Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 37, 2015, Pages 11672-11677

  Pelleau, Stéphane ^a   Moss, Eli L ^b   Dhingra, Satish K ^c   Volney, Béatrice ^a   Casteras, Jessica ^a   Gabryszewski, Stanislaw J ^c   Volkman, Sarah K ^b,d,e   Wirth, Dyann F ^b,d   Legrand, Eric ^a   Fidock, David A ^c   Neafsey, Daniel E ^b   Musset, Lise ^a  

^a INSTITUT PASTEUR DE LA GUYANE   (French Guiana)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c Columbia University College of Physicians and Surgeons ^*  (United States)

^d HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^e SIMMONS COLLEGE   (United States)

Author keywords

Drug resistance; Evolution; Malaria; PfCRT; Plasmodium falciparum

Indexed keywords

CHLOROQUINE; PIPERAQUINE; CARRIER PROTEIN; GENETIC MARKER; PFCRT PROTEIN, PLASMODIUM FALCIPARUM; PROTOZOAL PROTEIN; QUINOLINE DERIVATIVE;

ALLELE; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CONTROLLED STUDY; EVOLUTION; FRENCH GUIANA; GENE MUTATION; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENOME; HEALTH CARE SURVEY; HUMAN; IN VITRO STUDY; MALARIA FALCIPARUM; PLASMODIUM FALCIPARUM; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SOUTH AMERICA; WILD TYPE; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; GENETIC MARKER; GENETICS; GENOTYPE; HAPLOTYPE; IC50; MALARIA; MOLECULAR EVOLUTION; MUTATION; PHENOTYPE; PRINCIPAL COMPONENT ANALYSIS;

ALLELES; CHLOROQUINE; DRUG RESISTANCE; EVOLUTION, MOLECULAR; FRENCH GUIANA; GENETIC MARKERS; GENOME; GENOTYPE; HAPLOTYPES; HUMANS; INHIBITORY CONCENTRATION 50; MALARIA; MEMBRANE TRANSPORT PROTEINS; MUTATION; PHENOTYPE; PLASMODIUM FALCIPARUM; PREVALENCE; PRINCIPAL COMPONENT ANALYSIS; PROTOZOAN PROTEINS; QUINOLINES; RETROSPECTIVE STUDIES;

EID: 84941671295     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1507142112     Document Type: Article

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