1: a complex network. Biochim. Biophys. Acta 1755, 107-120
-
(2005)
Biochim. Biophys. Acta
, vol.1755
, pp. 107-120
-
-
Bardos, J.I.1
Ashcroft, M.2
-
2
-
-
33745328509
-
HIFing the brakes: Therapeutic opportunities for treatment of human malignancies
-
Garcia, J. A. (2006) HIFing the brakes: therapeutic opportunities for treatment of human malignancies, Science STKE, PE25
-
(2006)
Science STKE
-
-
Garcia, J.A.1
-
3
-
-
11144337759
-
Hypoxia-inducible factor 1: Regulation by hypoxic and non-hypoxic activators
-
Dery, M. A., Michaud, M. D. and Richard, D. E. (2005) Hypoxia-inducible factor 1: regulation by hypoxic and non-hypoxic activators. Int. J. Biochem. Cell Biol. 37, 535-540
-
(2005)
Int. J. Biochem. Cell Biol
, vol.37
, pp. 535-540
-
-
Dery, M.A.1
Michaud, M.D.2
Richard, D.E.3
-
4
-
-
33748187417
-
Regulating cellular oxygen sensing by hydroxylation
-
Fandrey, J., Gorr, T. A. and Gassmann, M. (2006) Regulating cellular oxygen sensing by hydroxylation. Cardiovasc. Res. 71, 642-651
-
(2006)
Cardiovasc. Res
, vol.71
, pp. 642-651
-
-
Fandrey, J.1
Gorr, T.A.2
Gassmann, M.3
-
5
-
-
0041465022
-
HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
-
Berra, E., Benizri, E., Ginouves, A., Volmat, V., Roux, D. and Pouyssegur, J. (2003) HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia. EMBO J. 22, 4082-4090
-
(2003)
EMBO J
, vol.22
, pp. 4082-4090
-
-
Berra, E.1
Benizri, E.2
Ginouves, A.3
Volmat, V.4
Roux, D.5
Pouyssegur, J.6
-
6
-
-
18844408840
-
Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: Identification of a functional hypoxia-responsive element
-
Metzen, E., Stiehl, D. P., Doege, K., Marxsen, J. H., Hellwig-Bürgel, T. and Jelkmann, W. (2005) Regulation of the prolyl hydroxylase domain protein 2 (phd2/egln-1) gene: identification of a functional hypoxia-responsive element. Biochem. J. 387, 711-717
-
(2005)
Biochem. J
, vol.387
, pp. 711-717
-
-
Metzen, E.1
Stiehl, D.P.2
Doege, K.3
Marxsen, J.H.4
Hellwig-Bürgel, T.5
Jelkmann, W.6
-
7
-
-
23944454868
-
Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene
-
Pescador, N., Cuevas, Y., Naranjo, S., Alcaide, M., Villar, D., Landazuri, M. O. and Del Peso, L. (2005) Identification of a functional hypoxia-responsive element that regulates the expression of the egl nine homologue 3 (egln3/phd3) gene. Biochem. J. 390, 189-197
-
(2005)
Biochem. J
, vol.390
, pp. 189-197
-
-
Pescador, N.1
Cuevas, Y.2
Naranjo, S.3
Alcaide, M.4
Villar, D.5
Landazuri, M.O.6
Del Peso, L.7
-
8
-
-
2942627920
-
Hypoxia-dependent regulation of PHD1: Cloning and characterization of the human PHD1/EGLN2 gene promoter
-
Erez, N., Stambolsky, P., Shats, I., Milyavsky, M., Kachko, T. and Rotter, V. (2004) Hypoxia-dependent regulation of PHD1: cloning and characterization of the human PHD1/EGLN2 gene promoter. FEBS Lett. 567, 311-315
-
(2004)
FEBS Lett
, vol.567
, pp. 311-315
-
-
Erez, N.1
Stambolsky, P.2
Shats, I.3
Milyavsky, M.4
Kachko, T.5
Rotter, V.6
-
9
