Direct evidence for the atovaquone action on the Plasmodium cytochrome bc1 complex

Parasitology International

Volumn 64, Issue 3, 2015, Pages 295-300

  Siregar, Josephine E ^a   Kurisu, Genji ^b   Kobayashi, Tamaki ^c   Matsuzaki, Motomichi ^c   Sakamoto, Kimitoshi ^c   Mi ichi, Fumika ^c   Watanabe, Yoh ichi ^c   Hirai, Makoto ^d   Matsuoka, Hiroyuki ^d   Syafruddin, Din ^a   Marzuki, Sangkot ^a   Kita, Kiyoshi ^c  

^a EIJKMAN INSTITUTE FOR MOLECULAR BIOLOGY   (Indonesia)

^b OSAKA UNIVERSITY   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

^d JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

Atovaquone resistance; Cytochrome bc1 complex; Malaria; Plasmodium

Indexed keywords

5 N HEPTYL 6 HYDROXY 4,7 DIOXOBENZOTHIAZOLE; ATOVAQUONE; BENZOTHIAZOLE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; STIGMATELLIN; UBIQUINOL CYTOCHROME C REDUCTASE; UNCLASSIFIED DRUG; ANTIMALARIAL AGENT; CYTOCHROME B; OXIDOREDUCTASE;

ANIMAL EXPERIMENT; APICOMPLEXA; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ERYTHROCYTE; HYDROGEN BOND; IC50; MITOCHONDRION; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PLASMODIUM; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RHODOBACTER CAPSULATUS; SACCHAROMYCES CEREVISIAE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; COMPUTER SIMULATION; DRUG EFFECTS; DRUG RESISTANCE; DRUG SENSITIVITY; GENETICS; METABOLISM; MITOCHONDRIAL GENE; MUTATION; SEQUENCE ALIGNMENT;

PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM PARASITES; PROTOZOA;

ANTIMALARIALS; ATOVAQUONE; BINDING SITES; COMPUTER SIMULATION; CYTOCHROMES B; DRUG RESISTANCE; ELECTRON TRANSPORT COMPLEX III; GENES, MITOCHONDRIAL; MODELS, MOLECULAR; MUTATION; OXIDOREDUCTASES; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; SEQUENCE ALIGNMENT;

EID: 84924404654     PISSN: 13835769     EISSN: 18730329     Source Type: Journal    
DOI: 10.1016/j.parint.2014.09.011     Document Type: Article

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