Dihydroartemisinin-piperaquine failure in Cambodia

New England Journal of Medicine

Volumn 371, Issue 5, 2014, Pages 484-485

  Saunders, David L ^a   Vanachayangkul, Pattaraporn ^a   Lon, Chanthap ^b  

^a ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES   (Thailand)

^b Armed Forces Research Institute of Medical Sciences   (Cambodia)

Author keywords

[No Author keywords available]

Indexed keywords

DIHYDROARTEMISININ PLUS PIPERAQUINE;

ANTIMALARIAL DRUG RESISTANCE; ANTIMALARIAL DRUG SUSCEPTIBILITY; CAMBODIA; DRUG EFFICACY; DRUG TREATMENT FAILURE; HUMAN; IC 50; LETTER; MALARIA FALCIPARUM; MULTIDRUG RESISTANCE; NONHUMAN; OPEN STUDY; PARASITE CLEARANCE; PARASITE LOAD; PARASITEMIA; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RECURRENT INFECTION; REINFECTION; TREATMENT RESPONSE;

ADULT; ANTIMALARIALS; ARTEMISININS; CAMBODIA; DRUG COMBINATIONS; HUMANS; MALARIA, FALCIPARUM; QUINOLINES; RECURRENCE; TREATMENT FAILURE;

EID: 84904861610     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMc1403007     Document Type: Letter

References (5)

1. Janssens B, van Herp M, Goubert L, et al. A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia. Trop Med Int Health 2007;12:251-9.
2. Gosi P, Lanteri CA, Tyner SD, et al. Evaluation of parasite subpopulations and genetic diversity of the msp1, msp2 and glurp genes during and following artesunate monotherapy treatment of Plasmodium falciparum malaria in Western Cambodia. Malar J 2013;12:403.
3. Lon C, Manning JE, Vanachayangkul P, et al. Efficacy of two versus three-day regimens of dihydroartemisinin-piperaquine for uncomplicated malaria in military personnel in northern Cambodia: an open-label randomized trial. PLoS One 2014;9(3):e93138.
4. Zwang J, Ashley EA, Karema C, et al. Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: a prospective multi-centre individual patient data analysis. PLoS One 2009;4(7):e6358.
5. Leang R, Barrette A, Bouth DM, et al. Efficacy of dihydro-artemisinin- piperaquine for treatment of uncomplicated Plasmodium falciparum and Plasmodium vivax in Cambodia, 2008 to 2010. Antimicrob Agents Chemother 2013;57:818-26.