Plasmodium falciparum dihydroartemisinin-piperaquine failures in Cambodia are associated with mutant K13 parasites presenting high survival rates in novel piperaquine in vitro assays: Retrospective and prospective investigations

BMC Medicine

Volumn 13, Issue 1, 2015, Pages

  Duru, Valentine ^a   Khim, Nimol ^a   Leang, Rithea ^b   Kim, Saorin ^a   Domergue, Anais ^a   Kloeung, Nimol ^a   Ke, Sopheakvatey ^a   Chy, Sophy ^a   Eam, Rotha ^a   Khean, Chanra ^a   Loch, Kaknika ^a   Ken, Malen ^a   Lek, Dysoley ^b   Beghain, Johann ^c   Ariey, Frédéric ^c   Guerin, Philippe J ^d,e   Huy, Rekol ^b   Mercereau Puijalon, Odile ^c   Witkowski, Benoit ^a   Menard, Didier ^a  

^a INSTITUT PASTEUR DU CAMBODGE   (Cambodia)

^b National Center for Parasitology Entomology and Malaria Control   (Cambodia)

^c INSTITUT PASTEUR   (France)

^d Sorbonne Paris Cité   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Artemisinin combination therapies; Artemisinin resistance; Cambodia; Ex vivo testing; Falciparum; In vitro testing; Malaria; Piperaquine resistance; Treatment failure

Indexed keywords

DIHYDROARTEMISININ PLUS PIPERAQUINE; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; DIHYDROARTEMISININ; PIPERAQUINE; QUINOLINE DERIVATIVE;

ADOLESCENT; ADULT; ALLELE; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CAMBODIA; COPY NUMBER VARIATION; DRUG TREATMENT FAILURE; FEMALE; GENE; GENE MUTATION; GENETIC POLYMORPHISM; GENETIC STRAIN; HETEROZYGOTE; HUMAN; IN VITRO STUDY; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALE; NONHUMAN; PARASITE SURVIVAL; PFCRT GENE; PFMDR 1 GENE; PHENOTYPE; PLASMODIUM FALCIPARUM; PROSPECTIVE STUDY; RECURRENCE RISK; RETROSPECTIVE STUDY; SURVIVAL RATE; ANIMAL; GENETICS; MALARIA, FALCIPARUM; MORTALITY; PARASITE; TREATMENT FAILURE; TREATMENT OUTCOME; YOUNG ADULT;

ADOLESCENT; ADULT; ANIMALS; ANTIMALARIALS; ARTEMISININS; CAMBODIA; FEMALE; HUMANS; MALARIA, FALCIPARUM; MALE; PARASITES; PLASMODIUM FALCIPARUM; PROSPECTIVE STUDIES; QUINOLINES; RETROSPECTIVE STUDIES; SURVIVAL RATE; TREATMENT FAILURE; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84951744000     PISSN: None     EISSN: 17417015     Source Type: Journal    
DOI: 10.1186/s12916-015-0539-5     Document Type: Article

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