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Volumn 32, Issue 9, 2016, Pages 682-696

Artemisinin Action and Resistance in Plasmodium falciparum

Author keywords

artemisinin resistance; Kelch13; malaria.; proteasome; ubiquitination; unfolded protein response

Indexed keywords

ARTEFENOMEL; ARTEMISININ; ARTEROLANE; ARTESUNATE PLUS MEFLOQUINE; K 13; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; PROTOZOAL PROTEIN;

EID: 84991594101     PISSN: 14714922     EISSN: 14715007     Source Type: Journal    
DOI: 10.1016/j.pt.2016.05.010     Document Type: Review
Times cited : (268)

References (127)
  • 1
    • 84968896486 scopus 로고    scopus 로고
    • World Malaria Report 2015
    • World Health Organization
    • 1 World Health Organization, World Malaria Report 2015., 2015, World Health Organization (http://www.who.int/malaria/publications/world-malaria-report-2015/report/en).
    • (2015)
    • World Health Organization1
  • 2
    • 78649251920 scopus 로고    scopus 로고
    • Heme as trigger and target for trioxane-containing antimalarial drugs
    • 2 Meunier, B., Robert, A., Heme as trigger and target for trioxane-containing antimalarial drugs. Acc. Chem. Res. 43 (2010), 1444–1451.
    • (2010) Acc. Chem. Res. , vol.43 , pp. 1444-1451
    • Meunier, B.1    Robert, A.2
  • 3
    • 2542640961 scopus 로고    scopus 로고
    • A medicinal chemistry perspective on artemisinin and related endoperoxides
    • 3 O'Neill, P.M., Posner, G.H., A medicinal chemistry perspective on artemisinin and related endoperoxides. J. Med. Chem. 47 (2004), 2945–2964.
    • (2004) J. Med. Chem. , vol.47 , pp. 2945-2964
    • O'Neill, P.M.1    Posner, G.H.2
  • 4
    • 70449732094 scopus 로고    scopus 로고
    • Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria
    • 4 Eastman, R.T., Fidock, D.A., Artemisinin-based combination therapies: a vital tool in efforts to eliminate malaria. Nat. Rev. Microbiol. 7 (2009), 864–874.
    • (2009) Nat. Rev. Microbiol. , vol.7 , pp. 864-874
    • Eastman, R.T.1    Fidock, D.A.2
  • 5
    • 42349104331 scopus 로고    scopus 로고
    • Qinghaosu (artemisinin): the price of success
    • 5 White, N.J., Qinghaosu (artemisinin): the price of success. Science 320 (2008), 330–334.
    • (2008) Science , vol.320 , pp. 330-334
    • White, N.J.1
  • 7
    • 68049123592 scopus 로고    scopus 로고
    • Artemisinin resistance in Plasmodium falciparum malaria
    • 7 Dondorp, A.M., et al. Artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 361 (2009), 455–467.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 455-467
    • Dondorp, A.M.1
  • 8
    • 77952376553 scopus 로고    scopus 로고
    • Malaria's drug miracle in danger
    • 8 Enserink, M., Malaria's drug miracle in danger. Science 328 (2010), 844–846.
    • (2010) Science , vol.328 , pp. 844-846
    • Enserink, M.1
  • 9
    • 84887416507 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic considerations in antimalarial dose optimization
    • 9 White, N.J., Pharmacokinetic and pharmacodynamic considerations in antimalarial dose optimization. Antimicrob. Agents Chemother. 57 (2013), 5792–5807.
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 5792-5807
    • White, N.J.1
  • 10
    • 4344630762 scopus 로고    scopus 로고
    • Identification of an antimalarial synthetic trioxolane drug development candidate
    • 10 Vennerstrom, J.L., et al. Identification of an antimalarial synthetic trioxolane drug development candidate. Nature 430 (2004), 900–904.
    • (2004) Nature , vol.430 , pp. 900-904
    • Vennerstrom, J.L.1
  • 11
    • 34547638282 scopus 로고    scopus 로고
    • Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160)
    • 11 Kaiser, M., et al. Peroxide bond-dependent antiplasmodial specificity of artemisinin and OZ277 (RBx11160). Antimicrob. Agents Chemother. 51 (2007), 2991–2993.
    • (2007) Antimicrob. Agents Chemother. , vol.51 , pp. 2991-2993
    • Kaiser, M.1
  • 12
    • 84930381560 scopus 로고    scopus 로고
    • Malaria medicines: a glass half full?
    • 12 Wells, T.N., et al. Malaria medicines: a glass half full?. Nat. Rev. Drug Discov. 14 (2015), 424–442.
    • (2015) Nat. Rev. Drug Discov. , vol.14 , pp. 424-442
    • Wells, T.N.1
  • 13
    • 84864962615 scopus 로고    scopus 로고
    • Arterolane maleate plus piperaquine phosphate for treatment of uncomplicated Plasmodium falciparum malaria: a comparative, multicenter, randomized clinical trial
    • 13 Valecha, N., et al. Arterolane maleate plus piperaquine phosphate for treatment of uncomplicated Plasmodium falciparum malaria: a comparative, multicenter, randomized clinical trial. Clin. Infect. Dis. 55 (2012), 663–671.
    • (2012) Clin. Infect. Dis. , vol.55 , pp. 663-671
    • Valecha, N.1
  • 14
    • 79952732772 scopus 로고    scopus 로고
    • Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria
    • 14 Charman, S.A., et al. Synthetic ozonide drug candidate OZ439 offers new hope for a single-dose cure of uncomplicated malaria. Proc. Natl. Acad. Sci. U.S.A. 108 (2011), 4400–4405.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 4400-4405
    • Charman, S.A.1
  • 15
    • 80054771436 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of arterolane maleate following multiple oral doses in adult patients with P. falciparum malaria
    • 15 Gautam, A., et al. Pharmacokinetics and pharmacodynamics of arterolane maleate following multiple oral doses in adult patients with P. falciparum malaria. J. Clin. Pharmacol. 51 (2011), 1519–1528.
    • (2011) J. Clin. Pharmacol. , vol.51 , pp. 1519-1528
    • Gautam, A.1
  • 16
    • 84898660982 scopus 로고    scopus 로고
    • Safety, tolerability and pharmacokinetic profile of single and multiple oral doses of arterolane (RBx11160) maleate in healthy subjects
    • 16 Saha, N., et al. Safety, tolerability and pharmacokinetic profile of single and multiple oral doses of arterolane (RBx11160) maleate in healthy subjects. J. Clin. Pharmacol. 54 (2014), 386–393.
