-
1
-
-
0035941075
-
Taking Cell-Matrix Adhesions to the Third Dimension
-
Cukierman E, Pankov R, Stevens D. R.. Taking Cell-Matrix Adhesions to the Third Dimension. Science 2001, 294, 1708–1712.
-
(2001)
Science
, vol.294
, pp. 1708-1712
-
-
Cukierman, E.1
Pankov, R.2
Stevens, D.R.3
-
2
-
-
0344845001
-
Tissue Architecture: The Ultimate Regulator of Breast Epithelial Function
-
Bissell M. J., Rizki A., Mian I, S. Tissue Architecture: The Ultimate Regulator of Breast Epithelial Function. Curr. Opin. Cell Biol. 2003, 15, 753–762.
-
(2003)
Curr. Opin. Cell Biol
, vol.15
, pp. 753-762
-
-
Bissell, M.J.1
Rizki, A.2
Mian, I.S.3
-
3
-
-
84862003156
-
Loss of Cancer Drug Activity in Colon Cancer HCT-116 Cells during Spheroid Formation in a New 3-D Spheroid Cell Culture System
-
Karlsson H., Fryknäs M., Larsson R.. Loss of Cancer Drug Activity in Colon Cancer HCT-116 Cells during Spheroid Formation in a New 3-D Spheroid Cell Culture System. Exp. Cell Res. 2012, 318, 1577–1585.
-
(2012)
Exp. Cell Res
, vol.318
, pp. 1577-1585
-
-
Karlsson, H.1
Fryknäs, M.2
Larsson, R.3
-
4
-
-
63449105639
-
Compact Spheroid Formation by Ovarian Cancer Cells Is Associated with Contractile behavior and an Invasive Phenotype
-
Sodek K. L., Ringuette M. J., Brown T. J., Compact Spheroid Formation by Ovarian Cancer Cells Is Associated with Contractile behavior and an Invasive Phenotype. Int. J. Cancer 2009, 124, 2060–2070.
-
(2009)
Int. J. Cancer
, vol.124
, pp. 2060-2070
-
-
Sodek, K.L.1
Ringuette, M.J.2
Brown, T.J.3
-
5
-
-
4344645978
-
Can the Pharmaceutical Industry Reduce Attrition Rates?
-
Kola I., Landis J., Can the Pharmaceutical Industry Reduce Attrition Rates? Nat. Rev. Drug Discov. 2004, 3, 711–715.
-
(2004)
Nat. Rev. Drug Discov
, vol.3
, pp. 711-715
-
-
Kola, I.1
Landis, J.2
-
6
-
-
77649234756
-
How to Improve R&D Productivity: The Pharmaceutical Industry’s Grand Challenge
-
Paul S. M., Mytelka D. S., Dunwiddie C. T.. How to Improve R&D Productivity: The Pharmaceutical Industry’s Grand Challenge. Nat. Rev. Drug Discov. 2010, 9, 203–214.
-
(2010)
Nat. Rev. Drug Discov
, vol.9
, pp. 203-214
-
-
Paul, S.M.1
Mytelka, D.S.2
Dunwiddie, C.T.3
-
7
-
-
79957889347
-
The Productivity Crisis in Pharmaceutical R&D
-
Pammolli F., Magazzini L., Riccaboni M., The Productivity Crisis in Pharmaceutical R&D. Nat. Rev. Drug Discov. 2011, 10, 428–438.
-
(2011)
Nat. Rev. Drug Discov
, vol.10
, pp. 428-438
-
-
Pammolli, F.1
Magazzini, L.2
Riccaboni, M.3
-
8
-
-
34547931078
-
Modeling Tissue Morphogenesis and Cancer in 3D
-
Yamada K. M., Cukierman E., Modeling Tissue Morphogenesis and Cancer in 3D. Cell 2007, 130, 601–610.
-
(2007)
Cell
, vol.130
, pp. 601-610
-
-
Yamada, K.M.1
Cukierman, E.2
-
9
-
-
84874700631
-
Three-Dimensional Cell Culture: The Missing Link in Drug Discovery
-
Breslin S., O’Driscoll L., Three-Dimensional Cell Culture: The Missing Link in Drug Discovery. Drug Discov. Today 2013, 18, 240–248.
-
(2013)
Drug Discov. Today
, vol.18
, pp. 240-248
-
-
Breslin, S.1
O’Driscoll, L.2
-
10
-
-
0014885887
-
A Multi-Component Radiation Survival Curve Using an In Vitro Tumour Model
-
Sutherland R. M., Inch W. R., McCredie J. A., Kruuv J., A Multi-Component Radiation Survival Curve Using an In Vitro Tumour Model. Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 1970, 18, 491–495.
-
(1970)
Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med
, vol.18
, pp. 491-495
-
-
Sutherland, R.M.1
Inch, W.R.2
McCredie, J.A.3
Kruuv, J.4
-
11
-
-
0014984766
-
Growth of Multicell Spheroids in Tissue Culture as a Model of Nodular Carcinomas
-
Sutherland R. M., McCredie J. A., Inch W. R., Growth of Multicell Spheroids in Tissue Culture as a Model of Nodular Carcinomas. J. Natl. Cancer Inst. 1971, 46, 113–120.
-
(1971)
J. Natl. Cancer Inst
, vol.46
, pp. 113-120
-
-
Sutherland, R.M.1
McCredie, J.A.2
Inch, W.R.3
-
12
-
-
84858723379
-
Advances in Establishment and Analysis of Three-Dimensional Tumor Spheroid-Based Functional Assays for Target Validation and Drug Evaluation
-
Vinci M., Gowan S., Boxall F.. Advances in Establishment and Analysis of Three-Dimensional Tumor Spheroid-Based Functional Assays for Target Validation and Drug Evaluation. BMC Biol. 2012, 10, 29.
-
(2012)
BMC Biol
, vol.10
, pp. 29
-
-
Vinci, M.1
Gowan, S.2
Boxall, F.3
-
13
-
-
78751560396
-
High-Throughput 3D Spheroid Culture and Drug Testing Using a 384 Hanging Drop Array
-
Tung Y. C., Hsiao A. Y., Allen S. G.. High-Throughput 3D Spheroid Culture and Drug Testing Using a 384 Hanging Drop Array. Analyst 2011, 136, 473–478.
-
(2011)
Analyst
, vol.136
, pp. 473-478
-
-
Tung, Y.C.1
Hsiao, A.Y.2
Allen, S.G.3
-
14
-
-
33745016900
-
Scale-up of Breast Cancer Stem Cell Aggregate Cultures to Suspension Bioreactors
-
Youn B. S., Sen A., Behie L. A.. Scale-up of Breast Cancer Stem Cell Aggregate Cultures to Suspension Bioreactors. Biotechnol. Prog. 2006, 22, 801–810.
-
(2006)
Biotechnol. Prog
, vol.22
, pp. 801-810
-
-
Youn, B.S.1
Sen, A.2
Behie, L.A.3
-
15
-
-
79959887793
-
The Use of Nanoimprinted Scaffolds as 3D Culture Models to Facilitate Spontaneous Tumor Cell Migration and Well-Regulated Spheroid Formation
-
Yoshii Y., Waki A., Yoshida K.. The Use of Nanoimprinted Scaffolds as 3D Culture Models to Facilitate Spontaneous Tumor Cell Migration and Well-Regulated Spheroid Formation. Biomaterials 2011, 32, 6052–6058.
-
(2011)
Biomaterials
, vol.32
, pp. 6052-6058
-
-
Yoshii, Y.1
Waki, A.2
Yoshida, K.3
-
16
-
-
84904396621
-
Organogenesis in a Dish: Modeling Development and Disease Using Organoid Technologies
-
Lancaster M. A., Knoblich J. A., Organogenesis in a Dish: Modeling Development and Disease Using Organoid Technologies. Science 2014, 345, 124–125.
-
(2014)
Science
, vol.345
, pp. 124-125
-
-
Lancaster, M.A.1
Knoblich, J.A.2
-
17
-
-
84938524694
-
Rise of the Organoids
-
Willyard C., Rise of the Organoids. Nature 2015, 523, 520–522.
-
(2015)
Nature
, vol.523
, pp. 520-522
-
-
Willyard, C.1
-
18
-
-
84910136913
-
Three-Dimensional Organotypic Culture: Experimental Models of Mammalian Biology and Disease
-
Shamir E. R., Ewald A. J., Three-Dimensional Organotypic Culture: Experimental Models of Mammalian Biology and Disease. Nat. Rev. Mol. Cell Biol. 2014, 15, 647–664.
