-
1
-
-
85029306612
-
-
World Health Organization WHO available at
-
World Health Organization. Fact Sheet: World Malaria Report 2016 (WHO, 2016); available at http://www.who.int/malaria/media/world-malaria-report-2016/en/.
-
(2016)
Fact Sheet: World Malaria Report 2016
-
-
-
2
-
-
84894101665
-
Malaria
-
White, N.J., et al. Malaria. Lancet 383, 723-735 (2014).
-
(2014)
Lancet
, vol.383
, pp. 723-735
-
-
White, N.J.1
-
3
-
-
84989243768
-
Artemisinin resistance-modelling the potential human and economic costs
-
Lubell, Y., et al. Artemisinin resistance-modelling the potential human and economic costs. Malar. J. 13, 452 (2014).
-
(2014)
Malar. J.
, vol.13
, pp. 452
-
-
Lubell, Y.1
-
4
-
-
84907567820
-
The peculiarities and paradoxes of Plasmodium heme metabolism
-
Sigala, P.A., Goldberg, D.E. The peculiarities and paradoxes of Plasmodium heme metabolism. Annu. Rev. Microbiol. 68, 259-278 (2014).
-
(2014)
Annu. Rev. Microbiol.
, vol.68
, pp. 259-278
-
-
Sigala, P.A.1
Goldberg, D.E.2
-
5
-
-
84872543098
-
Insights into the role of heme in the mechanism of action of antimalarials
-
Combrinck, J.M., et al. Insights into the role of heme in the mechanism of action of antimalarials. ACS Chem. Biol. 8, 133-137 (2013).
-
(2013)
ACS Chem. Biol.
, vol.8
, pp. 133-137
-
-
Combrinck, J.M.1
-
6
-
-
84991594101
-
Artemisinin action and resistance in Plasmodium falciparum
-
Tilley, L., Straimer, J., Gnädig, N.F., Ralph, S.A., Fidock, D.A. Artemisinin action and resistance in Plasmodium falciparum. Trends Parasitol. 32, 682-696 (2016).
-
(2016)
Trends Parasitol.
, vol.32
, pp. 682-696
-
-
Tilley, L.1
Straimer, J.2
Gnädig, N.F.3
Ralph, S.A.4
Fidock, D.A.5
-
7
-
-
84875498942
-
Altered temporal response of malaria parasites determines differential sensitivity to artemisinin
-
Klonis, N., et al. Altered temporal response of malaria parasites determines differential sensitivity to artemisinin. Proc. Natl. Acad. Sci. USA 110, 5157-5162 (2013).
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 5157-5162
-
-
Klonis, N.1
-
8
-
-
84957801889
-
Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
-
Xie, S.C., et al. Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins. J. Cell Sci. 129, 406-416 (2016).
-
(2016)
J. Cell Sci.
, vol.129
, pp. 406-416
-
-
Xie, S.C.1
-
9
-
-
70350526982
-
Artemisinin resistance in Plasmodium falciparum malaria
-
Dondorp, A.M., et al. Artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 361, 455-467 (2009).
-
(2009)
N. Engl. J. Med.
, vol.361
, pp. 455-467
-
-
Dondorp, A.M.1
-
10
-
-
57749099137
-
Evidence of artemisinin-resistant malaria in western Cambodia
-
Noedl, H., et al. Evidence of artemisinin-resistant malaria in western Cambodia. N. Engl. J. Med. 359, 2619-2620 (2008).
-
(2008)
N. Engl. J. Med.
, vol.359
, pp. 2619-2620
-
-
Noedl, H.1
-
11
-
-
84930526538
-
Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: A modelling approach
-
White, L.J., et al. Defining the in vivo phenotype of artemisinin-resistant falciparum malaria: A modelling approach. PLoS Med. 12, e1001823 (2015).
-
(2015)
PLoS Med.
, vol.12
, pp. e1001823
-
-
White, L.J.1
-
12
-
-
78651077288
-
Intrahost modeling of artemisinin resistance in Plasmodium falciparum
-
Saralamba, S., et al. Intrahost modeling of artemisinin resistance in Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 108, 397-402 (2011).
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 397-402
-
-
Saralamba, S.1
-
13
-
-
84887622121
-
Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: In-vitro and ex-vivo drug-response studies
-
Witkowski, B., et al. Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: In-vitro and ex-vivo drug-response studies. Lancet Infect. Dis. 13, 1043-1049 (2013).
-
(2013)
Lancet Infect. Dis.
, vol.13
, pp. 1043-1049
-
-
Witkowski, B.1
-
14
-
-
84892372929
-
A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
-
Ariey, F., et al. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature 505, 50-55 (2014).
-
(2014)
Nature
, vol.505
, pp. 50-55
-
-
Ariey, F.1
-
15
-
-
84905746811
-
Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system
-
Ghorbal, M., et al. Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system. Nat. Biotechnol. 32, 819-821 (2014).
-
(2014)
Nat. Biotechnol.
, vol.32
, pp. 819-821
-
-
Ghorbal, M.1
-
16
-
-
84921719133
-
K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
-
Straimer, J., et al. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates. Science 347, 428-431 (2015).
-
(2015)
Science
, vol.347
, pp. 428-431
-
-
Straimer, J.1
-
17
-
-
84904892931
-
Spread of artemisinin resistance in Plasmodium falciparum malaria
-
Ashley, E.A., et al. Spread of artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 371, 411-423 (2014).
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 411-423
-
-
Ashley, E.A.1
-
18
-
-
84924080547
-
Genetic architecture of artemisinin-resistant Plasmodium falciparum
-
Miotto, O., et al. Genetic architecture of artemisinin-resistant Plasmodium falciparum. Nat. Genet. 47, 226-234 (2015).
-
(2015)
Nat. Genet.
, vol.47
, pp. 226-234
-
-
Miotto, O.1
-
19
-
-
84942326846
-
Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia
-
Takala-Harrison, S., et al. Independent emergence of artemisinin resistance mutations among Plasmodium falciparum in Southeast Asia. J. Infect. Dis. 211, 670-679 (2015).
-
(2015)
J. Infect. Dis.
, vol.211
, pp. 670-679
-
-
Takala-Harrison, S.1
-
20
-
-
85029288235
-
MalariaGEN Plasmodium falciparum Community Project Genomic epidemiology of artemisinin resistant malaria
-
Malaria, G.E.N.P.C.P. MalariaGEN Plasmodium falciparum Community Project. Genomic epidemiology of artemisinin resistant malaria. eLife 5, e08714 (2016).
-
(2016)
ELife
, vol.5
, pp. e08714
-
-
Malaria, G.E.N.P.C.P.1
-
21
-
-
84975522970
-
A worldwide map of Plasmodium falciparum K13-propeller polymorphisms
-
Ménard, D., et al. A worldwide map of Plasmodium falciparum K13-propeller polymorphisms. N. Engl. J. Med. 374, 2453-2464 (2016).
-
(2016)
N. Engl. J. Med.
, vol.374
, pp. 2453-2464
-
-
Ménard, D.1
-
22
-
-
84995428289
-
Declining efficacy of artemisinin combination therapy against P. Falciparum malaria on the Thai-Myanmar border (2003-2013): The role of parasite genetic factors
-
Phyo, A.P., et al. Declining efficacy of artemisinin combination therapy against P. falciparum malaria on the Thai-Myanmar border (2003-2013): The role of parasite genetic factors. Clin. Infect. Dis. 63, 784-791 (2016).
-
(2016)
Clin. Infect. Dis.
, vol.63
, pp. 784-791
-
-
Phyo, A.P.1
-
23
-
-
85014952620
-
Population parameters underlying an ongoing soft sweep in Southeast Asian malaria parasites
-
Anderson, T.J., et al. Population parameters underlying an ongoing soft sweep in Southeast Asian malaria parasites. Mol. Biol. Evol. 34, 131-144 (2017).
-
(2017)
Mol. Biol. Evol.
, vol.34
, pp. 131-144
-
-
Anderson, T.J.1
-
24
-
-
85011304306
-
The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: A molecular epidemiology observational study
-
Imwong, M., et al. The spread of artemisinin-resistant Plasmodium falciparum in the Greater Mekong subregion: A molecular epidemiology observational study. Lancet Infect. Dis. 17, 491-497 (2017).
-
(2017)
Lancet Infect. Dis.
, vol.17
, pp. 491-497
-
-
Imwong, M.1
-
25
-
-
85015708924
-
Emergence of indigenous artemisinin-resistant Plasmodium falciparum in Africa
-
Lu, F., et al. Emergence of indigenous artemisinin-resistant Plasmodium falciparum in Africa. N. Engl. J. Med. 376, 991-993 (2017).
-
(2017)
N. Engl. J. Med.
, vol.376
, pp. 991-993
-
-
Lu, F.1
-
26
-
-
84921785363
-
Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance
-
Mok, S., et al. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance. Science 347, 431-435 (2015).
