Assessment of Plasmodium falciparum resistance to ferroquine (SSR97193) in field isolates and in W2 strain under pressure

Malaria Journal

Volumn 5, Issue , 2006, Pages

  Daher, Wassim ^a   Biot, Christophe ^b   Fandeur, Thierry ^c   Jouin, Helene ^a,d   Pelinski, Lydie ^b   Viscogliosi, Eric ^a   Fraisse, Laurent ^e   Pradines, Bruno ^f   Brocard, Jacques ^b   Khalife, Jamal ^a   Dive, Daniel ^a  

^a INSTITUT PASTEUR DE LILLE   (France)

^b Ecole Nationale Superieure de Chimie de Lille   (France)

^c CEMAGREF   (France)

^d INSTITUT PASTEUR   (France)

^e SANOFI   (France)

^f SERVICE DE SANTÉ DES ARMÉES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; FERROQUINE; MESSENGER RNA; SSR97193; UNCLASSIFIED DRUG;

ARTICLE; CAMBODIA; CONTROLLED STUDY; DRUG SCREENING; GENE EXPRESSION; GENE MUTATION; GENETIC POLYMORPHISM; GENOTYPE; IC 50; IN VITRO STUDY; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE ISOLATION; PLASMODIUM FALCIPARUM;

AMINO ACID SEQUENCE; AMINOQUINOLINES; ANIMALS; ANTIMALARIALS; BLOOD CELLS; CELLS, CULTURED; CHLOROQUINE; DRUG RESISTANCE; FERROUS COMPOUNDS; FLOW CYTOMETRY; GENETIC VARIATION; INHIBITORY CONCENTRATION 50; MEMBRANE TRANSPORT PROTEINS; PARASITIC SENSITIVITY TESTS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS;

EID: 33646352709     PISSN: 14752875     EISSN: 14752875     Source Type: Journal    
DOI: 10.1186/1475-2875-5-11     Document Type: Article

References (41)

