KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission

Antimicrobial Agents and Chemotherapy

Volumn 58, Issue 9, 2014, Pages 5060-5067

  Kuhen, Kelli L ^a   Chatterjee, Arnab K ^a,p   Rottmann, Matthias ^b,c   Gagaring, Kerstin ^a   Borboa, Rachel ^a   Buenviaje, Jennifer ^a   Chen, Zhong ^a   Francek, Carolyn ^a   Wu, Tao ^a   Nagle, Advait ^a   Barnes, S Whitney ^a   Plouffe, David ^a   Lee, Marcus C S ^d   Fidock, David A ^d   Graumans, Wouter ^e   Van De Vegte Bolmer, Marga ^e   Van Gemert, Geert J ^e   Wirjanata, Grennady ^f   Sebayang, Boni ^g   Marfurt, Jutta ^f   Russell, Bruce ^h   Suwanarusk, Rossarin ^h   Price, Ric N ^f,k   Nosten, Francois ^i,j,k   Tungtaeng, Anchalee ^l   Gettayacamin, Montip ^l   Sattabongkot, Jetsumon ^j,l   Taylor, Jennifer ^a   Walker, John R ^a   Tully, David ^a   Patra, Kailash P ^m   Flannery, Erika L ⁿ   Vinetz, Joseph M ^m   Renia, Laurent ^h   Sauerwein, Robert W ^e   Winzeler, Elizabeth A ^a,n   Glynne, Richard J ^a   Diagana, Thierry T ^o   more..

^a GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c UNIVERSITY OF BASEL   (Switzerland)

^d Department of Neurology and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain   (United States)

^e RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^f MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

^g EIJKMAN INSTITUTE FOR MOLECULAR BIOLOGY   (Indonesia)

^h AGENCY FOR SCIENCE   (Singapore)

ⁱ SHOKLO MALARIA RESEARCH UNIT   (Thailand)

^j MAHIDOL UNIVERSITY   (Thailand)

^k UNIVERSITY OF OXFORD   (United Kingdom)

^l ARMED FORCES RESEARCH INSTITUTE OF MEDICAL SCIENCES   (Thailand)

^m UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

ⁿ UNIVERSITY OF CALIFORNIA   (United States)

^o NOVARTIS INSTITUTE FOR TROPICAL DISEASES   (Singapore)

^p California Institute for Biomedical Research   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; ARTESUNATE; CHLOROQUINE; IMIDAZOLE DERIVATIVE; KAF 156; KAF156; MEFLOQUINE; PIPERAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANOPHELES; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; CONTROLLED STUDY; DISEASE ELIMINATION; DOSE TIME EFFECT RELATION; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SAFETY; FEMALE; GENETIC STRAIN; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALARIA CONTROL; MALARIA FALCIPARUM; MOUSE; MULTIPLE DRUG DOSE; NONHUMAN; PARASITE CLEARANCE; PARASITE TRANSMISSION; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX MALARIA; PRIORITY JOURNAL; RODENT MALARIA; SCHIZONT; SINGLE DRUG DOSE; SPOROZOITE; TREATMENT RESPONSE; ANIMAL; DRUG EFFECTS; IC50; INSTITUTE FOR CANCER RESEARCH MOUSE; MALARIA, FALCIPARUM; TRANSMISSION;

ANIMALS; ANTIMALARIALS; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MALARIA, FALCIPARUM; MICE; MICE, INBRED ICR; PIPERAZINES; PLASMODIUM FALCIPARUM; SPOROZOITES;

EID: 84906079854     PISSN: 00664804     EISSN: 10986596     Source Type: Journal    
DOI: 10.1128/AAC.02727-13     Document Type: Article

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