-
(2015)
Science
, vol.347
, pp. 431-435
-
-
Mok, S.1
-
27
-
-
84929493850
-
Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance
-
Dogovski, C., et al. Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance. PLoS Biol. 13, e1002132 (2015).
-
(2015)
PLoS Biol.
, vol.13
, pp. e1002132
-
-
Dogovski, C.1
-
28
-
-
84928814749
-
A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria
-
Mbengue, A., et al. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature 520, 683-687 (2015).
-
(2015)
Nature
, vol.520
, pp. 683-687
-
-
Mbengue, A.1
-
29
-
-
84869183087
-
Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites
-
Bhattacharjee, S., Stahelin, R.V., Haldar, K. Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites. Trends Parasitol. 28, 555-562 (2012).
-
(2012)
Trends Parasitol.
, vol.28
, pp. 555-562
-
-
Bhattacharjee, S.1
Stahelin, R.V.2
Haldar, K.3
-
30
-
-
85019160600
-
Plasmodium falciparum K13 mutations differentially impact ozonide susceptibility and parasite fitness in vitro
-
Straimer, J., et al. Plasmodium falciparum K13 mutations differentially impact ozonide susceptibility and parasite fitness in vitro. mBio 8, e00172-17 (2017).
-
(2017)
MBio
, vol.8
, pp. e00172-e00217
-
-
Straimer, J.1
-
31
-
-
84945157328
-
Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa
-
St Laurent, B., et al. Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa. Nat. Commun. 6, 8614 (2015).
-
(2015)
Nat. Commun.
, vol.6
, pp. 8614
-
-
St Laurent, B.1
-
32
-
-
33845663264
-
Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand
-
Uhlemann, A.C., et al. Intrahost selection of Plasmodium falciparum pfmdr1 alleles after antimalarial treatment on the northwestern border of Thailand. J. Infect. Dis. 195, 134-141 (2007).
-
(2007)
J. Infect. Dis.
, vol.195
, pp. 134-141
-
-
Uhlemann, A.C.1
-
33
-
-
33746302565
-
Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin
-
Sidhu, A.B.S., et al. Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. J. Infect. Dis. 194, 528-535 (2006).
-
(2006)
J. Infect. Dis.
, vol.194
, pp. 528-535
-
-
Sidhu, A.B.S.1
-
34
-
-
84888081678
-
In vitro piperaquine susceptibility is not associated with the Plasmodium falciparum chloroquine resistance transporter gene
-
Pascual, A., et al. In vitro piperaquine susceptibility is not associated with the Plasmodium falciparum chloroquine resistance transporter gene. Malar. J. 12, 431 (2013).
-
(2013)
Malar. J.
, vol.12
, pp. 431
-
-
Pascual, A.1
-
35
-
-
84935754128
-
Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter
-
Petersen, I., et al. Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter. Mol. Microbiol. 97, 381-395 (2015).
-
(2015)
Mol. Microbiol.
, vol.97
, pp. 381-395
-
-
Petersen, I.1
-
36
-
-
84904861610
-
Dihydroartemisinin-piperaquine failure in Cambodia
-
Saunders, D.L., Vanachayangkul, P., Lon, C. Dihydroartemisinin-piperaquine failure in Cambodia. N. Engl. J. Med. 371, 484-485 (2014).
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 484-485
-
-
Saunders, D.L.1
Vanachayangkul, P.2
Lon, C.3
-
37
-
-
84951744000
-
Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: Retrospective and prospective investigations
-
Duru, V., et al. Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: Retrospective and prospective investigations. BMC Med. 13, 305 (2015).
-
(2015)
BMC Med.
, vol.13
, pp. 305
-
-
Duru, V.1
-
38
-
-
84959170188
-
Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: A multisite prospective cohort study
-
Amaratunga, C., et al. Dihydroartemisinin-piperaquine resistance in Plasmodium falciparum malaria in Cambodia: A multisite prospective cohort study. Lancet Infect. Dis. 16, 357-365 (2016).
-
(2016)
Lancet Infect. Dis.
, vol.16
, pp. 357-365
-
-
Amaratunga, C.1
-
39
-
-
85006176728
-
Genetic markers associated with dihydroartemisinin-piperaquine failure in Plasmodium falciparum malaria in Cambodia: A genotype-phenotype association study
-
Amato, R., et al. Genetic markers associated with dihydroartemisinin-piperaquine failure in Plasmodium falciparum malaria in Cambodia: A genotype-phenotype association study. Lancet Infect. Dis. 17, 164-173 (2017).
-
(2017)
Lancet Infect. Dis.
, vol.17
, pp. 164-173
-
-
Amato, R.1
-
40
-
-
85006173671
-
A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: A phenotype-genotype association study
-
Witkowski, B., et al. A surrogate marker of piperaquine-resistant Plasmodium falciparum malaria: A phenotype-genotype association study. Lancet Infect. Dis. 17, 174-183 (2017).
-
(2017)
Lancet Infect. Dis.
, vol.17
, pp. 174-183
-
-
Witkowski, B.1
-
41
-
-
85022328720
-
A variant PfCRT isoform can contribute to Plasmodium falciparum resistance to the first-line partner drug piperaquine
-
Dhingra, S.K., et al. A variant PfCRT isoform can contribute to Plasmodium falciparum resistance to the first-line partner drug piperaquine. MBio 8, e00303-17 (2017).
-
(2017)
Mbio
, vol.8
, pp. e00303-e00317
-
-
Dhingra, S.K.1
-
42
-
-
79960306786
-
Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites
-
Eastman, R.T., Dharia, N.V., Winzeler, E.A., Fidock, D.A. Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites. Antimicrob. Agents Chemother. 55, 3908-3916 (2011).
-
(2011)
Antimicrob. Agents Chemother.
, vol.55
, pp. 3908-3916
-
-
Eastman, R.T.1
Dharia, N.V.2
Winzeler, E.A.3
Fidock, D.A.4
-
43
-
-
19344374172
-
The origins and spread of antimalarial drug resistance: Lessons for policy makers
-
Anderson, T.J., Roper, C. The origins and spread of antimalarial drug resistance: Lessons for policy makers. Acta Trop. 94, 269-280 (2005).
-
(2005)
Acta Trop.
, vol.94
, pp. 269-280
-
-
Anderson, T.J.1
Roper, C.2
-
44
-
-
0034978186
-
The public health impact of chloroquine resistance in Africa
-
Trape, J.F. The public health impact of chloroquine resistance in Africa. Am. J. Trop. Med. Hyg. 64 (Suppl. 1-2), 12-17 (2001).
-
(2001)
Am. J. Trop. Med. Hyg.
, vol.64
, pp. 12-17
-
-
Trape, J.F.1
-
45
-
-
85013745617
-
The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread
-
Woodrow, C.J., White, N.J. The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread. FEMS Microbiol. Rev. 41, 34-48 (2017).
-
(2017)
FEMS Microbiol. Rev.
, vol.41
, pp. 34-48
-
-
Woodrow, C.J.1
White, N.J.2
-
46
-
-
84904894267
-
The origins of antimalarial-drug resistance
-
Packard, R.M. The origins of antimalarial-drug resistance. N. Engl. J. Med. 371, 397-399 (2014).
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 397-399
-
-
Packard, R.M.1
-
47
-
-
70449732094
-
Artemisinin-based combination therapies: A vital tool in efforts to eliminate malaria
-
Eastman, R.T., Fidock, D.A. Artemisinin-based combination therapies: A vital tool in efforts to eliminate malaria. Nat. Rev. Microbiol. 7, 864-874 (2009).
-
(2009)
Nat. Rev. Microbiol.
, vol.7
, pp. 864-874
-
-
Eastman, R.T.1
Fidock, D.A.2
-
48
-
-
10744233894
-
Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria
-
Djimdé, A.A., et al. Clearance of drug-resistant parasites as a model for protective immunity in Plasmodium falciparum malaria. Am. J. Trop. Med. Hyg. 69, 558-563 (2003).
-
(2003)
Am. J. Trop. Med. Hyg.
, vol.69
, pp. 558-563
-
-
Djimdé, A.A.1
-
49
-
-
84878481415
-
Hemoglobinopathies: Slicing the Gordian knot of Plasmodium falciparum malaria pathog-nesis
-
Taylor, S.M., Cerami, C., Fairhurst, R.M. Hemoglobinopathies: Slicing the Gordian knot of Plasmodium falciparum malaria pathogenesis. PLoS Pathog. 9, e1003327 (2013).
-
(2013)
PLoS Pathog.
, vol.9
, pp. e1003327
-
-
Taylor, S.M.1
Cerami, C.2
Fairhurst, R.M.3
-
50
-
-
84908885451
-
Reappraisal of known malaria resistance loci in a large multicenter study
-
Rockett, K.A., et al. Reappraisal of known malaria resistance loci in a large multicenter study. Nat. Genet. 46, 1197-1204 (2014).
-
(2014)
Nat. Genet.