1. Egan TJ, Combrinck JM, Egan J, Hearne GR, Marques HM, Ntenteni S, Sewell BT, Smith PJ, Taylor D, van Schalkwyk DA, Walden JC: Fate of haem iron in the malaria parasite Plasmodium falciparum. Biochem J 2002, 365:343-347.
2. Ginsburg H, Ward SA, Bray PG: An integrated model of chloroquine action. Parasitol Today 1999, 15:357-360.
3. Sanchez CP, Stein W, Lanzer M: Trans stimulation provides evidence for a drug efflux carrier as the mechanism of chloroquine resistance in Plasmodium falciparum. Biochemistry 2003, 42:9383-9394.
4. Fidock DA, Nomura T, Talley AK, Cooper RA, Dzekunov SM, Ferdig MT, Ursos LM, Sidhu AB, Naude B, Deitsch KW, Su XZ, Wootton JC, Roepe PD, Wellems TE: Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistance. Mol Cell 2000, 6:861-871.
5. Djimde A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Diourte Y, Dicko A, Su XZ, Nomura T, Fidock DA, Wellems TE, Plowe CV, Coulibaly D: A molecular marker for chloroquine-resistant falciparum malaria. N Engl J Med 2001, 344:257-263.
6. Howard EM, Zhang H, Roepe PD: A novel transporter, Pfcrt, confers antimalarial drug resistance. J Membr Biol 2002, 190:1-8.
7. Wellems TE: Plasmodium chloroquine resistance and the search for a replacement antimalarial drug. Science 2002, 298:124-126.
8. Waller KL, Muhle RA, Ursos LM, Horrocks P, Verdier-Pinard D, Sidhu AB, Fujioka H, Roepe PD, Fidock DA: Chloroquine resistance modulated in vitro by expression levels of the Plasmodium falciparum chloroquine resistance transporter. J Biol Chem 2003, 278:33593-33601.
9. Biot C, Glorian G, Maciejewski LA, Brocard JS: Synthesis and antimalarial activity in vitro and in vivo of a new ferrocene-chloroquine analogue. J Med Chem 1997, 40:3715-3718.
10. Biot C: Ferroquine: a new weapon in the fight against malaria. Current Medicinal Chemistry-Anti Infective Agents 2004, 3:135-147.
11. Delhaës L, Abessolo H, Biot C, Deloron P, Karbwang J, Mortuaire M, Maciejewski LA, Camus D, Brocard J, Dive D: Ferrochloroquine, a ferrocenyl analogue of chloroquine, retains a potent activity against resistant Plasmodium falciparum in vitro and P. vinckei in vivo. Parasitol Res 2001, 87:239-244.
12. Delhaes L, Biot C, Berry L, Delcourt P, Maciejewski LA, Camus D, Brocard JS, Dive D: Synthesis of ferroquine enantiomers: first investigation of effects of metallocenic chirality upon antimalarial activity and cytotoxicity. Chembiochem 2002, 3:418-423.
13. Atteke C, Ndong JM, Aubouy A, Maciejewski L, Brocard J, Lebibi J, Deloron P: In vitro susceptibility to a new antimalarial organometallic analogue, ferroquine, of Plasmodium falciparum isolates from the Haut-Ogooue region of Gabon. J Antimicrob Chemother 2003, 51:1021-1024.
14. Domarle O, Blampain G, Agnaniet H, Nzadiyabi T, Lebibi J, Brocard J, Maciejewski L, Biot C, Georges AJ, Millet P: In vitro antimalarial activity of a new organometallic analog, ferrocene-chloroquine. Antimicrob Agents Chemother 1998, 42:540-544.
15. Pradines B, Fusai T, Daries W, Laloge V, Rogier C, Millet P, Panconi E, Kombila M, Parzy D: Ferrocene-chloroquine analogues as antimalarial agents: in vitro activity of ferrochloroquine against 103 Gabonese isolates of Plasmodium falciparum. J Antimicrob Chemother 2001, 48:179-184.
16. Pradines B, Tall A, Rogier C, Spiegel A, Mosnier J, Marrama L, Fusai T, Millet P, Panconi E, Trape JF, Parzy D: In vitro activities of ferrochloroquine against 55 Senegalese isolates of Plasmodium falciparum in comparison with those of standard antimalarial drugs. Trop Med Int Health 2002, 7:265-270.
17. Chim P, Lim P, Sem R, Nhem S, Maciejewski L, Fandeur T: The invitro antimalarial activity of ferrochloroquine, measured against Cambodian isolates of Plasmodium falciparum. Ann Trop Med Parasitol 2004, 98:419-424.
18. Durrand V, Berry A, Sem R, Glaziou P, Beaudou J, Fandeur T: Variations in the sequence and expression of the Plasmodium falciparum chloroquine resistance transporter (Pfcrt) and their relationship to chloroquine resistance in vitro. Mol Biochem Parasitol 2004, 136:273-285.