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando, D., Peet, D. J., Gorman, J. J., Whelan, D. A., Whitelaw, M. L. and Bruick, R. K. (2002) FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 16, 1466-1471
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
10
-
-
9444296528
-
Hyperglycemia regulates hypoxia-inducible factor-1α protein stability and function
-
Catrina, S. B., Okamoto, K., Pereira, T., Brismar, K. and Poellinger, L. (2004) Hyperglycemia regulates hypoxia-inducible factor-1α protein stability and function. Diabetes 53, 3226-3232
-
(2004)
Diabetes
, vol.53
, pp. 3226-3232
-
-
Catrina, S.B.1
Okamoto, K.2
Pereira, T.3
Brismar, K.4
Poellinger, L.5
-
11
-
-
18144391498
-
Hypoxia and angiogenesis in rheumatoid arthritis
-
Taylor, P. C. and Sivakumar, B. (2005) Hypoxia and angiogenesis in rheumatoid arthritis. Curr. Opin. Rheumatol. 17, 293-298
-
(2005)
Curr. Opin. Rheumatol
, vol.17
, pp. 293-298
-
-
Taylor, P.C.1
Sivakumar, B.2
-
12
-
-
34247187576
-
Reactive oxygen species activate the HIF-1α promoter via a functional NFκB site
-
Bonello, S., Zahringer, C., BelAiba, R. S., Djordjevic, T., Hess, J., Michiels, C., Kietzmann, T. and Gorlach, A. (2007) Reactive oxygen species activate the HIF-1α promoter via a functional NFκB site. Arterioscler. Thromb. Vasc. Biol. 27, 755-761
-
(2007)
Arterioscler. Thromb. Vasc. Biol
, vol.27
, pp. 755-761
-
-
Bonello, S.1
Zahringer, C.2
BelAiba, R.S.3
Djordjevic, T.4
Hess, J.5
Michiels, C.6
Kietzmann, T.7
Gorlach, A.8
-
13
-
-
38849199203
-
Shared principles in NF-κB signaling
-
Hayden, M. S. and Ghosh, S. (2008) Shared principles in NF-κB signaling. Cell 132, 344-362
-
(2008)
Cell
, vol.132
, pp. 344-362
-
-
Hayden, M.S.1
Ghosh, S.2
-
14
-
-
33645971047
-
Good cop, bad cop: The different faces of NF-κB
-
Perkins, N. D. and Gilmore, T. D. (2006) Good cop, bad cop: the different faces of NF-κB. Cell Death Differ. 13, 759-772
-
(2006)
Cell Death Differ
, vol.13
, pp. 759-772
-
-
Perkins, N.D.1
Gilmore, T.D.2
-
15
-
-
33750457370
-
Post-translational modifications regulating the activity and function of the nuclear factor κB pathway
-
Perkins, N. D. (2006) Post-translational modifications regulating the activity and function of the nuclear factor κB pathway. Oncogene 25, 6717-6730
-
(2006)
Oncogene
, vol.25
, pp. 6717-6730
-
-
Perkins, N.D.1
-
16
-
-
0037223362
-
Regulation of RelA (p65) function by the large subunit of replication factor C
-
Anderson, L. A. and Perkins, N. D. (2003) Regulation of RelA (p65) function by the large subunit of replication factor C. Mol. Cell. Biol. 23, 721-732
-
(2003)
Mol. Cell. Biol
, vol.23
, pp. 721-732
-
-
Anderson, L.A.1
Perkins, N.D.2
-
17
-
-
33750214678
-
Regulation of p53 tumour suppressor target gene expression by the p52 NF-κB subunit
-
Schumm, K., Rocha, S., Caamano, J. and Perkins, N. D. (2006) Regulation of p53 tumour suppressor target gene expression by the p52 NF-κB subunit. EMBO J. 25, 4820-4832
-
(2006)
EMBO J
, vol.25
, pp. 4820-4832
-
-
Schumm, K.1
Rocha, S.2
Caamano, J.3