, vol.46
, pp. 1197-1204
-
-
Rockett, K.A.1
-
51
-
-
84896485226
-
Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential
-
Antoine, T., et al. Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential. J. Antimicrob. Chemother. 69, 1005-1016 (2014).
-
(2014)
J. Antimicrob. Chemother.
, vol.69
, pp. 1005-1016
-
-
Antoine, T.1
-
52
-
-
84994527573
-
Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes
-
Cyrklaff, M., et al. Oxidative insult can induce malaria-protective trait of sickle and fetal erythrocytes. Nat. Commun. 7, 13401 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 13401
-
-
Cyrklaff, M.1
-
53
-
-
85019950581
-
Oxidative stress in malaria and artemisinin combination therapy: Pros and cons
-
Kavishe, R.A., Koenderink, J.B., Alifrangis, M. Oxidative stress in malaria and artemisinin combination therapy: Pros and cons. FEBS J. http://dx.doi.org/10.1111/febs.14097 (2017).
-
(2017)
FEBS J.
-
-
Kavishe, R.A.1
Koenderink, J.B.2
Alifrangis, M.3
-
54
-
-
85017110367
-
Association of glucose-6-phosphate dehydrogenase deficiency and malaria: A systematic review and meta-analysis
-
Mbanefo, E.C., et al. Association of glucose-6-phosphate dehydrogenase deficiency and malaria: A systematic review and meta-analysis. Sci. Rep. 7, 45963 (2017).
-
(2017)
Sci. Rep.
, vol.7
, pp. 45963
-
-
Mbanefo, E.C.1
-
55
-
-
0030829371
-
Variations in frequencies of drug resistance in Plasmodium falciparum
-
Rathod, P.K., McErlean, T., Lee, P.C. Variations in frequencies of drug resistance in Plasmodium falciparum. Proc. Natl. Acad. Sci. USA 94, 9389-9393 (1997).
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 9389-9393
-
-
Rathod, P.K.1
McErlean, T.2
Lee, P.C.3
-
56
-
-
84874788696
-
Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families
-
Bopp, S.E., et al. Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families. PLoS Genet. 9, e1003293 (2013).
-
(2013)
PLoS Genet.
, vol.9
, pp. e1003293
-
-
Bopp, S.E.1
-
57
-
-
84919667206
-
Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosis
-
Claessens, A., et al. Generation of antigenic diversity in Plasmodium falciparum by structured rearrangement of Var genes during mitosis. PLoS Genet. 10, e1004812 (2014).
-
(2014)
PLoS Genet.
, vol.10
, pp. e1004812
-
-
Claessens, A.1
-
58
-
-
84964665932
-
Evidence of a mild mutator phenotype in Cambodian Plasmodium falciparum malaria parasites
-
Lee, A.H., Fidock, D.A. Evidence of a mild mutator phenotype in Cambodian Plasmodium falciparum malaria parasites. PLoS One 11, e0154166 (2016).
-
(2016)
PLoS One
, vol.11
, pp. e0154166
-
-
Lee, A.H.1
Fidock, D.A.2
-
59
-
-
84878715473
-
Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
-
Miotto, O., et al. Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nat. Genet. 45, 648-655 (2013).
-
(2013)
Nat. Genet.
, vol.45
, pp. 648-655
-
-
Miotto, O.1
-
60
-
-
14144253009
-
Mechanisms of resistance of malaria parasites to antifolates
-
Gregson, A., Plowe, C.V. Mechanisms of resistance of malaria parasites to antifolates. Pharmacol. Rev. 57, 117-145 (2005).
-
(2005)
Pharmacol. Rev.
, vol.57
, pp. 117-145
-
-
Gregson, A.1
Plowe, C.V.2
-
61
-
-
55449133690
-
Adaptive copy number evolution in malaria parasites
-
Nair, S., et al. Adaptive copy number evolution in malaria parasites. PLoS Genet. 4, e1000243 (2008).
-
(2008)
PLoS Genet.
, vol.4
, pp. e1000243
-
-
Nair, S.1
-
62
-
-
84903750991
-
Origin of robustness in generating drug-resistant malaria parasites
-
Kümpornsin, K., et al. Origin of robustness in generating drug-resistant malaria parasites. Mol. Biol. Evol. 31, 1649-1660 (2014).
-
(2014)
Mol. Biol. Evol.
, vol.31
, pp. 1649-1660
-
-
Kümpornsin, K.1
-
63
-
-
84989172969
-
Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda
-
Kateera, F., et al. Molecular surveillance of Plasmodium falciparum drug resistance markers reveals partial recovery of chloroquine susceptibility but sustained sulfadoxine-pyrimethamine resistance at two sites of different malaria transmission intensities in Rwanda. Acta Trop. 164, 329-336 (2016).
-
(2016)
Acta Trop.
, vol.164
, pp. 329-336
-
-
Kateera, F.1
-
64
-
-
84992187924
-
Cost effectiveness of intermittent screening followed by treatment versus intermittent preventive treatment during pregnancy in West Africa: Analysis and modelling of results from a non-inferiority trial
-
Fernandes, S., et al. Cost effectiveness of intermittent screening followed by treatment versus intermittent preventive treatment during pregnancy in West Africa: Analysis and modelling of results from a non-inferiority trial. Malar. J. 15, 493 (2016).
-
(2016)
Malar. J.
, vol.15
, pp. 493
-
-
Fernandes, S.1
-
65
-
-
84960414013
-
Dihydroartemisinin-piperaquine for the prevention of malaria in pregnancy
-
Kakuru, A., et al. Dihydroartemisinin-piperaquine for the prevention of malaria in pregnancy. N. Engl. J. Med. 374, 928-939 (2016).
-
(2016)
N. Engl. J. Med.
, vol.374
, pp. 928-939
-
-
Kakuru, A.1
-
66
-
-
84992111218
-
Seasonal malaria chemoprevention with sulphadoxine-pyrimethamine and amodiaquine selects pfdhfr-dhps quintuple mutant genotype in Mali
-
Maiga, H., et al. Seasonal malaria chemoprevention with sulphadoxine-pyrimethamine and amodiaquine selects pfdhfr-dhps quintuple mutant genotype in Mali. PLoS One 11, e0162718 (2016).
-
(2016)
PLoS One
, vol.11
, pp. e0162718
-
-
Maiga, H.1
-
67
-
-
84867653932
-
Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target
-
Yuthavong, Y., et al. Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target. Proc. Natl. Acad. Sci. USA 109, 16823-16828 (2012).
-
(2012)
Proc. Natl. Acad. Sci. USA
, vol.109
, pp. 16823-16828
-
-
Yuthavong, Y.1
-
68
-
-
0030023406
-
Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand
-
Looareesuwan, S., et al. Clinical studies of atovaquone, alone or in combination with other antimalarial drugs, for treatment of acute uncomplicated malaria in Thailand. Am. J. Trop. Med. Hyg. 54, 62-66 (1996).
-
(1996)
Am. J. Trop. Med. Hyg.
, vol.54
, pp. 62-66
-
-
Looareesuwan, S.1
-
69
-
-
84907681239
-
The diminishing returns of atovaquone-proguanil for elimination of Plasmodium falciparum malaria: Modelling mass drug administration and treatment
-
Maude, R.J., Nguon, C., Dondorp, A.M., White, L.J., White, N.J. The diminishing returns of atovaquone-proguanil for elimination of Plasmodium falciparum malaria: Modelling mass drug administration and treatment. Malar. J. 13, 380 (2014).
-
(2014)
Malar. J.
, vol.13
, pp. 380
-
-
Maude, R.J.1
Nguon, C.2
Dondorp, A.M.3
White, L.J.4
White, N.J.5
-
70
-
-
84960332651
-
Atovaquone-proguanil remains a potential stopgap therapy for multidrug-resistant Plasmodium falciparum in areas along the Thai-Cambodian border
-
Saunders, D.L., et al. Atovaquone-proguanil remains a potential stopgap therapy for multidrug-resistant Plasmodium falciparum in areas along the Thai-Cambodian border. Antimicrob. Agents Chemother. 60, 1896-1898 (2016).
-
(2016)
Antimicrob. Agents Chemother.
, vol.60
, pp. 1896-1898
-
-
Saunders, D.L.1
-
71
-
-
84902007671
-
Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action
-
Birth, D., Kao, W.C., Hunte, C. Structural analysis of atovaquone-inhibited cytochrome bc1 complex reveals the molecular basis of antimalarial drug action. Nat. Commun. 5, 4029 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 4029
-
-
Birth, D.1
Kao, W.C.2
Hunte, C.3
-
72
-
-
84924404654
-
Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex
-
Siregar, J.E., et al. Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex. Parasitol. Int. 64, 295-300 (2015).
-
(2015)
Parasitol. Int.
, vol.64
, pp. 295-300
-
-
Siregar, J.E.1
-
73
-
-
33847398001
-
Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum
-
Painter, H.J., Morrisey, J.M., Mather, M.W., Vaidya, A.B. Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparum. Nature 446, 88-91 (2007).