-
(2014)
Nat. Rev. Mol. Cell Biol
, vol.15
, pp. 647-664
-
-
Shamir, E.R.1
Ewald, A.J.2
-
19
-
-
84942121762
-
Modeling Mouse and Human Development Using Organoid Cultures
-
Huch M., Koo B. K., Modeling Mouse and Human Development Using Organoid Cultures. Development 2015, 142, 3113–3125.
-
(2015)
Development
, vol.142
, pp. 3113-3125
-
-
Huch, M.1
Koo, B.K.2
-
20
-
-
84868374724
-
Generation of Functional Thyroid from Embryonic Stem Cells
-
Antonica F., Kasprzyk D. F., Opitz R.. Generation of Functional Thyroid from Embryonic Stem Cells. Nature 2012, 491, 66–71.
-
(2012)
Nature
, vol.491
, pp. 66-71
-
-
Antonica, F.1
Kasprzyk, D.F.2
Opitz, R.3
-
21
-
-
84885617460
-
Artificial Three-Dimensional Niches Deconstruct Pancreas Development In Vitro
-
Greggio C., De Franceschi F., Figueiredo-Larsen M.. Artificial Three-Dimensional Niches Deconstruct Pancreas Development In Vitro. Development 2013, 140, 4452–4462.
-
(2013)
Development
, vol.140
, pp. 4452-4462
-
-
Greggio, C.1
De Franceschi, F.2
Figueiredo-Larsen, M.3
-
22
-
-
84873712443
-
In Vitro Expansion of Single Lgr5+ Liver Stem Cells Induced by Wnt-Driven Regeneration
-
Huch M., Dorrell C., Boj S. F.. In Vitro Expansion of Single Lgr5+ Liver Stem Cells Induced by Wnt-Driven Regeneration. Nature 2013, 494, 247–250.
-
(2013)
Nature
, vol.494
, pp. 247-250
-
-
Huch, M.1
Dorrell, C.2
Boj, S.F.3
-
23
-
-
84881184980
-
Vascularized and Functional Human Liver from an iPSC-Derived Organ Bud Transplant
-
Takebe T., Sekine K., Enomura M.. Vascularized and Functional Human Liver from an iPSC-Derived Organ Bud Transplant. Nature 2013, 499, 481–484.
-
(2013)
Nature
, vol.499
, pp. 481-484
-
-
Takebe, T.1
Sekine, K.2
Enomura, M.3
-
24
-
-
73049116186
-
Lgr5(+ve) Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro
-
Barker N., Huch M., Kujala P.. Lgr5(+ve) Stem Cells Drive Self-Renewal in the Stomach and Build Long-Lived Gastric Units In Vitro. Cell Stem Cell 2010, 6, 25–36.
-
(2010)
Cell Stem Cell
, vol.6
, pp. 25-36
-
-
Barker, N.1
Huch, M.2
Kujala, P.3
-
25
-
-
84885672388
-
Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium
-
Stange D. E., Koo B. K., Huch M.. Differentiated Troy+ Chief Cells Act as Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium. Cell 2013, 155, 357–368.
-
(2013)
Cell
, vol.155
, pp. 357-368
-
-
Stange, D.E.1
Koo, B.K.2
Huch, M.3
-
26
-
-
79551686425
-
Directed Differentiation of Human Pluripotent Stem Cells into Intestinal Tissue In Vitro
-
Spence J. R., Mayhew C. N., Rankin S. A.. Directed Differentiation of Human Pluripotent Stem Cells into Intestinal Tissue In Vitro. Nature 2011, 470, 105–109.
-
(2011)
Nature
, vol.470
, pp. 105-109
-
-
Spence, J.R.1
Mayhew, C.N.2
Rankin, S.A.3
-
27
-
-
70349742562
-
Physiological Function and Transplantation of Scaffold-Free and Vascularized Human Cardiac Muscle Tissue
-
Stevens K. R., Kreutziger K. L., Dupras S. K.. Physiological Function and Transplantation of Scaffold-Free and Vascularized Human Cardiac Muscle Tissue. Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 16568–16573.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A
, vol.106
, pp. 16568-16573
-
-
Stevens, K.R.1
Kreutziger, K.L.2
Dupras, S.K.3
-
28
-
-
84884414984
-
Cerebral Organoids Model Human Brain Development and Microcephaly
-
Lancaster M. A., Renner M., Martin C. A.. Cerebral Organoids Model Human Brain Development and Microcephaly. Nature 2013, 501, 373–379.
-
(2013)
Nature
, vol.501
, pp. 373-379
-
-
Lancaster, M.A.1
Renner, M.2
Martin, C.A.3
-
29
-
-
84906865436
-
An Organized and Functional Thymus Generated from FOXN1-Reprogrammed Fibroblasts
-
Bredenkamp N., Ulyanchenko S., O’Neill K. E.. An Organized and Functional Thymus Generated from FOXN1-Reprogrammed Fibroblasts. Nat. Cell Biol. 2014, 16, 902–908.
-
(2014)
Nat. Cell Biol
, vol.16
, pp. 902-908
-
-
Bredenkamp, N.1
Ulyanchenko, S.2
O’Neill, K.E.3
-
30
-
-
84945283561
-
Kidney Organoids from Human iPS Cells Contain Multiple Lineages and Model Human Nephrogenesis
-
Takasato M., Er P. X., Chiu H. S.. Kidney Organoids from Human iPS Cells Contain Multiple Lineages and Model Human Nephrogenesis. Nature 2015, 526, 564–568.
-
(2015)
Nature
, vol.526
, pp. 564-568
-
-
Takasato, M.1
Er, P.X.2
Chiu, H.S.3
-
31
-
-
84945246096
-
Modelling Kidney Disease with CRISPR-Mutant Kidney Organoids Derived from Human Pluripotent Epiblast Spheroids
-
Freedman B. S., Brooks C. R., Lam A. Q.. Modelling Kidney Disease with CRISPR-Mutant Kidney Organoids Derived from Human Pluripotent Epiblast Spheroids. Nat. Comm. 2015, 6, 8715.
-
(2015)
Nat. Comm
, vol.6
, pp. 8715
-
-
Freedman, B.S.1
Brooks, C.R.2
Lam, A.Q.3
-
32
-
-
84893436164
-
Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis
-
Lee J. H., Bhang D. H., Beede A.. Lung Stem Cell Differentiation in Mice Directed by Endothelial Cells via a BMP4-NFATc1-Thrombospondin-1 Axis. Cell 2014, 156, 440–455.
-
(2014)
Cell
, vol.156
, pp. 440-455
-
-
Lee, J.H.1
Bhang, D.H.2
Beede, A.3
-
33
-
-
84862526635
-
Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs
-
Nakano T., Ando S., Takata N.. Self-Formation of Optic Cups and Storable Stratified Neural Retina from Human ESCs. Cell Stem Cell 2012, 10, 771–785.
-
(2012)
Cell Stem Cell
, vol.10
, pp. 771-785
-
-
Nakano, T.1
Ando, S.2
Takata, N.3
-
34
-
-
84956636989
-
Organoids and the Genetically Encoded Self-Assembly of Embryonic Stem Cells
-
Turner D. A., Baillie-Johnson P., Arias A. Z., Organoids and the Genetically Encoded Self-Assembly of Embryonic Stem Cells. Bioessays 2015, 38, 181–191.
-
(2015)
Bioessays
, vol.38
, pp. 181-191
-
-
Turner, D.A.1
Baillie-Johnson, P.2
Arias, A.Z.3
-
35
-
-
84855827259
-
Isolation and Characterization of Mouse and Human Esophageal Epithelial Cells in 3D Organotypic Culture
-
Kalabis J., Wong G. S., Vega M. E.. Isolation and Characterization of Mouse and Human Esophageal Epithelial Cells in 3D Organotypic Culture. Nat. Protoc. 2012, 7, 235–246.
-
(2012)
Nat. Protoc
, vol.7
, pp. 235-246
-
-
Kalabis, J.1
Wong, G.S.2
Vega, M.E.3
-
36
-
-
23744472983
-
Gene Expression Perturbation In Vitro: A Growing Case for Three-Dimensional (3D) Culture Systems
-
Birgersdotter A., Sandberg R., Ernberg I., Gene Expression Perturbation In Vitro: A Growing Case for Three-Dimensional (3D) Culture Systems. Semin. Cancer Biol. 2005, 15, 405–412.
