Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues

Nature Materials

Volumn 11, Issue 9, 2012, Pages 768-774

  Miller, Jordan S ^a   Stevens, Kelly R ^b   Yang, Michael T ^a   Baker, Brendon M ^a   Nguyen, Duc Huy T ^a   Cohen, Daniel M ^a   Toro, Esteban ^a   Chen, Alice A ^b   Galie, Peter A ^a   Yu, Xiang ^a   Chaturvedi, Ritika ^a   Bhatia, Sangeeta N ^b,c,d   Chen, Christopher S ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^d USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; CYTOLOGY; ENDOTHELIAL CELLS; HISTOLOGY; TISSUE CULTURE;

ENDOTHELIALIZATION; ENGINEERED TISSUES; EXTRACELLULAR MATRICES; INDEPENDENT CONTROL; METABOLIC FUNCTION; PRIMARY RAT HEPATOCYTES; SACRIFICIAL TEMPLATES; THREEDIMENSIONAL (3-D);

TISSUE;

BIOMATERIAL; CARBOHYDRATE; GLASS; TISSUE SCAFFOLD;

ANIMAL; ARTICLE; BLOOD VESSEL; CHEMISTRY; CYTOLOGY; DRUG EFFECT; HUMAN; LIVER CELL; METABOLISM; METHODOLOGY; PERFUSION; PRINTING; RAT; TIME; TISSUE ENGINEERING; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; BIOCOMPATIBLE MATERIALS; BLOOD VESSELS; CARBOHYDRATES; GLASS; HEPATOCYTES; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; PERFUSION; PRINTING; RATS; TIME FACTORS; TISSUE ENGINEERING; TISSUE SCAFFOLDS;

EID: 84866355664     PISSN: 14761122     EISSN: 14764660     Source Type: Journal    
DOI: 10.1038/nmat3357     Document Type: Article

References (27)

1. Radisic, M. et al. Medium perfusion enables engineering of compact and contractile cardiac tissue. Am. J. Physiol. Heart Circ. Physiol. 286, H507-H516 (2004).
2. Langer, R. & Vacanti, J. P. Tissue engineering. Science 260, 920-926 (1993).
3. Griffith, L. G. & Swartz, M. A. Capturing complex 3D tissue physiology in vitro. Nature Rev. Mol. Cell Biol. 7, 211-224 (2006).
4. Vunjak-Novakovic, G. & Scadden, D. T. Biomimetic platforms for human stem cell research. Cell Stem Cell 8, 252-261 (2011).
5. Schmidt-Nielsen, K. Scaling in biology: The consequences of size. J. Exp. Zool. 194, 287-307 (1975).
6. Golden, A. P. & Tien, J. Fabrication of microfluidic hydrogels using molded gelatin as a sacrificial element. Lab Chip 7, 720-725 (2007).
7. Ling, Y. et al. A cell-laden microfluidic hydrogel. Lab Chip 7, 756-762 (2007).
8. Choi, N. W. et al. Microfluidic scaffolds for tissue engineering. Nature Mater. 6, 908-915 (2007).
9. Cuchiara, M. P., Allen, A. C. B., Chen, T. M., Miller, J. S. & West, J. L. Multilayer microfluidic PEGDA hydrogels. Biomaterials 31, 5491-5497 (2010).
10. Visconti, R. P. et al. Towards organ printing: Engineering an intra-organ branched vascular tree. Exp. Opin. Biol. Therapy 10, 409-420 (2010).
11. Therriault, D., White, S. R. & Lewis, J. A. Chaotic mixing in three-dimensional microvascular networks fabricated by direct-write assembly. Nature Mater. 2, 265-271 (2003).
12. Bellan, L. M. et al. Fabrication of an artificial 3-dimensional vascular network using sacrificial sugar structures. Soft Matter 5, 1354-1357 (2009).
13. Wu, W. et al. Direct-write assembly of biomimetic microvascular networks for efficient fluid transport. Soft Matter 6, 739-742 (2010).
14. Reinheimer, M. A., Mussati, S. & Scenna, N. J. Influence of product composition and operating conditions on the unsteady behavior of hard candy cooling process. J. Food Eng. 101, 409-416 (2010).
15. Lutolf, M. P. & Hubbell, J. A. Synthetic biomaterials as instructive extracellular microenvironments for morphogenesis in tissue engineering. Nature Biotechnol. 23, 47-55 (2005).
16. Tibbitt, M. W. & Anseth, K. S. Hydrogels as extracellular matrix mimics for 3D cell culture. Biotechnol. Bioeng. 103, 655-663 (2009).
17. Heiber, J., Clemens, F., Graule, T. & Hülsenberg, D. Thermoplastic extrusion to highly-loaded thin green fibres containing Pb(Zr;Ti)O3. Adv. Eng. Mater. 7, 404-408 (2005).
18. Miller, J. S. et al. Bioactive hydrogels made from step-growth derived PEG-peptide macromers. Biomaterials 31, 3736-3743 (2010).
19. Moon, J. J., Hahn, M. S., Kim, I., Nsiah, B. A. & West, J. L. Micropatterning of poly(ethylene glycol) diacrylate hydrogels with biomolecules to regulate and guide endothelial morphogenesis. Tissue Eng. Part A 15, 579-585 (2009).
20. DeLong, S. A., Moon, J. J. & West, J. L. Covalently immobilized gradients of bFGF on hydrogel scaffolds for directed cell migration. Biomaterials 26, 3227-3234 (2005).
21. Stefonek, T. J. & Masters, K. S. Immobilized gradients of epidermal growth factor promote accelerated and directed keratinocyte migration. Wound Repair Regen. 15, 847-855 (2007).
22. Leslie-Barbick, J. E., Moon, J. J. & West, J. L. Covalently- immobilized vascular endothelial growth factor promotes endothelial cell tubulogenesis in poly(ethylene glycol) diacrylate hydrogels. J. Biomater. Sci. Poly. Edn 20, 1763-1779 (2009).
23. Sundararaghavan, H. G., Monteiro, G. A., Firestein, B. L. & Shreiber, D. I. Neurite growth in 3D collagen gels with gradients of mechanical properties. Biotechnol. Bioeng. 102, 632-643 (2009).
24. Nemir, S., Hayenga, H. N. & West, J. L. PEGDA hydrogels with patterned elasticity: Novel tools for the study of cell response to substrate rigidity. Biotechnol. Bioeng. 105, 636-644 (2010).
25. Tsang, V. L. et al. Fabrication of 3D hepatic tissues by additive photopatterning of cellular hydrogels. FASEB J. 21, 790-801 (2007).
26. Thorsen, T., Maerkl, S. J. & Quake, S. R. Microfluidic large-scale integration. Science 298, 580-584 (2002).
27. Atencia, J. & Beebe, D. J. Controlled microfluidic interfaces. Nature 437, 648-655 (2005).