-
(2007)
Nature
, vol.446
, pp. 88-91
-
-
Painter, H.J.1
Morrisey, J.M.2
Mather, M.W.3
Vaidya, A.B.4
-
74
-
-
84866975784
-
Naphthoquinones: Atovaquone, and other antimalarials targeting mitochondrial functions
-
eds. Staines, H.M., Krishna, S. Springer, Basel
-
Vaidya, A.B. Naphthoquinones: Atovaquone, and other antimalarials targeting mitochondrial functions. in Treatment and Prevention of Malaria (eds. Staines, H.M., Krishna, S.) 127-139 (Springer, Basel, 2012).
-
(2012)
Treatment and Prevention of Malaria
, pp. 127-139
-
-
Vaidya, A.B.1
-
75
-
-
18944385296
-
Emergence of atovaquone-proguanil resistance during treatment of Plasmodium falciparum malaria acquired by a non-immune north American traveller to west Africa
-
Kuhn, S., Gill, M.J., Kain, K.C. Emergence of atovaquone-proguanil resistance during treatment of Plasmodium falciparum malaria acquired by a non-immune north American traveller to west Africa. Am. J. Trop. Med. Hyg. 72, 407-409 (2005).
-
(2005)
Am. J. Trop. Med. Hyg.
, vol.72
, pp. 407-409
-
-
Kuhn, S.1
Gill, M.J.2
Kain, K.C.3
-
76
-
-
34249698953
-
Efficacy of atovaquone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand
-
Krudsood, S., et al. Efficacy of atovaquone-proguanil for treatment of acute multidrug-resistant Plasmodium falciparum malaria in Thailand. Am. J. Trop. Med. Hyg. 76, 655-658 (2007).
-
(2007)
Am. J. Trop. Med. Hyg.
, vol.76
, pp. 655-658
-
-
Krudsood, S.1
-
77
-
-
34547757436
-
Parallel evolution of adaptive mutations in Plasmodium falciparum mitochondrial DNA during atovaquone-proguanil treatment
-
Musset, L., Le Bras, J., Clain, J. Parallel evolution of adaptive mutations in Plasmodium falciparum mitochondrial DNA during atovaquone-proguanil treatment. Mol. Biol. Evol. 24, 1582-1585 (2007).
-
(2007)
Mol. Biol. Evol.
, vol.24
, pp. 1582-1585
-
-
Musset, L.1
Le Bras, J.2
Clain, J.3
-
78
-
-
60349110965
-
Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil
-
Sutherland, C.J., et al. Mutations in the Plasmodium falciparum cytochrome b gene are associated with delayed parasite recrudescence in malaria patients treated with atovaquone-proguanil. Malar. J. 7, 240 (2008).
-
(2008)
Malar. J.
, vol.7
, pp. 240
-
-
Sutherland, C.J.1
-
79
-
-
84877140359
-
Antimalarial pharmacology and therapeutics of atovaquone
-
Nixon, G.L., et al. Antimalarial pharmacology and therapeutics of atovaquone. J. Antimicrob. Chemother. 68, 977-985 (2013).
-
(2013)
J. Antimicrob. Chemother.
, vol.68
, pp. 977-985
-
-
Nixon, G.L.1
-
80
-
-
84858959356
-
Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression
-
Fisher, N., et al. Cytochrome b mutation Y268S conferring atovaquone resistance phenotype in malaria parasite results in reduced parasite bc1 catalytic turnover and protein expression. J. Biol. Chem. 287, 9731-9741 (2012).
-
(2012)
J. Biol. Chem.
, vol.287
, pp. 9731-9741
-
-
Fisher, N.1
-
81
-
-
84923252569
-
Molecular characterization of the cytochrome b gene and in vitro atovaquone susceptibility of Plasmodium falciparum isolates from Kenya
-
Ingasia, L.A., et al. Molecular characterization of the cytochrome b gene and in vitro atovaquone susceptibility of Plasmodium falciparum isolates from Kenya. Antimicrob. Agents Chemother. 59, 1818-1821 (2015).
-
(2015)
Antimicrob. Agents Chemother.
, vol.59
, pp. 1818-1821
-
-
Ingasia, L.A.1
-
82
-
-
84905401074
-
Emergence of resistance to atovaquone-proguanil in malaria parasites: Insights from computational modeling and clinical case reports
-
Cottrell, G., Musset, L., Hubert, V., Le Bras, J., Clain, J. Emergence of resistance to atovaquone-proguanil in malaria parasites: Insights from computational modeling and clinical case reports. Antimicrob. Agents Chemother. 58, 4504-4514 (2014).
-
(2014)
Antimicrob. Agents Chemother.
, vol.58
, pp. 4504-4514
-
-
Cottrell, G.1
Musset, L.2
Hubert, V.3
Le Bras, J.4
Clain, J.5
-
83
-
-
85006041878
-
Is the mitochondrion a good malaria drug target
-
Goodman, C.D., Buchanan, H.D., McFadden, G.I. Is the mitochondrion a good malaria drug target Trends Parasitol. 33, 185-193 (2017).
-
(2017)
Trends Parasitol
, vol.33
, pp. 185-193
-
-
Goodman, C.D.1
Buchanan, H.D.2
McFadden, G.I.3
-
84
-
-
0032781364
-
Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites
-
Srivastava, I.K., Morrisey, J.M., Darrouzet, E., Daldal, F., Vaidya, A.B. Resistance mutations reveal the atovaquone-binding domain of cytochrome b in malaria parasites. Mol. Microbiol. 33, 704-711 (1999).
-
(1999)
Mol. Microbiol.
, vol.33
, pp. 704-711
-
-
Srivastava, I.K.1
Morrisey, J.M.2
Darrouzet, E.3
Daldal, F.4
Vaidya, A.B.5
-
85
-
-
0033931237
-
Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site
-
Korsinczky, M., et al. Mutations in Plasmodium falciparum cytochrome b that are associated with atovaquone resistance are located at a putative drug-binding site. Antimicrob. Agents Chemother. 44, 2100-2108 (2000).
-
(2000)
Antimicrob. Agents Chemother.
, vol.44
, pp. 2100-2108
-
-
Korsinczky, M.1
-
86
-
-
3042686652
-
Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: Rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker
-
Schwöbel, B., Alifrangis, M., Salanti, A., Jelinek, T. Different mutation patterns of atovaquone resistance to Plasmodium falciparum in vitro and in vivo: Rapid detection of codon 268 polymorphisms in the cytochrome b as potential in vivo resistance marker. Malar. J. 2, 5 (2003).
-
(2003)
Malar. J.
, vol.2
, pp. 5
-
-
Schwöbel, B.1
Alifrangis, M.2
Salanti, A.3
Jelinek, T.4
-
87
-
-
84963727426
-
Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes
-
Goodman, C.D., et al. Parasites resistant to the antimalarial atovaquone fail to transmit by mosquitoes. Science 352, 349-353 (2016).
-
(2016)
Science
, vol.352
, pp. 349-353
-
-
Goodman, C.D.1
-
88
-
-
79952732772
-
Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
-
Charman, S.A., et al. Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proc. Natl. Acad. Sci. USA 108, 4400-4405 (2011).
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. 4400-4405
-
-
Charman, S.A.1
-
89
-
-
84994486632
-
Endoperoxide drug cross-resistance patterns for Plasmodium falciparum exhibiting an artemisinin delayed-clearance phenotype
-
Siriwardana, A., Iyengar, K., Roepe, P.D. Endoperoxide drug cross-resistance patterns for Plasmodium falciparum exhibiting an artemisinin delayed-clearance phenotype. Antimicrob. Agents Chemother. 60, 6952-6956 (2016).
-
(2016)
Antimicrob. Agents Chemother.
, vol.60
, pp. 6952-6956
-
-
Siriwardana, A.1
Iyengar, K.2
Roepe, P.D.3
-
90
-
-
84979517803
-
Comparison of the exposure time dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wild-type and mutant Plasmodium falciparum strains
-
Yang, T., et al. Comparison of the exposure time dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wild-type and mutant Plasmodium falciparum strains. Antimicrob. Agents Chemother. 60, 4501-4510 (2016).
-
(2016)
Antimicrob. Agents Chemother.
, vol.60
, pp. 4501-4510
-
-
Yang, T.1
-
91
-
-
85010952887
-
In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate
-
Baumgärtner, F., et al. In vitro activity of anti-malarial ozonides against an artemisinin-resistant isolate. Malar. J. 16, 45 (2017).
-
(2017)
Malar. J.
, vol.16
, pp. 45
-
-
Baumgärtner, F.1
-
92
-
-
84964384823
-
Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: An open-label phase 2 trial
-
Phyo, A.P., et al. Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: An open-label phase 2 trial. Lancet Infect. Dis. 16, 61-69 (2016).
-
(2016)
Lancet Infect. Dis.