-
(2005)
Semin. Cancer Biol
, vol.15
, pp. 405-412
-
-
Birgersdotter, A.1
Sandberg, R.2
Ernberg, I.3
-
37
-
-
0036132916
-
Hydrogel Properties Influence ECM Production by Chondrocytes Photoencapsulated in Poly(Ethylene Glycol) Hydrogels
-
Bryant S. J., Anseth K. S., Hydrogel Properties Influence ECM Production by Chondrocytes Photoencapsulated in Poly(Ethylene Glycol) Hydrogels. J. Biomed. Mater. Res. 2002, 59, 63–72.
-
(2002)
J. Biomed. Mater. Res
, vol.59
, pp. 63-72
-
-
Bryant, S.J.1
Anseth, K.S.2
-
38
-
-
67650169752
-
Hydrogels as Extracellular Matrix Mimics for 3D Cell Culture
-
Tibbitt M. W., Anseth K. S., Hydrogels as Extracellular Matrix Mimics for 3D Cell Culture. Biotechnol. Bioeng. 2009, 103, 655–663.
-
(2009)
Biotechnol. Bioeng
, vol.103
, pp. 655-663
-
-
Tibbitt, M.W.1
Anseth, K.S.2
-
39
-
-
0343938456
-
Fundamental Studies of a Novel, Biodegradable PEG-b-PLA Hydrogel
-
Metters A. T., Anseth K. S., Bowman C. N., Fundamental Studies of a Novel, Biodegradable PEG-b-PLA Hydrogel. Polymer 2000, 41, 3993–4004.
-
(2000)
Polymer
, vol.41
, pp. 3993-4004
-
-
Metters, A.T.1
Anseth, K.S.2
Bowman, C.N.3
-
40
-
-
0037965624
-
Synthetic Matrix Metalloproteinase-Sensitive Hydrogels for the Conduction of Tissue Regeneration: Engineering Cell-Invasion Characteristics
-
Lutolf M. P., Lauer-Fields J. L., Schmoekel H. G.. Synthetic Matrix Metalloproteinase-Sensitive Hydrogels for the Conduction of Tissue Regeneration: Engineering Cell-Invasion Characteristics. Proc. Natl. Acad. Sci. U.S.A. 2003, 100, 5413–5418.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A
, vol.100
, pp. 5413-5418
-
-
Lutolf, M.P.1
Lauer-Fields, J.L.2
Schmoekel, H.G.3
-
41
-
-
0036345151
-
Photopolymerizable Hydrogels for Tissue Engineering Applications
-
Nguyen K. T., West J. L., Photopolymerizable Hydrogels for Tissue Engineering Applications. Biomaterials 2002, 23, 4307–4314.
-
(2002)
Biomaterials
, vol.23
, pp. 4307-4314
-
-
Nguyen, K.T.1
West, J.L.2
-
42
-
-
52549116234
-
Small Functional Groups for Controlled Differentiation of Hydrogel-Encapsulated Human Mesenchymal Stem Cells
-
Benoit D. S., Schwartz M. P., Durney A. R.. Small Functional Groups for Controlled Differentiation of Hydrogel-Encapsulated Human Mesenchymal Stem Cells. Nat. Mater. 2008, 7, 816–823.
-
(2008)
Nat. Mater
, vol.7
, pp. 816-823
-
-
Benoit, D.S.1
Schwartz, M.P.2
Durney, A.R.3
-
43
-
-
84901242248
-
Materials as Stem Cell Regulators
-
Murphy W. L., McDevitt T. C., Engler A. J., Materials as Stem Cell Regulators. Nat. Mater. 2014, 13, 547–557.
-
(2014)
Nat. Mater
, vol.13
, pp. 547-557
-
-
Murphy, W.L.1
McDevitt, T.C.2
Engler, A.J.3
-
44
-
-
33747152561
-
Matrix Elasticity Directs Stem Cell Lineage Specification
-
Engler A. J., Sen S., Sweeney H. L.. Matrix Elasticity Directs Stem Cell Lineage Specification. Cell 2006, 126, 677–689.
-
(2006)
Cell
, vol.126
, pp. 677-689
-
-
Engler, A.J.1
Sen, S.2
Sweeney, H.L.3
-
45
-
-
84887016191
-
The 3D Printing of Gelatin Methacrylamide Cell-Laden Tissue-Engineered Constructs with High Cell Viability
-
Billiet T., Gevaert E., De Schryver T.. The 3D Printing of Gelatin Methacrylamide Cell-Laden Tissue-Engineered Constructs with High Cell Viability. Biomaterials 2014, 35, 49–62.
-
(2014)
Biomaterials
, vol.35
, pp. 49-62
-
-
Billiet, T.1
Gevaert, E.2
De Schryver, T.3
-
46
-
-
0035119040
-
Biodegradable Polymer Scaffolds with Well-Defined Interconnected Spherical Pore Network
-
Ma P. X., Choi J. W., Biodegradable Polymer Scaffolds with Well-Defined Interconnected Spherical Pore Network. Tissue Eng. 2001, 7, 23–33.
-
(2001)
Tissue Eng
, vol.7
, pp. 23-33
-
-
Ma, P.X.1
Choi, J.W.2
-
47
-
-
34547609666
-
Development of a 3D Cell Culture System for Investigating Cell Interactions with Electrospun Fibers
-
Sun T., Norton D., McKean R. J.. Development of a 3D Cell Culture System for Investigating Cell Interactions with Electrospun Fibers. Biotechnol. Bioeng. 2007, 97, 1318–1328.
-
(2007)
Biotechnol. Bioeng
, vol.97
, pp. 1318-1328
-
-
Sun, T.1
Norton, D.2
McKean, R.J.3
-
48
-
-
84887925650
-
Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size
-
Loh Q. L., Choong C., Three-Dimensional Scaffolds for Tissue Engineering Applications: Role of Porosity and Pore Size. Tissue Eng. Part B Rev. 2013, 19, 485–502.
-
(2013)
Tissue Eng. Part B Rev
, vol.19
, pp. 485-502
-
-
Loh, Q.L.1
Choong, C.2
-
49
-
-
84904264969
-
Expansion of Human Mesenchymal Stromal Cells from Fresh Bone Marrow in a 3D Scaffold-Based System under Direct Perfusion
-
Papadimitropoulos A., Piccinini E., Brachat S.. Expansion of Human Mesenchymal Stromal Cells from Fresh Bone Marrow in a 3D Scaffold-Based System under Direct Perfusion. PLoS One 2014, 9, e102359.
-
(2014)
PLoS One
, vol.9
, pp. e102359
-
-
Papadimitropoulos, A.1
Piccinini, E.2
Brachat, S.3
-
50
-
-
67049167743
-
Chondrogenic Differentiation of Human Mesenchymal Stem Cells on Oriented Nanofibrous Scaffolds: Engineering the Superficial Zone of Articular Cartilage
-
Wise J. K., Yarin A. L., Megaridis C. M.. Chondrogenic Differentiation of Human Mesenchymal Stem Cells on Oriented Nanofibrous Scaffolds: Engineering the Superficial Zone of Articular Cartilage. Tissue Eng. Part A 2009, 15, 913–921.
-
(2009)
Tissue Eng. Part A
, vol.15
, pp. 913-921
-
-
Wise, J.K.1
Yarin, A.L.2
Megaridis, C.M.3
-
52
-
-
33747117373
-
The Origins and the Future of Microfluidics
-
Whitesides G. M., The Origins and the Future of Microfluidics. Nature 2006, 442, 368–373.
-
(2006)
Nature
, vol.442
, pp. 368-373
-
-
Whitesides, G.M.1
-
53
-
-
81355146382
-
From 3D Cell Culture to Organs-on-Chips
-
Huh D., Hamilton G. A., Ingber D. E., From 3D Cell Culture to Organs-on-Chips. Trends Cell Biol. 2011, 21, 745–754.
-
(2011)
Trends Cell Biol
, vol.21
, pp. 745-754
-
-
Huh, D.1
Hamilton, G.A.2
Ingber, D.E.3
-
54
-
-
84905754409
-
Microfluidic Organs-on-Chip
-
Bhatia S. N., Ingber D. E., Microfluidic Organs-on-Chip. Nat. Biotechnol. 2014, 32, 760–772.
-
(2014)
Nat. Biotechnol
, vol.32
, pp. 760-772
-
-
Bhatia, S.N.1
Ingber, D.E.2
-
55
-
-
80355145673
-
The Three-Dimensional Human Skin Reconstruct Model: A Tool to Study Normal Skin and Melanoma Progression
-
Li L., Fukunaga-Kalabis M., Herlyn M., The Three-Dimensional Human Skin Reconstruct Model: A Tool to Study Normal Skin and Melanoma Progression. J. Vis. Exp. 2011, 54, 2937.