    • (2014) J. Clin. Pharmacol. , vol.54 , pp. 386-393
    • Saha, N.1
  • 17
    • 84964384823 scopus 로고    scopus 로고
    • Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial
    • 17 Phyo, A.P., et al. Antimalarial activity of artefenomel (OZ439), a novel synthetic antimalarial endoperoxide, in patients with Plasmodium falciparum and Plasmodium vivax malaria: an open-label phase 2 trial. Lancet Infect. Dis. 16 (2016), 61–69.
    • (2016) Lancet Infect. Dis. , vol.16 , pp. 61-69
    • Phyo, A.P.1
  • 18
    • 85027947965 scopus 로고    scopus 로고
    • Artefenomel: a promising new antimalarial drug
    • 18 Rosenthal, P.J., Artefenomel: a promising new antimalarial drug. Lancet Infect. Dis. 16 (2016), 6–8.
    • (2016) Lancet Infect. Dis. , vol.16 , pp. 6-8
    • Rosenthal, P.J.1
  • 19
    • 84872260566 scopus 로고    scopus 로고
    • First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials
    • 19 Moehrle, J.J., et al. First-in-man safety and pharmacokinetics of synthetic ozonide OZ439 demonstrates an improved exposure profile relative to other peroxide antimalarials. Br. J. Clin. Pharmacol. 75 (2013), 524–537.
    • (2013) Br. J. Clin. Pharmacol. , vol.75 , pp. 524-537
    • Moehrle, J.J.1
  • 20
    • 0026014249 scopus 로고
    • Artemisinin (Qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action
    • 20 Meshnick, S.R., et al. Artemisinin (Qinghaosu): the role of intracellular hemin in its mechanism of antimalarial action. Mol. Biochem. Parasitol. 49 (1991), 181–189.
    • (1991) Mol. Biochem. Parasitol. , vol.49 , pp. 181-189
    • Meshnick, S.R.1
  • 21
    • 84888137711 scopus 로고    scopus 로고
    • Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins
    • 21 Klonis, N., et al. Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins. Curr. Opin. Microbiol. 16 (2013), 722–727.
    • (2013) Curr. Opin. Microbiol. , vol.16 , pp. 722-727
    • Klonis, N.1
  • 22
    • 76649123110 scopus 로고    scopus 로고
    • Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum
    • 22 Abu Bakar, N.A., et al. Digestive-vacuole genesis and endocytic processes in the early intraerythrocytic stages of Plasmodium falciparum. J. Cell Sci. 123 (2010), 441–450.
    • (2010) J. Cell Sci. , vol.123 , pp. 441-450
    • Abu Bakar, N.A.1
  • 23
    • 84857694426 scopus 로고    scopus 로고
    • Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts
    • 23 Meyers, M.J., Goldberg, D.E., Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts. Curr. Top. Med. Chem. 12 (2012), 445–455.
    • (2012) Curr. Top. Med. Chem. , vol.12 , pp. 445-455
    • Meyers, M.J.1    Goldberg, D.E.2
  • 24
    • 80053336043 scopus 로고    scopus 로고
    • Falcipains and other cysteine proteases of malaria parasites
    • 24 Rosenthal, P.J., Falcipains and other cysteine proteases of malaria parasites. Adv. Exp. Med. Biol. 712 (2011), 30–48.
    • (2011) Adv. Exp. Med. Biol. , vol.712 , pp. 30-48
    • Rosenthal, P.J.1
  • 25
    • 38149035199 scopus 로고    scopus 로고
    • Haemozoin formation
    • 25 Egan, T.J., Haemozoin formation. Mol. Biochem. Parasitol. 157 (2008), 127–136.
    • (2008) Mol. Biochem. Parasitol. , vol.157 , pp. 127-136
    • Egan, T.J.1
  • 26
    • 84872543098 scopus 로고    scopus 로고
    • Insights into the role of heme in the mechanism of action of antimalarials
    • 26 Combrinck, J.M., et al. Insights into the role of heme in the mechanism of action of antimalarials. ACS Chem. Biol. 8 (2013), 133–137.
    • (2013) ACS Chem. Biol. , vol.8 , pp. 133-137
    • Combrinck, J.M.1
  • 27
    • 84875498942 scopus 로고    scopus 로고
    • Altered temporal response of malaria parasites determines differential sensitivity to artemisinin
    • 27 Klonis, N., et al. Altered temporal response of malaria parasites determines differential sensitivity to artemisinin. Proc. Natl. Acad. Sci. U.S.A. 110 (2013), 5157–5162.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 5157-5162
    • Klonis, N.1
  • 28
    • 82755197376 scopus 로고    scopus 로고
    • Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue
    • 28 Adjalley, S.H., et al. Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue. Proc. Natl. Acad. Sci. U.S.A. 108 (2011), E1214–E1223.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. E1214-E1223
    • Adjalley, S.H.1
  • 29
    • 83255176722 scopus 로고    scopus 로고
    • Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery
    • 29 Meister, S., et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science 334 (2011), 1372–1377.
    • (2011) Science , vol.334 , pp. 1372-1377
    • Meister, S.1
  • 30
    • 84957801889 scopus 로고    scopus 로고
    • Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins
    • 30 Xie, S.C., et al. Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins. J. Cell Sci. 129 (2016), 406–416.
    • (2016) J. Cell Sci. , vol.129 , pp. 406-416
    • Xie, S.C.1
  • 31
    • 0026785410 scopus 로고
    • De novo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite
    • 31 Surolia, N., Padmanaban, G., De novo biosynthesis of heme offers a new chemotherapeutic target in the human malarial parasite. Biochem. Biophys. Res. Commun. 187 (1992), 744–750.
    • (1992) Biochem. Biophys. Res. Commun. , vol.187 , pp. 744-750
    • Surolia, N.1    Padmanaban, G.2
  • 32
    • 84951850850 scopus 로고    scopus 로고
    • Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum
    • 32 Wang, J., et al. Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum. Nat. Commun., 6, 2015, 10111.
    • (2015) Nat. Commun. , vol.6 , pp. 10111
    • Wang, J.1
  • 33
    • 84918580707 scopus 로고    scopus 로고
    • The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages
    • 33 Ke, H., et al. The heme biosynthesis pathway is essential for Plasmodium falciparum development in mosquito stage but not in blood stages. J. Biol. Chem. 289 (2014), 34827–34837.
