Erratum: A human disease model of drug toxicity-Induced pulmonary edema in a lung-on-a-chip microdevice (Science Translational Medicine DOI: 10.1126/scitranslmed.3004249);A human disease model of drug toxicity-induced pulmonary edema in a lung-on-a-chip microdevice

Science Translational Medicine

Volumn 4, Issue 159, 2012, Pages

  Huh, Dongeun ^a,b,c   Leslie, Daniel C ^a,b   Matthews, Benjamin D ^b   Fraser, Jacob P ^a   Jurek, Samuel ^b   Hamilton, Geraldine A ^a   Thorneloe, Kevin S ^d   McAlexander, Michael Allen ^d   Ingber, Donald E ^a,b,e  

^a HARVARD UNIVERSITY   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c Seoul National University   (South Korea)

^d GLAXOSMITHKLINE   (United States)

^e HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 1; GSK 2193874; INTERLEUKIN 2; ION CHANNEL; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 4; VANILLOID RECEPTOR ANTAGONIST;

AIRFLOW; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOMIMETICS; CANCER PATIENT; DEVICES; DRUG TOXICITY INDUCED PULMONARY EDEMA; ENDOTHELIUM CELL; FLUID FLOW; HUMAN; IMMUNOCOMPETENT CELL; IMMUNOHISTOCHEMISTRY; LUNG ALVEOLUS EPITHELIUM; LUNG CAPILLARY; LUNG EDEMA; LUNG PERFUSION; LUNG VENTILATION; LUNG-ON-A-CHIP MICRODEVICE; MECHANICAL STIMULATION; MICROFLUIDICS; MOUSE; NONHUMAN; OXYGEN TRANSPORT; PRIORITY JOURNAL;

EID: 84869126274     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.aau4555     Document Type: Erratum

References (44)