-
(2011)
J. Vis. Exp
, vol.54
, pp. 2937
-
-
Li, L.1
Fukunaga-Kalabis, M.2
Herlyn, M.3
-
56
-
-
77954038080
-
Reconstituting Organ-Level Lung Functions on a Chip
-
Huh D., Matthews B. D., Mammoto A.. Reconstituting Organ-Level Lung Functions on a Chip. Science 2010, 328, 1662–1668.
-
(2010)
Science
, vol.328
, pp. 1662-1668
-
-
Huh, D.1
Matthews, B.D.2
Mammoto, A.3
-
57
-
-
84869126274
-
A Human Disease Model of Drug Toxicity-Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice
-
Huh D., Leslie D. C., Matthews B. D.. A Human Disease Model of Drug Toxicity-Induced Pulmonary Edema in a Lung-on-a-Chip Microdevice. Sci. Transl. Med. 2012, 4, 159ra147.
-
(2012)
Sci. Transl. Med
, vol.4
, pp. 159ra147
-
-
Huh, D.1
Leslie, D.C.2
Matthews, B.D.3
-
58
-
-
84996606989
-
Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip
-
Benam K. H., Novak R., Nawroth J.. Matched-Comparative Modeling of Normal and Diseased Human Airway Responses Using a Microengineered Breathing Lung Chip. Cell Syst. 2016, 3, 456–466.
-
(2016)
Cell Syst
, vol.3
, pp. 456-466
-
-
Benam, K.H.1
Novak, R.2
Nawroth, J.3
-
59
-
-
66849138510
-
Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells
-
Song J. W., Cavnar S. P., Walker A. C.. Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells. PLoS One 2009, 4, e5756.
-
(2009)
PLoS One
, vol.4
, pp. e5756
-
-
Song, J.W.1
Cavnar, S.P.2
Walker, A.C.3
-
60
-
-
84933039802
-
From Cardiac Tissue Engineering to Heart-on-a-Chip: Beating Challenges
-
Zhang Y. S., Aleman J., Arneri A.. From Cardiac Tissue Engineering to Heart-on-a-Chip: Beating Challenges. Biomed. Mater. 2015, 10, 034006.
-
(2015)
Biomed. Mater
, vol.10
, pp. 034006
-
-
Zhang, Y.S.1
Aleman, J.2
Arneri, A.3
-
61
-
-
79955368017
-
A Cell-Based Biosensor for Real-Time Detection of Cardiotoxicity Using Lensfree Imaging
-
Kim S. B., Bae H., Cha J. M.. A Cell-Based Biosensor for Real-Time Detection of Cardiotoxicity Using Lensfree Imaging. Lab Chip 2011, 11, 1801–1807.
-
(2011)
Lab Chip
, vol.11
, pp. 1801-1807
-
-
Kim, S.B.1
Bae, H.2
Cha, J.M.3
-
62
-
-
84904297370
-
Three-Dimensionally Printed Biological Machines Powered by Skeletal Muscle
-
Cvetkovic C., Raman R., Chan V.. Three-Dimensionally Printed Biological Machines Powered by Skeletal Muscle. Proc. Natl. Acad. Sci. U.S.A. 2014, 111, 10125–10130.
-
(2014)
Proc. Natl. Acad. Sci. U.S.A
, vol.111
, pp. 10125-10130
-
-
Cvetkovic, C.1
Raman, R.2
Chan, V.3
-
63
-
-
84862181007
-
Organotypic Liver Culture Models: Meeting Current Challenges in Toxicity Testing
-
LeCluyse E. L., Witek R. P., Andersen M. E.. Organotypic Liver Culture Models: Meeting Current Challenges in Toxicity Testing. Crit. Rev. Toxicol. 2012, 42, 501–548.
-
(2012)
Crit. Rev. Toxicol
, vol.42
, pp. 501-548
-
-
LeCluyse, E.L.1
Witek, R.P.2
Andersen, M.E.3
-
64
-
-
84872168458
-
Evaluation of Seven Drug Metabolisms and Clearances by Cryopreserved Human Primary Hepatocytes Cultivated in Microfluidic Biochips
-
Baudoin R., Prot J. M., Nicolas G.. Evaluation of Seven Drug Metabolisms and Clearances by Cryopreserved Human Primary Hepatocytes Cultivated in Microfluidic Biochips. Xenobiotica 2013, 43, 140–152.
-
(2013)
Xenobiotica
, vol.43
, pp. 140-152
-
-
Baudoin, R.1
Prot, J.M.2
Nicolas, G.3
-
65
-
-
67749115964
-
Evaluation of a Microfluidic Based Cell Culture Platform with Primary Human Hepatocytes for the Prediction of Hepatic Clearance in Human
-
Chao P., Maguire T., Novik E.. Evaluation of a Microfluidic Based Cell Culture Platform with Primary Human Hepatocytes for the Prediction of Hepatic Clearance in Human. Biochem. Pharmacol. 2009, 78, 625–632.
-
(2009)
Biochem. Pharmacol
, vol.78
, pp. 625-632
-
-
Chao, P.1
Maguire, T.2
Novik, E.3
-
66
-
-
84875830288
-
Characterization of Drug Permeability in Caco-2 Monolayers by Mass Spectrometry on a Membrane-Based Microfluidic Device
-
Gao D., Liu H., Lin J. M.. Characterization of Drug Permeability in Caco-2 Monolayers by Mass Spectrometry on a Membrane-Based Microfluidic Device. Lab Chip 2013, 13, 978–985.
-
(2013)
Lab Chip
, vol.13
, pp. 978-985
-
-
Gao, D.1
Liu, H.2
Lin, J.M.3
-
67
-
-
77951919817
-
Perfused Multiwell Plate for 3D Liver Tissue Engineering
-
Domansky K., Inman W., Serdy J.. Perfused Multiwell Plate for 3D Liver Tissue Engineering. Lab Chip 2010, 10, 51–58.
-
(2010)
Lab Chip
, vol.10
, pp. 51-58
-
-
Domansky, K.1
Inman, W.2
Serdy, J.3
-
68
-
-
84940377180
-
Metabolite Profiling and Pharmacokinetic Evaluation of Hydrocortisone in a Perfused Three-Dimensional Human Liver Bioreactor
-
Sarkar U., Rivera-Burgos D., Large E. M.. Metabolite Profiling and Pharmacokinetic Evaluation of Hydrocortisone in a Perfused Three-Dimensional Human Liver Bioreactor. Drug Metab. Dispos. 2015, 43, 1091–1099.
-
(2015)
Drug Metab. Dispos
, vol.43
, pp. 1091-1099
-
-
Sarkar, U.1
Rivera-Burgos, D.2
Large, E.M.3
-
69
-
-
84905725612
-
Atala, A 3D Bioprinting of Tissues and Organs
-
Murphy S. V., ; Atala, A 3D Bioprinting of Tissues and Organs. Nat. Biotechnol. 2014, 32, 773–785.
-
(2014)
Nat. Biotechnol
, vol.32
, pp. 773-785
-
-
Murphy, S.V.1
-
70
-
-
33845921327
-
Tissue Engineering and Developmental Biology: Going Biomimetic
-
Ingber D. E., Mow V. C., Butler D.. Tissue Engineering and Developmental Biology: Going Biomimetic. Tissue Eng. 2006, 12, 3265–3283.
-
(2006)
Tissue Eng
, vol.12
, pp. 3265-3283
-
-
Ingber, D.E.1
Mow, V.C.2
Butler, D.3
-
71
-
-
84869131568
-
Printing and Prototyping of Tissues and Scaffolds
-
Derby B., Printing and Prototyping of Tissues and Scaffolds. Science 2012, 338, 921–926.
-
(2012)
Science
, vol.338
, pp. 921-926
-
-
Derby, B.1
-
72
-
-
60549108145
-
Organ Printing: Tissue Spheroids as Building Blocks
-
Mironov V., Visconti R. P., Kasyanov V.. Organ Printing: Tissue Spheroids as Building Blocks. Biomaterials 2009, 30, 2164–2174.
-
(2009)
Biomaterials
, vol.30
, pp. 2164-2174
-
-
Mironov, V.1
Visconti, R.P.2
Kasyanov, V.3
-
73
-
-
77953688143
-
A Novel Concept for Scaffold-Free Vessel Tissue Engineering: Self-assembly of Microtissue Building Blocks
-
Kelm J. M., Lorber V., Snedeker J. G.. A Novel Concept for Scaffold-Free Vessel Tissue Engineering: Self-assembly of Microtissue Building Blocks. J. Biotechnol. 2010, 148, 46–55.