    • (2014) J. Biol. Chem. , vol.289 , pp. 34827-34837
    • Ke, H.1
  • 34
    • 84875814268 scopus 로고    scopus 로고
    • Parasite maturation and host serum iron influence the labile iron pool of erythrocyte stage Plasmodium falciparum
    • 34 Clark, M., et al. Parasite maturation and host serum iron influence the labile iron pool of erythrocyte stage Plasmodium falciparum. Br. J. Haematol. 161 (2013), 262–269.
    • (2013) Br. J. Haematol. , vol.161 , pp. 262-269
    • Clark, M.1
  • 35
    • 0033560719 scopus 로고    scopus 로고
    • Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials
    • 35 Loria, P., et al. Inhibition of the peroxidative degradation of haem as the basis of action of chloroquine and other quinoline antimalarials. Biochem. J. 339 (1999), 363–370.
    • (1999) Biochem. J. , vol.339 , pp. 363-370
    • Loria, P.1
  • 36
    • 0031792787 scopus 로고    scopus 로고
    • Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action
    • 36 Ginsburg, H., et al. Inhibition of glutathione-dependent degradation of heme by chloroquine and amodiaquine as a possible basis for their antimalarial mode of action. Biochem. Pharmacol. 56 (1998), 1305–1313.
    • (1998) Biochem. Pharmacol. , vol.56 , pp. 1305-1313
    • Ginsburg, H.1
  • 37
    • 0042860063 scopus 로고    scopus 로고
    • Artemisinins target the SERCA of Plasmodium falciparum
    • 37 Eckstein-Ludwig, U., et al. Artemisinins target the SERCA of Plasmodium falciparum. Nature 424 (2003), 957–961.
    • (2003) Nature , vol.424 , pp. 957-961
    • Eckstein-Ludwig, U.1
  • 38
    • 34548293148 scopus 로고    scopus 로고
    • Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs
    • 38 Stocks, P.A., et al. Evidence for a common non-heme chelatable-iron-dependent activation mechanism for semisynthetic and synthetic endoperoxide antimalarial drugs. Angew. Chem. Int. Ed. Engl. 46 (2007), 6278–6283.
    • (2007) Angew. Chem. Int. Ed. Engl. , vol.46 , pp. 6278-6283
    • Stocks, P.A.1
  • 39
    • 84870289054 scopus 로고    scopus 로고
    • Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model–a unifying proposal for drug action
    • 39 Haynes, R.K., et al. Interactions between artemisinins and other antimalarial drugs in relation to the cofactor model–a unifying proposal for drug action. ChemMedChem 7 (2012), 2204–2226.
    • (2012) ChemMedChem , vol.7 , pp. 2204-2226
    • Haynes, R.K.1
  • 40
    • 77949661216 scopus 로고    scopus 로고
    • Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation
    • 40 Wang, J., et al. Artemisinin directly targets malarial mitochondria through its specific mitochondrial activation. PLoS ONE, 5, 2010, e9582.
    • (2010) PLoS ONE , vol.5 , pp. e9582
    • Wang, J.1
  • 41
    • 84929493850 scopus 로고    scopus 로고
    • Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance
    • 41 Dogovski, C., et al. Targeting the cell stress response of Plasmodium falciparum to overcome artemisinin resistance. PLoS Biol., 13, 2015, e1002132.
    • (2015) PLoS Biol. , vol.13 , pp. e1002132
    • Dogovski, C.1
  • 42
    • 77950362015 scopus 로고    scopus 로고
    • The molecular mechanism of action of artemisinin – the debate continues
    • 42 O'Neill, P.M., et al. The molecular mechanism of action of artemisinin – the debate continues. Molecules 15 (2010), 1705–1721.
    • (2010) Molecules , vol.15 , pp. 1705-1721
    • O'Neill, P.M.1
  • 43
    • 77950362820 scopus 로고    scopus 로고
    • Biological actions of artemisinin: insights from medicinal chemistry studies
    • 43 Li, J., Zhou, B., Biological actions of artemisinin: insights from medicinal chemistry studies. Molecules 15 (2010), 1378–1397.
    • (2010) Molecules , vol.15 , pp. 1378-1397
    • Li, J.1    Zhou, B.2
  • 44
    • 0037021405 scopus 로고    scopus 로고
    • Artemisinin: mechanisms of action, resistance and toxicity
    • 44 Meshnick, S.R., Artemisinin: mechanisms of action, resistance and toxicity. Int. J. Parasitol. 32 (2002), 1655–1660.
    • (2002) Int. J. Parasitol. , vol.32 , pp. 1655-1660
    • Meshnick, S.R.1
  • 45
    • 7944222115 scopus 로고    scopus 로고
    • Artemisinins: mechanisms of action and potential for resistance
    • 45 Krishna, S., et al. Artemisinins: mechanisms of action and potential for resistance. Drug Resist. Updat. 7 (2004), 233–244.
    • (2004) Drug Resist. Updat. , vol.7 , pp. 233-244
    • Krishna, S.1
  • 46
    • 0027364698 scopus 로고
    • Morphologic effects of artemisinin in Plasmodium falciparum
    • 46 Maeno, Y., et al. Morphologic effects of artemisinin in Plasmodium falciparum. Am. J. Trop. Med. Hyg. 49 (1993), 485–491.
    • (1993) Am. J. Trop. Med. Hyg. , vol.49 , pp. 485-491
    • Maeno, Y.1
  • 47
    • 0033516474 scopus 로고    scopus 로고
    • Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite
    • 47 Pandey, A.V., et al. Artemisinin, an endoperoxide antimalarial, disrupts the hemoglobin catabolism and heme detoxification systems in malarial parasite. J. Biol. Chem. 274 (1999), 19383–19388.
    • (1999) J. Biol. Chem. , vol.274 , pp. 19383-19388
    • Pandey, A.V.1
  • 48
    • 37849019012 scopus 로고    scopus 로고
    • Artemisinin and a series of novel endoperoxide antimalarials exert early effects on digestive vacuole morphology
    • 48 Crespo, M.D.P., et al. Artemisinin and a series of novel endoperoxide antimalarials exert early effects on digestive vacuole morphology. Antimicrob. Agents Chemother. 52 (2008), 98–109.
