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Volumn 9, Issue 9, 2014, Pages 1115-1128

Three-dimensional models of cancer for pharmacology and cancer cell biology: Capturing tumor complexity in vitro/ex vivo

Author keywords

3D models; Bioreactors; Cancer; Drug discovery; Tissue slices

Indexed keywords

BIOREACTORS; CYTOLOGY; DRUG PRODUCTS; TUMORS;

EID: 84906816780     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201300492     Document Type: Review
Times cited : (309)

References (165)
  • 1
    • 84901946024 scopus 로고    scopus 로고
    • Lessons learned from the fate of AstraZeneca's drug pipeline: A five-dimensional framework.
    • Cook, D., Brown, D., Alexander, R., March, R. et al., Lessons learned from the fate of AstraZeneca's drug pipeline: A five-dimensional framework. Nat. Rev. Drug Discov. 2014, 13, 419-431.
    • (2014) Nat. Rev. Drug Discov. , vol.13 , pp. 419-431
    • Cook, D.1    Brown, D.2    Alexander, R.3    March, R.4
  • 2
    • 84900026507 scopus 로고    scopus 로고
    • Cancer cell lines for drug discovery and development.
    • Wilding, J. L., Bodmer, W. F., Cancer cell lines for drug discovery and development. Cancer Res. 2014, 74, 2377-2384.
    • (2014) Cancer Res. , vol.74 , pp. 2377-2384
    • Wilding, J.L.1    Bodmer, W.F.2
  • 4
    • 84867220176 scopus 로고    scopus 로고
    • Biomedicine. Pharma firms push for sharing of cancer trial data.
    • Bhattacharjee, Y., Biomedicine. Pharma firms push for sharing of cancer trial data. Science 2012, 338.
    • (2012) Science , pp. 338
    • Bhattacharjee, Y.1
  • 5
    • 79551575056 scopus 로고    scopus 로고
    • Trial watch: Phase III and submission failures: 2007-2010.
    • Arrowsmith, J., Trial watch: Phase III and submission failures: 2007-2010. Nat. Rev. Drug Discov. 2011, 10, 87.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 87
    • Arrowsmith, J.1
  • 6
    • 84859169877 scopus 로고    scopus 로고
    • The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity.
    • Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K. et al., The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature 2012, 483, 603-607.
    • (2012) Nature , vol.483 , pp. 603-607
    • Barretina, J.1    Caponigro, G.2    Stransky, N.3    Venkatesan, K.4
  • 7
    • 84859187259 scopus 로고    scopus 로고
    • Systematic identification of genomic markers of drug sensitivity in cancer cells.
    • Garnett, M. J., Edelman, E. J., Heidorn, S. J., Greenman, C. D. et al., Systematic identification of genomic markers of drug sensitivity in cancer cells. Nature 2012, 483, 570-575.
    • (2012) Nature , vol.483 , pp. 570-575
    • Garnett, M.J.1    Edelman, E.J.2    Heidorn, S.J.3    Greenman, C.D.4
  • 8
    • 84890553061 scopus 로고    scopus 로고
    • Inconsistency in large pharmacogenomic studies.
    • Haibe-Kains, B., El-Hachem, N., Birkbak, N. J., Jin, A. C. et al., Inconsistency in large pharmacogenomic studies. Nature 2013, 504, 389-393.
    • (2013) Nature , vol.504 , pp. 389-393
    • Haibe-Kains, B.1    El-Hachem, N.2    Birkbak, N.J.3    Jin, A.C.4
  • 9
    • 77955928161 scopus 로고    scopus 로고
    • Tumors as organs: Complex tissues that interface with the entire organism.
    • Egeblad, M., Nakasone, E. S., Werb, Z., Tumors as organs: Complex tissues that interface with the entire organism. Dev. Cell 2010, 18, 884-901.
    • (2010) Dev. Cell , vol.18 , pp. 884-901
    • Egeblad, M.1    Nakasone, E.S.2    Werb, Z.3
  • 10
    • 84899938064 scopus 로고    scopus 로고
    • Cell-based drug testing; this world is not flat.
    • Grainger, D. W., Cell-based drug testing; this world is not flat. Adv. Drug Deliv. Rev. 2014, 69-70, vii-xi.
    • (2014) Adv. Drug Deliv. Rev. , vol.69-70 , pp. 7-11
    • Grainger, D.W.1
  • 11
    • 84899945356 scopus 로고    scopus 로고
    • 3D cell culture systems modeling tumor growth determinants in cancer target discovery.
    • Thoma, C. R., Zimmermann, M., Agarkova, I., Kelm, J. M., Krek, W., 3D cell culture systems modeling tumor growth determinants in cancer target discovery. Adv. Drug Deliv. Rev. 2014, 69-70, 29-41.
    • (2014) Adv. Drug Deliv. Rev. , vol.69-70 , pp. 29-41
    • Thoma, C.R.1    Zimmermann, M.2    Agarkova, I.3    Kelm, J.M.4    Krek, W.5
  • 12
    • 2442707379 scopus 로고
    • Cytotoxicity in human cell cultures as a primary screen for the detection of anti-tumor agents.
    • Eagle, H., Foley, G. E., Cytotoxicity in human cell cultures as a primary screen for the detection of anti-tumor agents. Cancer Res. 1958, 18, 1017-1025.
    • (1958) Cancer Res. , vol.18 , pp. 1017-1025
    • Eagle, H.1    Foley, G.E.2
  • 13
    • 84873773312 scopus 로고
    • Tissue culture in cancer chemotherapy screening.
    • Hirschberg, E., Tissue culture in cancer chemotherapy screening. Cancer Res. 1958, 18, 869-878.
    • (1958) Cancer Res. , vol.18 , pp. 869-878
    • Hirschberg, E.1
  • 14
    • 0017785769 scopus 로고
    • Primary bioassay of human tumor stem cells.
    • Hamburger, A. W., Salmon, S. E., Primary bioassay of human tumor stem cells. Science 1977, 197, 461-463.
    • (1977) Science , vol.197 , pp. 461-463
    • Hamburger, A.W.1    Salmon, S.E.2
  • 15
    • 0021883048 scopus 로고
    • Application of a human tumor colony-forming assay to new drug screening.
    • Shoemaker, R. H., Wolpert-DeFilippes, M. K., Kern, D. H., Lieber, M. M. et al., Application of a human tumor colony-forming assay to new drug screening. Cancer Res. 1985, 45, 2145-2153.
    • (1985) Cancer Res. , vol.45 , pp. 2145-2153
    • Shoemaker, R.H.1    Wolpert-DeFilippes, M.K.2    Kern, D.H.3    Lieber, M.M.4
  • 16
    • 1942518912 scopus 로고    scopus 로고
    • Clonogenic assay with established human tumour xenografts: Correlation of in vitro to in vivo activity as a basis for anticancer drug discovery.
    • Fiebig, H. H., Maier, A., Burger, A. M., Clonogenic assay with established human tumour xenografts: Correlation of in vitro to in vivo activity as a basis for anticancer drug discovery. Eur. J. Cancer (Oxford Engl.) 2004, 40, 802-820.
    • (2004) Eur. J. Cancer (Oxford Engl.) , vol.40 , pp. 802-820
    • Fiebig, H.H.1    Maier, A.2    Burger, A.M.3
  • 17
    • 0032896336 scopus 로고    scopus 로고
    • Review of the efficacy of individualized chemotherapy selected by in vitro drug sensitivity testing for patients with cancer.
    • Cortazar, P., Johnson, B. E., Review of the efficacy of individualized chemotherapy selected by in vitro drug sensitivity testing for patients with cancer. J. Clin. Oncol. 1999, 17, 1625-1631.
    • (1999) J. Clin. Oncol. , vol.17 , pp. 1625-1631
    • Cortazar, P.1    Johnson, B.E.2
  • 18
    • 33749011163 scopus 로고    scopus 로고
    • The NCI60 human tumour cell line anticancer drug screen.
    • Shoemaker, R. H., The NCI60 human tumour cell line anticancer drug screen. Nat. Rev. Cancer 2006, 6, 813-823.
    • (2006) Nat. Rev. Cancer , vol.6 , pp. 813-823
    • Shoemaker, R.H.1
  • 19
    • 84880861468 scopus 로고    scopus 로고
    • The exomes of the NCI-60 panel: A genomic resource for cancer biology and systems pharmacology.
    • Abaan, O. D., Polley, E. C., Davis, S. R., Zhu, Y. J. et al., The exomes of the NCI-60 panel: A genomic resource for cancer biology and systems pharmacology. Cancer Res. 2013, 73, 4372-4382.
    • (2013) Cancer Res. , vol.73 , pp. 4372-4382
    • Abaan, O.D.1    Polley, E.C.2    Davis, S.R.3    Zhu, Y.J.4
  • 20
    • 77949685981 scopus 로고    scopus 로고
    • RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
    • Hatzivassiliou, G., Song, K., Yen, I., Brandhuber, B. J. et al., RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth. Nature 2010, 464, 431-435.
    • (2010) Nature , vol.464 , pp. 431-435
    • Hatzivassiliou, G.1    Song, K.2    Yen, I.3    Brandhuber, B.J.4
  • 21
    • 77949732073 scopus 로고    scopus 로고
    • RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF.
    • Poulikakos, P. I., Zhang, C., Bollag, G., Shokat, K. M., Rosen, N., RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 2010, 464, 427-430.
    • (2010) Nature , vol.464 , pp. 427-430
    • Poulikakos, P.I.1    Zhang, C.2    Bollag, G.3    Shokat, K.M.4    Rosen, N.5
  • 22
    • 32944457518 scopus 로고    scopus 로고
    • mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt.
    • O'Reilly, K. E., Rojo, F., She, Q.-B., Solit, D. et al., mTOR inhibition induces upstream receptor tyrosine kinase signaling and activates Akt. Cancer Res. 2006, 66, 1500-1508.
    • (2006) Cancer Res. , vol.66 , pp. 1500-1508
    • O'Reilly, K.E.1    Rojo, F.2    She, Q.-B.3    Solit, D.4
  • 23
    • 84864285794 scopus 로고    scopus 로고
    • Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion.
