Generation of functional thyroid from embryonic stem cells

Nature

Volumn 491, Issue 7422, 2012, Pages 66-71

  Antonica, Francesco ^a   Kasprzyk, Dominika Figini ^a   Opitz, Robert ^a   Iacovino, Michelina ^b   Liao, Xiao Hui ^c   Dumitrescu, Alexandra Mihaela ^c   Refetoff, Samuel ^c   Peremans, Kathelijne ^d   Manto, Mario ^a   Kyba, Michael ^b   Costagliola, Sabine ^a  

^a UNIVERSITÉ LIBRE DE BRUXELLES   (Belgium)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c UNIVERSITY OF CHICAGO   (United States)

^d GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CD31 ANTIGEN; IODIDE; MESSENGER RNA; THYROID HORMONE; THYROTROPIN; THYROTROPIN RECEPTOR; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR NKX2 1; TRANSCRIPTION FACTOR PAX8; UNCLASSIFIED DRUG;

BIOLOGICAL DEVELOPMENT; CYTOLOGY; EMBRYO; FUNCTIONAL ROLE; GENE EXPRESSION; GROWTH REGULATOR; HORMONE; IODINE; METABOLISM; MORPHOGENESIS; PHYSIOLOGY; RODENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL DIFFERENTIATION; CELL STRUCTURE; CONTROLLED STUDY; EMBRYO; EMBRYONIC STEM CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SYNTHESIS; STRUCTURE ANALYSIS; THYROID FOLLICLE CELL; THYROID GLAND; THYROID HORMONE BLOOD LEVEL; UPREGULATION;

ANIMALS; CELL DIFFERENTIATION; DISEASE MODELS, ANIMAL; EMBRYONIC STEM CELLS; FEMALE; HUMANS; HYPOTHYROIDISM; MICE; NUCLEAR PROTEINS; PAIRED BOX TRANSCRIPTION FACTORS; THYROID GLAND; THYROTROPIN; THYROXINE; TRANSCRIPTION FACTORS;

MUS;

EID: 84868374724     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11525     Document Type: Article

References (33)