19. Rathod PK, McErlean T, Lee PC: Variations in frequencies of drug resistance in Plasmodium falciparum. Proc Natl Acad Sci U S A 1997, 94:9389-9393.
20. Gassis S, Rathod PK: Frequency of drug resistance in Plasmodium falciparum: a nonsynergistic combination of 5-fluoroorotate and atovaquone suppresses in vitro resistance. Antimicrob Agents Chemother 1996, 40:914-919.
21. Cooper RA, Ferdig MT, Su XZ, Ursos LM, Mu J, Nomura T, Fujioka H, Fidock DA, Roepe PD, Wellems TE: Alternative mutations at position 76 of the vacuolar transmembrane protein PfCRT are associated with chloroquine resistance and unique stereospecific quinine and quinidine responses in Plasmodium falciparum. Mol Pharmacol 2002, 61:35-42.
22. Trager W, Jensen JB: Human malaria parasites in continuous culture. Science 1976, 193:673-675.
23. Desjardins RE, Canfield CJ, Haynes JD, Chulay JD: Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrob Agents Chemother 1979, 16:710-718.
24. Millet J, Alibert S, Torrentino-Madamet M, Rogier C, Santelli-Rouvier C, Bigot P, Mosnier J, Baret E, Barbe J, Parzy D, Pradines B: Polymorphism in Plasmodium falciparum drug transporter proteins and reversal of in vitro chloroquine resistance by a 9, 10-dihydroethanoanthracene derivative. Antimicrob Agents Chemother 2004, 48:4869-4872.
25. [http://jwbrown.mbio.ncsu.edu/BioEdit/bioedit.html].
26. Huelsenbeck JP, Ronquist F: MRBAYES: Bayesian inference of phylogenetic trees. Bioinformatics 2001, 17:754-755.
27. Jones DT, Taylor WR, Thornton JM: The rapid generation of mutation data matrices from protein sequences. Comput Appl Biosci 1992, 8:275-282.
28. Green PJ: Reversible jump Markov chain Monte Carlo computation and Bayesian model determination. Biometrika 1995, 82:711-732.
29. Jouin H, Daher W, Khalife J, Ricard I, Puijalon OM, Capron M, Dive D: Double staining of Plasmodium falciparum nucleic acids with hydroethidine and thiazole orange for cell cycle stage analysis by flow cytometry. Cytometry A 2004, 57:34-38.
30. Martin RE, Kirk K: The malaria parasite's chloroquine resistance transporter is a member of the drug/metabolite transporter superfamily. Mol Biol Evol 2004, 21:1938-1949.
31. Warhurst DC: Polymorphism in the Plasmodium falciparum chloroquine-resistance transporter protein links verapamil enhancement of chloroquine sensitivity with the clinical efficacy of amodiaquine. Malar J 2003, 2:31-43.
32. Walliker D, Hunt P, Babiker H: Fitness of drug-resistant malaria parasites. Acta Trop 2005, 94:251-259.
33. Hastings IM, Donnelly MJ: The impact of antimalarial drug resistance mutations on parasite fitness, and its implications for the evolution of resistance. Drug Resist Updat 2005, 8:43-50.
34. Hayward R, Saliba KJ, Kirk K: pfmdr1 mutations associated with chloroquine resistance incur a fitness cost in Plasmodium falciparum. Mol Microbiol 2005, 55:1285-1295.
35. Paget-McNicol S, Saul A: Mutation rates in the dihydrofolate reductase gene of Plasmodium falciparum. Parasitology 2001, 122:497-505.
36. Anderson TJ, Roper C: The origins and spread of antimalarial drug resistance: lessons for policy makers. Acta Trop 2005, 94:269-280.
37. Price RN, Uhlemann AC, Brockman A, McGready R, Ashley E, Phaipun L, Patel R, Laing K, Looareesuwan S, White NJ, Nosten F, Krishna S: Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number. Lancet 2004, 364:438-447.
38. Klokouzas A, Shahi S, Hladky SB, Barrand MA, van Veen HW: ABC transporters and drug resistance in parasitic protozoa. Int J Antimicrob Agents 2003, 22:301-317.
39. Mu J, Ferdig MT, Feng X, Joy DA, Duan J, Furuya T, Subramanian G, Aravind L, Cooper RA, Wootton JC, Xiong M, Su XZ: Multiple transporters associated with malaria parasite responses to chloroquine and quinine. Mol Microbiol 2003, 49:977-989.
40. Ferdig MT, Cooper RA, Mu J, Deng B, Joy DA, Su XZ, Wellems TE: Dissecting the loci of low-level quinine resistance in malaria parasites. Mol Microbiol 2004, 52:985-997.
41. Trotta RF, Brown ML, Terrell JC, Geyer JA: Defective DNA repair as a potential mechanism for the rapid development of drug resistance in Plasmodium falciparum. Biochemistry 2004, 43:4885-4891.