    • Straussman, R., Morikawa, T., Shee, K., Barzily-Rokni, M. et al., Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature 2012, 487, 500-504.
    • (2012) Nature , vol.487 , pp. 500-504
    • Straussman, R.1    Morikawa, T.2    Shee, K.3    Barzily-Rokni, M.4
  • 24
    • 84864286442 scopus 로고    scopus 로고
    • Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    • Wilson, T. R., Fridlyand, J., Yan, Y., Penuel, E. et al., Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature 2012, 487, 505-509.
    • (2012) Nature , vol.487 , pp. 505-509
    • Wilson, T.R.1    Fridlyand, J.2    Yan, Y.3    Penuel, E.4
  • 25
    • 0037701271 scopus 로고    scopus 로고
    • Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types.
    • Kelm, J. M., Timmins, N. E., Brown, C. J., Fussenegger, M., Nielsen, L. K., Method for generation of homogeneous multicellular tumor spheroids applicable to a wide variety of cell types. Biotechnol. Bioeng. 2003, 83, 173-180.
    • (2003) Biotechnol. Bioeng. , vol.83 , pp. 173-180
    • Kelm, J.M.1    Timmins, N.E.2    Brown, C.J.3    Fussenegger, M.4    Nielsen, L.K.5
  • 26
    • 60549103259 scopus 로고    scopus 로고
    • Spheroid-based drug screen: Considerations and practical approach.
    • Friedrich, J., Seidel, C., Ebner, R., Kunz-Schughart, L. A., Spheroid-based drug screen: Considerations and practical approach. Nat. Protoc. 2009, 4, 309-324.
    • (2009) Nat. Protoc. , vol.4 , pp. 309-324
    • Friedrich, J.1    Seidel, C.2    Ebner, R.3    Kunz-Schughart, L.A.4
  • 27
    • 84877255483 scopus 로고    scopus 로고
    • A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro.
    • Lee, J. M., Mhawech-Fauceglia, P., Lee, N., Parsanian, L. C. et al., A three-dimensional microenvironment alters protein expression and chemosensitivity of epithelial ovarian cancer cells in vitro. Lab. Invest. 2013, 93, 528-542.
    • (2013) Lab. Invest. , vol.93 , pp. 528-542
    • Lee, J.M.1    Mhawech-Fauceglia, P.2    Lee, N.3    Parsanian, L.C.4
  • 28
    • 84858723379 scopus 로고    scopus 로고
    • Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation.
    • Vinci, M., Gowan, S., Boxall, F., Patterson, L. et al., Advances in establishment and analysis of three-dimensional tumor spheroid-based functional assays for target validation and drug evaluation. BMC Biol. 2012, 10, 29.
    • (2012) BMC Biol. , vol.10 , pp. 29
    • Vinci, M.1    Gowan, S.2    Boxall, F.3    Patterson, L.4
  • 29
    • 34249931302 scopus 로고    scopus 로고
    • Three-dimensional expansion: In suspension culture of SD rat's osteoblasts in a rotating wall vessel bioreactor.
    • Song, K.-D., Liu, T.-Q., Li, X.-Q., Cui, Z.-F. et al., Three-dimensional expansion: In suspension culture of SD rat's osteoblasts in a rotating wall vessel bioreactor. Biomed. Environ. Sci. 2007, 20, 91-98.
    • (2007) Biomed. Environ. Sci. , vol.20 , pp. 91-98
    • Song, K.-D.1    Liu, T.-Q.2    Li, X.-Q.3    Cui, Z.-F.4
  • 30
    • 58749093939 scopus 로고    scopus 로고
    • Recent advances in three-dimensional multicellular spheroid culture for biomedical research.
    • Lin, R.-Z., Lin, R.-Z., Chang, H.-Y., Recent advances in three-dimensional multicellular spheroid culture for biomedical research. Biotechnol. J. 2008, 3, 1172-1184.
    • (2008) Biotechnol. J. , vol.3 , pp. 1172-1184
    • Lin, R.-Z.1    Lin, R.-Z.2    Chang, H.-Y.3
  • 31
    • 33646368912 scopus 로고    scopus 로고
    • Dynamic analysis of hepatoma spheroid formation: Roles of E-cadherin and beta1-integrin.
    • Lin, R.-Z., Chou, L.-F., Chien, C.-C. M., Chang, H.-Y., Dynamic analysis of hepatoma spheroid formation: Roles of E-cadherin and beta1-integrin. Cell Tissue Res. 2006, 324, 411-422.
    • (2006) Cell Tissue Res. , vol.324 , pp. 411-422
    • Lin, R.-Z.1    Chou, L.-F.2    Chien, C.-C.M.3    Chang, H.-Y.4
  • 32
    • 0033101647 scopus 로고    scopus 로고
    • Multicellular tumor spheroids: Intermediates between monolayer culture and in vivo tumor.
    • Kunz-Schughart, L. A., Multicellular tumor spheroids: Intermediates between monolayer culture and in vivo tumor. Cell Biol. Int. 1999, 23, 157-161.
    • (1999) Cell Biol. Int. , vol.23 , pp. 157-161
    • Kunz-Schughart, L.A.1
  • 33
    • 0024281372 scopus 로고
    • Cell and environment interactions in tumor microregions: The multicell spheroid model.
    • Sutherland, R. M., Cell and environment interactions in tumor microregions: The multicell spheroid model. Science 1988, 240, 177-184.
    • (1988) Science , vol.240 , pp. 177-184
    • Sutherland, R.M.1
  • 34
    • 0030950758 scopus 로고    scopus 로고
    • Abrogation of taxol-induced G2-M arrest and apoptosis in human ovarian cancer cells grown as multicellular tumor spheroids.
    • Frankel, A., Buckman, R., Kerbel, R. S., Abrogation of taxol-induced G2-M arrest and apoptosis in human ovarian cancer cells grown as multicellular tumor spheroids. Cancer Res. 1997, 57, 2388-2393.
    • (1997) Cancer Res. , vol.57 , pp. 2388-2393
    • Frankel, A.1    Buckman, R.2    Kerbel, R.S.3
  • 35
    • 0022556862 scopus 로고
    • The effect of adriamycin and 4'-deoxydoxorubicin on cell survival of human lung tumour cells grown in monolayer and as spheroids.
    • Kerr, D. J., Wheldon, T. E., Kerr, A. M., Freshney, R. I., Kaye, S. B., The effect of adriamycin and 4'-deoxydoxorubicin on cell survival of human lung tumour cells grown in monolayer and as spheroids. Br. J. Cancer 1986, 54, 423-429.
    • (1986) Br. J. Cancer , vol.54 , pp. 423-429
    • Kerr, D.J.1    Wheldon, T.E.2    Kerr, A.M.3    Freshney, R.I.4    Kaye, S.B.5
  • 36
    • 0027530122 scopus 로고
    • Acquired multicellular-mediated resistance to alkylating agents in cancer.
    • Kobayashi, H., Man, S., Graham, C. H., Kapitain, S. J. et al., Acquired multicellular-mediated resistance to alkylating agents in cancer. Proc. Natl. Acad. Sci. USA 1993, 90, 3294-3298.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3294-3298
    • Kobayashi, H.1    Man, S.2    Graham, C.H.3    Kapitain, S.J.4
  • 37
    • 84874239307 scopus 로고    scopus 로고
    • 3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing.
    • Longati, P., Jia, X., Eimer, J., Wagman, A. et al., 3D pancreatic carcinoma spheroids induce a matrix-rich, chemoresistant phenotype offering a better model for drug testing. BMC Cancer 2013, 13, 95.
    • (2013) BMC Cancer , vol.13 , pp. 95
    • Longati, P.1    Jia, X.2    Eimer, J.3    Wagman, A.4
  • 38
    • 78751560396 scopus 로고    scopus 로고
    • High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array.
    • Tung, Y.-C., Hsiao, A. Y., Allen, S. G., Torisawa, Y. et al., High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array. The Analyst 2011, 136, 473-478.
    • (2011) The Analyst , vol.136 , pp. 473-478
    • Tung, Y.-C.1    Hsiao, A.Y.2    Allen, S.G.3    Torisawa, Y.4
  • 39
    • 0032978250 scopus 로고    scopus 로고
    • Penetration of anticancer drugs through solid tissue: A factor that limits the effectiveness of chemotherapy for solid tumors.
    • Tunggal, J. K., Cowan, D. S., Shaikh, H., Tannock, I. F., Penetration of anticancer drugs through solid tissue: A factor that limits the effectiveness of chemotherapy for solid tumors. Clin. Cancer Res. 1999, 5, 1583-1586.
    • (1999) Clin. Cancer Res. , vol.5 , pp. 1583-1586
    • Tunggal, J.K.1    Cowan, D.S.2    Shaikh, H.3    Tannock, I.F.4
  • 40
    • 84896494087 scopus 로고    scopus 로고
    • 3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions.
    • Wenzel, C., Riefke, B., Gründemann, S., Krebs, A. et al., 3D high-content screening for the identification of compounds that target cells in dormant tumor spheroid regions. Exp. Cell Res. 2014, 323, 131-143.
    • (2014) Exp. Cell Res. , vol.323 , pp. 131-143
    • Wenzel, C.1    Riefke, B.2    Gründemann, S.3    Krebs, A.4
  • 41
    • 0032534450 scopus 로고    scopus 로고
    • Blockade of tumor cell transforming growth factor-betas enhances cell cycle progression and sensitizes human breast carcinoma cells to cytotoxic chemotherapy.
    • Ohmori, T., Yang, J. L., Price, J. O., Arteaga, C. L., Blockade of tumor cell transforming growth factor-betas enhances cell cycle progression and sensitizes human breast carcinoma cells to cytotoxic chemotherapy. Exp. Cell Res. 1998, 245, 350-359.
    • (1998) Exp. Cell Res. , vol.245 , pp. 350-359
    • Ohmori, T.1    Yang, J.L.2    Price, J.O.3    Arteaga, C.L.4
  • 42
    • 3242693775 scopus 로고    scopus 로고
    • Antiadhesive antibodies targeting E-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro.
