Three-dimensional cell culture: The missing link in drug discovery

Drug Discovery Today

Volumn 18, Issue 5-6, 2013, Pages 240-249

  Breslin, Susan ^a   O'Driscoll, Lorraine ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FLUOROURACIL; PROTEIN KINASE B; TIRAPAZAMINE;

AGITATION BASED APPROACH; ANTIPROLIFERATIVE ACTIVITY; CANCER RESISTANCE; CELL CULTURE; CELL GROWTH; CELL INTERACTION; CELL SIZE; CELL VIABILITY; COST EFFECTIVENESS ANALYSIS; CULTURE TECHNIQUE; DRUG ABSORPTION; DRUG CONTAMINATION; DRUG DEVELOPMENT; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG EXCRETION; DRUG METABOLISM; DRUG SAFETY; DRUG SCREENING; FORCED FLOATING METHOD; HANGING DROP METHOD; HUMAN; MICROFLUIDIC ANALYSIS; MICROFLUIDIC CELL CULTURE PLATFORM; NONHUMAN; PROTEIN PHOSPHORYLATION; REVIEW; ROTATING CELL CULTURE BIOREACTOR; SPINNER FLASK BIOREACTOR;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL CULTURE TECHNIQUES; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS;

EID: 84874700631     PISSN: 13596446     EISSN: 18785832     Source Type: Journal    
DOI: 10.1016/j.drudis.2012.10.003     Document Type: Review

References (63)

