Host targeting of virulence determinants and phosphoinositides in blood stage malaria parasites

Trends in Parasitology

Volumn 28, Issue 12, 2012, Pages 555-562

  Bhattacharjee, Souvik ^a   Stahelin, Robert V ^a,b   Haldar, Kasturi ^a  

^a UNIVERSITY OF NOTRE DAME   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Blood cells; Endoplasmic reticulum; Export; Host targeting; Malaria; Pathogenic secretion; Phosphoinositides

Indexed keywords

ASPARTIC PROTEINASE; PHOSPHATIDYLINOSITOL 3 PHOSPHATE; PLASMEPSIN V; UNCLASSIFIED DRUG;

ENDOPLASMIC RETICULUM; ERYTHROCYTE; HOST CELL; HUMAN; MALARIA; NONHUMAN; PARASITE VIRULENCE; PLASMODIUM FALCIPARUM; REVIEW;

ENDOPLASMIC RETICULUM; ERYTHROCYTES; HOST-PATHOGEN INTERACTIONS; HUMANS; MALARIA, FALCIPARUM; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHATIDYLINOSITOLS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; VIRULENCE FACTORS;

EID: 84869183087     PISSN: 14714922     EISSN: 14715007     Source Type: Journal    
DOI: 10.1016/j.pt.2012.09.004     Document Type: Review

References (33)

1. Price R.N., Douglas N.M. Artemisinin combination therapy for malaria: beyond good efficacy. Clin. Infect. Dis. 2009, 49:1638-1640.
2. Collins W.E. Plasmodium knowlesi: a malaria parasite of monkeys and humans. Annu. Rev. Entomol. 2012, 57:107-121.
3. Miller L.H., et al. The pathogenic basis of malaria. Nature 2002, 415:673-679.
4. Bhattacharjee S., et al. Endoplasmic reticulum PI(3)P lipid binding targets malaria proteins to the host cell. Cell 2012, 148:201-212.
5. Haldar K., Mohandas N. Erythrocyte remodeling by malaria parasites. Curr. Opin. Hematol. 2007, 14:203-209.
6. Dixon M.W., et al. Genetic ablation of a Maurer's cleft protein prevents assembly of the Plasmodium falciparum virulence complex. Mol. Microbiol. 2011, 81:982-993.
7. Lauer S.A., et al. A membrane network for nutrient import in red cells infected with the malaria parasite. Science 1997, 276:1122-1125.
8. Sargeant T.J., et al. Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites. Genome Biol. 2006, 7:R12.
9. van Ooij C., et al. The malaria secretome: from algorithms to essential function in blood stage infection. PLoS Pathog. 2008, 4:e1000084.
10. Hiller N.L., et al. A host-targeting signal in virulence proteins reveals a secretome in malarial infection. Science 2004, 306:1934-1937.
11. Marti M., et al. Targeting malaria virulence and remodeling proteins to the host erythrocyte. Science 2004, 306:1930-1933.
12. Tamez P.A., et al. An erythrocyte vesicle protein exported by the malaria parasite promotes tubovesicular lipid import from the host cell surface. PLoS Pathog. 2008, 4:e1000118.
13. Przyborski J.M., Lanzer M. Protein transport and trafficking in Plasmodium falciparum-infected erythrocytes. Parasitology 2005, 130:373-388.
14. Cooke B.M., et al. A Maurer's cleft-associated protein is essential for expression of the major malaria virulence antigen on the surface of infected red blood cells. J. Cell Biol. 2006, 172:899-908.
15. Spielmann T., Gilberger T.W. Protein export in malaria parasites: do multiple export motifs add up to multiple export pathways?. Trends Parasitol. 2010, 26:6-10.
16. Gehde N., et al. Protein unfolding is an essential requirement for transport across the parasitophorous vacuolar membrane of Plasmodium falciparum. Mol. Microbiol. 2009, 71:613-628.
17. Chang H.H., et al. N-terminal processing of proteins exported by malaria parasites. Mol. Biochem. Parasitol. 2008, 160:107-115.
18. Boddey J.A., et al. Role of the Plasmodium export element in trafficking parasite proteins to the infected erythrocyte. Traffic 2009, 10:285-299.
19. Osborne A.R., et al. The host targeting motif in exported Plasmodium proteins is cleaved in the parasite endoplasmic reticulum. Mol. Biochem. Parasitol. 2010, 171:25-31.
20. Boddey J.A., et al. An aspartyl protease directs malaria effector proteins to the host cell. Nature 2010, 463:627-631.
21. Russo I., et al. Plasmepsin V licenses Plasmodium proteins for export into the host erythrocyte. Nature 2010, 463:632-636.
22. Lee S.A., et al. Targeting of the FYVE domain to endosomal membranes is regulated by a histidine switch. Proc. Natl. Acad. Sci. U.S.A. 2005, 102:13052-13057.
23. Mayinger P. Phosphoinositides and vesicular membrane traffic. Biochim. Biophys. Acta 2012, 1821:1104-1113.
24. Mishra A., et al. Structural basis for Rab GTPase recognition and endosome tethering by the C2H2 zinc finger of Early Endosomal Autoantigen 1 (EEA1). Proc. Natl. Acad. Sci. U.S.A. 2010, 107:10866-10871.
25. Tawk L., et al. Phosphatidylinositol 3-phosphate, an essential lipid in Plasmodium, localizes to the food vacuole membrane and the apicoplast. Eukaryot. Cell 2010, 9:1519-1530.
26. Waller R.F., McFadden G.I. The apicoplast: a review of the derived plastid of apicomplexan parasites. Curr. Issues Mol. Biol. 2005, 7:57-79.
27. Tawk L., et al. Phosphatidylinositol 3-monophosphate is involved in toxoplasma apicoplast biogenesis. PLoS Pathog. 2010, 7:e1001286.
28. Vaid A., et al. PfPI3K, a phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking. Blood 2010, 115:2500-2507.
29. Kale S.D., et al. External lipid PI3P mediates entry of eukaryotic pathogen effectors into plant and animal host cells. Cell 2010, 142:284-295.
30. Bhattacharjee S., et al. The malarial host-targeting signal is conserved in the Irish potato famine pathogen. PLoS Pathog. 2006, 2:e50.
31. Lopez-Estrano C., et al. Cooperative domains define a unique host cell-targeting signal in Plasmodium falciparum-infected erythrocytes. Proc. Natl. Acad. Sci. U.S.A. 2003, 100:12402-12407.
32. de Koning-Ward T.F., et al. A newly discovered protein export machine in malaria parasites. Nature 2009, 459:945-949.
33. Bullen H.E., et al. Biosynthesis, localization, and macromolecular arrangement of the Plasmodium falciparum translocon of exported proteins (PTEX). J. Biol. Chem. 2012, 287:7871-7884.