    • Green, S. K., Francia, G., Isidoro, C., Kerbel, R. S., Antiadhesive antibodies targeting E-cadherin sensitize multicellular tumor spheroids to chemotherapy in vitro. Mol. Cancer Ther. 2004, 3, 149-159.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 149-159
    • Green, S.K.1    Francia, G.2    Isidoro, C.3    Kerbel, R.S.4
  • 43
    • 34748840281 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures.
    • Howes, A. L., Chiang, G. G., Lang, E. S., Ho, C. B. et al., The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures. Mol. Cancer Ther. 2007, 6, 2505-2514.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 2505-2514
    • Howes, A.L.1    Chiang, G.G.2    Lang, E.S.3    Ho, C.B.4
  • 44
    • 4444223702 scopus 로고    scopus 로고
    • Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling.
    • Ihle, N. T., Williams, R., Chow, S., Chew, W. et al., Molecular pharmacology and antitumor activity of PX-866, a novel inhibitor of phosphoinositide-3-kinase signaling. Mol. Cancer Ther. 2004, 3, 763-772.
    • (2004) Mol. Cancer Ther. , vol.3 , pp. 763-772
    • Ihle, N.T.1    Williams, R.2    Chow, S.3    Chew, W.4
  • 45
    • 77956004085 scopus 로고    scopus 로고
    • Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma.
    • Koul, D., Shen, R., Kim, Y.-W., Kondo, Y. et al., Cellular and in vivo activity of a novel PI3K inhibitor, PX-866, against human glioblastoma. Neuro-Oncology 2010, 12, 559-569.
    • (2010) Neuro-Oncology , vol.12 , pp. 559-569
    • Koul, D.1    Shen, R.2    Kim, Y.-W.3    Kondo, Y.4
  • 46
    • 84874650275 scopus 로고    scopus 로고
    • Development of PI3K inhibitors: Lessons learned from early clinical trials.
    • Rodon, J., Dienstmann, R., Serra, V., Tabernero, J., Development of PI3K inhibitors: Lessons learned from early clinical trials. Nat. Rev. Clin. Oncol. 2013, 10, 143-153.
    • (2013) Nat. Rev. Clin. Oncol. , vol.10 , pp. 143-153
    • Rodon, J.1    Dienstmann, R.2    Serra, V.3    Tabernero, J.4
  • 47
    • 84887869938 scopus 로고    scopus 로고
    • A high-throughput-compatible 3D microtissue co-culture system for phenotypic RNAi screening applications.
    • Thoma, C. R., Stroebel, S., Rösch, N., Calpe, B. et al., A high-throughput-compatible 3D microtissue co-culture system for phenotypic RNAi screening applications. J. Biomol. Screen. 2013, 18, 1330-1337.
    • (2013) J. Biomol. Screen. , vol.18 , pp. 1330-1337
    • Thoma, C.R.1    Stroebel, S.2    Rösch, N.3    Calpe, B.4
  • 48
    • 33645707133 scopus 로고    scopus 로고
    • Brave little world: Spheroids as an in vitro model to study tumor-immune-cell interactions.
    • Gottfried, E., Kunz-Schughart, L. A., Andreesen, R., Kreutz, M., Brave little world: Spheroids as an in vitro model to study tumor-immune-cell interactions. Cell Cycle (Georgetown Tex.) 2006, 5, 691-695.
    • (2006) Cell Cycle (Georgetown Tex.) , vol.5 , pp. 691-695
    • Gottfried, E.1    Kunz-Schughart, L.A.2    Andreesen, R.3    Kreutz, M.4
  • 49
    • 0027765545 scopus 로고
    • Macrophages and multicellular tumor spheroids in co-culture: A three-dimensional model to study tumor-host interactions. Evidence for macrophage-mediated tumor cell proliferation and migration.
    • Hauptmann, S., Zwadlo-Klarwasser, G., Jansen, M., Klosterhalfen, B., Kirkpatrick, C. J., Macrophages and multicellular tumor spheroids in co-culture: A three-dimensional model to study tumor-host interactions. Evidence for macrophage-mediated tumor cell proliferation and migration. Am. J. Pathol. 1993, 143, 1406-1415.
    • (1993) Am. J. Pathol. , vol.143 , pp. 1406-1415
    • Hauptmann, S.1    Zwadlo-Klarwasser, G.2    Jansen, M.3    Klosterhalfen, B.4    Kirkpatrick, C.J.5
  • 50
    • 33646421684 scopus 로고    scopus 로고
    • Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro.
    • Kunz-Schughart, L. A., Schroeder, J. A., Wondrak, M., van Rey, F. et al., Potential of fibroblasts to regulate the formation of three-dimensional vessel-like structures from endothelial cells in vitro. Am. J. Physiol. Cell Physiol. 2006, 290, C1385-C1398.
    • (2006) Am. J. Physiol. Cell Physiol. , vol.290
    • Kunz-Schughart, L.A.1    Schroeder, J.A.2    Wondrak, M.3    van Rey, F.4
  • 51
    • 0035872250 scopus 로고    scopus 로고
    • A heterologous 3-D coculture model of breast tumor cells and fibroblasts to study tumor-associated fibroblast differentiation.
    • Kunz-Schughart, L. A., Heyder, P., Schroeder, J., Knuechel, R., A heterologous 3-D coculture model of breast tumor cells and fibroblasts to study tumor-associated fibroblast differentiation. Exp. Cell Res. 2001, 266, 74-86.
    • (2001) Exp. Cell Res. , vol.266 , pp. 74-86
    • Kunz-Schughart, L.A.1    Heyder, P.2    Schroeder, J.3    Knuechel, R.4
  • 52
    • 0037058309 scopus 로고    scopus 로고
    • Three-dimensional fibroblast-tumor cell interaction causes downregulation of RACK1 mRNA expression in breast cancer cells in vitro.
    • Seidl, P., Huettinger, R., Knuechel, R., Kunz-Schughart, L. A., Three-dimensional fibroblast-tumor cell interaction causes downregulation of RACK1 mRNA expression in breast cancer cells in vitro. Int. J. Cancer 2002, 102, 129-136.
    • (2002) Int. J. Cancer , vol.102 , pp. 129-136
    • Seidl, P.1    Huettinger, R.2    Knuechel, R.3    Kunz-Schughart, L.A.4
  • 53
    • 0028013275 scopus 로고
    • Myofibroblast and concurrent ED-B fibronectin phenotype in human stromal cells cultured from non-malignant and malignant breast tissue.
    • Brouty-Boyé, D., Magnien, V., Myofibroblast and concurrent ED-B fibronectin phenotype in human stromal cells cultured from non-malignant and malignant breast tissue. Eur. J. Cancer (Oxford Engl.) 1990 1994, 30A, 66-73.
    • (1994) Eur. J. Cancer (Oxford Engl.) 1990 , vol.30 A , pp. 66-73
    • Brouty-Boyé, D.1    Magnien, V.2
  • 54
    • 84903276548 scopus 로고    scopus 로고
    • Optimization of liquid overlay technique to formulate heterogenic 3D co-cultures models.
    • Costa, E. C., Gaspar, V. M., Coutinho, P., Correia, I. J., Optimization of liquid overlay technique to formulate heterogenic 3D co-cultures models. Biotechnol. Bioeng. 2014, 111, 1672-1685.
    • (2014) Biotechnol. Bioeng. , vol.111 , pp. 1672-1685
    • Costa, E.C.1    Gaspar, V.M.2    Coutinho, P.3    Correia, I.J.4
  • 55
    • 84899752915 scopus 로고    scopus 로고
    • Development of an innovative 3D cell culture system to study tumour-stroma interactions in non-small cell lung cancer cells.
    • Amann, A., Zwierzina, M., Gamerith, G., Bitsche, M. et al., Development of an innovative 3D cell culture system to study tumour-stroma interactions in non-small cell lung cancer cells. PLoS ONE 2014, 9, e92511.
    • (2014) PLoS ONE , vol.9
    • Amann, A.1    Zwierzina, M.2    Gamerith, G.3    Bitsche, M.4
  • 56
    • 77956287380 scopus 로고    scopus 로고
    • A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses.
    • Härmä, V., Virtanen, J., Mäkelä, R., Happonen, A. et al., A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses. PLoS ONE 2010, 5, e10431.
    • (2010) PLoS ONE , vol.5
    • Härma, V.1    Virtanen, J.2    Mäkela, R.3    Happonen, A.4
  • 57
    • 84860697028 scopus 로고    scopus 로고
    • The tumor microenvironment is a dominant force in multidrug resistance.
    • Correia, A. L., Bissell, M. J., The tumor microenvironment is a dominant force in multidrug resistance. Drug Resist. Updat. 2012, 15, 39-49.
    • (2012) Drug Resist. Updat. , vol.15 , pp. 39-49
    • Correia, A.L.1    Bissell, M.J.2
  • 58
    • 0033032317 scopus 로고    scopus 로고
    • Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo.
    • Sethi, T., Rintoul, R. C., Moore, S. M., MacKinnon, A. C. et al., Extracellular matrix proteins protect small cell lung cancer cells against apoptosis: A mechanism for small cell lung cancer growth and drug resistance in vivo. Nat. Med. 1999, 5, 662-668.
    • (1999) Nat. Med. , vol.5 , pp. 662-668
    • Sethi, T.1    Rintoul, R.C.2    Moore, S.M.3    MacKinnon, A.C.4
  • 59
    • 0035899331 scopus 로고    scopus 로고
    • Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells.
    • Aoudjit, F., Vuori, K., Integrin signaling inhibits paclitaxel-induced apoptosis in breast cancer cells. Oncogene 2001, 20, 4995-5004.
    • (2001) Oncogene , vol.20 , pp. 4995-5004
    • Aoudjit, F.1    Vuori, K.2
  • 60
    • 80052181422 scopus 로고    scopus 로고
    • β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib.
    • Huang, C., Park, C. C., Hilsenbeck, S. G., Ward, R. et al., β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib. Breast Cancer Res. 2011, 13, R84.