-
(2010)
J. Biotechnol
, vol.148
, pp. 46-55
-
-
Kelm, J.M.1
Lorber, V.2
Snedeker, J.G.3
-
74
-
-
84964440193
-
3D Bioprinting for Tissue and Organ Fabrication
-
Zhang Y. S., Yue K., Aleman J.. 3D Bioprinting for Tissue and Organ Fabrication. Ann. Biomed. Eng. 2017, 45, 148–163.
-
(2017)
Ann. Biomed. Eng
, vol.45
, pp. 148-163
-
-
Zhang, Y.S.1
Yue, K.2
Aleman, J.3
-
75
-
-
84991237189
-
Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics
-
Peng W., Unutmaz D., Ozbolat I. T., Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics. Trends Biotechnol. 2016, 34, 722–732.
-
(2016)
Trends Biotechnol
, vol.34
, pp. 722-732
-
-
Peng, W.1
Unutmaz, D.2
Ozbolat, I.T.3
-
77
-
-
79961007572
-
Trends in the Exploitation of Novel Drug Targets
-
Rask-Andersen M., Almén M. S., Schiöth H. B., Trends in the Exploitation of Novel Drug Targets. Nat. Rev. Drug Discov. 2011, 10, 579–590.
-
(2011)
Nat. Rev. Drug Discov
, vol.10
, pp. 579-590
-
-
Rask-Andersen, M.1
Almén, M.S.2
Schiöth, H.B.3
-
78
-
-
84928255903
-
Beyond 3D Culture Models of Cancer
-
Tanner K., Gottesman M. M., Beyond 3D Culture Models of Cancer. Sci. Transl. Med. 2015, 7, 283ps9.
-
(2015)
Sci. Transl. Med
, vol.7
, pp. 283ps9
-
-
Tanner, K.1
Gottesman, M.M.2
-
79
-
-
40449103297
-
A Human Breast Cell Model of Preinvasive to Invasive Transition
-
Rizki A., Weaver V. M., Lee S. Y.. A Human Breast Cell Model of Preinvasive to Invasive Transition. Cancer Res. 2008, 68, 1378–1387.
-
(2008)
Cancer Res
, vol.68
, pp. 1378-1387
-
-
Rizki, A.1
Weaver, V.M.2
Lee, S.Y.3
-
80
-
-
24944547482
-
Tensional Homeostasis and the Malignant Phenotype
-
Paszek M. J., Zahir N., Johnson K. R.. Tensional Homeostasis and the Malignant Phenotype. Cancer Cell 2005, 8, 241–254.
-
(2005)
Cancer Cell
, vol.8
, pp. 241-254
-
-
Paszek, M.J.1
Zahir, N.2
Johnson, K.R.3
-
81
-
-
84929103936
-
Sequential Cancer Mutations in Cultured Human Intestinal Stem Cells
-
Drost J., van Jaarsveld R. H., Ponsioen B.. Sequential Cancer Mutations in Cultured Human Intestinal Stem Cells. Nature 2015, 521, 43–47.
-
(2015)
Nature
, vol.521
, pp. 43-47
-
-
Drost, J.1
van Jaarsveld, R.H.2
Ponsioen, B.3
-
82
-
-
84964693878
-
Spherical Cancer Models in Tumor Biology
-
Weiswald L. B., Bellet D., Dangles-Marie V., Spherical Cancer Models in Tumor Biology. Neoplasia 2015, 17, 1–15.
-
(2015)
Neoplasia
, vol.17
, pp. 1-15
-
-
Weiswald, L.B.1
Bellet, D.2
Dangles-Marie, V.3
-
83
-
-
80053904142
-
Distinct Types of Tumor-Initiating Cells form Human Colon Cancer Tumors and Metastases
-
Dieter S. M., Ball C. R., Hoffmann C. M.. Distinct Types of Tumor-Initiating Cells form Human Colon Cancer Tumors and Metastases. Cell Stem Cell 2011, 9, 357–365.
-
(2011)
Cell Stem Cell
, vol.9
, pp. 357-365
-
-
Dieter, S.M.1
Ball, C.R.2
Hoffmann, C.M.3
-
84
-
-
79952284127
-
Hallmarks of Cancer: The Next Generation
-
Hanahan D., Weinberg R. A., Hallmarks of Cancer: The Next Generation. Cell 2011, 144, 646–674.
-
(2011)
Cell
, vol.144
, pp. 646-674
-
-
Hanahan, D.1
Weinberg, R.A.2
-
85
-
-
67650067285
-
Endothelial Cell Traction and ECM Density Influence Both Capillary Morphogenesis and Maintenance in 3-D
-
Kniazeva E., Putnam A. J., Endothelial Cell Traction and ECM Density Influence Both Capillary Morphogenesis and Maintenance in 3-D. Am. J. Physiol. Cell Physiol. 2009, 297, C179–C187.
-
(2009)
Am. J. Physiol. Cell Physiol
, vol.297
, pp. C179-C187
-
-
Kniazeva, E.1
Putnam, A.J.2
-
86
-
-
84900524184
-
Cell Invasion in the Spheroid Sprouting Assay: A Spatial Organization Analysis Adaptable to Cell Behaviour
-
Blacher S., Erpicum C., Lenoir B.. Cell Invasion in the Spheroid Sprouting Assay: A Spatial Organization Analysis Adaptable to Cell Behaviour. PLoS One 2014, 9, e97019.
-
(2014)
PLoS One
, vol.9
, pp. e97019
-
-
Blacher, S.1
Erpicum, C.2
Lenoir, B.3
-
87
-
-
34548410347
-
Use of Multicellular Tumor Spheroids to Dissect Endothelial Cell–Tumor Cell Interactions: A Role for T-Cadherin in Tumor Angiogenesis
-
Ghosh S., Joshi M. B., Ivanov D.. Use of Multicellular Tumor Spheroids to Dissect Endothelial Cell–Tumor Cell Interactions: A Role for T-Cadherin in Tumor Angiogenesis. FEBS Lett. 2007, 581, 4523–4528.
-
(2007)
FEBS Lett
, vol.581
, pp. 4523-4528
-
-
Ghosh, S.1
Joshi, M.B.2
Ivanov, D.3
-
88
-
-
84906875681
-
Label-Free Single Cell Quantification of the Invasion of Spheroidal Colon Cancer Cells through 3D Matrigel
-
Febles N. K., Ferrie A. M., Fang Y., Label-Free Single Cell Quantification of the Invasion of Spheroidal Colon Cancer Cells through 3D Matrigel. Anal. Chem. 2014, 86, 8842–8849.
-
(2014)
Anal. Chem
, vol.86
, pp. 8842-8849
-
-
Febles, N.K.1
Ferrie, A.M.2
Fang, Y.3
-
89
-
-
84924408845
-
PTEN Deletion Potentiates Invasion of Colorectal Cancer Spheroidal Cells through 3D Matrigel
-
Chandrasekaran S., Deng H., Fang Y., PTEN Deletion Potentiates Invasion of Colorectal Cancer Spheroidal Cells through 3D Matrigel. Integr. Biol. (Camb.) 2015, 7, 324–334.
-
(2015)
Integr. Biol. (Camb.)
, vol.7
, pp. 324-334
-
-
Chandrasekaran, S.1
Deng, H.2
Fang, Y.3
-
90
-
-
84865798086
-
Stem Cell-Derived Human Intestinal Organoids as an Infection Model for Rotaviruses
-
Finkbeiner S. R., Zeng X. L., Utama B.. Stem Cell-Derived Human Intestinal Organoids as an Infection Model for Rotaviruses. Mbio. 2012, 3, e00159-12.
-
(2012)
Mbio
, vol.3
, pp. e00159-e00212
-
-
Finkbeiner, S.R.1
Zeng, X.L.2
Utama, B.3
-
91
-
-
84877811759
-
Human Primary Intestinal Epithelial Cells as an Improved In Vitro Model for Cryptosporidium parvum Infection
-
Castellanos-Gonzalez A., Cabada M. M., Nichols J.. Human Primary Intestinal Epithelial Cells as an Improved In Vitro Model for Cryptosporidium parvum Infection. Infect. Immun. 2013, 81, 1996–2001.
