The three-dimensional human skin reconstruct model: A tool to study normal skin and melanoma progression

Journal of Visualized Experiments

Volumn , Issue 54, 2011, Pages

  Li, Ling ^a   Fukunaga Kalabis, Mizuho ^a   Herlyn, Meenhard ^a  

^a WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 80355145673     PISSN: 1940087X     EISSN: None     Source Type: Journal    
DOI: 10.3791/2937     Document Type: Article

References (10)

1. Sun, T., Jackson, S., Haycock, J.W., & MacNeil, S. Culture of skin cells in 3D rather than 2D improves their ability to survive exposure to cytotoxic agents. J Biotechnol. 122 (3), 372-81 (2006).
2. Smalley, K.S., Lioni, M., & Herlyn, M. Life isn't flat: taking cancer biology to the next dimension. In Vitro Cell Dev Biol Anim. 42 (8-9), 242-7 (2006).
3. Sun, T., Norton, D., McKean, R.J., Haycock, J.W., Ryan, A.J., & MacNeil, S. Development of a 3D cell culture system for investigating cell interactions with electrospun fibers. Biotechnol Bioeng. 97 (5), 1318-28 (2007).
4. Kremer, M., Lang, E., & Berger, A. Organotypical engineering of differentiated composite-skin equivalents of human keratinocytes in a collagen-GAG matrix (INTEGRA Artificial Skin) in a perfusion culture system. Langenbecks Arch Surg. 386 (5), 357-63 (2001).
5. Escámez, M.J., García, M., Larcher, F., Meana, A., Muñoz, E., Jorcano, J.L. & Del Río, M. An in vivo model of wound healing in genetically modified skin-humanized mice. J Invest Dermatol. 123 (6), 1182-91 (2004).
6. Li, L., Fukunaga-Kalabis, M., Yu, H., Xu, X., Kong, J., Lee, J.T., & Herlyn, M. Human dermal stem cells differentiate into functional epidermal melanocytes. J Cell Sci. 123, 853-860 (2010).
7. Meier, F., Nesbit, M., Hsu, M.Y., Martin, B., Van Belle, P., Elder, D.E., Schaumburg-Lever, G., Garbe, C., Walz, T.M., Donatien, P., Crombleholme, T.M., & Herlyn, M. Human melanoma progression in skin reconstructs: biological significance of bFGF. Am J Pathol. 156(1), 193-200 (2000).
8. Yu, H., McDaid, R., Lee, J., Li, L., Kumar, S.M., Elder, D.E., Van Belle, P., Gimotty, P., Guerra, M., Hammond, R., Nathanson, K.L., Dalla Palma, M., Herlyn, M., & Xu, X. The role of BRAF mutation and p53 inactivation during transformation of a subpopulation of primary human melanocytes. Am J Pathol. 174(6), 2367-77 (2009).
9. Lee, J.T., Li, L., Brafford, P.A., van den Eijnden, M., Halloran, M.B., Sproesser, K., Haass, N.K., Smalley, K.S., Tsai, J., Bollag, G., & Herlyn, M. PLX4032, a potent inhibitor of the B-Raf V600E oncogene, selectively inhibits V600E-positive melanomas. Pigment Cell Melanoma Res. 23(6), 820-7, (2010).
10. Tsai, J., Lee, J.T., Wang, W., Zhang, J., Cho, H., Mamo, S., Bremer, R., Gillette, S., Kong, J., Haass, N.K., Sproesser, K., Li, L., Smalley, K.S., Fong, D., Zhu, Y.L., Marimuthu, A., Nguyen, H., Lam, B., Liu, J., Cheung, I., Rice, J., Suzuki, Y., Luu, C., Settachatgul, C., Shellooe, R., Cantwell, J., Kim, S.H., Schlessinger, J., Zhang, K.Y., West, B.L., Powell, B., Habets, G., Zhang, C., Ibrahim, P.N., Hirth, P., Artis, D.R., Herlyn, M., & Bollag, G. Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity. Proc Natl Acad Sci U S A. 105 (8), 3041-6 (2008).