    • (2011) Breast Cancer Res. , vol.13
    • Huang, C.1    Park, C.C.2    Hilsenbeck, S.G.3    Ward, R.4
  • 61
    • 13444291204 scopus 로고    scopus 로고
    • A novel CYR61-triggered "CYR61-alphavbeta3 integrin loop" regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway.
    • Menendez, J. A., Vellon, L., Mehmi, I., Teng, P. K. et al., A novel CYR61-triggered "CYR61-alphavbeta3 integrin loop" regulates breast cancer cell survival and chemosensitivity through activation of ERK1/ERK2 MAPK signaling pathway. Oncogene 2005, 24, 761-779.
    • (2005) Oncogene , vol.24 , pp. 761-779
    • Menendez, J.A.1    Vellon, L.2    Mehmi, I.3    Teng, P.K.4
  • 62
    • 84917673291 scopus 로고    scopus 로고
    • Integrin signaling as a cancer drug target.
    • Danen, E. H. J., Integrin signaling as a cancer drug target. ISRN Cell Biol. 2013, 2013, 1-14.
    • (2013) ISRN Cell Biol. , vol.2013 , pp. 1-14
    • Danen, E.H.J.1
  • 63
    • 1842426730 scopus 로고    scopus 로고
    • Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment.
    • McBeath, R., Pirone, D. M., Nelson, C. M., Bhadriraju, K., Chen, C. S., Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev. Cell 2004, 6, 483-495.
    • (2004) Dev. Cell , vol.6 , pp. 483-495
    • McBeath, R.1    Pirone, D.M.2    Nelson, C.M.3    Bhadriraju, K.4    Chen, C.S.5
  • 64
    • 79953025653 scopus 로고    scopus 로고
    • The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β.
    • Park, J. S., Chu, J. S., Tsou, A. D., Diop, R. et al., The effect of matrix stiffness on the differentiation of mesenchymal stem cells in response to TGF-β. Biomaterials 2011, 32, 3921-3930.
    • (2011) Biomaterials , vol.32 , pp. 3921-3930
    • Park, J.S.1    Chu, J.S.2    Tsou, A.D.3    Diop, R.4
  • 65
    • 70450222098 scopus 로고    scopus 로고
    • Matrix crosslinking forces tumor progression by enhancing integrin signaling.
    • Levental, K. R., Yu, H., Kass, L., Lakins, J. N. et al., Matrix crosslinking forces tumor progression by enhancing integrin signaling. Cell 2009, 139, 891-906.
    • (2009) Cell , vol.139 , pp. 891-906
    • Levental, K.R.1    Yu, H.2    Kass, L.3    Lakins, J.N.4
  • 66
    • 84862998696 scopus 로고    scopus 로고
    • Independent regulation of tumor cell migration by matrix stiffness and confinement.
    • Pathak, A., Kumar, S., Independent regulation of tumor cell migration by matrix stiffness and confinement. Proc. Natl. Acad. Sci. USA 2012, 109, 10334-10339.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 10334-10339
    • Pathak, A.1    Kumar, S.2
  • 67
    • 84864311480 scopus 로고    scopus 로고
    • Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness.
    • Soman, P., Kelber, J. A., Lee, J. W., Wright, T. N. et al., Cancer cell migration within 3D layer-by-layer microfabricated photocrosslinked PEG scaffolds with tunable stiffness. Biomaterials 2012, 33, 7064-7070.
    • (2012) Biomaterials , vol.33 , pp. 7064-7070
    • Soman, P.1    Kelber, J.A.2    Lee, J.W.3    Wright, T.N.4
  • 68
    • 79953736762 scopus 로고    scopus 로고
    • Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells.
    • Schrader, J., Gordon-Walker, T. T., Aucott, R. L., van Deemter, M. et al., Matrix stiffness modulates proliferation, chemotherapeutic response, and dormancy in hepatocellular carcinoma cells. Hepatology (Baltimore Md.) 2011, 53, 1192-1205.
    • (2011) Hepatology (Baltimore Md.) , vol.53 , pp. 1192-1205
    • Schrader, J.1    Gordon-Walker, T.T.2    Aucott, R.L.3    van Deemter, M.4
  • 69
    • 84890803299 scopus 로고    scopus 로고
    • Multiwell stiffness assay for the study of cell responsiveness to cytotoxic drugs.
    • Zustiak, S., Nossal, R., Sackett, D. L., Multiwell stiffness assay for the study of cell responsiveness to cytotoxic drugs. Biotechnol. Bioeng. 2014, 111, 396-403.
    • (2014) Biotechnol. Bioeng. , vol.111 , pp. 396-403
    • Zustiak, S.1    Nossal, R.2    Sackett, D.L.3
  • 70
    • 0017339126 scopus 로고
    • A murine tumor producing a matrix of basement membrane.
    • Orkin, R. W., Gehron, P., McGoodwin, E. B., Martin, G. R. et al., A murine tumor producing a matrix of basement membrane. J. Exp. Med. 1977, 145, 204-220.
    • (1977) J. Exp. Med. , vol.145 , pp. 204-220
    • Orkin, R.W.1    Gehron, P.2    McGoodwin, E.B.3    Martin, G.R.4
  • 71
    • 77956399506 scopus 로고    scopus 로고
    • Matrigel: A complex protein mixture required for optimal growth of cell culture.
    • Hughes, C. S., Postovit, L. M., Lajoie, G. A., Matrigel: A complex protein mixture required for optimal growth of cell culture. Proteomics 2010, 10, 1886-1890.
    • (2010) Proteomics , vol.10 , pp. 1886-1890
    • Hughes, C.S.1    Postovit, L.M.2    Lajoie, G.A.3
  • 72
    • 2842527893 scopus 로고
    • Hormonal effects on intracellular and secreted casein in cultures of mouse mammary epithelial cells on floating collagen membranes.
    • Emerman, J. T., Enami, J., Pitelka, D. R., Nandi, S., Hormonal effects on intracellular and secreted casein in cultures of mouse mammary epithelial cells on floating collagen membranes. Proc. Natl. Acad. Sci. USA 1977, 74, 4466-4470.
    • (1977) Proc. Natl. Acad. Sci. USA , vol.74 , pp. 4466-4470
    • Emerman, J.T.1    Enami, J.2    Pitelka, D.R.3    Nandi, S.4
  • 73
    • 0017654607 scopus 로고
    • Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes.
    • Emerman, J. T., Pitelka, D. R., Maintenance and induction of morphological differentiation in dissociated mammary epithelium on floating collagen membranes. In Vitro 1977, 13, 316-328.
    • (1977) In Vitro , vol.13 , pp. 316-328
    • Emerman, J.T.1    Pitelka, D.R.2
  • 74
    • 0024505367 scopus 로고
    • Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane.
    • Barcellos-Hoff, M. H., Aggeler, J., Ram, T. G., Bissell, M. J., Functional differentiation and alveolar morphogenesis of primary mammary cultures on reconstituted basement membrane. Dev. (Cambridge England) 1989, 105, 223-235.
    • (1989) Dev. (Cambridge England) , vol.105 , pp. 223-235
    • Barcellos-Hoff, M.H.1    Aggeler, J.2    Ram, T.G.3    Bissell, M.J.4
  • 75
    • 0026738947 scopus 로고
    • Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells.
    • Petersen, O. W., Rønnov-Jessen, L., Howlett, A. R., Bissell, M. J., Interaction with basement membrane serves to rapidly distinguish growth and differentiation pattern of normal and malignant human breast epithelial cells. Proc. Natl. Acad. Sci. USA 1992, 89, 9064-9068.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 9064-9068
    • Petersen, O.W.1    Rønnov-Jessen, L.2    Howlett, A.R.3    Bissell, M.J.4
  • 76
    • 33746894693 scopus 로고    scopus 로고
    • Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer.
    • Fournier, M. V., Martin, K. J., Kenny, P. A., Xhaja, K. et al., Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer. Cancer Res. 2006, 66, 7095-7102.
    • (2006) Cancer Res. , vol.66 , pp. 7095-7102
    • Fournier, M.V.1    Martin, K.J.2    Kenny, P.A.3    Xhaja, K.4
  • 77
    • 52149124653 scopus 로고    scopus 로고
    • Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets.
    • Martin, K. J., Patrick, D. R., Bissell, M. J., Fournier, M. V., Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets. PLoS ONE 2008, 3, e2994.
    • (2008) PLoS ONE , vol.3
    • Martin, K.J.1    Patrick, D.R.2    Bissell, M.J.3    Fournier, M.V.4
  • 78
    • 34248650697 scopus 로고    scopus 로고
    • The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression.
    • Kenny, P. A., Lee, G. Y., Myers, C. A., Neve, R. M. et al., The morphologies of breast cancer cell lines in three-dimensional assays correlate with their profiles of gene expression. Mol. Oncol. 2007, 1, 84-96.
    • (2007) Mol. Oncol. , vol.1 , pp. 84-96
    • Kenny, P.A.1    Lee, G.Y.2    Myers, C.A.3    Neve, R.M.4
  • 79
    • 84875444552 scopus 로고    scopus 로고
    • Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines.
    • Luca, A. C., Mersch, S., Deenen, R., Schmidt, S. et al., Impact of the 3D microenvironment on phenotype, gene expression, and EGFR inhibition of colorectal cancer cell lines. PLoS ONE 2013, 8, e59689.
    • (2013) PLoS ONE , vol.8
    • Luca, A.C.1    Mersch, S.2    Deenen, R.3    Schmidt, S.4
  • 80
    • 84859142802 scopus 로고    scopus 로고
    • Growth of lung cancer cells in three-dimensional microenvironments reveals key features of tumor malignancy.
    • Cichon, M. A., Gainullin, V. G., Zhang, Y., Radisky, D. C., Growth of lung cancer cells in three-dimensional microenvironments reveals key features of tumor malignancy. Integr. Biol. Quant. Biosci. Nano Macro 2012, 4, 440-448.