, vol.16
, pp. 61-69
-
-
Phyo, A.P.1
-
93
-
-
84925354867
-
Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: A cross-sectional survey of the K13 molecular marker
-
Tun, K.M., et al. Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: A cross-sectional survey of the K13 molecular marker. Lancet Infect. Dis. 15, 415-421 (2015).
-
(2015)
Lancet Infect. Dis.
, vol.15
, pp. 415-421
-
-
Tun, K.M.1
-
94
-
-
85000348667
-
Emerging polymorphisms in falciparum Kelch 13 gene in Northeastern region of India
-
Mishra, N., et al. Emerging polymorphisms in falciparum Kelch 13 gene in Northeastern region of India. Malar. J. 15, 583 (2016).
-
(2016)
Malar. J.
, vol.15
, pp. 583
-
-
Mishra, N.1
-
95
-
-
85019697683
-
A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance
-
O'Neill, P.M., et al. A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance. Nat. Commun. 8, 15159 (2017).
-
(2017)
Nat. Commun.
, vol.8
, pp. 15159
-
-
O'Neill, P.M.1
-
96
-
-
84958046387
-
Structure-A nd function-based design of Plasmodium-selective proteasome inhibitors
-
Li, H., et al. Structure-A nd function-based design of Plasmodium-selective proteasome inhibitors. Nature 530, 233-236 (2016).
-
(2016)
Nature
, vol.530
, pp. 233-236
-
-
Li, H.1
-
97
-
-
85029279472
-
Protein degradation systems as antimalarial therapeutic targets
-
in the press
-
Ng, C.L., Fidock, D.A., Bogyo, M. Protein degradation systems as antimalarial therapeutic targets. Trends Parasitol. (in the press).
-
Trends Parasitol
-
-
Ng, C.L.1
Fidock, D.A.2
Bogyo, M.3
-
98
-
-
77956280420
-
Spiroindolones, a potent compound class for the treatment of malaria
-
Rottmann, M., et al. Spiroindolones, a potent compound class for the treatment of malaria. Science 329, 1175-1180 (2010).
-
(2010)
Science
, vol.329
, pp. 1175-1180
-
-
Rottmann, M.1
-
99
-
-
84904909454
-
Spiroindolone KAE609 for falciparum and vivax malaria
-
White, N.J., et al. Spiroindolone KAE609 for falciparum and vivax malaria. N. Engl. J. Med. 371, 403-410 (2014).
-
(2014)
N. Engl. J. Med.
, vol.371
, pp. 403-410
-
-
White, N.J.1
-
100
-
-
84919363336
-
(+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium
-
Jiménez-Diáz, M.B., et al. (+)-SJ733, a clinical candidate for malaria that acts through ATP4 to induce rapid host-mediated clearance of Plasmodium. Proc. Natl. Acad. Sci. USA 111, E5455-E5462 (2014).
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. E5455-E5462
-
-
Jiménez-Diáz, M.B.1
-
101
-
-
84923311088
-
Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum
-
Vaidya, A.B., et al. Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum. Nat. Commun. 5, 5521 (2014).
-
(2014)
Nat. Commun.
, vol.5
, pp. 5521
-
-
Vaidya, A.B.1
-
102
-
-
84945261954
-
Ion regulation in the malaria parasite
-
Kirk, K. Ion regulation in the malaria parasite. Annu. Rev. Microbiol. 69, 341-359 (2015).
-
(2015)
Annu. Rev. Microbiol.
, vol.69
, pp. 341-359
-
-
Kirk, K.1
-
103
-
-
84873901917
-
Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials
-
Spillman, N.J., et al. Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials. Cell Host Microbe 13, 227-237 (2013).
-
(2013)
Cell Host Microbe
, vol.13
, pp. 227-237
-
-
Spillman, N.J.1
-
104
-
-
84862571445
-
The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector
-
van Pelt-Koops, J.C., et al. The spiroindolone drug candidate NITD609 potently inhibits gametocytogenesis and blocks Plasmodium falciparum transmission to Anopheles mosquito vector. Antimicrob. Agents Chemother. 56, 3544-3548 (2012).
-
(2012)
Antimicrob. Agents Chemother.
, vol.56
, pp. 3544-3548
-
-
Van Pelt-Koops, J.C.1
-
105
-
-
84937141039
-
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria
-
Phillips, M.A., et al. A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci. Transl. Med. 7, 296ra111 (2015).
-
(2015)
Sci. Transl. Med.
, vol.7
, pp. 296ra111
-
-
Phillips, M.A.1
-
106
-
-
85016636532
-
Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: A two-part first-in-human phase 1a/1b randomised study
-
McCarthy, J.S., et al. Safety, tolerability, pharmacokinetics, and activity of the novel long-acting antimalarial DSM265: A two-part first-in-human phase 1a/1b randomised study. Lancet Infect. Dis. 17, 626-635 (2017).
-
(2017)
Lancet Infect. Dis.
, vol.17
, pp. 626-635
-
-
McCarthy, J.S.1
-
107
-
-
84865176348
-
A framework for assessing the risk of resistance for anti-malarials in development
-
Ding, X.C., Ubben, D., Wells, T.N. A framework for assessing the risk of resistance for anti-malarials in development. Malar. J. 11, 292 (2012).
-
(2012)
Malar. J.
, vol.11
, pp. 292
-
-
Ding, X.C.1
Ubben, D.2
Wells, T.N.3
-
108
-
-
84898542016
-
Pharmacological considerations in the design of anti-malarial drug combination therapies-is matching half-lives enough
-
Hastings, I.M., Hodel, E.M. Pharmacological considerations in the design of anti-malarial drug combination therapies-is matching half-lives enough Malar. J. 13, 62 (2014).
-
(2014)
Malar. J.
, vol.13
, pp. 62
-
-
Hastings, I.M.1
Hodel, E.M.2
-
109
-
-
84892582609
-
Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance
-
Lukens, A.K., et al. Harnessing evolutionary fitness in Plasmodium falciparum for drug discovery and suppressing resistance. Proc. Natl. Acad. Sci. USA 111, 799-804 (2014).
-
(2014)
Proc. Natl. Acad. Sci. USA
, vol.111
, pp. 799-804
-
-
Lukens, A.K.1
-
110
-
-
84923327067
-
Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials
-
Flannery, E.L., et al. Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials. ACS Chem. Biol. 10, 413-420 (2015).
-
(2015)
ACS Chem. Biol.
, vol.10
, pp. 413-420
-
-
Flannery, E.L.1
-
111
-
-
83255176722
-
Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
-
Meister, S., et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science 334, 1372-1377 (2011).
-
(2011)
Science
, vol.334
, pp. 1372-1377
-
-
Meister, S.1
-
112
-
-
84906079854
-
KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission
-
Kuhen, K.L., et al. KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrob. Agents Chemother. 58, 5060-5067 (2014).
-
(2014)
Antimicrob. Agents Chemother.
, vol.58
, pp. 5060-5067
-
-
Kuhen, K.L.1
-
113
-
-
84988838007
-
Antimalarial activity of KAF156 in falciparum and vivax malaria
-
White, N.J., et al. Antimalarial activity of KAF156 in falciparum and vivax malaria. N. Engl. J. Med. 375, 1152-1160 (2016).
-
(2016)
N. Engl. J. Med.
, vol.375
, pp. 1152-1160
-
-
White, N.J.1
-
114
-
-
84986587289
-
Mutations in the Plasmodium falciparum cyclic amine resistance locus (PfCARL) confer multidrug resistance
-
LaMonte, G., et al. Mutations in the Plasmodium falciparum cyclic amine resistance locus (PfCARL) confer multidrug resistance. MBio 7, e00696-16 (2016).
-
(2016)
Mbio
, vol.7
, pp. e00696-e00716
-
-
LaMonte, G.1
-
115
-
-
84988311223
-
UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes
-
Lim, M.Y., et al. UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes. Nat. Microbiol. 1, 16166 (2016).
-
(2016)
Nat. Microbiol.
, vol.1
, pp. 16166
-
-
Lim, M.Y.1
-
116
-
-
84995380249
-
Plasmodium falciparum cyclic amine resistance locus (PfCARL), a resistance mechanism for two distinct compound classes
-
Magistrado, P.A., et al. Plasmodium falciparum cyclic amine resistance locus (PfCARL), a resistance mechanism for two distinct compound classes. ACS Infect. Dis. 2, 816-826 (2016).
-
(2016)
ACS Infect. Dis.
, vol.2
, pp. 816-826
-
-
Magistrado, P.A.1
-
117
-
-
85018309975
-
Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase
-
Paquet, T., et al. Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci. Transl. Med. 9, eaad9735 (2017).
-
(2017)
Sci. Transl. Med.
, vol.9
, pp. eaad9735
-
-
Paquet, T.1
-
118
-
-
84890428942
-
Targeting Plasmodium PI(4)K to eliminate malaria
-
McNamara, C.W., et al. Targeting Plasmodium PI(4)K to eliminate malaria. Nature 504, 248-253 (2013).