1. F. Pampaloni, E. G. Reynaud, E. H. Stelzer, The third dimension bridges the gap between cell culture and live tissue. Nat. Rev. Mol. Cell Biol. 8, 839-845 (2007).
2. D. Huh, G. A. Hamilton, D. E. Ingber, From 3D cell culture to organs-on-chips. Trends Cell Biol. 21, 745-754 (2011).
3. K. J. Jang, K. Y. Suh, A multi-layer microfluidic device for efficient culture and analysis of renal tubular cells. Lab Chip 10, 36-42 (2010).
4. D. Huh, B. D. Matthews, A. Mammoto, M. Montoya-Zavala, H. Y. Hsin, D. E. Ingber, Reconstituting organ-level lung functions on a chip. Science 328, 1662-1668 (2010).
5. P. J. Lee, P. J. Hung, L. P. Lee, An artificial liver sinusoid with a microfluidic endothelial-like barrier for primary hepatocyte culture. Biotechnol. Bioeng. 97, 1340-1346 (2007).
6. J. H. Sung, M. L. Shuler, A micro cell culture analog (microCCA) with 3-D hydrogel culture of multiple cell lines to assess metabolism-dependent cytotoxicity of anti-cancer drugs. Lab Chip 9, 1385-1394 (2009).
7. D. Huh, H. Fujioka, Y. C. Tung, N. Futai, R. Paine III, J. B. Grotberg, S. Takayama, Acoustically detectable cellular-level lung injury induced by fluid mechanical stresses in microfluidic airway systems. Proc. Natl. Acad. Sci. U.S.A. 104, 18886-18891 (2007).
8. A. Grosberg, P. W. Alford, M. L. McCain, K. K. Parker, Ensembles of engineered cardiac tissues for physiological and pharmacological study: Heart on a chip. Lab Chip 11, 4165-4173 (2011).
9. H. J. Kim, D. Huh, G. Hamilton, D. E. Ingber, Human gut-on-a-chip inhabited by microbial flora that experiences intestinal peristalsis-like motions and flow. Lab Chip 12, 2165-2174 (2012).
10. K. Domansky, W. Inman, J. Serdy, A. Dash, M. H. Lim, L. G. Griffith, Perfused multiwell plate for 3D liver tissue engineering. Lab Chip 10, 51-58 (2010).
11. N. J. Douville, P. Zamankhan, Y. C. Tung, R. Li, B. L. Vaughan, C. F. Tai, J. White, P. J. Christensen, J. B. Grotberg, S. Takayama, Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model. Lab Chip 11, 609-619 (2011).
12. Y. S. Torisawa, B. Mosadegh, T. Bersano-Begey, J. M. Steele, K. E. Luker, G. D. Luker, S. Takayama, Microfluidic platform for chemotaxis in gradients formed by CXCL12 source-sink cells. Integr. Biol. 2, 680-686 (2010).
13. S. Chung, R. Sudo, P. J. Mack, C. R. Wan, V. Vickerman, R. D. Kamm, Cell migration into scaffolds under co-culture conditions in a microfluidic platform. Lab Chip 9, 269-275 (2009).
14. K. E. Sung, N. Yang, C. Pehlke, P. J. Keely, K. W. Eliceiri, A. Friedl, D. J. Beebe, Transition to invasion in breast cancer: A microfluidic in vitro model enables examination of spatial and temporal effects. Integr. Biol. 3, 439-450 (2011).
15. J. W. Song, S. P. Cavnar, A. C. Walker, K. E. Luker, M. Gupta, Y. C. Tung, G. D. Luker, S. Takayama, Microfluidic endothelium for studying the intravascular adhesion of metastatic breast cancer cells. PLoS One 4, e5756 (2009).
16. E. D. Robin, C. E. Cross, R. Zelis, Pulmonary edema. 1. N. Engl. J. Med. 288, 239-246 (1973).
17. E. D. Robin, C. E. Cross, R. Zelis, Pulmonary edema. 2. N. Engl. J. Med. 288, 292-304 (1973).
18. J. V. Hurley, Current views on the mechanisms of pulmonary oedema. J. Pathol. 125, 59-79 (1978).
19. L. B. Ware, M. A. Matthay, Clinical practice. Acute pulmonary edema. N. Engl. J. Med. 353, 2788-2796 (2005).
20. K. S. Thorneloe, M. Cheung, W. Bao, H. Alsaid, S. Lenhard, M.-Y. Jian, M. Costell, K. Maniscalco-Hauk, J. A. Krawiec, A. Olzinski, E. Gordon, I. Lozinskaya, L. Elefante, P. Qin, D. S. Matasic, C. James, J. Tunstead, B. Donovan, L. Kallal, A. Waszkiewicz, K. Vaidya, E. A. Davenport, J. Larkin, M. Burgert, L. N. Casillas, R. W. Marquis, G. Ye, H. S. Eidam, K. B. Goodman, J. R. Toomey, T. J. Roethke, B. M. Jucker, C. G. Schnackenberg, M. I. Townsley, J. J. Lepore, R. N. Willette, An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure. Sci. Transl. Med. 4, 159ra148 (2012).
21. R. Baluna, E. S. Vitetta, Vascular leak syndrome: A side effect of immunotherapy. Immunopharmacology 37, 117-132 (1997).
22. M. Rosenstein, S. E. Ettinghausen, S. A. Rosenberg, Extravasation of intravascular fluid mediated by the systemic administration of recombinant interleukin 2. J. Immunol. 137, 1735-1742 (1986).
23. E. F. Conant, K. R. Fox, W. T. Miller, Pulmonary edema as a complication of interleukin-2 therapy. AJR Am. J. Roentgenol. 152, 749-752 (1989).