    • (2012) Integr. Biol. Quant. Biosci. Nano Macro , vol.4 , pp. 440-448
    • Cichon, M.A.1    Gainullin, V.G.2    Zhang, Y.3    Radisky, D.C.4
  • 81
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche.
    • Sato, T., Vries, R. G., Snippert, H. J., van de Wetering, M. et al., Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 2009, 459, 262-265.
    • (2009) Nature , vol.459 , pp. 262-265
    • Sato, T.1    Vries, R.G.2    Snippert, H.J.3    van de Wetering, M.4
  • 82
    • 84886028975 scopus 로고    scopus 로고
    • High-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells.
    • Hongisto, V., Jernström, S., Fey, V., Mpindi, J.-P. et al., High-throughput 3D screening reveals differences in drug sensitivities between culture models of JIMT1 breast cancer cells. PLoS ONE 2013, 8, e77232.
    • (2013) PLoS ONE , vol.8
    • Hongisto, V.1    Jernström, S.2    Fey, V.3    Mpindi, J.-P.4
  • 83
    • 77955457903 scopus 로고    scopus 로고
    • Influence of Tumor pH on Therapeutic Response.
    • Teicher, B. A. (Ed.), Cancer drug discovery and development: Cancer drug resistance. Humana Press Inc., Totowa NJ
    • Song, C. W., Griffin, R., Park, H. J., Influence of Tumor pH on Therapeutic Response. In: Teicher, B. A. (Ed.), Cancer drug discovery and development: Cancer drug resistance. Humana Press Inc., Totowa NJ 2006, pp. 21-42.
    • (2006) , pp. 21-42
    • Song, C.W.1    Griffin, R.2    Park, H.J.3
  • 84
    • 84899500056 scopus 로고    scopus 로고
    • Janus-faced tumor microenvironment and redox.
    • Khramtsov, V. V., Gillies, R. J., Janus-faced tumor microenvironment and redox. Antioxid. Redox Signal. 2014, 21, 723-729.
    • (2014) Antioxid. Redox Signal. , vol.21 , pp. 723-729
    • Khramtsov, V.V.1    Gillies, R.J.2
  • 85
    • 84920200511 scopus 로고    scopus 로고
    • Hypoxia and hypoxia inducible factors in tumor metabolism
    • in press.
    • Zeng, W., Liu, P., Pan, W., Singh, S. R., Wei, Y., Hypoxia and hypoxia inducible factors in tumor metabolism. Cancer Lett. 2014, in press.
    • (2014) Cancer Lett
    • Zeng, W.1    Liu, P.2    Pan, W.3    Singh, S.R.4    Wei, Y.5
  • 86
    • 82955173029 scopus 로고    scopus 로고
    • Changing the energy habitat of the cancer cell in order to impact therapeutic resistance.
    • Getzenberg, R. H., Coffey, D. S., Changing the energy habitat of the cancer cell in order to impact therapeutic resistance. Mol. Pharm. 2011, 8, 2089-2093.
    • (2011) Mol. Pharm. , vol.8 , pp. 2089-2093
    • Getzenberg, R.H.1    Coffey, D.S.2
  • 87
    • 84884549757 scopus 로고    scopus 로고
    • Biomechanical effects of fluid dynamics and mass transport on cell growth in perfusion bioreactors for tissue engineering.
    • Lim, K.-T., Seonwoo, H., Son, H.-M., Baik, S.-J. et al., Biomechanical effects of fluid dynamics and mass transport on cell growth in perfusion bioreactors for tissue engineering. Tissue Eng. Regen. Med. 2009, 6, 1327-1342.
    • (2009) Tissue Eng. Regen. Med. , vol.6 , pp. 1327-1342
    • Lim, K.-T.1    Seonwoo, H.2    Son, H.-M.3    Baik, S.-J.4
  • 88
    • 84861345298 scopus 로고    scopus 로고
    • Process engineering of human pluripotent stem cells for clinical application.
    • Serra, M., Brito, C., Correia, C., Alves, P. M., Process engineering of human pluripotent stem cells for clinical application. Trends Biotechnol. 2012, 30, 350-359.
    • (2012) Trends Biotechnol. , vol.30 , pp. 350-359
    • Serra, M.1    Brito, C.2    Correia, C.3    Alves, P.M.4
  • 91
    • 84881665292 scopus 로고    scopus 로고
    • Microfabricated polymeric vessel mimetics for 3-D cancer cell culture.
    • Jaeger, A. A., Das, C. K., Morgan, N. Y., Pursley, R. H. et al., Microfabricated polymeric vessel mimetics for 3-D cancer cell culture. Biomaterials 2013, 34, 8301-8313.
    • (2013) Biomaterials , vol.34 , pp. 8301-8313
    • Jaeger, A.A.1    Das, C.K.2    Morgan, N.Y.3    Pursley, R.H.4
  • 92
    • 84894387037 scopus 로고    scopus 로고
    • Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model.
    • Stratmann, A. T., Fecher, D., Wangorsch, G., Göttlich, C. et al., Establishment of a human 3D lung cancer model based on a biological tissue matrix combined with a Boolean in silico model. Mol. Oncol. 2014, 8, 351-365.
    • (2014) Mol. Oncol. , vol.8 , pp. 351-365
    • Stratmann, A.T.1    Fecher, D.2    Wangorsch, G.3    Göttlich, C.4
  • 93
    • 84883802117 scopus 로고    scopus 로고
    • Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro.
    • Alessandri, K., Sarangi, B. R., Gurchenkov, V. V., Sinha, B. et al., Cellular capsules as a tool for multicellular spheroid production and for investigating the mechanics of tumor progression in vitro. Proc. Natl. Acad. Sci. USA 2013, 110, 14843-14848.
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 14843-14848
    • Alessandri, K.1    Sarangi, B.R.2    Gurchenkov, V.V.3    Sinha, B.4
  • 95
    • 33745016900 scopus 로고    scopus 로고
    • Scale-up of breast cancer stem cell aggregate cultures to suspension bioreactors.
    • Youn, B. S., Sen, A., Behie, L. A., Girgis-Gabardo, A., Hassell, J. A., Scale-up of breast cancer stem cell aggregate cultures to suspension bioreactors. Biotechnol. Prog. 2006, 22, 801-810.
    • (2006) Biotechnol. Prog. , vol.22 , pp. 801-810
    • Youn, B.S.1    Sen, A.2    Behie, L.A.3    Girgis-Gabardo, A.4    Hassell, J.A.5
  • 96
    • 70350726541 scopus 로고    scopus 로고
    • Integrating human stem cell expansion and neuronal differentiation in bioreactors.
    • Serra, M., Brito, C., Costa, E. M., Sousa, M. F. Q., Alves, P. M., Integrating human stem cell expansion and neuronal differentiation in bioreactors. BMC Biotechnol. 2009, 9, 82.
    • (2009) BMC Biotechnol. , vol.9 , pp. 82
    • Serra, M.1    Brito, C.2    Costa, E.M.3    Sousa, M.F.Q.4    Alves, P.M.5
  • 97
    • 67349198548 scopus 로고    scopus 로고
    • Effects of dissolved oxygen tension and agitation rate on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors.
    • Tang, Y.-J., Li, H.-M., Hamel, J.-F. P., Effects of dissolved oxygen tension and agitation rate on the production of heat-shock protein glycoprotein 96 by MethA tumor cell suspension culture in stirred-tank bioreactors. Bioprocess Biosyst. Eng. 2008, 32, 475-484.
    • (2008) Bioprocess Biosyst. Eng. , vol.32 , pp. 475-484
    • Tang, Y.-J.1    Li, H.-M.2    Hamel, J.-F.P.3
  • 99
    • 84859119473 scopus 로고    scopus 로고
    • Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing.
    • Tostões, R. M., Leite, S. B., Serra, M., Jensen, J. et al., Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing. Hepatology (Baltimore Md.) 2012, 55, 1227-1236.
    • (2012) Hepatology (Baltimore Md.) , vol.55 , pp. 1227-1236
    • Tostões, R.M.1    Leite, S.B.2    Serra, M.3    Jensen, J.4
  • 100
    • 79961158737 scopus 로고    scopus 로고
    • Microencapsulation technology: A powerful tool for integrating expansion and cryopreservation of human embryonic stem cells.
    • Serra, M., Correia, C., Malpique, R., Brito, C. et al., Microencapsulation technology: A powerful tool for integrating expansion and cryopreservation of human embryonic stem cells. PLoS ONE 2011, 6, e23212.
    • (2011) PLoS ONE , vol.6
    • Serra, M.1    Correia, C.2    Malpique, R.3    Brito, C.4
  • 101
    • 84860470339 scopus 로고    scopus 로고
    • 3D cultures of human neural progenitor cells: Dopaminergic differentiation and genetic modification [corrected].
    • Brito, C., Simão, D., Costa, I., Malpique, R. et al., 3D cultures of human neural progenitor cells: Dopaminergic differentiation and genetic modification [corrected]. Methods (San Diego Calif.) 2012, 56, 452-460.
    • (2012) Methods (San Diego Calif.) , vol.56 , pp. 452-460
    • Brito, C.1    Simão, D.2    Costa, I.3    Malpique, R.4
  • 102
    • 0029934546 scopus 로고    scopus 로고
    • Growth and radiation response of cells grown in macroporous gelatin microcarriers (CultiSpher-G).
    • Rasey, J. S., Cornwell, M. M., Maurer, B. J., Boyles, D. J. et al., Growth and radiation response of cells grown in macroporous gelatin microcarriers (CultiSpher-G). Br. J. Cancer. Suppl. 1996, 27, S78-S81.
    • (1996) Br. J. Cancer. Suppl. , vol.27
    • Rasey, J.S.1    Cornwell, M.M.2    Maurer, B.J.3    Boyles, D.J.4
  • 103
    • 77958053173 scopus 로고    scopus 로고
    • Efficacy of catumaxomab in tumor spheroid killing is mediated by its trifunctional mode of action.
    • Hirschhaeuser, F., Walenta, S., Mueller-Klieser, W., Efficacy of catumaxomab in tumor spheroid killing is mediated by its trifunctional mode of action. Cancer Immunol. Immunother. CII 2010, 59, 1675-1684.