-
(2013)
Nature
, vol.504
, pp. 248-253
-
-
McNamara, C.W.1
-
119
-
-
84994158172
-
Targeting protein translation in organelles of the Apicomplexa
-
Goodman, C.D., Pasaje, C.F., Kennedy, K., McFadden, G.I., Ralph, S.A. Targeting protein translation in organelles of the Apicomplexa. Trends Parasitol. 32, 953-965 (2016).
-
(2016)
Trends Parasitol.
, vol.32
, pp. 953-965
-
-
Goodman, C.D.1
Pasaje, C.F.2
Kennedy, K.3
McFadden, G.I.4
Ralph, S.A.5
-
120
-
-
85014594044
-
A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue
-
Sonoiki, E., et al. A potent antimalarial benzoxaborole targets a Plasmodium falciparum cleavage and polyadenylation specificity factor homologue. Nat. Commun. 8, 14574 (2017).
-
(2017)
Nat. Commun.
, vol.8
, pp. 14574
-
-
Sonoiki, E.1
-
121
-
-
85015276832
-
Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis
-
Wong, W., et al. Mefloquine targets the Plasmodium falciparum 80S ribosome to inhibit protein synthesis. Nat. Microbiol. 2, 17031 (2017).
-
(2017)
Nat. Microbiol.
, vol.2
, pp. 17031
-
-
Wong, W.1
-
122
-
-
84934976258
-
A novel multiple-stage antimalarial agent that inhibits protein synthesis
-
Baraganã, B., et al. A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature 522, 315-320 (2015).
-
(2015)
Nature
, vol.522
, pp. 315-320
-
-
Baraganã, B.1
-
123
-
-
84992417810
-
Diversity-oriented synthesis yields novel multistage antimalarial inhibitors
-
Kato, N., et al. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature 538, 344-349 (2016).
-
(2016)
Nature
, vol.538
, pp. 344-349
-
-
Kato, N.1
-
124
-
-
84887416507
-
Pharmacokinetic and pharmacodynamic considerations in antimalarial dose optimization
-
White, N.J. Pharmacokinetic and pharmacodynamic considerations in antimalarial dose optimization. Antimicrob. Agents Chemother. 57, 5792-5807 (2013).
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 5792-5807
-
-
White, N.J.1
-
125
-
-
33646352709
-
Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure
-
Daher, W., et al. Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure. Malar. J. 5, 11 (2006).
-
(2006)
Malar. J.
, vol.5
, pp. 11
-
-
Daher, W.1
-
127
-
-
84960366822
-
Ferroquine and artesunate in African adults and children with Plasmodium falciparum malaria: A phase 2, multicentre, randomised, double-blind, dose-ranging, non-inferiority study
-
Held, J., et al. Ferroquine and artesunate in African adults and children with Plasmodium falciparum malaria: A phase 2, multicentre, randomised, double-blind, dose-ranging, non-inferiority study. Lancet Infect. Dis. 15, 1409-1419 (2015).
-
(2015)
Lancet Infect. Dis.
, vol.15
, pp. 1409-1419
-
-
Held, J.1
-
128
-
-
84992199802
-
A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study
-
McCarthy, J.S., et al. A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study. Malar. J. 15, 469 (2016).
-
(2016)
Malar. J.
, vol.15
, pp. 469
-
-
McCarthy, J.S.1
-
129
-
-
85008452867
-
How to tackle antimalarial resistance
-
Leroy, D. How to tackle antimalarial resistance EMBO Mol. Med. 9, 133-134 (2017).
-
(2017)
EMBO Mol. Med.
, vol.9
, pp. 133-134
-
-
Leroy, D.1
-
130
-
-
84920119702
-
Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine for treatment of uncomplicated malaria in children in Zaire and Uíge Provinces, Angola
-
Plucinski, M.M., et al. Efficacy of artemether-lumefantrine and dihydroartemisinin-piperaquine for treatment of uncomplicated malaria in children in Zaire and Uíge Provinces, angola. Antimicrob. Agents Chemother. 59, 437-443 (2015).
-
(2015)
Antimicrob. Agents Chemother.
, vol.59
, pp. 437-443
-
-
Plucinski, M.M.1
-
131
-
-
84975055690
-
A broad analysis of resistance development in the malaria parasite
-
Corey, V.C., et al. A broad analysis of resistance development in the malaria parasite. Nat. Commun. 7, 11901 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 11901
-
-
Corey, V.C.1
-
132
-
-
82755197376
-
Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue
-
Adjalley, S.H., et al. Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue. Proc. Natl. Acad. Sci. USA 108, E1214-E1223 (2011).
-
(2011)
Proc. Natl. Acad. Sci. USA
, vol.108
, pp. E1214-E1223
-
-
Adjalley, S.H.1
-
133
-
-
85013374677
-
A high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase-based mature gametocyte assay
-
Siciliano, G., et al. A high susceptibility to redox imbalance of the transmissible stages of Plasmodium falciparum revealed with a luciferase-based mature gametocyte assay. Mol. Microbiol. 104, 306-318 (2017).
-
(2017)
Mol. Microbiol.
, vol.104
, pp. 306-318
-
-
Siciliano, G.1
-
134
-
-
67349189204
-
Discovery of dual function acridones as a new antimalarial chemotype
-
Kelly, J.X., et al. Discovery of dual function acridones as a new antimalarial chemotype. Nature 459, 270-273 (2009).
-
(2009)
Nature
, vol.459
, pp. 270-273
-
-
Kelly, J.X.1
-
135
-
-
85029278964
-
Simplified reversed chloroquines to overcome malaria resistance to quinoline-based drugs
-
Gunsaru, B., et al. Simplified reversed chloroquines to overcome malaria resistance to quinoline-based drugs. Antimicrob. Agents Chemother. 61, e01913-16 (2017).
-
(2017)
Antimicrob. Agents Chemother.
, vol.61
, pp. e01913-e01916
-
-
Gunsaru, B.1
-
136
-
-
84887053611
-
CRIMALDDI: Platform technologies and novel anti-malarial drug targets
-
Vial, H., et al. CRIMALDDI: Platform technologies and novel anti-malarial drug targets. Malar. J. 12, 396 (2013).
-
(2013)
Malar. J.
, vol.12
, pp. 396
-
-
Vial, H.1
-
137
-
-
84922145857
-
Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites
-
Smith, C.M., et al. Red cells from ferrochelatase-deficient erythropoietic protoporphyria patients are resistant to growth of malarial parasites. Blood 125, 534-541 (2015).
-
(2015)
Blood
, vol.125
, pp. 534-541
-
-
Smith, C.M.1
-
138
-
-
84992390892
-
Inhibition of an erythrocyte tyrosine kinase with imatinib prevents Plasmodium falciparum egress and terminates parasitemia
-
Kesely, K.R., Pantaleo, A., Turrini, F.M., Olupot-Olupot, P., Low, P.S. Inhibition of an erythrocyte tyrosine kinase with imatinib prevents Plasmodium falciparum egress and terminates parasitemia. PLoS One 11, e0164895 (2016).
-
(2016)
PLoS One
, vol.11
, pp. e0164895
-
-
Kesely, K.R.1
Pantaleo, A.2
Turrini, F.M.3
Olupot-Olupot, P.4
Low, P.S.5
-
139
-
-
84962538329
-
Host-directed therapies for infectious diseases: Current status, recent progress, and future prospects
-
Zumla, A., et al. Host-directed therapies for infectious diseases: Current status, recent progress, and future prospects. Lancet Infect. Dis. 16, e47-e63 (2016).
-
(2016)
Lancet Infect. Dis.
, vol.16
, pp. e47-e63
-
-
Zumla, A.1
-
140
-
-
84959473542
-
High-throughput assay and discovery of small molecules that interrupt malaria transmission
-
Plouffe, D.M., et al. High-throughput assay and discovery of small molecules that interrupt malaria transmission. Cell Host Microbe 19, 114-126 (2016).
-
(2016)
Cell Host Microbe
, vol.19
, pp. 114-126
-
-
Plouffe, D.M.1
-
141
-
-
84965006875
-
A chemical susceptibility profile of the Plasmodium falciparum transmission stages by complementary cell-based gametocyte assays
-
D'Alessandro, S., et al. A chemical susceptibility profile of the Plasmodium falciparum transmission stages by complementary cell-based gametocyte assays. J. Antimicrob. Chemother. 71, 1148-1158 (2016).
-
(2016)
J. Antimicrob. Chemother.
, vol.71
, pp. 1148-1158
-
-
D'Alessandro, S.1
-
142
-
-
84963746006
-
Luciferase-based high-throughput assay for screening and profiling transmission-blocking compounds against Plasmodium falciparum gametocytes
-
Lucantoni, L., Fidock, D.A., Avery, V.M. Luciferase-based, high-throughput assay for screening and profiling transmission-blocking compounds against Plasmodium falciparum gametocytes. Antimicrob. Agents Chemother. 60, 2097-2107 (2016).
-
(2016)
Antimicrob. Agents Chemother.
