Evaluation of seven drug metabolisms and clearances by cryopreserved human primary hepatocytes cultivated in microfluidic biochips

Xenobiotica

Volumn 43, Issue 2, 2013, Pages 140-152

  Baudoin, Régis ^a   Prot, Jean Matthieu ^a   Nicolas, Grégory ^b   Brocheton, Jessy ^c   Brochot, Céline ^d   Legallais, Cécile ^a   Benech, Henri ^b   Leclerc, Eric ^a  

^a UNIVERSITÉ DE TECHNOLOGIE DE COMPIÈGNE   (France)

^b Service de Pharmacologie et Immunoanalyse   (France)

^c INSTITUT COCHIN   (France)

^d INSTITUT NATIONAL DE L ENVIRONNEMENT INDUSTRIEL ET DES RISQUES INERIS   (France)

Author keywords

Clearances; Drug metabolism; Human cryopreserved hepatocytes; IDCCM; Microfluidic biochips

Indexed keywords

CAFFEINE; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C19; CYTOCHROME P450 2C8; CYTOCHROME P450 2C9; CYTOCHROME P450 2D6; CYTOCHROME P450 2E1; CYTOCHROME P450 3A4; DEXTROMETHORPHAN; FLUORESCEIN DIACETATE; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; MESSENGER RNA; MIDAZOLAM; OMEPRAZOLE; PARACETAMOL; REPAGLINIDE; TOLBUTAMIDE;

ARTICLE; CELL ADHESION; CELL POLARITY; CONTROLLED STUDY; CRYOPRESERVATION; DRUG CLEARANCE; DRUG METABOLISM; DRUG SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER CELL; MICROFLUIDICS; PREDICTION; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; THAWING;

CELL DIFFERENTIATION; CELLS, CULTURED; HEPATOCYTES; HUMANS; KINETICS; METABOLIC CLEARANCE RATE; METABOLIC DETOXICATION, DRUG; MICROFLUIDIC ANALYTICAL TECHNIQUES; XENOBIOTICS;

EID: 84872168458     PISSN: 00498254     EISSN: 13665928     Source Type: Journal    
DOI: 10.3109/00498254.2012.706725     Document Type: Article

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