    • (2010) Cancer Immunol. Immunother. CII , vol.59 , pp. 1675-1684
    • Hirschhaeuser, F.1    Walenta, S.2    Mueller-Klieser, W.3
  • 105
    • 78649424262 scopus 로고    scopus 로고
    • Perfusion of 3D encapsulated hepatocytes - a synergistic effect enhancing long-term functionality in bioreactors.
    • Tostões, R. M., Leite, S. B., Miranda, J. P., Sousa, M. et al., Perfusion of 3D encapsulated hepatocytes - a synergistic effect enhancing long-term functionality in bioreactors. Biotechnol. Bioeng. 2011, 108, 41-49.
    • (2011) Biotechnol. Bioeng. , vol.108 , pp. 41-49
    • Tostões, R.M.1    Leite, S.B.2    Miranda, J.P.3    Sousa, M.4
  • 106
    • 84867753850 scopus 로고    scopus 로고
    • Three-dimensional HepaRG model as an attractive tool for toxicity testing.
    • Leite, S. B., Wilk-Zasadna, I., Zaldivar, J. M., Airola, E. et al., Three-dimensional HepaRG model as an attractive tool for toxicity testing. Toxicol. Sci. 2012, 130, 106-116.
    • (2012) Toxicol. Sci. , vol.130 , pp. 106-116
    • Leite, S.B.1    Wilk-Zasadna, I.2    Zaldivar, J.M.3    Airola, E.4
  • 107
  • 108
    • 0026751999 scopus 로고
    • Morphologic differentiation of colon carcinoma cell lines HT-29 and HT-29KM in rotating-wall vessels.
    • Goodwin, T. J., Jessup, J. M., Wolf, D. A., Morphologic differentiation of colon carcinoma cell lines HT-29 and HT-29KM in rotating-wall vessels. Vitro Cell. Dev. Biol. 1992, 28A, 47-60.
    • (1992) Vitro Cell. Dev. Biol. , vol.28 A , pp. 47-60
    • Goodwin, T.J.1    Jessup, J.M.2    Wolf, D.A.3
  • 109
    • 0027533527 scopus 로고
    • Prospects for use of microgravity-based bioreactors to study three-dimensional host-tumor interactions in human neoplasia.
    • Jessup, J. M., Goodwin, T. J., Spaulding, G., Prospects for use of microgravity-based bioreactors to study three-dimensional host-tumor interactions in human neoplasia. J. Cell. Biochem. 1993, 51, 290-300.
    • (1993) J. Cell. Biochem. , vol.51 , pp. 290-300
    • Jessup, J.M.1    Goodwin, T.J.2    Spaulding, G.3
  • 110
    • 0027409038 scopus 로고
    • Three-dimensional growth and differentiation of ovarian tumor cell line in high aspect rotating-wall vessel: Morphologic and embryologic considerations.
    • Becker, J. L., Prewett, T. L., Spaulding, G. F., Goodwin, T. J., Three-dimensional growth and differentiation of ovarian tumor cell line in high aspect rotating-wall vessel: Morphologic and embryologic considerations. J. Cell. Biochem. 1993, 51, 283-289.
    • (1993) J. Cell. Biochem. , vol.51 , pp. 283-289
    • Becker, J.L.1    Prewett, T.L.2    Spaulding, G.F.3    Goodwin, T.J.4
  • 111
    • 77958084893 scopus 로고    scopus 로고
    • Organotypic 3D cell culture models: Using the rotating wall vessel to study host-pathogen interactions.
    • Barrila, J., Radtke, A. L., Crabbé, A., Sarker, S. F. et al., Organotypic 3D cell culture models: Using the rotating wall vessel to study host-pathogen interactions. Nat. Rev. Microbiol. 2010, 8, 791-801.
    • (2010) Nat. Rev. Microbiol. , vol.8 , pp. 791-801
    • Barrila, J.1    Radtke, A.L.2    Crabbé, A.3    Sarker, S.F.4
  • 112
    • 84876827850 scopus 로고    scopus 로고
    • Using space-based investigations to inform cancer research on Earth.
    • Becker, J. L., Souza, G. R., Using space-based investigations to inform cancer research on Earth. Nat. Rev. Cancer 2013, 13, 315-327.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 315-327
    • Becker, J.L.1    Souza, G.R.2
  • 113
    • 0035003457 scopus 로고    scopus 로고
    • Permanent phenotypic and genotypic changes of prostate cancer cells cultured in a three-dimensional rotating-wall vessel.
    • Rhee, H. W., Zhau, H. E., Pathak, S., Multani, A. S. et al., Permanent phenotypic and genotypic changes of prostate cancer cells cultured in a three-dimensional rotating-wall vessel. In Vitro Cell. Dev. Biol. Anim. 2001, 37, 127-140.
    • (2001) In Vitro Cell. Dev. Biol. Anim. , vol.37 , pp. 127-140
    • Rhee, H.W.1    Zhau, H.E.2    Pathak, S.3    Multani, A.S.4
  • 114
    • 23844475131 scopus 로고    scopus 로고
    • Three-dimensional co-culture models to study prostate cancer growth, progression, and metastasis to bone.
    • Wang, R., Xu, J., Juliette, L., Castilleja, A. et al., Three-dimensional co-culture models to study prostate cancer growth, progression, and metastasis to bone. Semin. Cancer Biol. 2005, 15, 353-364.
    • (2005) Semin. Cancer Biol. , vol.15 , pp. 353-364
    • Wang, R.1    Xu, J.2    Juliette, L.3    Castilleja, A.4
  • 115
    • 84897066502 scopus 로고    scopus 로고
    • Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space.
    • Ma, X., Pietsch, J., Wehland, M., Schulz, H. et al., Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space. FASEB J. 2014, 28, 813-835.
    • (2014) FASEB J. , vol.28 , pp. 813-835
    • Ma, X.1    Pietsch, J.2    Wehland, M.3    Schulz, H.4
  • 116
    • 84887615628 scopus 로고    scopus 로고
    • Microfluidics-assisted in vitro drug screening and carrier production.
    • Tsui, J. H., Lee, W., Pun, S. H., Kim, J., Kim, D.-H., Microfluidics-assisted in vitro drug screening and carrier production. Adv. Drug Deliv. Rev. 2013, 65, 1575-1588.
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 1575-1588
    • Tsui, J.H.1    Lee, W.2    Pun, S.H.3    Kim, J.4    Kim, D.-H.5
  • 117
  • 118
    • 84874731689 scopus 로고    scopus 로고
    • Perspective: Flicking with flow: Can microfluidics revolutionize the cancer research?
    • Das, T., Chakraborty, S., Perspective: Flicking with flow: Can microfluidics revolutionize the cancer research? Biomicrofluidics 2013, 7, 11811.
    • (2013) Biomicrofluidics , vol.7 , pp. 11811
    • Das, T.1    Chakraborty, S.2
  • 119
    • 84874753291 scopus 로고    scopus 로고
    • Biomimetic tumor microenvironment on a microfluidic platform.
    • Ma, H., Xu, H., Qin, J., Biomimetic tumor microenvironment on a microfluidic platform. Biomicrofluidics 2013, 7, 11501.
    • (2013) Biomicrofluidics , vol.7 , pp. 11501
    • Ma, H.1    Xu, H.2    Qin, J.3
  • 120
    • 84899993200 scopus 로고    scopus 로고
    • Miniaturized pre-clinical cancer models as research and diagnostic tools.
    • Håkanson, M., Cukierman, E., Charnley, M., Miniaturized pre-clinical cancer models as research and diagnostic tools. Adv. Drug Deliv. Rev. 2014, 69-70, 52-66.
    • (2014) Adv. Drug Deliv. Rev. , vol.69-70 , pp. 52-66
    • Håkanson, M.1    Cukierman, E.2    Charnley, M.3
  • 121
    • 84891742591 scopus 로고    scopus 로고
    • A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone.
    • Bersini, S., Jeon, J. S., Dubini, G., Arrigoni, C. et al., A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone. Biomaterials 2014, 35, 2454-2461.
    • (2014) Biomaterials , vol.35 , pp. 2454-2461
    • Bersini, S.1    Jeon, J.S.2    Dubini, G.3    Arrigoni, C.4
  • 122
    • 84867324985 scopus 로고    scopus 로고
    • Thick-tissue bioreactor as a platform for long-term organotypic culture and drug delivery.
    • Markov, D. A., Lu, J. Q., Samson, P. C., Wikswo, J. P., McCawley, L. J., Thick-tissue bioreactor as a platform for long-term organotypic culture and drug delivery. Lab Chip 2012, 12, 4560-4568.
    • (2012) Lab Chip , vol.12 , pp. 4560-4568
    • Markov, D.A.1    Lu, J.Q.2    Samson, P.C.3    Wikswo, J.P.4    McCawley, L.J.5
  • 124
    • 84884368877 scopus 로고    scopus 로고
    • Influence of tumour micro-environment heterogeneity on therapeutic response.
    • Junttila, M. R., de Sauvage, F. J., Influence of tumour micro-environment heterogeneity on therapeutic response. Nature 2013, 501, 346-354.
    • (2013) Nature , vol.501 , pp. 346-354
    • Junttila, M.R.1    de Sauvage, F.J.2
  • 125
    • 0034576767 scopus 로고    scopus 로고
    • Human cancer cell lines: Fact and fantasy.
    • Masters, J. R., Human cancer cell lines: Fact and fantasy. Nat. Rev. Mol. Cell Biol. 2000, 1, 233-236.
    • (2000) Nat. Rev. Mol. Cell Biol. , vol.1 , pp. 233-236
    • Masters, J.R.1
  • 126
    • 0001483173 scopus 로고
    • Versuche an überlebendem Karzinomgewebe.
    • Warburg, O., Versuche an überlebendem Karzinomgewebe. Biochem. Ztg. 1923, 142, 317-333.
    • (1923) Biochem. Ztg. , vol.142 , pp. 317-333
    • Warburg, O.1
  • 127
  • 128
    • 79958844674 scopus 로고
    • Tissue culture of intracranial tumors with a note on the meningiomas.