    • (2008) Antimicrob. Agents Chemother. , vol.52 , pp. 98-109
    • Crespo, M.D.P.1
  • 49
    • 58249143778 scopus 로고    scopus 로고
    • Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent
    • 49 Hartwig, C.L., et al. Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent. Biochem. Pharmacol. 77 (2009), 322–336.
    • (2009) Biochem. Pharmacol. , vol.77 , pp. 322-336
    • Hartwig, C.L.1
  • 50
    • 84959253636 scopus 로고    scopus 로고
    • Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7
    • 50 Ismail, H.M., et al. Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7. Proc. Natl. Acad. Sci. U.S.A. 113 (2016), 2080–2085.
    • (2016) Proc. Natl. Acad. Sci. U.S.A. , vol.113 , pp. 2080-2085
    • Ismail, H.M.1
  • 51
    • 0037015602 scopus 로고    scopus 로고
    • A proteomic view of the Plasmodium falciparum life cycle
    • 51 Florens, L., et al. A proteomic view of the Plasmodium falciparum life cycle. Nature 419 (2002), 520–526.
    • (2002) Nature , vol.419 , pp. 520-526
    • Florens, L.1
  • 52
    • 77954726224 scopus 로고    scopus 로고
    • Protein export marks the early phase of gametocytogenesis of the human malaria parasite Plasmodium falciparum
    • 52 Silvestrini, F., et al. Protein export marks the early phase of gametocytogenesis of the human malaria parasite Plasmodium falciparum. Mol. Cell. Proteomics 9 (2010), 1437–1448.
    • (2010) Mol. Cell. Proteomics , vol.9 , pp. 1437-1448
    • Silvestrini, F.1
  • 53
    • 80054901700 scopus 로고    scopus 로고
    • The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites’ boundaries
    • 53 Treeck, M., et al. The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites’ boundaries. Cell Host Microbe 10 (2011), 410–419.
    • (2011) Cell Host Microbe , vol.10 , pp. 410-419
    • Treeck, M.1
  • 54
    • 84908399993 scopus 로고    scopus 로고
    • Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate
    • 54 Lisewski, A.M., et al. Supergenomic network compression and the discovery of EXP1 as a glutathione transferase inhibited by artesunate. Cell 158 (2014), 916–928.
    • (2014) Cell , vol.158 , pp. 916-928
    • Lisewski, A.M.1
  • 55
    • 0033035811 scopus 로고    scopus 로고
    • Artemisinin and its derivatives are transported by a vacuolar-network of Plasmodium falciparum and their antimalarial activities are additive with toxic sphingolipid analogues that block the network
    • 55 Akompong, T., et al. Artemisinin and its derivatives are transported by a vacuolar-network of Plasmodium falciparum and their antimalarial activities are additive with toxic sphingolipid analogues that block the network. Mol. Biochem. Parasitol. 101 (1999), 71–79.
    • (1999) Mol. Biochem. Parasitol. , vol.101 , pp. 71-79
    • Akompong, T.1
  • 56
    • 79960992639 scopus 로고    scopus 로고
    • Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion
    • 56 Klonis, N., et al. Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion. Proc. Natl. Acad. Sci. U.S.A. 108 (2011), 11405–11410.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 11405-11410
    • Klonis, N.1
  • 57
    • 84928814749 scopus 로고    scopus 로고
    • A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria
    • 57 Mbengue, A., et al. A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature 520 (2015), 683–687.
    • (2015) Nature , vol.520 , pp. 683-687
    • Mbengue, A.1
  • 58
    • 77950612934 scopus 로고    scopus 로고
    • PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking
    • 58 Vaid, A., et al. PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking. Blood 115 (2010), 2500–2507.
    • (2010) Blood , vol.115 , pp. 2500-2507
    • Vaid, A.1
  • 59
    • 3042628994 scopus 로고    scopus 로고
    • Antimalarial quinolines and artemisinin inhibit endocytosis in Plasmodium falciparum. Antimicrob
    • 59 Hoppe, H.C., et al. Antimalarial quinolines and artemisinin inhibit endocytosis in Plasmodium falciparum. Antimicrob. Agents Chemother. 48 (2004), 2370–2378.
    • (2004) Agents Chemother. , vol.48 , pp. 2370-2378
    • Hoppe, H.C.1
  • 60
    • 84960470369 scopus 로고    scopus 로고
    • Plasmodium falciparum: multifaceted resistance to artemisinins
    • 60 Paloque, L., et al. Plasmodium falciparum: multifaceted resistance to artemisinins. Malar. J., 15, 2016, 149.
    • (2016) Malar. J. , vol.15 , pp. 149
    • Paloque, L.1
  • 61
    • 84875870963 scopus 로고    scopus 로고
    • Artemisinin resistance in rodent malaria–mutation in the AP2 adaptor mu-chain suggests involvement of endocytosis and membrane protein trafficking
    • 61 Henriques, G., et al. Artemisinin resistance in rodent malaria–mutation in the AP2 adaptor mu-chain suggests involvement of endocytosis and membrane protein trafficking. Malar. J., 12, 2013, 118.
    • (2013) Malar. J. , vol.12 , pp. 118
    • Henriques, G.1
  • 62
    • 84880306767 scopus 로고    scopus 로고
    • Correlation between Plasmodium yoelii nigeriensis susceptibility to artemisinin and alkylation of heme by the drug
    • 62 Robert, A., et al. Correlation between Plasmodium yoelii nigeriensis susceptibility to artemisinin and alkylation of heme by the drug. Antimicrob. Agents Chemother. 57 (2013), 3998–4000.
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 3998-4000
    • Robert, A.1
  • 63
    • 84904892931 scopus 로고    scopus 로고
    • Spread of artemisinin resistance in Plasmodium falciparum malaria
    • 63 Ashley, E.A., et al. Spread of artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 371 (2014), 411–423.
    • (2014) N. Engl. J. Med. , vol.371 , pp. 411-423
    • Ashley, E.A.1
  • 64
    • 84959375968 scopus 로고    scopus 로고
    • Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of eighth biannual meeting (September 2015)
    • 64 WHO Malaria Policy Advisory Committee and Secretariat, Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of eighth biannual meeting (September 2015). Malar. J., 15, 2016, 117.
    • (2016) Malar. J. , vol.15 , pp. 117
    • WHO Malaria Policy Advisory Committee and Secretariat1
  • 65
    • 84861461519 scopus 로고    scopus 로고
    • Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study
    • 65 Phyo, A.P., et al. Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet 379 (2012), 1960–1966.
