Determining target engagement in living systems

Nature Chemical Biology

Volumn 9, Issue 4, 2013, Pages 200-205

  Simon, Gabriel M ^a   Niphakis, Micah J ^b   Cravatt, Benjamin F ^b  

^a Abide Therapeutics   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; CARFILZOMIB; DOPAMINE RECEPTOR BLOCKING AGENT; DRUG; HISTONE DEACETYLASE; IBRUTINIB; METHYLTRANSFERASE; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PHOSPHOTRANSFERASE; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN; PROTEINASE; RADIOLIGAND; VORINOSTAT;

AUTOPHOSPHORYLATION; BIOLOGICAL ACTIVITY; CELLS; DRUG DETERMINATION; DRUG EFFICACY; DRUG INDUSTRY; DRUG MECHANISM; DRUG SCREENING; DRUG SELECTIVITY; DRUG TARGETING; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; GENE MUTATION; HUMAN; IN VIVO STUDY; NONHUMAN; NOTE; PERIPHERAL BLOOD MONONUCLEAR CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEOMICS; TECHNOLOGY;

ANIMALS; BIOMARKERS, PHARMACOLOGICAL; CELL CULTURE TECHNIQUES; CHROMATOGRAPHY, LIQUID; DRUG EVALUATION, PRECLINICAL; HUMANS; IMMUNOPRECIPITATION; MOLECULAR PROBES; MOLECULAR TARGETED THERAPY; PROTEIN ARRAY ANALYSIS; RADIOPHARMACEUTICALS; TANDEM MASS SPECTROMETRY; VALIDATION STUDIES AS TOPIC;

EID: 84875428718     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.1211     Document Type: Note

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