Haemoglobin degradation underpins the sensitivity of early ring stage Plasmodium falciparum to artemisinins

Journal of Cell Science

Volumn 129, Issue 2, 2016, Pages 406-416

  Xie, Stanley C ^a   Dogovski, Con ^a   Hanssen, Eric ^a,b   Chiu, Francis ^c   Yang, Tuo ^a   Crespo, Maria P ^d,e   Stafford, Che ^a   Batinovic, Steven ^a   Teguh, Silvia ^a   Charman, Susan ^c   Klonis, Nectarios ^a   Tilley, Leann ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSIDAD DEL VALLE   (Colombia)

^e UNIVERSIDAD SANTIAGO DE CALI   (Colombia)

Author keywords

Artemisinin; Falcipains; Haemoglobin degradation; Malaria; Plasmodium; Resistance

Indexed keywords

ALOXISTATIN; ARTEMISININ DERIVATIVE; CYSTEINE PROTEINASE; FALCIPAIN 2; FERRIC ION; HEMOGLOBIN; IRON CHELATING AGENT; ANTIMALARIAL AGENT; CYSTEINE PROTEINASE INHIBITOR; FALCIPAIN; LEUCINE; PROTOZOAL PROTEIN;

ARTICLE; CHEMICAL ANALYSIS; DOWN REGULATION; DRUG ACTIVITY; DRUG EXPOSURE; GENE EXPRESSION REGULATION; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTIST LIFE CYCLE STAGE; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; ANALOGS AND DERIVATIVES; DRUG EFFECTS; DRUG POTENTIATION; DRUG RESISTANCE; ENZYMOLOGY; HUMAN; LD50; MALARIA, FALCIPARUM; METABOLISM; PRECLINICAL STUDY; PROTEIN DEGRADATION;

ANTIMALARIALS; ARTEMISININS; CYSTEINE ENDOPEPTIDASES; CYSTEINE PROTEINASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE; DRUG SYNERGISM; HEMOGLOBINS; HUMANS; LETHAL DOSE 50; LEUCINE; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; PROTEOLYSIS; PROTOZOAN PROTEINS;

EID: 84957801889     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.178830     Document Type: Article

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