Perkins, N.D.4
-
18
-
-
17144422434
-
Regulation of NF-κB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor
-
Rocha, S., Garrett, M. D., Campbell, K. J., Schumm, K. and Perkins, N. D. (2005) Regulation of NF-κB and p53 through activation of ATR and Chk1 by the ARF tumour suppressor. EMBO J. 24, 1157-1169
-
(2005)
EMBO J
, vol.24
, pp. 1157-1169
-
-
Rocha, S.1
Garrett, M.D.2
Campbell, K.J.3
Schumm, K.4
Perkins, N.D.5
-
19
-
-
0032167784
-
The human hypoxia-inducible factor 1α gene: HIF1A structure and evolutionary conservation
-
Iyer, N. V., Leung, S. W. and Semenza, G. L. (1998) The human hypoxia-inducible factor 1α gene: HIF1A structure and evolutionary conservation. Genomics 52, 159-165
-
(1998)
Genomics
, vol.52
, pp. 159-165
-
-
Iyer, N.V.1
Leung, S.W.2
Semenza, G.L.3
-
20
-
-
0033516997
-
HIF1A gene transcription is dependent on a core promoter sequence encompassing activating and inhibiting sequences located upstream from the transcription initiation site and cis elements located within the 5′UTR
-
Minet, E., Ernest, I., Michel, G., Roland, I., Remacle, J., Raes, M. and Michiels, C. (1999) HIF1A gene transcription is dependent on a core promoter sequence encompassing activating and inhibiting sequences located upstream from the transcription initiation site and cis elements located within the 5′UTR. Biochem. Biophys. Res. Commun. 261, 534-540
-
(1999)
Biochem. Biophys. Res. Commun
, vol.261
, pp. 534-540
-
-
Minet, E.1
Ernest, I.2
Michel, G.3
Roland, I.4
Remacle, J.5
Raes, M.6
Michiels, C.7
-
21
-
-
15444357762
-
Requirement for NF-κB in osteoclast and B-cell development
-
Franzoso, G., Carlson, L., Xing, L., Poljak, L., Shores, E. W., Brown, K. D., Leonardi, A., Tran, T., Boyce, B. F. and Siebenlist, U. (1997) Requirement for NF-κB in osteoclast and B-cell development. Genes Dev. 11, 3482-3496
-
(1997)
Genes Dev
, vol.11
, pp. 3482-3496
-
-
Franzoso, G.1
Carlson, L.2
Xing, L.3
Poljak, L.4
Shores, E.W.5
Brown, K.D.6
Leonardi, A.7
Tran, T.8
Boyce, B.F.9
Siebenlist, U.10
-
22
-
-
0030715563
-
Osteopetrosis in mice lacking NF-κB1 and NF-κB2
-
Iotsova, V., Caamano, J., Loy, J., Yang, Y., Lewin, A. and Bravo, R. (1997) Osteopetrosis in mice lacking NF-κB1 and NF-κB2. Nat. Med. 3, 1285-1289
-
(1997)
Nat. Med
, vol.3
, pp. 1285-1289
-
-
Iotsova, V.1
Caamano, J.2
Loy, J.3
Yang, Y.4
Lewin, A.5
Bravo, R.6
-
23
-
-
34547153223
-
Gene regulation under low oxygen: Holding your breath for transcription
-
Rocha, S. (2007) Gene regulation under low oxygen: holding your breath for transcription. Trends Biochem. Sci. 32, 389-397
-
(2007)
Trends Biochem. Sci
, vol.32
, pp. 389-397
-
-
Rocha, S.1
-
24
-
-
0037444823
-
Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor κB activation
-
Jung, Y., Isaacs, J. S., Lee, S., Trepel, J., Liu, Z. G. and Neckers, L. (2003) Hypoxia-inducible factor induction by tumour necrosis factor in normoxic cells requires receptor-interacting protein-dependent nuclear factor κB activation. Biochem. J. 370, 1011-1017
-