    • (2012) Lancet , vol.379 , pp. 1960-1966
    • Phyo, A.P.1
  • 66
    • 84867917706 scopus 로고    scopus 로고
    • Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study
    • 66 Amaratunga, C., et al. Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study. Lancet Infect. Dis. 12 (2012), 851–858.
    • (2012) Lancet Infect. Dis. , vol.12 , pp. 851-858
    • Amaratunga, C.1
  • 67
    • 84887622121 scopus 로고    scopus 로고
    • Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies
    • 67 Witkowski, B., et al. Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies. Lancet Infect. Dis. 13 (2013), 1043–1049.
    • (2013) Lancet Infect. Dis. , vol.13 , pp. 1043-1049
    • Witkowski, B.1
  • 68
    • 84900838464 scopus 로고    scopus 로고
    • Artemisinin resistance in Plasmodium falciparum
    • 68 Amaratunga, C., et al. Artemisinin resistance in Plasmodium falciparum. Lancet Infect. Dis. 14 (2014), 449–450.
    • (2014) Lancet Infect. Dis. , vol.14 , pp. 449-450
    • Amaratunga, C.1
  • 69
    • 84859506329 scopus 로고    scopus 로고
    • A major genome region underlying artemisinin resistance in malaria
    • 69 Cheeseman, I.H., et al. A major genome region underlying artemisinin resistance in malaria. Science 336 (2012), 79–82.
    • (2012) Science , vol.336 , pp. 79-82
    • Cheeseman, I.H.1
  • 70
    • 84871944250 scopus 로고    scopus 로고
    • Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia
    • 70 Takala-Harrison, S., et al. Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia. Proc. Natl. Acad. Sci. U.S.A. 110 (2013), 240–245.
    • (2013) Proc. Natl. Acad. Sci. U.S.A. , vol.110 , pp. 240-245
    • Takala-Harrison, S.1
  • 71
    • 84878715473 scopus 로고    scopus 로고
    • Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia
    • 71 Miotto, O., et al. Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nat. Genet. 45 (2013), 648–655.
    • (2013) Nat. Genet. , vol.45 , pp. 648-655
    • Miotto, O.1
  • 72
    • 77951220629 scopus 로고    scopus 로고
    • Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism
    • 72 Witkowski, B., et al. Increased tolerance to artemisinin in Plasmodium falciparum is mediated by a quiescence mechanism. Antimicrob. Agents Chemother. 54 (2010), 1872–1877.
    • (2010) Antimicrob. Agents Chemother. , vol.54 , pp. 1872-1877
    • Witkowski, B.1
  • 73
    • 84892372929 scopus 로고    scopus 로고
    • A molecular marker of artemisinin-resistant Plasmodium falciparum malaria
    • 73 Ariey, F., et al. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature 505 (2014), 50–55.
    • (2014) Nature , vol.505 , pp. 50-55
    • Ariey, F.1
  • 74
    • 84905746811 scopus 로고    scopus 로고
    • Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system
    • 74 Ghorbal, M., et al. Genome editing in the human malaria parasite Plasmodium falciparum using the CRISPR-Cas9 system. Nat. Biotechnol. 32 (2014), 819–821.
    • (2014) Nat. Biotechnol. , vol.32 , pp. 819-821
    • Ghorbal, M.1
  • 75
    • 84921719133 scopus 로고    scopus 로고
    • K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates
    • 75 Straimer, J., et al. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates. Science 347 (2015), 428–431.
    • (2015) Science , vol.347 , pp. 428-431
    • Straimer, J.1
  • 76
    • 84929492770 scopus 로고    scopus 로고
    • Selection and spread of artemisinin-resistant alleles in Thailand prior to the global artemisinin resistance containment campaign
    • 76 Talundzic, E., et al. Selection and spread of artemisinin-resistant alleles in Thailand prior to the global artemisinin resistance containment campaign. PLoS Pathog., 11, 2015, e1004789.
    • (2015) PLoS Pathog. , vol.11 , pp. e1004789
    • Talundzic, E.1
  • 77
    • 84928014326 scopus 로고    scopus 로고
    • Prevalence of K13-propeller polymorphisms in Plasmodium falciparum from China–Myanmar border in 2007-2012
    • 77 Wang, Z., et al. Prevalence of K13-propeller polymorphisms in Plasmodium falciparum from China–Myanmar border in 2007-2012. Malar. J., 14, 2015, 168.
    • (2015) Malar. J. , vol.14 , pp. 168
    • Wang, Z.1
  • 78
    • 84983059142 scopus 로고    scopus 로고
    • A single mutation in K13 predominates in southern China and is associated with delayed clearance of Plasmodium falciparum following artemisinin treatment
    • 78 Huang, F., et al. A single mutation in K13 predominates in southern China and is associated with delayed clearance of Plasmodium falciparum following artemisinin treatment. J. Infect. Dis. 212 (2015), 1629–1635.
    • (2015) J. Infect. Dis. , vol.212 , pp. 1629-1635
    • Huang, F.1
  • 79
    • 84961932806 scopus 로고    scopus 로고
    • Genomic epidemiology of artemisinin resistant malaria
    • 79 MalariaGEN Plasmodium falciparum Community Project, Genomic epidemiology of artemisinin resistant malaria. eLife, 5, 2016, e08714.
    • (2016) eLife , vol.5 , pp. e08714
    • MalariaGEN Plasmodium falciparum Community Project1
  • 80
    • 84930607163 scopus 로고    scopus 로고
    • Polymorphisms in the K13-propeller gene in artemisinin-susceptible Plasmodium falciparum parasites from Bougoula-Hameau and Bandiagara
    • 80 Ouattara, A., et al. Polymorphisms in the K13-propeller gene in artemisinin-susceptible Plasmodium falciparum parasites from Bougoula-Hameau and Bandiagara. Mali. A. J. Trop. Med. Hyg. 92 (2015), 1202–1206.
    • (2015) Mali. A. J. Trop. Med. Hyg. , vol.92 , pp. 1202-1206
    • Ouattara, A.1
  • 81
    • 84939865009 scopus 로고    scopus 로고
    • Lack of artemisinin resistance in Plasmodium falciparum in Uganda based on parasitological and molecular assays
    • 81 Cooper, R.A., et al. Lack of artemisinin resistance in Plasmodium falciparum in Uganda based on parasitological and molecular assays. Antimicrob. Agents Chemother. 59 (2015), 5061–5064.