, vol.60
, pp. 2097-2107
-
-
Lucantoni, L.1
Fidock, D.A.2
Avery, V.M.3
-
143
-
-
85006783238
-
Targeting the parasite to suppress malaria transmission
-
Sinden, R.E. Targeting the parasite to suppress malaria transmission. Adv. Parasitol. 97, 147-185 (2017).
-
(2017)
Adv. Parasitol.
, vol.97
, pp. 147-185
-
-
Sinden, R.E.1
-
144
-
-
84965187410
-
Primaquine or other 8-aminoquinoline for reducing Plasmodium falciparum transmission
-
Graves, P.M., Gelband, H., Garner, P. Primaquine or other 8-aminoquinoline for reducing Plasmodium falciparum transmission. Cochrane Database Syst. Rev. (2), CD008152 (2015).
-
(2015)
Cochrane Database Syst. Rev.
, vol.2
, pp. CD008152
-
-
Graves, P.M.1
Gelband, H.2
Garner, P.3
-
145
-
-
84920774125
-
Primaquine: The risks and the benefits
-
Ashley, E.A., Recht, J., White, N.J. Primaquine: The risks and the benefits. Malar. J. 13, 418 (2014).
-
(2014)
Malar. J.
, vol.13
, pp. 418
-
-
Ashley, E.A.1
Recht, J.2
White, N.J.3
-
146
-
-
84961613394
-
Genomes of cryptic chimpanzee Plasmodium species reveal key evolutionary events leading to human malaria
-
Sundararaman, S.A., et al. Genomes of cryptic chimpanzee Plasmodium species reveal key evolutionary events leading to human malaria. Nat. Commun. 7, 11078 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 11078
-
-
Sundararaman, S.A.1
-
147
-
-
84938740767
-
Active migration and passive transport of malaria parasites
-
Douglas, R.G., Amino, R., Sinnis, P., Frischknecht, F. Active migration and passive transport of malaria parasites. Trends Parasitol. 31, 357-362 (2015).
-
(2015)
Trends Parasitol.
, vol.31
, pp. 357-362
-
-
Douglas, R.G.1
Amino, R.2
Sinnis, P.3
Frischknecht, F.4
-
148
-
-
84925060831
-
Brain swelling and death in children with cerebral malaria
-
Seydel, K.B., et al. Brain swelling and death in children with cerebral malaria. N. Engl. J. Med. 372, 1126-1137 (2015).
-
(2015)
N. Engl. J. Med.
, vol.372
, pp. 1126-1137
-
-
Seydel, K.B.1
-
149
-
-
84958109267
-
Immunity to malaria in an era of declining malaria transmission
-
Fowkes, F.J., Boeuf, P., Beeson, J.G. Immunity to malaria in an era of declining malaria transmission. Parasitology 143, 139-153 (2016).
-
(2016)
Parasitology
, vol.143
, pp. 139-153
-
-
Fowkes, F.J.1
Boeuf, P.2
Beeson, J.G.3
-
150
-
-
2142659388
-
Antimalarial drug resistance
-
White, N.J. Antimalarial drug resistance. J. Clin. Invest. 113, 1084-1092 (2004).
-
(2004)
J. Clin. Invest.
, vol.113
, pp. 1084-1092
-
-
White, N.J.1
-
151
-
-
79955069542
-
Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination
-
Bousema, T., Drakeley, C. Epidemiology and infectivity of Plasmodium falciparum and Plasmodium vivax gametocytes in relation to malaria control and elimination. Clin. Microbiol. Rev. 24, 377-410 (2011).
-
(2011)
Clin. Microbiol. Rev.
, vol.24
, pp. 377-410
-
-
Bousema, T.1
Drakeley, C.2
-
152
-
-
13444251395
-
Calculation of liver-to-blood inocula, parasite growth rates, and preerythrocytic vaccine efficacy, from serial quantitative polymerase chain reaction studies of volunteers challenged with malaria sporozoites
-
Bejon, P., et al. Calculation of liver-to-blood inocula, parasite growth rates, and preerythrocytic vaccine efficacy, from serial quantitative polymerase chain reaction studies of volunteers challenged with malaria sporozoites. J. Infect. Dis. 191, 619-626 (2005).
-
(2005)
J. Infect. Dis.
, vol.191
, pp. 619-626
-
-
Bejon, P.1
-
153
-
-
70350348409
-
Probability of emergence of antimalarial resistance in different stages of the parasite life cycle
-
Pongtavornpinyo, W., et al. Probability of emergence of antimalarial resistance in different stages of the parasite life cycle. Evol. Appl. 2, 52-61 (2009).
-
(2009)
Evol. Appl.
, vol.2
, pp. 52-61
-
-
Pongtavornpinyo, W.1
-
154
-
-
84891624138
-
Drug resistance in vectorborne parasites: Multiple actors and scenarios for an evolutionary arms race
-
Vanaerschot, M., Huijben, S., Van den Broeck, F., Dujardin, J.C. Drug resistance in vectorborne parasites: Multiple actors and scenarios for an evolutionary arms race. FEMS Microbiol. Rev. 38, 41-55 (2014).
-
(2014)
FEMS Microbiol. Rev.
, vol.38
, pp. 41-55
-
-
Vanaerschot, M.1
Huijben, S.2
Van Den Broeck, F.3
Dujardin, J.C.4
-
155
-
-
78649887837
-
-
World Health Organization WHO available at Chang, C., Lin-Hua, T., Jantanavivat, C. Studies on a new antimalarial compound: Pyronaridine. Trans. R. Soc. Trop. Med. Hyg. 86, 7-10
-
World Health Organization. Guidelines for the treatment of malaria.Third edition (WHO, 2015); available at http://www.who.int/malaria/publications/atoz/9789241549127/en/.156. Chang, C., Lin-Hua, T., Jantanavivat, C. Studies on a new antimalarial compound: Pyronaridine. Trans. R. Soc. Trop. Med. Hyg. 86, 7-10 (1992).
-
(2015)
Guidelines for the Treatment of Malaria.Third Edition
, vol.1992
-
-
-
156
-
-
40049110830
-
Artemisinin-based combination treatment of falciparum malaria
-
Nosten, F., White, N.J. Artemisinin-based combination treatment of falciparum malaria. Am. J. Trop. Med. Hyg. 77 (Suppl. 6), 181-192 (2007).
-
(2007)
Am. J. Trop. Med. Hyg.
, vol.77
, pp. 181-192
-
-
Nosten, F.1
White, N.J.2
-
157
-
-
84872849978
-
Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia 2008 to 2010
-
Leang, R., et al. Efficacy of dihydroartemisinin-piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010. Antimicrob. Agents Chemother. 57, 818-826 (2013).
-
(2013)
Antimicrob. Agents Chemother.
, vol.57
, pp. 818-826
-
-
Leang, R.1
-
158
-
-
84867843026
-
PfCRT and its role in antimalarial drug resistance
-
Ecker, A., Lehane, A.M., Clain, J., Fidock, D.A. PfCRT and its role in antimalarial drug resistance. Trends Parasitol. 28, 504-514 (2012).
-
(2012)
Trends Parasitol.
, vol.28
, pp. 504-514
-
-
Ecker, A.1
Lehane, A.M.2
Clain, J.3
Fidock, D.A.4
-
159
-
-
77950033492
-
Origins and spread of pfdhfr mutant alleles in Plasmodium falciparum
-
Mita, T. Origins and spread of pfdhfr mutant alleles in Plasmodium falciparum. Acta Trop. 114, 166-170 (2010).
-
(2010)
Acta Trop.
, vol.114
, pp. 166-170
-
-
Mita, T.1
-
160
-
-
77955351148
-
Origin and dissemination across the Colombian Andes mountain range of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum
-
Corredor, V., et al. Origin and dissemination across the Colombian Andes mountain range of sulfadoxine-pyrimethamine resistance in Plasmodium falciparum. Antimicrob. Agents Chemother. 54, 3121-3125 (2010).
-
(2010)
Antimicrob. Agents Chemother.
, vol.54
, pp. 3121-3125
-
-
Corredor, V.1
-
161
-
-
0037420464
-
Antifolate antimalarial resistance in southeast Africa: A population-based analysis
-
Roper, C., et al. Antifolate antimalarial resistance in southeast Africa: A population-based analysis. Lancet 361, 1174-1181 (2003).
-
(2003)
Lancet
, vol.361
, pp. 1174-1181
-
-
Roper, C.1
-
162
-
-
77950921613
-
Transmission and cross-mating of high-level resistance Plasmodium falciparum dihydrofolate reductase haplotypes in the Gambia
-
Kheir, A., et al. Transmission and cross-mating of high-level resistance Plasmodium falciparum dihydrofolate reductase haplotypes in The Gambia. Am. J. Trop. Med. Hyg. 82, 535-541 (2010).
-
(2010)
Am. J. Trop. Med. Hyg.