(2003)
Biochem. J
, vol.370
, pp. 1011-1017
-
-
Jung, Y.1
Isaacs, J.S.2
Lee, S.3
Trepel, J.4
Liu, Z.G.5
Neckers, L.6
-
25
-
-
33745003285
-
Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB
-
Frede, S., Stockmann, C., Freitag, P. and Fandrey, J. (2006) Bacterial lipopolysaccharide induces HIF-1 activation in human monocytes via p44/42 MAPK and NF-κB. Biochem. J. 396, 517-527
-
(2006)
Biochem. J
, vol.396
, pp. 517-527
-
-
Frede, S.1
Stockmann, C.2
Freitag, P.3
Fandrey, J.4
-
26
-
-
35648983903
-
Inflammation and cancer: An ancient link with novel potentials
-
Perwez Hussain, S. and Harris, C. C. (2007) Inflammation and cancer: an ancient link with novel potentials. Int. J. Cancer 121, 2373-2380
-
(2007)
Int. J. Cancer
, vol.121
, pp. 2373-2380
-
-
Perwez Hussain, S.1
Harris, C.C.2
-
27
-
-
15444342958
-
2 homeostasis by hypoxia-inducible factor 1α
-
2 homeostasis by hypoxia-inducible factor 1α. Genes Dev. 12, 149-162
-
(1998)
Genes Dev
, vol.12
, pp. 149-162
-
-
Iyer, N.V.1
Kotch, L.E.2
Agani, F.3
Leung, S.W.4
Laughner, E.5
Wenger, R.H.6
Gassmann, M.7
Gearhart, J.D.8
Lawler, A.M.9
Yu, A.Y.10
Semenza, G.L.11
-
28
-
-
0032100732
-
HIF-1α is required for solid tumor formation and embryonic vascularization
-
Ryan, H. E., Lo, J. and Johnson, R. S. (1998) HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J. 17, 3005-3015
-
(1998)
EMBO J
, vol.17
, pp. 3005-3015
-
-
Ryan, H.E.1
Lo, J.2
Johnson, R.S.3
-
29
-
-
0034661272
-
Complete lack of NF-κB activity in IKK1 and IKK2 double-deficient mice: Additional defect in neurulation
-
Li, Q., Estepa, G., Memet, S., Israel, A. and Verma, I. M. (2000) Complete lack of NF-κB activity in IKK1 and IKK2 double-deficient mice: additional defect in neurulation. Genes Dev. 14, 1729-1733
-
(2000)
Genes Dev
, vol.14
, pp. 1729-1733
-
-
Li, Q.1
Estepa, G.2
Memet, S.3
Israel, A.4
Verma, I.M.5
-
30
-
-
33845730779
-
Tumor necrosis factor-α increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: A potential mechanism for inflammation-induced carcinogenesis
-
Babbar, N. and Casero, Jr, R. A. (2006) Tumor necrosis factor-α increases reactive oxygen species by inducing spermine oxidase in human lung epithelial cells: a potential mechanism for inflammation-induced carcinogenesis. Cancer Res. 66, 11125-11130
-
(2006)
Cancer Res
, vol.66
, pp. 11125-11130
-
-
Babbar, N.1
Casero Jr, R.A.2
-
31
-
-
35248871643
-
Mitochondrial oxygen sensing: Regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species
-
Bell, E. L. and Chandel, N. S. (2007) Mitochondrial oxygen sensing: regulation of hypoxia-inducible factor by mitochondrial generated reactive oxygen species. Essays Biochem. 43, 17-27
-
(2007)
Essays Biochem
, vol.43
, pp. 17-27
-
-
Bell, E.L.1
Chandel, N.S.2
-
32
-
-
38149059911
-
Mitochondria and cellular oxygen sensing in the HIF pathway
-
Taylor, C. T. (2008) Mitochondria and cellular oxygen sensing in the HIF pathway. Biochem. J. 409, 19-26
-
(2008)
Biochem. J
, vol.409
, pp. 19-26
-
-
Taylor, C.T.1
|