    • (2015) Antimicrob. Agents Chemother. , vol.59 , pp. 5061-5064
    • Cooper, R.A.1
  • 82
    • 84955624727 scopus 로고    scopus 로고
    • Lack of K13 mutations in Plasmodium falciparum persisting after artemisinin combination therapy treatment of Kenyan children
    • 82 Muwanguzi, J., et al. Lack of K13 mutations in Plasmodium falciparum persisting after artemisinin combination therapy treatment of Kenyan children. Malar. J., 15, 2016, 36.
    • (2016) Malar. J. , vol.15 , pp. 36
    • Muwanguzi, J.1
  • 83
    • 84942313095 scopus 로고    scopus 로고
    • Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study
    • 83 Taylor, S.M., et al. Absence of putative artemisinin resistance mutations among Plasmodium falciparum in Sub-Saharan Africa: a molecular epidemiologic study. J. Infect. Dis. 211 (2015), 680–688.
    • (2015) J. Infect. Dis. , vol.211 , pp. 680-688
    • Taylor, S.M.1
  • 84
    • 84945129853 scopus 로고    scopus 로고
    • Understanding artemisinin-resistant malaria: what a difference a year makes
    • 84 Fairhurst, R.M., Understanding artemisinin-resistant malaria: what a difference a year makes. Curr. Opin. Infect. Dis. 28 (2015), 417–425.
    • (2015) Curr. Opin. Infect. Dis. , vol.28 , pp. 417-425
    • Fairhurst, R.M.1
  • 85
    • 34250899722 scopus 로고    scopus 로고
    • Signal integration in the endoplasmic reticulum unfolded protein response
    • 85 Ron, D., Walter, P., Signal integration in the endoplasmic reticulum unfolded protein response. Nat. Rev. Mol. Cell. Biol. 8 (2007), 519–529.
    • (2007) Nat. Rev. Mol. Cell. Biol. , vol.8 , pp. 519-529
    • Ron, D.1    Walter, P.2
  • 86
    • 84890204277 scopus 로고    scopus 로고
    • Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system
    • 86 Amm, I., et al. Protein quality control and elimination of protein waste: the role of the ubiquitin-proteasome system. Biochim. Biophys. Acta 1843 (2014), 182–196.
    • (2014) Biochim. Biophys. Acta , vol.1843 , pp. 182-196
    • Amm, I.1
  • 87
    • 84863230381 scopus 로고    scopus 로고
    • PK4, a eukaryotic initiation factor 2α (eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium
    • 87 Zhang, M., et al. PK4, a eukaryotic initiation factor 2α (eIF2α) kinase, is essential for the development of the erythrocytic cycle of Plasmodium. Proc. Natl. Acad. Sci. U.S.A. 109 (2012), 3956–3961.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 3956-3961
    • Zhang, M.1
  • 88
    • 84455161818 scopus 로고    scopus 로고
    • Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparum
    • 88 Tucker, M.S., et al. Phenotypic and genotypic analysis of in vitro-selected artemisinin-resistant progeny of Plasmodium falciparum. Antimicrob. Agents Chemother. 56 (2012), 302–314.
    • (2012) Antimicrob. Agents Chemother. , vol.56 , pp. 302-314
    • Tucker, M.S.1
  • 89
    • 84943782868 scopus 로고    scopus 로고
    • Artemisinin-resistant Plasmodium falciparum parasites exhibit altered patterns of development in infected erythrocytes
    • 89 Hott, A., et al. Artemisinin-resistant Plasmodium falciparum parasites exhibit altered patterns of development in infected erythrocytes. Antimicrob. Agents Chemother. 59 (2015), 3156–3167.
    • (2015) Antimicrob. Agents Chemother. , vol.59 , pp. 3156-3167
    • Hott, A.1
  • 90
    • 84921785363 scopus 로고    scopus 로고
    • Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance
    • 90 Mok, S., et al. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance. Science 347 (2014), 431–435.
    • (2014) Science , vol.347 , pp. 431-435
    • Mok, S.1
  • 91
    • 84958046387 scopus 로고    scopus 로고
    • Structure- and function-based design of Plasmodium-selective proteasome inhibitors
    • 91 Li, H., et al. Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Nature 530 (2016), 233–236.
    • (2016) Nature , vol.530 , pp. 233-236
    • Li, H.1
  • 92
    • 34250662528 scopus 로고    scopus 로고
    • Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites
    • 92 Hunt, P., et al. Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites. Mol. Microbiol. 65 (2007), 27–40.
    • (2007) Mol. Microbiol. , vol.65 , pp. 27-40
    • Hunt, P.1
  • 93
    • 0033961690 scopus 로고    scopus 로고
    • The kelch repeat superfamily of proteins: propellers of cell function
    • 93 Adams, J., et al. The kelch repeat superfamily of proteins: propellers of cell function. Trends Cell. Biol. 10 (2000), 17–24.
    • (2000) Trends Cell. Biol. , vol.10 , pp. 17-24
    • Adams, J.1
  • 94
    • 84890307627 scopus 로고    scopus 로고
    • Update on the Kelch-like (KLHL) gene family
    • 94 Dhanoa, B.S., et al. Update on the Kelch-like (KLHL) gene family. Hum. Genomics, 7, 2013, 13.
    • (2013) Hum. Genomics , vol.7 , pp. 13
    • Dhanoa, B.S.1
  • 95
    • 0028040875 scopus 로고
    • The POZ domain: a conserved protein–protein interaction motif
    • 95 Bardwell, V.J., Treisman, R., The POZ domain: a conserved protein–protein interaction motif. Genes Dev. 8 (1994), 1664–1677.
    • (1994) Genes Dev. , vol.8 , pp. 1664-1677
    • Bardwell, V.J.1    Treisman, R.2
  • 96
    • 33845534761 scopus 로고    scopus 로고
    • Born to bind: the BTB protein–protein interaction domain
    • 96 Perez-Torrado, R., et al. Born to bind: the BTB protein–protein interaction domain. Bioessays 28 (2006), 1194–1202.
    • (2006) Bioessays , vol.28 , pp. 1194-1202
    • Perez-Torrado, R.1
  • 97
    • 43249090401 scopus 로고    scopus 로고
    • Characterization and expression of a human KCTD1 gene containing the BTB domain, which mediates transcriptional repression and homomeric interactions
    • 97 Ding, X.F., et al. Characterization and expression of a human KCTD1 gene containing the BTB domain, which mediates transcriptional repression and homomeric interactions. DNA Cell Biol. 27 (2008), 257–265.
