Pyrazoleamide compounds are potent antimalarials that target Na+ homeostasis in intraerythrocytic Plasmodium falciparum

Nature Communications

Volumn 5, Issue , 2014, Pages

  Vaidya, Akhil B ^a   Morrisey, Joanne M ^a   Zhang, Zhongsheng ^b   Das, Sudipta ^a   Daly, Thomas M ^a   Otto, Thomas D ^c   Spillman, Natalie J ^d   Wyvratt, Matthew ^e   Siegl, Peter ^e   Marfurt, Jutta ^f   Wirjanata, Grennady ^f   Sebayang, Boni F ^g   Price, Ric N ^f,h   Chatterjee, Arnab ⁱ   Nagle, Advait ⁱ   Stasiak, Marcin ^b   Charman, Susan A ^j   Angulo Barturen, Iñigo ^k   Ferrer, Santiago ^k   Belén Jiménez Díaz, María ^k   Martínez, María Santos ^k   Gamo, Francisco Javier ^k   Avery, Vicky M ^l   Ruecker, Andrea ^m   Delves, Michael ^m   Kirk, Kiaran ^d   Berriman, Matthew ^c   Kortagere, Sandhya ^a   Burrows, Jeremy ^e   Fan, Erkang ^b   Bergman, Lawrence W ^a   more..

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

^d AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^e Medicines for Malaria Venture   (Switzerland)

^f MENZIES SCHOOL OF HEALTH RESEARCH   (Australia)

^g EIJKMAN INSTITUTE FOR MOLECULAR BIOLOGY   (Indonesia)

^h UNIVERSITY OF OXFORD   (United Kingdom)

ⁱ GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^j MONASH UNIVERSITY   (Australia)

^k GLAXOSMITHKLINE   (Spain)

^l GRIFFITH UNIVERSITY   (Australia)

^m IMPERIAL COLLEGE LONDON   (United Kingdom)

more..

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 4 (4 FLUOROPHENYL) N [4 (4 FLUOROPHENYL) 1,3 DIMETHYL 1H PYRAZOL 5 YL]BUTANAMIDE; ADENOSINE TRIPHOSPHATASE; AMIDE; ANTIMALARIAL AGENT; CALCIUM ION; CHLOROQUINE; N [4 (4 CHLORO 2 FLUOROPHENYL) 1,3 DIMETHYL 1H PYRAZOL 5 YL) 2 (2 ISOPROPYL 1H BENZO[D]IMIDAZOL 1 YL]ACETAMIDE; N [4 (4 CHLORO 2 FLUOROPHENYL) 3 (TRIFLUOROMETHYL) 1 METHYL 1H PYRAZOL 5 YL) 2 (2 ISOPROPYL 1H BENZO[D]IMIDAZOL 1 YL]ACETAMIDE; PROTEIN KINASE; PYRAZOLE DERIVATIVE; SODIUM ION; UNCLASSIFIED DRUG; CALCIUM-DEPENDENT PROTEIN KINASE; PROTOZOAL PROTEIN; PYRAZOLE; SODIUM;

CHEMICAL COMPOUND; DRUG; ENZYME ACTIVITY; GENOME; HOMEOSTASIS; MALARIA; PARASITE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; AREA UNDER THE CURVE; ARTICLE; CELL PH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; EC50; ENDOPLASMIC RETICULUM; ERYTHROCYTE; EX VIVO STUDY; FEMALE; GAMETOCYTE; GENE MUTATION; GENE SEQUENCE; GENE TRANSFER; GROWTH INHIBITION; HOMEOSTASIS; HUMAN; HUMAN CELL; IN VIVO STUDY; MALARIA FALCIPARUM; MALE; MEROZOITE; MOLECULE; NONHUMAN; PARASITE CLEARANCE; PARASITEMIA; PH; PLASMODIUM; PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; SCHIZONT; SODIUM HOMEOSTASIS; TROPHOZOITE; DRUG EFFECTS; ENZYMOLOGY; GENETICS; MALARIA; METABOLISM; PARASITOLOGY; PLASMODIUM BERGHEI;

PLASMODIUM FALCIPARUM;

ADENOSINE TRIPHOSPHATASES; AMIDES; ANTIMALARIALS; ERYTHROCYTES; FEMALE; HOMEOSTASIS; HUMANS; MALARIA; MALE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTEIN KINASES; PROTOZOAN PROTEINS; PYRAZOLES; SODIUM;

EID: 84923311088     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms6521     Document Type: Article

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