Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials

ACS Chemical Biology

Volumn 10, Issue 2, 2015, Pages 413-420

  Flannery, Erika L ^a   McNamara, Case W ^c   Kim, Sang Wan ^a   Kato, Tomoyo Sakata ^c   Li, Fengwu ^b   Teng, Christine H ^a   Gagaring, Kerstin ^c   Manary, Micah J ^a   Barboa, Rachel ^c   Meister, Stephan ^a   Kuhen, Kelli ^c   Vinetz, Joseph M ^b   Chatterjee, Arnab K ^c   Winzeler, Elizabeth A ^a  

^a Division of Pharmacology and Drug Discovery   (United States)

^b UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^c GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; AMINOPYRAZOLE DERIVATIVE; ANTIMALARIAL AGENT; P TYPE CATION TRANSPORTER ADENOSINE TRIPHOSPHATASE 4; PROTEIN; SODIUM; SPIROINDOLONE DERIVATIVE; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; INDOLE DERIVATIVE; PYRAZOLE DERIVATIVE;

AMINO ACID SUBSTITUTION; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; DRUG MECHANISM; PARASITE TRANSMISSION; PHARMACOPHORE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SODIUM CELL LEVEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; DRUG RESISTANCE; ENZYMOLOGY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; MOLECULAR MODEL; MUTATION; PROTEIN CONFORMATION;

PLASMODIUM FALCIPARUM;

ADENOSINE TRIPHOSPHATASES; ANTIMALARIALS; DRUG RESISTANCE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTATION; PLASMODIUM FALCIPARUM; PROTEIN CONFORMATION; PYRAZOLES; SODIUM;

EID: 84923327067     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb500616x     Document Type: Article

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