    • (2008) DNA Cell Biol. , vol.27 , pp. 257-265
    • Ding, X.F.1
  • 98
    • 0242575197 scopus 로고    scopus 로고
    • Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases
    • 98 Furukawa, M., et al. Targeting of protein ubiquitination by BTB–Cullin 3–Roc1 ubiquitin ligases. Nat. Cell Biol. 5 (2003), 1001–1007.
    • (2003) Nat. Cell Biol. , vol.5 , pp. 1001-1007
    • Furukawa, M.1
  • 99
    • 34548105127 scopus 로고    scopus 로고
    • Sequence and structural analysis of BTB domain proteins
    • 99 Stogios, P.J., et al. Sequence and structural analysis of BTB domain proteins. Genome Biol., 6, 2005, R82.
    • (2005) Genome Biol. , vol.6 , pp. R82
    • Stogios, P.J.1
  • 100
    • 84889889353 scopus 로고    scopus 로고
    • Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy
    • 100 Digaleh, H., et al. Nrf2 and Nrf1 signaling and ER stress crosstalk: implication for proteasomal degradation and autophagy. Cell. Mol. Life Sci. 70 (2013), 4681–4694.
    • (2013) Cell. Mol. Life Sci. , vol.70 , pp. 4681-4694
    • Digaleh, H.1
  • 101
    • 0141752795 scopus 로고    scopus 로고
    • Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
    • 101 Cullinan, S.B., et al. Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival. Mol. Cell. Biol. 23 (2003), 7198–7209.
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 7198-7209
    • Cullinan, S.B.1
  • 102
    • 84969804371 scopus 로고    scopus 로고
    • Beyond antioxidant genes in the ancient Nrf2 regulatory network
    • 102 Lacher, S.E., et al. Beyond antioxidant genes in the ancient Nrf2 regulatory network. Free Radic. Biol. Med. 88 (2015), 452–465.
    • (2015) Free Radic. Biol. Med. , vol.88 , pp. 452-465
    • Lacher, S.E.1
  • 103
    • 84971009760 scopus 로고    scopus 로고
    • Bioinformatics analyses provide insight into distant homology of the Keap1–Nrf2 pathway
    • 103 Gacesa, R., et al. Bioinformatics analyses provide insight into distant homology of the Keap1–Nrf2 pathway. Free Radic. Biol. Med. 88 (2015), 373–380.
    • (2015) Free Radic. Biol. Med. , vol.88 , pp. 373-380
    • Gacesa, R.1
  • 104
    • 76749100261 scopus 로고    scopus 로고
    • In silico and biological survey of transcription-associated proteins implicated in the transcriptional machinery during the erythrocytic development of Plasmodium falciparum
    • 104 Bischoff, E., Vaquero, C., In silico and biological survey of transcription-associated proteins implicated in the transcriptional machinery during the erythrocytic development of Plasmodium falciparum. BMC Genomics, 11, 2010, 34.
    • (2010) BMC Genomics , vol.11 , pp. 34
    • Bischoff, E.1    Vaquero, C.2
  • 105
    • 84924080547 scopus 로고    scopus 로고
    • Genetic architecture of artemisinin resistant Plasmodium falciparum
    • 105 Miotto, O., et al. Genetic architecture of artemisinin resistant Plasmodium falciparum. Nat. Genet. 47 (2015), 226–234.
    • (2015) Nat. Genet. , vol.47 , pp. 226-234
    • Miotto, O.1
  • 106
    • 0037020024 scopus 로고    scopus 로고
    • Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations
    • 106 Sidhu, A.B., et al. Chloroquine resistance in Plasmodium falciparum malaria parasites conferred by pfcrt mutations. Science 298 (2002), 210–213.
    • (2002) Science , vol.298 , pp. 210-213
    • Sidhu, A.B.1
  • 107
    • 2142769136 scopus 로고    scopus 로고
    • Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number
    • 107 Price, R.N., et al. Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet 364 (2004), 438–447.
    • (2004) Lancet , vol.364 , pp. 438-447
    • Price, R.N.1
  • 108
    • 33746302565 scopus 로고    scopus 로고
    • Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin
    • 108 Sidhu, A.B., et al. Decreasing pfmdr1 copy number in Plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisinin. J. Infect. Dis. 194 (2006), 528–535.
    • (2006) J. Infect. Dis. , vol.194 , pp. 528-535
    • Sidhu, A.B.1
  • 109
    • 79957580467 scopus 로고    scopus 로고
    • Drug-resistant malaria: molecular mechanisms and implications for public health
    • 109 Petersen, I., et al. Drug-resistant malaria: molecular mechanisms and implications for public health. FEBS Lett. 585 (2011), 1551–1562.
    • (2011) FEBS Lett. , vol.585 , pp. 1551-1562
    • Petersen, I.1
  • 110
    • 84969945025 scopus 로고    scopus 로고
    • Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies
    • 110 Veiga, M.I., et al. Globally prevalent PfMDR1 mutations modulate Plasmodium falciparum susceptibility to artemisinin-based combination therapies. Nat. Commun., 7, 2016, 11553.
    • (2016) Nat. Commun. , vol.7 , pp. 11553
    • Veiga, M.I.1
  • 111
    • 84906937961 scopus 로고    scopus 로고
    • Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether–lumefantrine and artesunate–amodiaquine
    • 111 Venkatesan, M., et al. Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether–lumefantrine and artesunate–amodiaquine. Am. J. Trop. Med. Hyg. 91 (2014), 833–843.
    • (2014) Am. J. Trop. Med. Hyg. , vol.91 , pp. 833-843
    • Venkatesan, M.1
  • 112
    • 84935754128 scopus 로고    scopus 로고
    • Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter
    • 112 Petersen, I., et al. Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter. Mol. Microbiol. 97 (2015), 381–395.
    • (2015) Mol. Microbiol. , vol.97 , pp. 381-395
    • Petersen, I.1
  • 113
    • 84979517803 scopus 로고    scopus 로고
    • A comparison of the exposure time-dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wildtype and mutant Plasmodium falciparum
    • 113 Yang, T., et al. A comparison of the exposure time-dependence of the activities of synthetic ozonide antimalarials and dihydroartemisinin against K13 wildtype and mutant Plasmodium falciparum. Antimicrob. Agents Chemother., 2016, 10.1128/AAC.00574-16.