, vol.82
, pp. 535-541
-
-
Kheir, A.1
-
163
-
-
83655183202
-
A new world malaria map: Plasmodium falciparum endemicity in 2010
-
Gething, P.W., et al. A new world malaria map: Plasmodium falciparum endemicity in 2010. Malar. J. 10, 378 (2011).
-
(2011)
Malar. J.
, vol.10
, pp. 378
-
-
Gething, P.W.1
-
164
-
-
84939645264
-
Functional comparison of 45 naturally occurring isoforms of the Plasmodium falciparum chloroquine resistance transporter (PfCRT)
-
Callaghan, P.S., Hassett, M.R., Roepe, P.D. Functional comparison of 45 naturally occurring isoforms of the Plasmodium falciparum chloroquine resistance transporter (PfCRT). Biochemistry 54, 5083-5094 (2015).
-
(2015)
Biochemistry
, vol.54
, pp. 5083-5094
-
-
Callaghan, P.S.1
Hassett, M.R.2
Roepe, P.D.3
-
165
-
-
84942844889
-
Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities
-
Pulcini, S., et al. Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities. Sci. Rep. 5, 14552 (2015).
-
(2015)
Sci. Rep.
, vol.5
, pp. 14552
-
-
Pulcini, S.1
-
166
-
-
84941671295
-
Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt
-
Pelleau, S., et al. Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt. Proc. Natl. Acad. Sci. USA 112, 11672-11677 (2015).
-
(2015)
Proc. Natl. Acad. Sci. USA
, vol.112
, pp. 11672-11677
-
-
Pelleau, S.1
-
167
-
-
73149118025
-
Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine
-
Sá, J.M., et al. Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine. Proc. Natl. Acad. Sci. USA 106, 18883-18889 (2009).
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 18883-18889
-
-
Sá, J.M.1
-
168
-
-
84964581380
-
Combinatorial genetic modeling of pfcrt-mediated drug resistance evolution in Plasmodium falciparum
-
Gabryszewski, S.J., Modchang, C., Musset, L., Chookajorn, T., Fidock, D.A. Combinatorial genetic modeling of pfcrt-mediated drug resistance evolution in Plasmodium falciparum. Mol. Biol. Evol. 33, 1554-1570 (2016).
-
(2016)
Mol. Biol. Evol.
, vol.33
, pp. 1554-1570
-
-
Gabryszewski, S.J.1
Modchang, C.2
Musset, L.3
Chookajorn, T.4
Fidock, D.A.5
-
169
-
-
61849097741
-
In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa
-
Sisowath, C., et al. In vivo selection of Plasmodium falciparum parasites carrying the chloroquine-susceptible pfcrt K76 allele after treatment with artemether-lumefantrine in Africa. J. Infect. Dis. 199, 750-757 (2009).
-
(2009)
J. Infect. Dis.
, vol.199
, pp. 750-757
-
-
Sisowath, C.1
-
170
-
-
84903195977
-
Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children
-
Conrad, M.D., et al. Comparative impacts over 5 years of artemisinin-based combination therapies on Plasmodium falciparum polymorphisms that modulate drug sensitivity in Ugandan children. J. Infect. Dis. 210, 344-353 (2014).
-
(2014)
J. Infect. Dis.
, vol.210
, pp. 344-353
-
-
Conrad, M.D.1
-
171
-
-
84906937961
-
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: Parasite risk factors that affect treatment outcomes for P. Falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine
-
Venkatesan, M., et al. Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: Parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine. Am. J. Trop. Med. Hyg. 91, 833-843 (2014).
-
(2014)
Am. J. Trop. Med. Hyg.
, vol.91
, pp. 833-843
-
-
Venkatesan, M.1
-
172
-
-
46249086673
-
A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites
-
Lehane, A.M., Hayward, R., Saliba, K.J., Kirk, K. A verapamil-sensitive chloroquine-associated H+ leak from the digestive vacuole in chloroquine-resistant malaria parasites. J. Cell Sci. 121, 1624-1632 (2008).
-
(2008)
J. Cell Sci.
, vol.121
, pp. 1624-1632
-
-
Lehane, A.M.1
Hayward, R.2
Saliba, K.J.3
Kirk, K.4
-
173
-
-
79957580467
-
Drug-resistant malaria: Molecular mechanisms and implications for public health
-
Petersen, I., Eastman, R., Lanzer, M. Drug-resistant malaria: Molecular mechanisms and implications for public health. FEBS Lett. 585, 1551-1562 (2011).
-
(2011)
FEBS Lett.
, vol.585
, pp. 1551-1562
-
-
Petersen, I.1
Eastman, R.2
Lanzer, M.3
-
174
-
-
52949104808
-
Photoaffinity labeling of the Plasmodium falciparum chloroquine resistance transporter with a novel perfluorophenylazido chloroquine
-
Lekostaj, J.K., Natarajan, J.K., Paguio, M.F., Wolf, C., Roepe, P.D. Photoaffinity labeling of the Plasmodium falciparum chloroquine resistance transporter with a novel perfluorophenylazido chloroquine. Biochemistry 47, 10394-10406 (2008).
-
(2008)
Biochemistry
, vol.47
, pp. 10394-10406
-
-
Lekostaj, J.K.1
Natarajan, J.K.2
Paguio, M.F.3
Wolf, C.4
Roepe, P.D.5
-
175
-
-
84982995100
-
Molecular mechanisms for drug hypersensitivity induced by the malaria parasite's chloroquine resistance transporter
-
Richards, S.N., et al. Molecular mechanisms for drug hypersensitivity induced by the malaria parasite's chloroquine resistance transporter. PLoS Pathog. 12, e1005725 (2016).
-
(2016)
PLoS Pathog.
, vol.12
, pp. e1005725
-
-
Richards, S.N.1
-
176
-
-
84927799735
-
Antimalarial drug resistance in Africa: Key lessons for the future
-
Takala-Harrison, S., Laufer, M.K. Antimalarial drug resistance in Africa: Key lessons for the future. Ann. NY Acad. Sci. 1342, 62-67 (2015).
-
(2015)
Ann. NY Acad. Sci.
, vol.1342
, pp. 62-67
-
-
Takala-Harrison, S.1
Laufer, M.K.2
-
177
-
-
84896724410
-
Metabolic QTL analysis links chloroquine resistance in Plasmodium falciparum to impaired hemoglobin catabolism
-
Lewis, I.A., et al. Metabolic QTL analysis links chloroquine resistance in Plasmodium falciparum to impaired hemoglobin catabolism. PLoS Genet. 10, e1004085 (2014).
-
(2014)
PLoS Genet.
, vol.10
, pp. e1004085
-
-
Lewis, I.A.1
-
178
-
-
85001950339
-
Evolution of fitness cost-neutral mutant PfCRT conferring P. Falciparum 4-aminoquinoline drug resistance is accompanied by altered parasite metabolism and digestive vacuole physiology
-
Gabryszewski, S.J., et al. Evolution of fitness cost-neutral mutant PfCRT conferring P. falciparum 4-aminoquinoline drug resistance is accompanied by altered parasite metabolism and digestive vacuole physiology. PLoS Pathog. 12, e1005976 (2016).
-
(2016)
PLoS Pathog.
, vol.12
, pp. e1005976
-
-
Gabryszewski, S.J.1
-
179
-
-
84969945025
-
Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies
-
Veiga, M.I., et al. Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies. Nat. Commun. 7, 11553 (2016).
-
(2016)
Nat. Commun.
, vol.7
, pp. 11553
-
-
Veiga, M.I.1
-
180
-
-
84964494870
-
Population structure shapes copy number variation in malaria parasites
-
Cheeseman, I.H., et al. Population structure shapes copy number variation in malaria parasites. Mol. Biol. Evol. 33, 603-620 (2016).
-
(2016)
Mol. Biol. Evol.
, vol.33
, pp. 603-620
-
-
Cheeseman, I.H.1
-
181
-
-
84884284782
-
The interplay between drug resistance and fitness in malaria parasites
-
Rosenthal, P.J. The interplay between drug resistance and fitness in malaria parasites. Mol. Microbiol. 89, 1025-1038 (2013).
-
(2013)
Mol. Microbiol.
, vol.89
, pp. 1025-1038
-
-
Rosenthal, P.J.1
-
182
-
-
84901611021
-
A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum
-
Sanchez, C.P., et al. A HECT ubiquitin-protein ligase as a novel candidate gene for altered quinine and quinidine responses in Plasmodium falciparum. PLoS Genet. 10, e1004382 (2014).
-
(2014)
PLoS Genet.
, vol.10
, pp. e1004382
-
-
Sanchez, C.P.1
-
183
-
-
3142772962
-
Dissecting the loci of low-level quinine resistance in malaria parasites
-
Ferdig, M.T., et al. Dissecting the loci of low-level quinine resistance in malaria parasites. Mol. Microbiol. 52, 985-997 (2004).
-
(2004)
Mol. Microbiol.
, vol.52
, pp. 985-997
-
-
Ferdig, M.T.1
|