    • Kredel, F. E., Tissue culture of intracranial tumors with a note on the meningiomas. Am. J. Pathol. 1928, 4, 337-3403.
    • (1928) Am. J. Pathol. , vol.4 , pp. 337-3403
    • Kredel, F.E.1
  • 129
    • 73649187550 scopus 로고
    • Further investigation of the relation between the clinical and tissue culture response to chemotherapeutic agents on human cancer.
    • Wright, J. C., Cobb, J. P., Gumport, S. L., Safadi, D. et al., Further investigation of the relation between the clinical and tissue culture response to chemotherapeutic agents on human cancer. Cancer 1962, 15, 284-293.
    • (1962) Cancer , vol.15 , pp. 284-293
    • Wright, J.C.1    Cobb, J.P.2    Gumport, S.L.3    Safadi, D.4
  • 130
    • 58149429758 scopus 로고
    • Selection of anticancer drug for palliation using tissue culture sensitivity studies.
    • Hurley, J. D., Yount, L. J., Selection of anticancer drug for palliation using tissue culture sensitivity studies. Am. J. Surg. 1965, 109, 39-42.
    • (1965) Am. J. Surg. , vol.109 , pp. 39-42
    • Hurley, J.D.1    Yount, L.J.2
  • 131
    • 0013901750 scopus 로고
    • Studies on the organ culture of human tumors.
    • Röller, M. R., Owen, S. P., Heidelberger, C., Studies on the organ culture of human tumors. Cancer Res. 1966, 26, 626-637.
    • (1966) Cancer Res. , vol.26 , pp. 626-637
    • Röller, M.R.1    Owen, S.P.2    Heidelberger, C.3
  • 132
    • 0001371293 scopus 로고
    • Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium.
    • Gey, G. O., Coffman, W. D., Kubicek, M. T., Tissue culture studies of the proliferative capacity of cervical carcinoma and normal epithelium. Cancer Res. 1952, 12, 264-265.
    • (1952) Cancer Res. , vol.12 , pp. 264-265
    • Gey, G.O.1    Coffman, W.D.2    Kubicek, M.T.3
  • 133
    • 0019313649 scopus 로고
    • A new instrument for the rapid preparation of tissue slices.
    • Krumdieck, C. L., dos Santos, J. E., Ho, K. J., A new instrument for the rapid preparation of tissue slices. Anal. Biochem. 1980, 104, 118-123.
    • (1980) Anal. Biochem. , vol.104 , pp. 118-123
    • Krumdieck, C.L.1    dos Santos, J.E.2    Ho, K.J.3
  • 134
    • 0025186584 scopus 로고
    • Preservation of steroid hormone receptors in organ cultures of human breast carcinomas.
    • Mira-y-Lopez, R., Ossowski, L., Preservation of steroid hormone receptors in organ cultures of human breast carcinomas. Cancer Res. 1990, 50, 78-83.
    • (1990) Cancer Res. , vol.50 , pp. 78-83
    • Mira-y-Lopez, R.1    Ossowski, L.2
  • 135
    • 33646234463 scopus 로고    scopus 로고
    • Short term culture of breast cancer tissues to study the activity of the anticancer drug taxol in an intact tumor environment.
    • van der Kuip, H., Mürdter, T. E., Sonnenberg, M., McClellan, M. et al., Short term culture of breast cancer tissues to study the activity of the anticancer drug taxol in an intact tumor environment. BMC Cancer 2006, 6, 86.
    • (2006) BMC Cancer , vol.6 , pp. 86
    • van der Kuip, H.1    Mürdter, T.E.2    Sonnenberg, M.3    McClellan, M.4
  • 136
    • 84874663933 scopus 로고    scopus 로고
    • The practicalities of using tissue slices as preclinical organotypic breast cancer models.
    • Holliday, D. L., Moss, M. A., Pollock, S., Lane, S. et al., The practicalities of using tissue slices as preclinical organotypic breast cancer models. J. Clin. Pathol. 2013, 66, 253-255.
    • (2013) J. Clin. Pathol. , vol.66 , pp. 253-255
    • Holliday, D.L.1    Moss, M.A.2    Pollock, S.3    Lane, S.4
  • 137
    • 77954758122 scopus 로고    scopus 로고
    • Human breast tumor slices: A model for identification of vitamin D regulated genes in the tumor microenvironment.
    • Milani, C., Welsh, J., Katayama, M. L. H., Lyra, E. C. et al., Human breast tumor slices: A model for identification of vitamin D regulated genes in the tumor microenvironment. J. Steroid Biochem. Mol. Biol. 2010, 121, 151-155.
    • (2010) J. Steroid Biochem. Mol. Biol. , vol.121 , pp. 151-155
    • Milani, C.1    Welsh, J.2    Katayama, M.L.H.3    Lyra, E.C.4
  • 138
    • 60549103300 scopus 로고    scopus 로고
    • Highly variable response to cytotoxic chemotherapy in carcinoma-associated fibroblasts (CAFs) from lung and breast.
    • Sonnenberg, M., van der Kuip, H., Haubeis, S., Fritz, P. et al., Highly variable response to cytotoxic chemotherapy in carcinoma-associated fibroblasts (CAFs) from lung and breast. BMC Cancer 2008, 8, 364.
    • (2008) BMC Cancer , vol.8 , pp. 364
    • Sonnenberg, M.1    van der Kuip, H.2    Haubeis, S.3    Fritz, P.4
  • 139
    • 84863208047 scopus 로고    scopus 로고
    • γ-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells.
    • Séveno, C., Loussouarn, D., Bréchet, S., Campone, M. et al., γ-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells. Breast Cancer Res. 2012, 14, R96.
    • (2012) Breast Cancer Res. , vol.14
    • Séveno, C.1    Loussouarn, D.2    Bréchet, S.3    Campone, M.4
  • 140
    • 77952329787 scopus 로고    scopus 로고
    • Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors.
    • Vaira, V., Fedele, G., Pyne, S., Fasoli, E. et al., Preclinical model of organotypic culture for pharmacodynamic profiling of human tumors. Proc. Natl. Acad. Sci. USA 2010, 107, 8352-8356.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 8352-8356
    • Vaira, V.1    Fedele, G.2    Pyne, S.3    Fasoli, E.4
  • 141
    • 80053563026 scopus 로고    scopus 로고
    • Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA.
    • Dong, M., Philippi, C., Loretz, B., Nafee, N. et al., Tissue slice model of human lung cancer to investigate telomerase inhibition by nanoparticle delivery of antisense 2'-O-methyl-RNA. Int. J. Pharm. 2011, 419, 33-42.
    • (2011) Int. J. Pharm. , vol.419 , pp. 33-42
    • Dong, M.1    Philippi, C.2    Loretz, B.3    Nafee, N.4
  • 142
    • 84869237364 scopus 로고    scopus 로고
    • Cancer cells cue the p53 response of cancer-associated fibroblasts to cisplatin.
    • Schmid, J. O., Dong, M., Haubeiss, S., Friedel, G. et al., Cancer cells cue the p53 response of cancer-associated fibroblasts to cisplatin. Cancer Res. 2012, 72, 5824-5832.
    • (2012) Cancer Res. , vol.72 , pp. 5824-5832
    • Schmid, J.O.1    Dong, M.2    Haubeiss, S.3    Friedel, G.4
  • 143
    • 79959965210 scopus 로고    scopus 로고
    • Efficacy of adenovirally expressed soluble TRAIL in human glioma organotypic slice culture and glioma xenografts.
    • Liu, Y., Lang, F., Xie, X., Prabhu, S. et al., Efficacy of adenovirally expressed soluble TRAIL in human glioma organotypic slice culture and glioma xenografts. Cell Death Dis. 2011, 2, e121.
    • (2011) Cell Death Dis. , vol.2
    • Liu, Y.1    Lang, F.2    Xie, X.3    Prabhu, S.4
  • 144
    • 77955473208 scopus 로고    scopus 로고
    • Tissue slice cultures from humans or rodents: A new tool to evaluate biological effects of heavy ions.
    • Merz, F., Müller, M., Taucher-Scholz, G., Rödel, F. et al., Tissue slice cultures from humans or rodents: A new tool to evaluate biological effects of heavy ions. Radiat. Environ. Biophys. 2010, 49, 457-462.
    • (2010) Radiat. Environ. Biophys. , vol.49 , pp. 457-462
    • Merz, F.1    Müller, M.2    Taucher-Scholz, G.3    Rödel, F.4
  • 145
    • 84887840619 scopus 로고    scopus 로고
    • Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL.
    • Meijer, A., Kruyt, F. A. E., van der Zee, A. G. J., Hollema, H. et al., Nutlin-3 preferentially sensitises wild-type p53-expressing cancer cells to DR5-selective TRAIL over rhTRAIL. Br. J. Cancer 2013, 109, 2685-2695.
    • (2013) Br. J. Cancer , vol.109 , pp. 2685-2695
    • Meijer, A.1    Kruyt, F.A.E.2    van der Zee, A.G.J.3    Hollema, H.4
  • 146
    • 34247132169 scopus 로고    scopus 로고
    • Efficacy of anti-death receptor 5 (DR5) antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue slice model.
    • Estes, J. M., Oliver, P. G., Straughn, J. M. Jr., Zhou, T. et al., Efficacy of anti-death receptor 5 (DR5) antibody (TRA-8) against primary human ovarian carcinoma using a novel ex vivo tissue slice model. Gynecol. Oncol. 2007, 105, 291-298.
    • (2007) Gynecol. Oncol. , vol.105 , pp. 291-298
    • Estes, J.M.1    Oliver, P.G.2    Straughn Jr, J.M.3    Zhou, T.4
  • 147
    • 39249083325 scopus 로고    scopus 로고
    • Anti-tumor activity of the TRA-8 anti-DR5 antibody in combination with cisplatin in an ex vivo human cervical cancer model.
