K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

Science

Volumn 347, Issue 6220, 2015, Pages 428-431

  Straimer, Judith ^a   Gnädig, Nina F ^a   Witkowski, Benoit ^b   Amaratunga, Chanaki ^c   Duru, Valentine ^b   Ramadani, Arba Pramundita ^d,e,h   Dacheux, Mélanie ^a   Khim, Nimol ^b   Zhang, Lei ^f   Lam, Stephen ^f   Gregory, Philip D ^f   Urnov, Fyodor D ^f   Mercereau Puijalon, Odile ^g   Benoit Vical, Franҫoise ^d,e   Fairhurst, Rick M ^c   Ménard, Didier ^b   Fidock, David A ^a  

^a Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^b INSTITUT PASTEUR DU CAMBODGE   (Cambodia)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d CNRS   (France)

^e UNIVERSITÉ DE TOULOUSE   (France)

^f SANGAMO BIOSCIENCES INC   (United States)

^g INSTITUT PASTEUR   (France)

^h GADJAH MADA UNIVERSITY   (Indonesia)

Author keywords

[No Author keywords available]

Indexed keywords

ARTEMISININ; DNA; ZINC FINGER NUCLEASE; ANTIMALARIAL AGENT; ARTEMISININ DERIVATIVE; PROTOZOAL PROTEIN;

DRUG RESISTANCE; GENETICALLY MODIFIED ORGANISM; MALARIA; MUTATION; PROTOZOAN; PUBLIC HEALTH; SURVIVAL;

ARTICLE; CAMBODIA; DNA MODIFICATION; DRUG EXPOSURE; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; HEREDITY; IN VITRO STUDY; NONHUMAN; PARASITE CLEARANCE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SURVIVAL RATE; AMINO ACID SEQUENCE; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; HUMAN; MALARIA, FALCIPARUM; MOLECULAR GENETICS; MUTATION; PARASITOLOGY; PROTEIN TERTIARY STRUCTURE;

SOUTHEAST ASIA;

PLASMODIUM FALCIPARUM;

AMINO ACID SEQUENCE; ANTIMALARIALS; ARTEMISININS; CAMBODIA; DRUG RESISTANCE; GENETIC LOCI; HUMANS; MALARIA, FALCIPARUM; MOLECULAR SEQUENCE DATA; MUTATION; PLASMODIUM FALCIPARUM; PROTEIN STRUCTURE, TERTIARY; PROTOZOAN PROTEINS;

EID: 84921719133     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1260867     Document Type: Article

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