-
(2013)
Infect. Immun
, vol.81
, pp. 1996-2001
-
-
Castellanos-Gonzalez, A.1
Cabada, M.M.2
Nichols, J.3
-
93
-
-
84879726891
-
Genetic Reconstitution of Tumorigenesis in Primary Intestinal Cells
-
Onuma K., Ochiai M., Orihashi K.. Genetic Reconstitution of Tumorigenesis in Primary Intestinal Cells. Proc. Natl. Acad. Sci. U.S.A. 2013, 110, 11127–11132.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A
, vol.110
, pp. 11127-11132
-
-
Onuma, K.1
Ochiai, M.2
Orihashi, K.3
-
94
-
-
84892928479
-
TTC7A Mutations Disrupt Intestinal Epithelial Apicobasal Polarity
-
Bigorgne A. E., Farin H. F., Lemoine R.. TTC7A Mutations Disrupt Intestinal Epithelial Apicobasal Polarity. J. Clin. Invest. 2013, 124, 328–337.
-
(2013)
J. Clin. Invest
, vol.124
, pp. 328-337
-
-
Bigorgne, A.E.1
Farin, H.F.2
Lemoine, R.3
-
95
-
-
84880292828
-
A Functional CFTR Assay Using Primary Cystic Fibrosis Intestinal Organoids
-
Dekkers J. F., Wiegerinck C. L., de Jonge H. R.. A Functional CFTR Assay Using Primary Cystic Fibrosis Intestinal Organoids. Nat. Med. 2013, 19, 939–945.
-
(2013)
Nat. Med
, vol.19
, pp. 939-945
-
-
Dekkers, J.F.1
Wiegerinck, C.L.2
de Jonge, H.R.3
-
96
-
-
84924422753
-
Modeling Colorectal Cancer Using CRISPR-Cas9-Mediated Engineering of Human Intestinal Organoids
-
Matano M., Date S., Shimokawa M.. Modeling Colorectal Cancer Using CRISPR-Cas9-Mediated Engineering of Human Intestinal Organoids. Nat. Med. 2015, 21, 256–262.
-
(2015)
Nat. Med
, vol.21
, pp. 256-262
-
-
Matano, M.1
Date, S.2
Shimokawa, M.3
-
97
-
-
84875428718
-
Determining Target Engagement in Living Systems
-
Simon G. M., Niphakis M. J., Cravatt B. F., Determining Target Engagement in Living Systems. Nat. Chem. Biol. 2013, 9, 200–205.
-
(2013)
Nat. Chem. Biol
, vol.9
, pp. 200-205
-
-
Simon, G.M.1
Niphakis, M.J.2
Cravatt, B.F.3
-
98
-
-
21644487903
-
Three-Dimensional Culture of Melanoma Cells Profoundly Affects Gene Expression Profile: A High Density Oligonucleotide Array Study
-
Ghosh S., Spagnoli G. C., Martin I.. Three-Dimensional Culture of Melanoma Cells Profoundly Affects Gene Expression Profile: A High Density Oligonucleotide Array Study. J. Cell Physiol. 2005, 204, 522–531.
-
(2005)
J. Cell Physiol
, vol.204
, pp. 522-531
-
-
Ghosh, S.1
Spagnoli, G.C.2
Martin, I.3
-
99
-
-
85014577074
-
Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma
-
Barbone D., Van Dam L., Follo C.. Analysis of Gene Expression in 3D Spheroids Highlights a Survival Role for ASS1 in Mesothelioma. PLoS One 2016, 11, e0150044.
-
(2016)
PLoS One
, vol.11
, pp. e0150044
-
-
Barbone, D.1
Van Dam, L.2
Follo, C.3
-
101
-
-
67650070045
-
Multi-Parameter Phenotypic Profiling: Using Cellular Effects to Characterize Small-Molecule Compounds
-
Feng Y., Mitchison T. J., Bender A.. Multi-Parameter Phenotypic Profiling: Using Cellular Effects to Characterize Small-Molecule Compounds. Nat. Rev. Drug Discov. 2009, 8, 567–578.
-
(2009)
Nat. Rev. Drug Discov
, vol.8
, pp. 567-578
-
-
Feng, Y.1
Mitchison, T.J.2
Bender, A.3
-
102
-
-
84906268621
-
Label-Free Cell Phenotypic Drug Discovery
-
Fang Y., Label-Free Cell Phenotypic Drug Discovery. Comb. Chem. High Throughput Screen. 2014, 17, 566–578.
-
(2014)
Comb. Chem. High Throughput Screen
, vol.17
, pp. 566-578
-
-
Fang, Y.1
-
103
-
-
84940945364
-
Label-Free Chemical and Phenotypic Profiling of Living Cells
-
Fang Y., Label-Free Chemical and Phenotypic Profiling of Living Cells. Sci. Lett. 2015, 4, 156.
-
(2015)
Sci. Lett
, vol.4
, pp. 156
-
-
Fang, Y.1
-
104
-
-
84926408953
-
Organs-on-Chips at the Frontiers of Drug Discovery
-
Esch E. W., Bahinski A., Huh D., Organs-on-Chips at the Frontiers of Drug Discovery. Nat. Rev. Drug Discov. 2015, 14, 248–260.
-
(2015)
Nat. Rev. Drug Discov
, vol.14
, pp. 248-260
-
-
Esch, E.W.1
Bahinski, A.2
Huh, D.3
-
105
-
-
84942097070
-
Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer
-
Senkowski W., Zhang X., Olofsson M. H.. Three-Dimensional Cell Culture-Based Screening Identifies the Anthelmintic Drug Nitazoxanide as a Candidate for Treatment of Colorectal Cancer. Mol. Cancer Ther. 2015, 14, 1504–1516.
-
(2015)
Mol. Cancer Ther
, vol.14
, pp. 1504-1516
-
-
Senkowski, W.1
Zhang, X.2
Olofsson, M.H.3
-
106
-
-
84896494087
-
3D High-Content Screening for the Identification of Compounds That Target Cells in Dormant Tumor Spheroid Regions
-
Wenzel C., Riefke B., Gründemann S.. 3D High-Content Screening for the Identification of Compounds That Target Cells in Dormant Tumor Spheroid Regions. Exp. Cell Res. 2014, 323, 131–143.
-
(2014)
Exp. Cell Res
, vol.323
, pp. 131-143
-
-
Wenzel, C.1
Riefke, B.2
Gründemann, S.3
-
107
-
-
84923197615
-
Quantitative High Throughput Screening Using a Primary Human Three-Dimensional Organotypic Culture Predicts In Vivo Efficacy
-
Kenny H. A., Lal-Nag M., White E. A.. Quantitative High Throughput Screening Using a Primary Human Three-Dimensional Organotypic Culture Predicts In Vivo Efficacy. Nat. Commun. 2015, 6, 6220.
-
(2015)
Nat. Commun
, vol.6
, pp. 6220
-
-
Kenny, H.A.1
Lal-Nag, M.2
White, E.A.3
-
108
-
-
84892153139
-
Clinical Development Success Rates for Investigational Drugs
-
Hay M., Thomas D. W., Craighead J. L.. Clinical Development Success Rates for Investigational Drugs. Nat. Biotechnol. 2014, 32, 40–51.
-
(2014)
Nat. Biotechnol
, vol.32
, pp. 40-51
-
-
Hay, M.1
Thomas, D.W.2
Craighead, J.L.3
-
109
-
-
84869495994
-
Opportunities and Challenges for Use of Tumor Spheroids as Models to Test Drug Delivery and Efficacy
-
Mehta G., Hsiao A. Y., Ingram M.. Opportunities and Challenges for Use of Tumor Spheroids as Models to Test Drug Delivery and Efficacy. J. Control Release 2012, 164, 192–204.
-
(2012)
J. Control Release
, vol.164
, pp. 192-204
-
-
Mehta, G.1
Hsiao, A.Y.2
Ingram, M.3
-
110
-
-
84906816780
-
IMI PREDECT Consortium. Three-Dimensional Models of Cancer for Pharmacology and Cancer Cell Biology: Capturing Tumor Complexity In Vitro/Ex Vivo
-
Hickman J. A., Graeser R., de Hoogt R.. IMI PREDECT Consortium. Three-Dimensional Models of Cancer for Pharmacology and Cancer Cell Biology: Capturing Tumor Complexity In Vitro/Ex Vivo. Biotechnol. J. 2014, 9, 1115–1128.
-
(2014)
Biotechnol. J
, vol.9
, pp. 1115-1128
-
-
Hickman, J.A.1
Graeser, R.2
de Hoogt, R.3
-
111
-
-
84959357347
-
Organoids as an In Vitro Model of Human Development and Disease
-
Fatehullah A., Tan S. H., Barker N., Organoids as an In Vitro Model of Human Development and Disease. Nat. Cell Biol. 2015, 8, 246–254.
