Artemisinin-resistant Plasmodium falciparum clinical isolates can infect diverse mosquito vectors of Southeast Asia and Africa

Nature Communications

Volumn 6, Issue , 2015, Pages

  St Laurent, Brandyce ^a   Miller, Becky ^a   Burton, Timothy A ^a   Amaratunga, Chanaki ^a   Men, Sary ^b   Sovannaroth, Siv ^b   Fay, Michael P ^a   Miotto, Olivo ^c,d,e   Gwadz, Robert W ^a   Anderson, Jennifer M ^a   Fairhurst, Rick M ^a  

^a NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^b National Centre for Parasitology Entomology and Malaria Control   (Cambodia)

^c MAHIDOL UNIVERSITY   (Thailand)

^d WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DISEASE SPREAD; DISEASE VECTOR; DRUG; DRUG RESISTANCE; GAMETE; MALARIA; MOSQUITO; PARASITE; PROTOZOAN;

AFRICA; CAMBODIA;

ANOPHELES DIRUS; ANOPHELES GAMBIAE; ANOPHELES MINIMUS; PLASMODIUM FALCIPARUM;

ANTIMALARIAL AGENT; ARTEMISININ; ARTEMISININ DERIVATIVE; PROTOZOAL PROTEIN;

AFRICA; ANIMAL; ANOPHELES; ANOPHELES GAMBIAE; ANTIBIOTIC RESISTANCE; CAMBODIA; GENETICS; HUMAN; INSECT VECTOR; MALARIA FALCIPARUM; MOSQUITO; PARASITOLOGY; PATHOGENICITY; PLASMODIUM FALCIPARUM; SOUTHEAST ASIA; SPOROZOITE; TRANSMISSION;

AFRICA; ANIMALS; ANOPHELES; ANOPHELES GAMBIAE; ANTIMALARIALS; ARTEMISININS; ASIA, SOUTHEASTERN; CAMBODIA; CULICIDAE; DRUG RESISTANCE, MICROBIAL; HUMANS; INSECT VECTORS; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; SPOROZOITES;

EID: 84945157328     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms9614     Document Type: Article

References (33)

1. Fairhurst, R. M. Understanding artemisinin-resistant malaria: what a difference a year makes. Curr. Opin. Infect. Dis. 28, 417-425 (2015).
2. Dondorp, A. M. et al. The threat of artemisinin-resistant malaria. N. Engl. J. Med. 365, 1073-1075 (2011).
3. Spring, M. D. et al. Dihydroartemisinin-piperaquine failure associated with a triple mutant including kelch13 C580Y in Cambodia: an observational cohort study. Lancet Infect. Dis. 15, 683-691 (2015).
4. Leang, R. et al. Evidence of falciparum malaria multidrug resistance to artemisinin and piperaquine in western Cambodia: dihydroartemisinin-piperaquine open-label multicenter clinical assessment. Antimicrob. Agents. Chemother. 59, 4719-4726 (2015).
5. Dondorp, A. M. et al. Artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 361, 455-467 (2009).
6. Amaratunga, C. et al. Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study. Lancet Infect. Dis. 12, 851-858 (2012).
7. Phyo, A. P. et al. Emergence of artemisinin-resistant malaria on the western border of Thailand: a longitudinal study. Lancet 379, 1960-1966 (2012).
8. Ariey, F. et al. A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature 505, 50-55 (2014).
9. Ashley, E. A. et al. Spread of artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 371, 411-423 (2014).
10. Tun, K. M. et al. Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker. Lancet Infect. Dis. 15, 415-421 (2015).
11. Miotto, O. et al. Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia. Nat. Genet. 45, 648-655 (2013).
12. Miotto, O. et al. Genetic architecture of artemisinin-resistant Plasmodium falciparum. Nat. Genet. 47, 226-234 (2015).
13. Witkowski, B. et al. Novel phenotypic assays for the detection of artemisininresistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies. Lancet Infect. Dis. 13, 1043-1049 (2013).
14. Amaratunga, C., Neal, A. T. & Fairhurst, R. M. Flow cytometry-based analysis of artemisinin-resistant Plasmodium falciparum in the ring-stage survival assay. Antimicrob. Agents Chemother. 58, 4938-4940 (2014).
15. Straimer, J. et al. Drug resistance. K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates. Science 347, 428-431 (2015).
16. Mok, S. et al. Drug resistance. Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance. Science 347, 431-435 (2015).
17. Durnez, L. et al. Outdoor malaria transmission in forested villages of Cambodia. Malar. J. 12, 329 (2013).
18. Rosenberg, R., Andre, R. G. & Somchit, L. Highly efficient dry season transmission of malaria in Thailand. Trans. R. Soc. Trop. Med. Hyg. 84, 22-28 (1990).
19. Cui, L. et al. Malaria in the Greater Mekong Subregion: heterogeneity and complexity. Acta Trop. 121, 227-239 (2012).
20. Graves, P. M. et al. Effects of transmission-blocking monoclonal antibodies on different isolates of Plasmodium falciparum. Infect. Immun. 48, 611-616 (1985).
21. Medley, G. F. et al. Heterogeneity in patterns of malarial oocyst infections in the mosquito vector. Parasitology 106, 441-449 (1993).
22. Cohuet, A. et al. Anopheles and Plasmodium: from laboratory models to natural systems in the field. EMBO Rep. 7, 1285-1289 (2006).
23. Coetzee, M. et al. Anopheles coluzzii and Anopheles amharicus, new members of the Anopheles gambiae complex. Zootaxa 3619, 246-274 (2013).
24. Neafsey, D. E. et al. Mosquito genomics. Highly evolvable malaria vectors: the genomes of 16 Anopheles mosquitoes. Science 347, 1258522 (2015).
25. Annan, Z. et al. Population genetic structure of Plasmodium falciparum in the two main African vectors, Anopheles gambiae and Anopheles funestus. Proc. Natl Acad. Sci. USA 104, 7987-7992 (2007).
26. Mitri, C. & Vernick, K. D. Anopheles gambiae pathogen susceptibility: the intersection of genetics, immunity and ecology. Curr. Opin. Microbiol. 15, 285-291 (2012).
27. Graves, P. M. et al. Measurement of malarial infectivity of human populations to mosquitoes in the Madang area, Papua, New Guinea. Parasitology 96(Pt 2): 251-263 (1988).
28. Ramphul, U. N., Garver, L. S., Molina-Cruz, A., Canepa, G. E. & Barillas-Mury, C. Plasmodium falciparum evades mosquito immunity by disrupting JNK-mediated apoptosis of invaded midgut cells. Proc. Natl Acad. Sci. USA 112, 1273-1280 (2015).
29. Molina-Cruz, A. et al. The human malaria parasite Pfs47 gene mediates evasion of the mosquito immune system. Science 340, 984-987 (2013).
30. Manske, M. et al. Analysis of Plasmodium falciparum diversity in natural infections by deep sequencing. Nature 487, 375-379 (2012).
31. Walton, C. et al. Identification of five species of the Anopheles dirus complex from Thailand, using allele-specific polymerase chain reaction. Med. Vet. Entomol. 13, 24-32 (1999).
32. Fanello, C., Santolamazza, F. & della Torre, A. Simultaneous identification of species and molecular forms of the Anopheles gambiae complex by PCR-RFLP. Med. Vet. Entomol. 16, 461-464 (2002).
33. Wright, S. P. Adjusted p-values for simultaneous inference. Biometrics 48, 1005-1013 (1992).