24. E. Briasoulis, N. Pavlidis, Noncardiogenic pulmonary edema: An unusual and serious complication of anticancer therapy. Oncologist 6, 153-161 (2001).
25. R. L. Kradin, L. A. Boyle, F. I. Preffer, R. J. Callahan, M. Barlai-Kovach, H. W. Strauss, S. Dubinett, J. T. Kurnick, Tumor-derived interleukin-2-dependent lymphocytes in adoptive immunotherapy of lung cancer. Cancer Immunol. Immunother. 24, 76-85 (1987).
26. R. Satchi-Fainaro, R. Mamluk, L. Wang, S. M. Short, J. A. Nagy, D. Feng, A. M. Dvorak, H. F. Dvorak, M. Puder, D. Mukhopadhyay, J. Folkman, Inhibition of vessel permeability by TNP-470 and its polymer conjugate, caplostatin. Cancer Cell 7, 251-261 (2005).
27. J. A. Bastarache, L. Wang, T. Geiser, Z. Wang, K. H. Albertine, M. A. Matthay, L. B. Ware, The alveolar epithelium can initiate the extrinsic coagulation cascade through expression of tissue factor. Thorax 62, 608-616 (2007).
28. S. M. Parikh, T. Mammoto, A. Schultz, H. T. Yuan, D. Christiani, S. A. Karumanchi, V. P. Sukhatme, Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med. 3, e46 (2006).
29. D. C. Gallagher, R. S. Bhatt, S. M. Parikh, P. Patel, V. Seery, D. F. McDermott, M. B. Atkins, V. P. Sukhatme, Angiopoietin 2 is a potential mediator of high-dose interleukin 2-induced vascular leak. Clin. Cancer Res. 13, 2115-2120 (2007).
30. K. G. Peters, Vascular endothelial growth factor and the angiopoietins: Working together to build a better blood vessel. Circ. Res. 83, 342-343 (1998).
31. P. C. Maisonpierre, C. Suri, P. F. Jones, S. Bartunkova, S. J. Wiegand, C. Radziejewski, D. Compton, J. McClain, T. H. Aldrich, N. Papadopoulos, T. J. Daly, S. Davis, T. N. Sato, G. D. Yancopoulos, Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. Science 277, 55-60 (1997).
32. K. Hamanaka, M. Y. Jian, D. S. Weber, D. F. Alvarez, M. I. Townsley, A. B. Al-Mehdi, J. A. King, W. Liedtke, J. C. Parker, TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs. Am. J. Physiol. Lung Cell. Mol. Physiol. 293, L923-L932 (2007).
33. D. F. Alvarez, J. A. King, D. Weber, E. Addison, W. Liedtke, M. I. Townsley, Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: A novel mechanism of acute lung injury. Circ. Res. 99, 988-995 (2006).
34. C. K. Thodeti, B. Matthews, A. Ravi, A. Mammoto, K. Ghosh, A. L. Bracha, D. E. Ingber, TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling. Circ. Res. 104, 1123-1130 (2009).
35. H. Guan, P. S. Nagarkatti, M. Nagarkatti, Blockade of hyaluronan inhibits IL-2-induced vascular leak syndrome and maintains effectiveness of IL-2 treatment for metastatic melanoma. J. Immunol. 179, 3715-3723 (2007).
36. J. Zhang, R. J. Wenthold Jr., Z. X. Yu, E. H. Herman, V. J. Ferrans, Characterization of the pulmonary lesions induced in rats by human recombinant interleukin-2. Toxicol. Pathol. 23, 653-666 (1995).
37. B. M. Corfe, C. Dive, D. R. Garrod, Changes in intercellular junctions during apoptosis precede nuclear condensation or phosphatidylserine exposure on the cell surface. Cell Death Differ. 7, 234-235 (2000).
38. E. Assier, V. Jullien, J. Lefort, J. L. Moreau, J. P. Di Santo, B. B. Vargaftig, J. R. Lapa e Silva, J. Thèze, NK cells and polymorphonuclear neutrophils are both critical for IL-2-induced pulmonary vascular leak syndrome. J. Immunol. 172, 7661-7668 (2004).
39. + T regulatory cells in IL-2-induced vascular leak. Int. Immunol. 18, 1461-1471 (2006).
40. The Acute Respiratory Distress Syndrome Network, Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N. Engl. J. Med. 342, 1301-1308 (2000).
41. J. Lipes, A. Bojmehrani, F. Lellouche, Low tidal volume ventilation in patients without acute respiratory distress syndrome: A paradigm shift in mechanical ventilation. Crit. Care Res. Pract. 2012, 416862 (2012).
42. L. B. Ware, M. A. Matthay, Alveolar fluid clearance is impaired in the majority of patients with acute lung injury and the acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 163, 1376-1383 (2001).
43. M. A. Matthay, H. G. Folkesson, C. Clerici, Lung epithelial fluid transport and the resolution of pulmonary edema. Physiol. Rev. 82, 569-600 (2002).
44. M. I. Hermanns, R. E. Unger, K. Kehe, K. Peters, C. J. Kirkpatrick, Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: Development of an alveolo-capillary barrier in vitro. Lab. Invest. 84, 736-752 (2004).