-
(2015)
Nat. Cell Biol
, vol.8
, pp. 246-254
-
-
Fatehullah, A.1
Tan, S.H.2
Barker, N.3
-
112
-
-
84964781223
-
Testing Chemotherapy Efficacy in HER2 Negative Breast Cancer Using Patient-Derived Spheroids
-
Halfter K., Hoffmann O., Ditsch N.. Testing Chemotherapy Efficacy in HER2 Negative Breast Cancer Using Patient-Derived Spheroids. J. Transl. Med. 2016, 14, 112.
-
(2016)
J. Transl. Med
, vol.14
, pp. 112
-
-
Halfter, K.1
Hoffmann, O.2
Ditsch, N.3
-
113
-
-
85006091110
-
Evidence for Differential Viral Oncolytic Efficacy in an In Vitro Model of Epithelial Ovarian Cancer Metastasis
-
Tong J. G., Valdes Y. R., Barrett J. W.. Evidence for Differential Viral Oncolytic Efficacy in an In Vitro Model of Epithelial Ovarian Cancer Metastasis. Mol. Ther. Oncol. 2015, 2, 15013.
-
(2015)
Mol. Ther. Oncol
, vol.2
, pp. 15013
-
-
Tong, J.G.1
Valdes, Y.R.2
Barrett, J.W.3
-
114
-
-
84873309547
-
Screening Therapeutic EMT Blocking Agents in a Three-Dimensional Microenvironment
-
Aref A. R., Huang R. Y., Yu W.. Screening Therapeutic EMT Blocking Agents in a Three-Dimensional Microenvironment. Integr. Biol. (Camb.). 2013, 5, 381–389.
-
(2013)
Integr. Biol. (Camb.)
, vol.5
, pp. 381-389
-
-
Aref, A.R.1
Huang, R.Y.2
Yu, W.3
-
115
-
-
35748961114
-
Identifying Genetic Risk Factors for Serious Adverse Drug Reactions: Current Progress and Challenges
-
Wilke R. A., Lin D. W., Roden D. M.. Identifying Genetic Risk Factors for Serious Adverse Drug Reactions: Current Progress and Challenges. Nat. Rev. Drug Discov. 2007, 6, 904–916.
-
(2007)
Nat. Rev. Drug Discov
, vol.6
, pp. 904-916
-
-
Wilke, R.A.1
Lin, D.W.2
Roden, D.M.3
-
116
-
-
84943372486
-
Human Pluripotent Stem Cell-Derived Neural Constructs for Predicting Neural Toxicity
-
Schwartz M. P., Hou Z., Propson N. E.. Human Pluripotent Stem Cell-Derived Neural Constructs for Predicting Neural Toxicity. Proc. Natl. Acad. Sci. U.S.A. 2015, 112, 12516–12521.
-
(2015)
Proc. Natl. Acad. Sci. U.S.A
, vol.112
, pp. 12516-12521
-
-
Schwartz, M.P.1
Hou, Z.2
Propson, N.E.3
-
117
-
-
84876802415
-
3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies
-
Gunness P., Mueller D., Shevchenko V.. 3D Organotypic Cultures of Human HepaRG Cells: A Tool for In Vitro Toxicity Studies. Toxicol. Sci. 2013, 133, 67–78.
-
(2013)
Toxicol. Sci
, vol.133
, pp. 67-78
-
-
Gunness, P.1
Mueller, D.2
Shevchenko, V.3
-
118
-
-
84965172494
-
Characterization of Primary Human Hepatocyte Spheroids as a Model System for Drug-Induced Liver Injury, Liver Function and Disease
-
Bell C. C., Hendriks D. F., Moro S. M.. Characterization of Primary Human Hepatocyte Spheroids as a Model System for Drug-Induced Liver Injury, Liver Function and Disease. Sci. Rep. 2016, 6, 25187.
-
(2016)
Sci. Rep
, vol.6
, pp. 25187
-
-
Bell, C.C.1
Hendriks, D.F.2
Moro, S.M.3
-
119
-
-
84887098518
-
Organ-on-a-Chip Technology and Microfluidic Whole-Body Models for Pharmacokinetic Drug Toxicity Screening
-
Lee J. B., Sung J. H., Organ-on-a-Chip Technology and Microfluidic Whole-Body Models for Pharmacokinetic Drug Toxicity Screening. Biotechnol. J. 2013, 8, 1258–1266.
-
(2013)
Biotechnol. J
, vol.8
, pp. 1258-1266
-
-
Lee, J.B.1
Sung, J.H.2
-
120
-
-
84887561836
-
Accelerating Drug Discovery via Organs-on-Chips
-
Chan C. Y., Huang P. H., Guo F.. Accelerating Drug Discovery via Organs-on-Chips. Lab Chip 2013, 13, 4697–4710.
-
(2013)
Lab Chip
, vol.13
, pp. 4697-4710
-
-
Chan, C.Y.1
Huang, P.H.2
Guo, F.3
-
121
-
-
84882245384
-
Scaling and Systems Biology for Integrating Multiple Organs-on-a-Chip
-
Wikswo J. P., Curtis E. L., Eagleton Z. E.. Scaling and Systems Biology for Integrating Multiple Organs-on-a-Chip. Lab Chip 2013, 13, 3496–3511.
-
(2013)
Lab Chip
, vol.13
, pp. 3496-3511
-
-
Wikswo, J.P.1
Curtis, E.L.2
Eagleton, Z.E.3
-
122
-
-
84859427951
-
Scaffold-Free Culture of Mesenchymal Stem Cell Spheroids in Suspension Preserves Multilineage Potential
-
Baraniak P. R., McDevitt T. C., Scaffold-Free Culture of Mesenchymal Stem Cell Spheroids in Suspension Preserves Multilineage Potential. Cell Tissue Res. 2012, 347, 701–711.
-
(2012)
Cell Tissue Res
, vol.347
, pp. 701-711
-
-
Baraniak, P.R.1
McDevitt, T.C.2
-
123
-
-
84875468183
-
The Mesenchymal Stromal Cells Dilemma—Does a Negative Phase III Trial of Random Donor Mesenchymal Stromal Cells in Steroid-Resistant Graft-Versus-Host Disease Represent a Death Knell or a Bump in the Road?
-
Galipeau J., The Mesenchymal Stromal Cells Dilemma—Does a Negative Phase III Trial of Random Donor Mesenchymal Stromal Cells in Steroid-Resistant Graft-Versus-Host Disease Represent a Death Knell or a Bump in the Road? Cytotherapy 2013, 15, 2–8.
-
(2013)
Cytotherapy
, vol.15
, pp. 2-8
-
-
Galipeau, J.1
-
124
-
-
79955512050
-
Stem and Progenitor Cell-Based Therapy in Ischaemic Heart Disease: Promise, Uncertainties, and Challenges
-
Tongers J., Losordo D. W., Landmesser U., Stem and Progenitor Cell-Based Therapy in Ischaemic Heart Disease: Promise, Uncertainties, and Challenges. Eur. Heart J. 2011, 32, 1197–1206.
-
(2011)
Eur. Heart J
, vol.32
, pp. 1197-1206
-
-
Tongers, J.1
Losordo, D.W.2
Landmesser, U.3
-
125
-
-
77957331042
-
Changes in the Expression Pattern of Mesenchymal and Pluripotent Markers in Human Adipose-Derived Stem Cells
-
Park E., Patel A. N., Changes in the Expression Pattern of Mesenchymal and Pluripotent Markers in Human Adipose-Derived Stem Cells. Cell Biol. Int. 2010, 34, 979–984.
-
(2010)
Cell Biol. Int
, vol.34
, pp. 979-984
-
-
Park, E.1
Patel, A.N.2
-
126
-
-
75449110366
-
Human Adipose-Derived Mesenchymal Stem Cells In Vitro: Evaluation of an Optimal Expansion Medium Preserving Stemness
-
Baer P. C., Griesche N., Luttmann W.. Human Adipose-Derived Mesenchymal Stem Cells In Vitro: Evaluation of an Optimal Expansion Medium Preserving Stemness. Cytotherapy 2010, 12, 96–106.
-
(2010)
Cytotherapy
, vol.12
, pp. 96-106
-
-
Baer, P.C.1
Griesche, N.2
Luttmann, W.3
-
127
-
-
84948798671
-
Spheroid Culture of Mesenchymal Stem Cells
-
Cesarz Z., Tamama K., Spheroid Culture of Mesenchymal Stem Cells. Stem Cells Int. 2016, 2016, 9176357.