    • (2016) Antimicrob. Agents Chemother.
    • Yang, T.1
  • 114
    • 84871609304 scopus 로고    scopus 로고
    • Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity
    • 114 Li, H., et al. Validation of the proteasome as a therapeutic target in Plasmodium using an epoxyketone inhibitor with parasite-specific toxicity. Chem. Biol. 19 (2012), 1535–1545.
    • (2012) Chem. Biol. , vol.19 , pp. 1535-1545
    • Li, H.1
  • 115
    • 84880323005 scopus 로고    scopus 로고
    • Broad-spectrum antimalarial activity of peptido sulfonyl fluorides, a new class of proteasome inhibitors
    • 115 Tschan, S., et al. Broad-spectrum antimalarial activity of peptido sulfonyl fluorides, a new class of proteasome inhibitors. Antimicrob. Agents Chemother. 57 (2013), 3576–3584.
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 3576-3584
    • Tschan, S.1
  • 116
    • 84949141033 scopus 로고    scopus 로고
    • Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome
    • 116 Li, H., et al. Identification of potent and selective non-covalent inhibitors of the Plasmodium falciparum proteasome. J. Am. Chem. Soc. 136 (2014), 13562–13565.
    • (2014) J. Am. Chem. Soc. , vol.136 , pp. 13562-13565
    • Li, H.1
  • 117
    • 84863769005 scopus 로고    scopus 로고
    • The Keap1–Nrf2 cell defense pathway–a promising therapeutic target?
    • 117 Copple, I.M., The Keap1–Nrf2 cell defense pathway–a promising therapeutic target?. Adv. Pharmacol. 63 (2012), 43–79.
    • (2012) Adv. Pharmacol. , vol.63 , pp. 43-79
    • Copple, I.M.1
  • 118
    • 84959170188 scopus 로고    scopus 로고
    • Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study
    • 118 Amaratunga, C., et al. Dihydroartemisinin–piperaquine resistance in Plasmodium falciparum malaria in Cambodia: a multisite prospective cohort study. Lancet Infect. Dis. 16 (2016), 357–365.
    • (2016) Lancet Infect. Dis. , vol.16 , pp. 357-365
    • Amaratunga, C.1
  • 119
    • 84929513620 scopus 로고    scopus 로고
    • Dihydroartemisinin–piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study
    • 119 Spring, M.D., et al. Dihydroartemisinin–piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study. Lancet Infect. Dis. 15 (2015), 683–691.
    • (2015) Lancet Infect. Dis. , vol.15 , pp. 683-691
    • Spring, M.D.1
  • 120
    • 84904861610 scopus 로고    scopus 로고
    • Dihydroartemisinin–piperaquine failure in Cambodia
    • 120 Saunders, D.L., et al. Dihydroartemisinin–piperaquine failure in Cambodia. N. Eng. J. Med. 371 (2014), 484–485.
    • (2014) N. Eng. J. Med. , vol.371 , pp. 484-485
    • Saunders, D.L.1
  • 121
    • 84872849978 scopus 로고    scopus 로고
    • Efficacy of dihydroartemisinin–piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010
    • 121 Leang, R., et al. Efficacy of dihydroartemisinin–piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010. Antimicrob. Agents Chemother. 57 (2013), 818–826.
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 818-826
    • Leang, R.1
  • 122
    • 84939832774 scopus 로고    scopus 로고
    • Evidence of Plasmodium falciparum malaria multidrug resistance to artemisinin and piperaquine in Western Cambodia: dihydroartemisinin–piperaquine open-label multicenter clinical assessment
    • 122 Leang, R., et al. Evidence of Plasmodium falciparum malaria multidrug resistance to artemisinin and piperaquine in Western Cambodia: dihydroartemisinin–piperaquine open-label multicenter clinical assessment. Antimicrob. Agents Chemother. 59 (2015), 4719–4726.
    • (2015) Antimicrob. Agents Chemother. , vol.59 , pp. 4719-4726
    • Leang, R.1
  • 123
    • 77957557403 scopus 로고    scopus 로고
    • Declining in efficacy of a three-day combination regimen of mefloquine–artesunate in a multi-drug resistance area along the Thai–Myanmar border
    • 123 Na-Bangchang, K., et al. Declining in efficacy of a three-day combination regimen of mefloquine–artesunate in a multi-drug resistance area along the Thai–Myanmar border. Malar. J., 9, 2010, 273.
    • (2010) Malar. J. , vol.9 , pp. 273
    • Na-Bangchang, K.1
  • 124
    • 84875419985 scopus 로고    scopus 로고
    • Malaria burden and artemisinin resistance in the mobile and migrant population on the Thai–Myanmar border, 1999-2011: an observational study
    • 124 Carrara, V.I., et al. Malaria burden and artemisinin resistance in the mobile and migrant population on the Thai–Myanmar border, 1999-2011: an observational study. PLoS Med., 10, 2013, e1001398.
    • (2013) PLoS Med. , vol.10 , pp. e1001398
    • Carrara, V.I.1
  • 125
    • 84872858923 scopus 로고    scopus 로고
    • Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia
    • 125 Witkowski, B., et al. Reduced artemisinin susceptibility of Plasmodium falciparum ring stages in western Cambodia. Antimicrob. Agents Chemother. 57 (2013), 914–923.
    • (2013) Antimicrob. Agents Chemother. , vol.57 , pp. 914-923
    • Witkowski, B.1
  • 126
    • 84922496747 scopus 로고    scopus 로고
    • Plasmodium falciparum clearance is rapid and pitting independent in immune Malian children treated with artesunate for malaria
    • 126 Ndour, P.A., et al. Plasmodium falciparum clearance is rapid and pitting independent in immune Malian children treated with artesunate for malaria. J. Infect. Dis. 15 (2014), 290–297.
    • (2014) J. Infect. Dis. , vol.15 , pp. 290-297
    • Ndour, P.A.1
  • 127
    • 0033844946 scopus 로고    scopus 로고
    • The mechanisms of parasite clearance after antimalarial treatment of Plasmodium falciparum malaria
    • 127 Chotivanich, K., et al. The mechanisms of parasite clearance after antimalarial treatment of Plasmodium falciparum malaria. J. Infect. Dis. 182 (2000), 629–633.
    • (2000) J. Infect. Dis. , vol.182 , pp. 629-633
    • Chotivanich, K.1


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