    • Kendrick, J. E., Straughn, J. M. Jr., Oliver, P. G., Wang, W. et al., Anti-tumor activity of the TRA-8 anti-DR5 antibody in combination with cisplatin in an ex vivo human cervical cancer model. Gynecol. Oncol. 2008, 108, 591-597.
    • (2008) Gynecol. Oncol. , vol.108 , pp. 591-597
    • Kendrick, J.E.1    Straughn Jr, J.M.2    Oliver, P.G.3    Wang, W.4
  • 148
    • 84885142368 scopus 로고    scopus 로고
    • The soluble decoy receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma.
    • Weissinger, D., Tagscherer, K. E., Macher-Göppinger, S., Haferkamp, A. et al., The soluble decoy receptor 3 is regulated by a PI3K-dependent mechanism and promotes migration and invasion in renal cell carcinoma. Mol. Cancer 2013, 12, 120.
    • (2013) Mol. Cancer , vol.12 , pp. 120
    • Weissinger, D.1    Tagscherer, K.E.2    Macher-Göppinger, S.3    Haferkamp, A.4
  • 150
    • 33646812524 scopus 로고    scopus 로고
    • Ex vivo analysis of antineoplastic agents in precision-cut tissue slices of human origin: Effects of cyclooxygenase-2 inhibition in hepatocellular carcinoma.
    • Kern, M. A., Haugg, A. M., Eiteneuer, E., Konze, E. et al., Ex vivo analysis of antineoplastic agents in precision-cut tissue slices of human origin: Effects of cyclooxygenase-2 inhibition in hepatocellular carcinoma. Liver Int. 2006, 26, 604-612.
    • (2006) Liver Int. , vol.26 , pp. 604-612
    • Kern, M.A.1    Haugg, A.M.2    Eiteneuer, E.3    Konze, E.4
  • 151
    • 69449083646 scopus 로고    scopus 로고
    • Effect of TRA-8 anti-death receptor 5 antibody in combination with chemotherapy in an ex vivo human ovarian cancer model.
    • Frederick, P. J., Kendrick, J. E., Straughn, J. M. Jr., Della Manna, D. L. et al., Effect of TRA-8 anti-death receptor 5 antibody in combination with chemotherapy in an ex vivo human ovarian cancer model. Int. J. Gynecol. Cancer 2009, 19, 814-819.
    • (2009) Int. J. Gynecol. Cancer , vol.19 , pp. 814-819
    • Frederick, P.J.1    Kendrick, J.E.2    Straughn Jr, J.M.3    Della Manna, D.L.4
  • 152
    • 84878613117 scopus 로고    scopus 로고
    • Breast cancer tissue slices as a model for evaluation of response to rapamycin.
    • Grosso, S. H. G., Katayama, M. L. H., Roela, R. A., Nonogaki, S. et al., Breast cancer tissue slices as a model for evaluation of response to rapamycin. Cell Tissue Res. 2013, 352, 671-684.
    • (2013) Cell Tissue Res. , vol.352 , pp. 671-684
    • Grosso, S.H.G.1    Katayama, M.L.H.2    Roela, R.A.3    Nonogaki, S.4
  • 153
    • 84892912259 scopus 로고    scopus 로고
    • Slice cultures from head and neck squamous cell carcinoma: A novel test system for drug susceptibility and mechanisms of resistance.
    • Gerlach, M. M., Merz, F., Wichmann, G., Kubick, C. et al., Slice cultures from head and neck squamous cell carcinoma: A novel test system for drug susceptibility and mechanisms of resistance. Br. J. Cancer 2014, 110, 479-488.
    • (2014) Br. J. Cancer , vol.110 , pp. 479-488
    • Gerlach, M.M.1    Merz, F.2    Wichmann, G.3    Kubick, C.4
  • 154
    • 84878280164 scopus 로고    scopus 로고
    • Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments.
    • Merz, F., Gaunitz, F., Dehghani, F., Renner, C. et al., Organotypic slice cultures of human glioblastoma reveal different susceptibilities to treatments. Neuro-Oncology 2013, 15, 670-681.
    • (2013) Neuro-Oncology , vol.15 , pp. 670-681
    • Merz, F.1    Gaunitz, F.2    Dehghani, F.3    Renner, C.4
  • 155
    • 84857826513 scopus 로고    scopus 로고
    • Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors.
    • Salmon, H., Franciszkiewicz, K., Damotte, D., Dieu-Nosjean, M.-C. et al., Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors. J. Clin. Invest. 2012, 122, 899-910.
    • (2012) J. Clin. Invest. , vol.122 , pp. 899-910
    • Salmon, H.1    Franciszkiewicz, K.2    Damotte, D.3    Dieu-Nosjean, M.-C.4
  • 156
    • 19944426089 scopus 로고    scopus 로고
    • A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicity.
    • Kirby, T. O., Rivera, A., Rein, D., Wang, M. et al., A novel ex vivo model system for evaluation of conditionally replicative adenoviruses therapeutic efficacy and toxicity. Clin. Cancer Res. 2004, 10, 8697-8703.
    • (2004) Clin. Cancer Res. , vol.10 , pp. 8697-8703
    • Kirby, T.O.1    Rivera, A.2    Rein, D.3    Wang, M.4
  • 157
    • 33644648085 scopus 로고    scopus 로고
    • Gene transfer to carcinoma of the breast with fiber-modified adenoviral vectors in a tissue slice model system.
    • Stoff-Khalili, M. A., Stoff, A., Rivera, A. A., Mathis, J. M. et al., Gene transfer to carcinoma of the breast with fiber-modified adenoviral vectors in a tissue slice model system. Cancer Biol. Ther. 2005, 4, 1203-1210.
    • (2005) Cancer Biol. Ther. , vol.4 , pp. 1203-1210
    • Stoff-Khalili, M.A.1    Stoff, A.2    Rivera, A.A.3    Mathis, J.M.4
  • 158
    • 67649446838 scopus 로고    scopus 로고
    • Human precision-cut liver tumor slices as a tumor patient-individual predictive test system for oncolytic measles vaccine viruses.
    • Zimmermann, M., Armeanu, S., Smirnow, I., Kupka, S. et al., Human precision-cut liver tumor slices as a tumor patient-individual predictive test system for oncolytic measles vaccine viruses. Int. J. Oncol. 2009, 34, 1247-1256.
    • (2009) Int. J. Oncol. , vol.34 , pp. 1247-1256
    • Zimmermann, M.1    Armeanu, S.2    Smirnow, I.3    Kupka, S.4
  • 159
    • 65649125540 scopus 로고    scopus 로고
    • Ex-vivo evaluation of gene therapy vectors in human pancreatic (cancer) tissue slices.
    • Van Geer, M.-A., Kuhlmann, K. F. D., Bakker, C. T., ten Kate, F. J. W. et al., Ex-vivo evaluation of gene therapy vectors in human pancreatic (cancer) tissue slices. World J. Gastroenterol. 2009, 15, 1359-1366.
    • (2009) World J. Gastroenterol. , vol.15 , pp. 1359-1366
    • Van Geer, M.-A.1    Kuhlmann, K.F.D.2    Bakker, C.T.3    ten Kate, F.J.W.4
  • 160
    • 77956931305 scopus 로고    scopus 로고
    • The utility of a tissue slice model system to determine breast cancer infectivity by oncolytic adenoviruses.
    • Pennington, K., Chu, Q. D., Curiel, D. T., Li, B. D. L., Mathis, J. M., The utility of a tissue slice model system to determine breast cancer infectivity by oncolytic adenoviruses. J. Surg. Res. 2010, 163, 270-275.
    • (2010) J. Surg. Res. , vol.163 , pp. 270-275
    • Pennington, K.1    Chu, Q.D.2    Curiel, D.T.3    Li, B.D.L.4    Mathis, J.M.5
  • 161
    • 84870563886 scopus 로고    scopus 로고
    • Preparation and culture of precision-cut organ slices from human and animal.
    • Fisher, R. L., Vickers, A. E. M., Preparation and culture of precision-cut organ slices from human and animal. Xenobiotica 2013, 43, 8-14.
    • (2013) Xenobiotica , vol.43 , pp. 8-14
    • Fisher, R.L.1    Vickers, A.E.M.2
  • 162
    • 84867121875 scopus 로고    scopus 로고
    • Intratumor heterogeneity: Evolution through space and time.
    • Swanton, C., Intratumor heterogeneity: Evolution through space and time. Cancer Res. 2012, 72, 4875-4882.
    • (2012) Cancer Res. , vol.72 , pp. 4875-4882
    • Swanton, C.1
  • 163
    • 77952883292 scopus 로고    scopus 로고
    • Improved reproducibility in preparing precision-cut liver tissue slices.
    • Zimmermann, M., Lampe, J., Lange, S., Smirnow, I. et al., Improved reproducibility in preparing precision-cut liver tissue slices. Cytotechnology 2009, 61, 145-152.
    • (2009) Cytotechnology , vol.61 , pp. 145-152
    • Zimmermann, M.1    Lampe, J.2    Lange, S.3    Smirnow, I.4
  • 164
    • 84906806241 scopus 로고    scopus 로고
    • Drug molecules and biology: Network and systems aspects
    • In: Morphy, R., Harris, C. J. (Eds.), Designing multi-target drugs. Royal Society of Chemistry, Cambridge, UK 2012
    • Young, M., Zimmer, S., Whitmore, A., Drug molecules and biology: Network and systems aspects. In: Morphy, R., Harris, C. J. (Eds.), Designing multi-target drugs. Royal Society of Chemistry, Cambridge, UK 2012, pp. 32-49.
    • Young, M.1    Zimmer, S.2    Whitmore, A.3
  • 165
    • 84893809132 scopus 로고    scopus 로고
    • Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells.
    • Huijbers, I. J., Bin Ali, R., Pritchard, C., Cozijnsen, M. et al., Rapid target gene validation in complex cancer mouse models using re-derived embryonic stem cells. EMBO Mol. Med. 2014, 6, 212-225.
    • (2014) EMBO Mol. Med. , vol.6 , pp. 212-225
    • Huijbers, I.J.1    Bin Ali, R.2    Pritchard, C.3    Cozijnsen, M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.