-
(2016)
Stem Cells Int
, vol.2016
, pp. 9176357
-
-
Cesarz, Z.1
Tamama, K.2
-
128
-
-
84929493585
-
Compaction, Fusion, and Functional Activation of Three-Dimensional Human Mesenchymal Stem Cell Aggregate
-
Tsai A. C., Liu Y., Yuan X.. Compaction, Fusion, and Functional Activation of Three-Dimensional Human Mesenchymal Stem Cell Aggregate. Tissue Eng. A 2015, 21, 1705–1719.
-
(2015)
Tissue Eng. A
, vol.21
, pp. 1705-1719
-
-
Tsai, A.C.1
Liu, Y.2
Yuan, X.3
-
129
-
-
56249113001
-
Emergence of Patterned Stem Cell Differentiation within Multicellular Structures
-
Ruiz S. A., Chen C. S., Emergence of Patterned Stem Cell Differentiation within Multicellular Structures. Stem Cells 2008, 26, 2921–2927.
-
(2008)
Stem Cells
, vol.26
, pp. 2921-2927
-
-
Ruiz, S.A.1
Chen, C.S.2
-
130
-
-
34547187820
-
Mesenchymal Stem Cells Support Migration, Extracellular Matrix Invasion, Proliferation, and Survival of Endothelial Cells In Vitro
-
Potapova I. A., Gaudette G. R., Brink P. R.. Mesenchymal Stem Cells Support Migration, Extracellular Matrix Invasion, Proliferation, and Survival of Endothelial Cells In Vitro. Stem Cells 2007, 25, 1761–1768.
-
(2007)
Stem Cells
, vol.25
, pp. 1761-1768
-
-
Potapova, I.A.1
Gaudette, G.R.2
Brink, P.R.3
-
131
-
-
84977537191
-
3D Spheroid Culture Enhances Survival and Therapeutic Capacities of MSCs Injected into Ischemic Kidney
-
Xu Y., Shi T., Xu A.. 3D Spheroid Culture Enhances Survival and Therapeutic Capacities of MSCs Injected into Ischemic Kidney. J. Cell Mol. Med. 2016, 20, 1203–1213.
-
(2016)
J. Cell Mol. Med
, vol.20
, pp. 1203-1213
-
-
Xu, Y.1
Shi, T.2
Xu, A.3
-
132
-
-
84945262406
-
Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents with Bleomycin-Induced Pulmonary Fibrosis
-
Henry E., Cores J., Hensley M. T.. Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents with Bleomycin-Induced Pulmonary Fibrosis. Stem Cells Transl. Med. 2015, 4, 1265–1274.
-
(2015)
Stem Cells Transl. Med
, vol.4
, pp. 1265-1274
-
-
Henry, E.1
Cores, J.2
Hensley, M.T.3
-
133
-
-
84937957074
-
Concise Review: Manufacturing of Pancreatic Endoderm Cells for Clinical Trials in Type 1 Diabetes
-
Schulz T. C., Concise Review: Manufacturing of Pancreatic Endoderm Cells for Clinical Trials in Type 1 Diabetes. Stem Cells Transl. Med. 2015, 4, 927–931.
-
(2015)
Stem Cells Transl. Med
, vol.4
, pp. 927-931
-
-
Schulz, T.C.1
-
134
-
-
84891737192
-
Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells
-
Taguchi A., Kaku Y., Ohmori T.. Redefining the In Vivo Origin of Metanephric Nephron Progenitors Enables Generation of Complex Kidney Structures from Pluripotent Stem Cells. Cell Stem Cell 2014, 14, 53–67.
-
(2014)
Cell Stem Cell
, vol.14
, pp. 53-67
-
-
Taguchi, A.1
Kaku, Y.2
Ohmori, T.3
-
135
-
-
84890051386
-
Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury
-
Fordham R. P., Yui S., Hannan N. R.. Transplantation of Expanded Fetal Intestinal Progenitors Contributes to Colon Regeneration after Injury. Cell Stem Cell 2013, 13, 734–744.
-
(2013)
Cell Stem Cell
, vol.13
, pp. 734-744
-
-
Fordham, R.P.1
Yui, S.2
Hannan, N.R.3
-
136
-
-
84862777784
-
Functional Engraftment of Colon Epithelium Expanded In Vitro from a Single Adult Lgr5+ Stem Cell
-
Yui S., Nakamura T., Sato T.. Functional Engraftment of Colon Epithelium Expanded In Vitro from a Single Adult Lgr5+ Stem Cell. Nat. Med. 2012, 18, 618–623.
-
(2012)
Nat. Med
, vol.18
, pp. 618-623
-
-
Yui, S.1
Nakamura, T.2
Sato, T.3
-
137
-
-
33646052556
-
Tissue-Engineered Autologous Bladders for Patients Needing Cystoplasty
-
Atala A., Bauer S. B., Soker S.. Tissue-Engineered Autologous Bladders for Patients Needing Cystoplasty. Lancet 2006, 367, 1241–1246.
-
(2006)
Lancet
, vol.367
, pp. 1241-1246
-
-
Atala, A.1
Bauer, S.B.2
Soker, S.3
-
138
-
-
84878243724
-
Metre-Long Cell-Laden Microfibres Exhibit Tissue Morphologies and Functions
-
Onoe H., Okitsu T., Itou A.. Metre-Long Cell-Laden Microfibres Exhibit Tissue Morphologies and Functions. Nat. Mater. 2013, 12, 584–590.
-
(2013)
Nat. Mater
, vol.12
, pp. 584-590
-
-
Onoe, H.1
Okitsu, T.2
Itou, A.3
-
140
-
-
69249208450
-
Scaffold-Free Vascular Tissue Engineering Using Bioprinting
-
Norotte C., Marga F. S., Niklason L. E.. Scaffold-Free Vascular Tissue Engineering Using Bioprinting. Biomaterials 2009, 30, 5910–5917.
-
(2009)
Biomaterials
, vol.30
, pp. 5910-5917
-
-
Norotte, C.1
Marga, F.S.2
Niklason, L.E.3
-
141
-
-
76949095529
-
Towards Organ Printing: Engineering an Intra-Organ Branched Vascular Tree
-
Visconti R. P., Kasyanov V., Gentile C.. Towards Organ Printing: Engineering an Intra-Organ Branched Vascular Tree. Expert Opin. Biol. Ther. 2010, 10, 409–420.
-
(2010)
Expert Opin. Biol. Ther
, vol.10
, pp. 409-420
-
-
Visconti, R.P.1
Kasyanov, V.2
Gentile, C.3
-
142
-
-
84866355664
-
Rapid Casting of Patterned Vascular Networks for Perfusable Engineered Three-Dimensional Tissues
-
Miller J. S., Stevens K. R., Yang M. T.. Rapid Casting of Patterned Vascular Networks for Perfusable Engineered Three-Dimensional Tissues. Nat. Mater. 2012, 11, 768–774.
-
(2012)
Nat. Mater
, vol.11
, pp. 768-774
-
-
Miller, J.S.1
Stevens, K.R.2
Yang, M.T.3
-
143
-
-
84958179628
-
High-Throughput Imaging: Focusing in on Drug Discovery in 3D
-
Li L., Zhou Q., Voss T. C.. High-Throughput Imaging: Focusing in on Drug Discovery in 3D. Methods 2016, 96, 97–102.
-
(2016)
Methods
, vol.96
, pp. 97-102
-
-
Li, L.1
Zhou, Q.2
Voss, T.C.3
-
144
-
-
84988515925
-
Development of a 3D Tissue Culture-Based High-Content Screening Platform That Uses Phenotypic Profiling to Discriminate Selective Inhibitors of Receptor Tyrosine Kinases
-
Booij T. H., Klop M. J., Yan K.. Development of a 3D Tissue Culture-Based High-Content Screening Platform That Uses Phenotypic Profiling to Discriminate Selective Inhibitors of Receptor Tyrosine Kinases. J. Biomol. Screen. 2016, 21, 912–922.
-
(2016)
J. Biomol. Screen
, vol.21
, pp. 912-922
-
-
Booij, T.H.1
Klop, M.J.2
Yan, K.3
-
146
-
-
85019697951
-
The promise and potential of “organs-on-chips” as preclinical models
-
Bahinski A., Horland R., Huh D.. The promise and potential of “organs-on-chips” as preclinical models. Appl. In Vitro Toxicol. 2015, 1, 235–242.
-
(2015)
Appl. In Vitro Toxicol
, vol.1
, pp. 235-242
-
-
Bahinski, A.1
Horland, R.2
Huh, D.3
|