1. De Felice, M. Thyroid development and its disorders: genetics and molecular mechanisms. Endocr. Rev. 25, 722-746 (2004).
2. De Felice, M. & Di Lauro, R. Minireview: intrinsic and extrinsic factors in thyroid gland development: an update. Endocrinology 152, 2948-2956 (2011).
3. Mauchamp, J., Mirrione, A., Alquier, C. & Andre, F. Follicle-like structure and polarizedmonolayer: role of the extracellular matrix on thyroid cell organization in primary culture. Biol. Cell 90, 369-380 (1998).
4. Nunez, J. & Pommier, J. Formation of thyroid hormones. Vitam. Horm. 39, 175-229 (1982).
5. Kimura, S. et al. The T/ebp null mouse: thyroid-specific enhancer-binding protein is essential for the organogenesis of the thyroid, lung, ventral forebrain, and pituitary. Genes Dev. 10, 60-69 (1996).
6. Mansouri, A., Chowdhury, K.& Gruss, P. Follicular cells of the thyroid gland require Pax8 gene function. Nature Genet. 19, 87-90 (1998).
7. Lazzaro, D., Price, M., de Felice, M. & Di Lauro, R. The transcription factor TTF-1 is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the foetal brain. Development 113, 1093-1104 (1991).
8. Plachov, D. et al. Pax8, a murine paired box gene expressed in the developing excretory system and thyroid gland. Development 110, 643-651 (1990).
9. Kyba, M., Perlingeiro, R. C. & Daley, G. Q. HoxB4 confers definitive lymphoidmyeloidengraftment potentialonembryonic stemcell and yolk sac hematopoietic progenitors. Cell 109, 29-37 (2002).
10. Ahfeldt, T. et al. Programming human pluripotent stem cells into white and brown adipocytes. Nature Cell Biol. 14, 209-219 (2012).
11. Kamiya, D. et al. Intrinsic transition of embryonic stem-cell differentiation into neural progenitors. Nature 470, 503-509 (2011).
12. Eiraku, M. et al. Self-organizing optic-cup morphogenesis in three-dimensional culture. Nature 472, 51-56 (2011).
13. Suga, H. et al. Self-formation of functional adenohypophysis in three-dimensional culture. Nature 480, 57-62 (2011).
14. Eiraku, M. & Sasai, Y. Mouse embryonic stem cell culture for generation of threedimensional retinal and cortical tissues. Nature Protocols 7, 69-79 (2012).
15. Iacovino, M. et al. Inducible cassette exchange: a rapid and efficient system enabling conditional gene expression in embryonic stem and primary cells. Stem Cells 29, 1580-1588 (2011).
16. De Felice, M. et al. A mouse model for hereditary thyroid dysgenesis and cleft palate. Nature Genet. 19, 395-398 (1998).
17. Dai, G., Levy, O. & Carrasco, N. Cloning and characterization of the thyroid iodide transporter. Nature 379, 458-460 (1996).
18. Carrasco, N. Iodide transport in the thyroid gland. Biochim. Biophys. Acta 1154, 65-82 (1993).
19. Hartog, M. T. D., Boer, M. D., Veenboer, G. J. M. & Vijlder, J. J. M. D. Generation and characterization of monoclonal antibodies directed against noniodinated and iodinated thyroglobulin, among which are antibodies against hormonogenic sites. Endocrinology 127, 3160-3165 (1990).
20. Fontaine, J. Multistep migration of calcitonin cell precursors during ontogeny of the mouse pharynx. Gen. Comp. Endocrinol. 37, 81-92 (1979).
21. Moeller, L. C. et al. Hypothyroidism in thyroid transcription factor 1 haploinsufficiency is caused by reduced expression of the thyroid-stimulating hormone receptor. Mol. Endocrinol. 17, 2295-2302 (2003).
22. Sato, T. et al. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459, 262-265 (2009).
23. Yui, S. et al. Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr51 stem cell. Nature Med. 18, 618-623 (2012).
24. Lin, R. Y., Kubo, A., Keller, G. M. & Davies, T. F. Committing embryonic stem cells to differentiate into thyrocyte-like cells in vitro. Endocrinology 144, 2644-2649 (2003).
25. Arufe, M. C. et al. Directed differentiation of mouse embryonic stem cells into thyroid follicular cells. Endocrinology 147, 3007-3015 (2006).
26. Jiang, N. et al. Differentiation of E14 mouse embryonic stem cells into thyrocytes in vitro. Thyroid 20, 77-84 (2010).
27. Longmire, T. A. et al. Efficient derivation of purified lung and thyroid progenitors from embryonic stem cells. Cell Stem Cell 10, 398-411 (2012).
28. Grüters, A. & Krude, H. Detection and treatment of congenital hypothyroidism. Nature Rev. Endocrinol. 8, 104-113 (2012).
29. Bondue, A. et al. Mesp1 acts as a master regulator of multipotent cardiovascular progenitor specification. Cell Stem Cell 3, 69-84 (2008).
30. Abel, E. D. et al. Divergent roles for thyroid hormone receptor b isoforms in the endocrine axis and auditory system. J. Clin. Invest. 104, 291-300 (1999).
31. Rodriguez, W. et al. Deletion of theRNaseIII enzymedicer in thyroid follicular cells causes hypothyroidismwith signs of neoplastic alterations. PLoSONE 7, e29929 (2012).
32. Poulsom, R. et al. Bone marrow contributes to renal parenchymal turnover and regeneration. J. Pathol. 195, 229-235 (2001).
33. Pohlenz, J. et al. Improved radioimmunoassay for measurement of mouse thyrotropin in serum: strain differences in thyrotropin concentration and thyrotroph sensitivity to thyroid hormone. Thyroid 9, 1265-1271 (1999).