The use of nanoimprinted scaffolds as 3D culture models to facilitate spontaneous tumor cell migration and well-regulated spheroid formation

Biomaterials

Volumn 32, Issue 26, 2011, Pages 6052-6058

  Yoshii, Yukie ^a,b   Waki, Atsuo ^a,b,c   Yoshida, Kaori ^c   Kakezuka, Anna ^c   Kobayashi, Maki ^c   Namiki, Hideo ^d   Kuroda, Yusei ^b   Kiyono, Yasushi ^b   Yoshii, Hiroshi ^a   Furukawa, Takako ^a,b   Asai, Tatsuya ^b   Okazawa, Hidehiko ^b   Gelovani, Juri G ^e   Fujibayashi, Yasuhisa ^a,b  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b UNIVERSITY OF FUKUI   (Japan)

^c SCIVAX Corporation   (Japan)

^d WASEDA UNIVERSITY   (Japan)

^e UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

3D cell culture; Hypoxia; Multi cellular spheroid; Nanoimprinting technology; Tumor cell migration

Indexed keywords

3-D CELL CULTURE; HYPOXIA; MULTI-CELLULAR SPHEROID; NANOIMPRINTING TECHNOLOGY; TUMOR CELL MIGRATION;

CELL ADHESION; CELL CULTURE; CELL PROLIFERATION; CELLS; DRUG THERAPY; SUBSTRATES; THREE DIMENSIONAL; TUMORS;

SCAFFOLDS (BIOLOGY);

ANTINEOPLASTIC AGENT; MOLECULAR SCAFFOLD;

ANIMAL CELL; ARTICLE; CANCER THERAPY; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CELL VIABILITY; HIGH THROUGHPUT SCREENING; HUMAN; IN VIVO STUDY; MOUSE; NANOTECHNOLOGY; NONHUMAN; PRIORITY JOURNAL; REPRODUCIBILITY; SPECTROPHOTOMETRY; SPHEROID CELL; TUMOR CELL; TUMOR GROWTH;

ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; CELL SURVIVAL; HUMANS; MICE; SPHEROIDS, CELLULAR; TISSUE SCAFFOLDS;

EID: 79959887793     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.04.076     Document Type: Article

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