Genetic reconstitution of tumorigenesis in primary intestinal cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 27, 2013, Pages 11127-11132

  Onuma, Kunishige ^a   Ochiai, Masako ^a   Orihashi, Kaoru ^a   Takahashi, Mami ^a   Imai, Toshio ^a   Nakagama, Hitoshi ^a   Hippo, Yoshitaka ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

Author keywords

Colon carcinogenesis; Matrigel; Primary culture; shRNA; Validation

Indexed keywords

APC PROTEIN; BIOLOGICAL MARKER; LENTIVIRUS VECTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; SHORT HAIRPIN RNA; WNT PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER STEM CELL; CARCINOGENESIS; CELL TRANSFORMATION; COLORECTAL CANCER; CONTROLLED STUDY; GENE INACTIVATION; GENE INTERACTION; GENE REPRESSION; GENE SILENCING; GENETIC TRANSDUCTION; IN VITRO STUDY; INTESTINE CELL; INTESTINE EPITHELIUM; METASTASIS; MOUSE; NONHUMAN; ONCOGENE K RAS; PRIORITY JOURNAL; RETRANSPLANTATION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR MICROENVIRONMENT; TUMOR MODEL; TUMOR SUPPRESSOR GENE; WILD TYPE;

COLON CARCINOGENESIS; MATRIGEL; PRIMARY CULTURE; SHRNA; VALIDATION;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; GENE KNOCKDOWN TECHNIQUES; GENES, APC; GENES, P53; HUMANS; INTESTINAL MUCOSA; LENTIVIRUS; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MICE, NUDE; RNA, SMALL INTERFERING; TRANSDUCTION, GENETIC; WNT SIGNALING PATHWAY;

ANIMALIA; MURINAE; MUS; MUS MUSCULUS;

EID: 84879726891     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1221926110     Document Type: Article

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