1. J. Arrondeau Development of anti-cancer drugs Discov. Med. 10 2010 355 362
2. W.N. Hait Anticancer drug development: the grand challenges Nat. Rev. Drug Discov. 9 2010 253 254
3. A.L. Hopkins Network pharmacology: the next paradigm in drug discovery Nat. Chem. Biol. 4 2008 682 690
4. I. Kola The state of innovation in drug development Clin. Pharmacol. Ther. 83 2008 227 230
5. J.A. DiMasi, and H.G. Grabowski Economics of new oncology drug development J. Clin. Oncol. 25 2007 209 216
6. G. Mazzoleni Modelling tissues in 3D: the next future of pharmaco-toxicology and food research? Genes Nutr. 4 2009 13 22
7. L.A. Kunz-Schughart The use of 3-D cultures for high-throughput screening: the multicellular spheroid model J. Biomol. Screen. 9 2004 273 285
8. K. Bhadriraju, and C.S. Chen Engineering cellular microenvironments to improve cell-based drug testing Drug Discov. Today 7 2002 612 620
9. M.J. Bissell Tissue architecture: the ultimate regulator of breast epithelial function Curr. Opin. Cell Biol. 15 2003 753 762
10. V.M. Weaver Reversion of the malignant phenotype of human breast cells in three-dimensional culture and in vivo by integrin blocking antibodies J. Cell Biol. 137 1997 231 245
11. A. Abbott Cell culture: biology's new dimension Nature 424 2003 870 872
12. M.J. Bissell, and D. Radisky Putting tumours in context Nat. Rev. Cancer 1 2001 46 54
13. J. Debnath, and J.S. Brugge Modelling glandular epithelial cancers in three-dimensional cultures Nat. Rev. Cancer 5 2005 675 688
14. K.M. Yamada, and E. Cukierman Modeling tissue morphogenesis and cancer in 3D Cell 130 2007 601 610
15. R.G. Harrison Observations of the living developing nerve fiber Anat. Rec. 1 1907 116 128
16. R.G. Harrison The outgrowth of the nerve fiber as a mode of protoplasmic movement J. Exp. Zool. 9 1910 787 846
17. M.J. Bissell The organizing principle: microenvironmental influences in the normal and malignant breast Differentiation 70 2002 537 546
18. L.E. O'Brien Building epithelial architecture: insights from three-dimensional culture models Nat. Rev. Mol. Cell Biol. 3 2002 531 537
19. R.Z. Lin, and H.Y. Chang Recent advances in three-dimensional multicellular spheroid culture for biomedical research Biotechnol. J. 3 2008 1172 1184
20. A. Ivascu, and M. Kubbies Rapid generation of single-tumor spheroids for high-throughput cell function and toxicity analysis J. Biomol. Screen. 11 2006 922 932
21. J. Friedrich Spheroid-based drug screen: considerations and practical approach Nat. Protoc. 4 2009 309 324
22. Q. Li 3D models of epithelial-mesenchymal transition in breast cancer metastasis J. Biomol. Screen. 16 2011 141 154
23. Y. Oda Induction of pluripotent stem cells from human third molar mesenchymal stromal cells J. Biol. Chem. 285 2010 29270 29278
24. A. Morizane Small-molecule inhibitors of bone morphogenic protein and activin/nodal signals promote highly efficient neural induction from human pluripotent stem cells J. Neurosci. Res. 89 2011 117 126
25. J.M. Kelm Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types Biotechnol. Bioeng. 83 2003 173 180
26. H. Kurosawa Methods for inducing embryoid body formation: in vitro differentiation system of embryonic stem cells J. Biosci. Bioeng. 103 2007 389 398
27. Y-C. Tung High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array Analyst 136 2011 473 478
28. J.B. Kim Three-dimensional tissue culture models in cancer biology Semin. Cancer Biol. 15 2005 365 377
29. T.J. Goodwin Reduced shear stress: a major component in the ability of mammalian tissues to form three-dimensional assemblies in simulated microgravity J. Cell. Biochem. 51 1993 301 311
30. B. Rodday Semiautomatic growth analysis of multicellular tumor spheroids J. Biomol. Screen. 16 2011 1119 1124
31. F. Hirschhaeuser Test system for trifunctional antibodies in 3D MCTS culture J. Biomol. Screen. 14 2009 980 990
32. J. Barrila Organotypic 3D cell culture models: using the rotating wall vessel to study host-pathogen interactions Nat. Rev. Microbiol. 8 2010 791 801
33. J. Alcaraz Biomechanical approaches for studying integration of tissue structure and function in mammary epithelia J. Mammary Gland Biol. Neoplasia 9 2004 361 374
34. H.K. Kleinman, and G.R. Martin Matrigel: basement membrane matrix with biological activity Semin. Cancer Biol. 15 2005 378 386
35. G.Y. Lee Three-dimensional culture models of normal and malignant breast epithelial cells Nat. Methods 4 2007 359 365
36. T.R. Sodunke Micropatterns of Matrigel for three-dimensional epithelial cultures Biomaterials 28 2007 4006 4016
37. A. Sourla Three-dimensional type I collagen gel system containing MG-63 osteoblasts-like cells as a model for studying local bone reaction caused by metastatic cancer cells Anticancer Res. 16 1996 2773 2780
38. R. Glicklis Hepatocyte behavior within three-dimensional porous alginate scaffolds Biotechnol. Bioeng. 67 2000 344 353
39. W. Tan Evaluation of nanostructured composite collagen-chitosan matrices for tissue engineering Tissue Eng. 7 2001 203 210
40. B.A. Justice 3D cell culture opens new dimensions in cell-based assays Drug Discov. Today 14 2009 102 107
41. J.J. Schmidt Hydrogels used for cell-based drug delivery J. Biomed. Mater. Res. Part A 87A 2008 1113 1122
42. C. Ji Enhancing cell penetration and proliferation in chitosan hydrogels for tissue engineering applications Biomaterials 32 2011 9719 9729
43. P.J. Lee Microfluidic system for automated cell-based assays J. Assoc. Lab. Autom. 12 2007 363 367
44. M.H. Wu Microfluidic cell culture systems for drug research Lab Chip 10 2010 939 956
45. Y.C. Toh A novel 3D mammalian cell perfusion-culture system in microfluidic channels Lab Chip 7 2007 302 309
46. I. Zervantonakis Concentration gradients in microfluidic 3D matrix cell culture systems Int. J. Micro-Nano Scale Transp. 1 2010 27 36
47. Y. Gao A versatile valve-enabled microfluidic cell co-culture platform and demonstration of its applications to neurobiology and cancer biology Biomed. Microdevices 13 2011 539 548
48. D. Huh From 3D cell culture to organs-on-chips Trends Cell Biol. 21 2011 745 754
49. S.Y. Chen Microfluidic array for three-dimensional perfusion culture of human mammary epithelial cells Biomed. Microdevices 13 2011 753 758
50. D.J. Slamon Studies of the HER-2/neu proto-oncogene in human breast and ovarian cancer Science 244 1989 707 712
51. M. Pickl, and C.H. Ries Comparison of 3D and 2D tumor models reveals enhanced HER2 activation in 3D associated with an increased response to trastuzumab Oncogene 28 2008 461 468
52. W.R. Wilson, and M.P. Hay Targeting hypoxia in cancer therapy Nat. Rev. Cancer 11 2011 393 410
53. P. Vaupel, and A. Mayer Hypoxia and anemia: effects on tumor biology and treatment resistance Transfus. Clin. Biol. 12 2005 5 10
54. V.M. Weaver [beta]4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium Cancer Cell 2 2002 205 216
55. Q. Li Three-dimensional overlay culture models of human breast cancer reveal a critical sensitivity to mitogen-activated protein kinase kinase inhibitors J. Pharmacol. Exp. Ther. 332 2010 821 828
56. L. David Hyaluronan hydrogel: an appropriate three-dimensional model for evaluation of anticancer drug sensitivity Acta Biomater. 4 2008 256 263
57. A. Ivascu, and M. Kubbies Diversity of cell-mediated adhesions in breast cancer spheroids Int. J. Oncol. 31 2007 1403 1413
58. G.M. Thurber, and K.D. Wittrup Quantitative spatiotemporal analysis of antibody fragment diffusion and endocytic consumption in tumor spheroids Cancer Res. 68 2008 3334 3341
59. K. Smalley Life ins't flat: taking cancer biology to the next dimension In Vitro Cell. Dev. Biol. Anim. 42 2006 242 247
60. J. Lee Engineering liver tissue spheroids with inverted colloidal crystal scaffolds Biomaterials 30 2009 4687 4694
61. I. Kola, and J. Landis Can the pharmaceutical industry reduce attrition rates? Nat. Rev. Drug Discov. 3 2004 711 715
62. P. Correa de Sampaio A heterogeneous in vitro three dimensional model of tumour-stroma interactions regulating sprouting angiogenesis PLoS One 7 2012 E30753
63. D.W. Hutmacher Translating tissue engineering technology platforms into cancer research J. Cell. Mol. Med. 13 2009 1417 1427