3D Printing of Organs for Transplantation: Where Are We and Where Are We Heading?

Current Transplantation Reports

Volumn 3, Issue 1, 2016, Pages 93-99

  Munoz Abraham, Armando Salim ^a   Rodriguez Davalos, Manuel I ^a   Bertacco, Alessandra ^a   Wengerter, Brian ^a   Geibel, John P ^a   Mulligan, David C ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

3D bioprinting; 3D printing; Organ engineering; Regenerative medicine; Tissue engineered vascular grafts

Indexed keywords

EID: 85019725121     PISSN: None     EISSN: 21963029     Source Type: Journal    
DOI: 10.1007/s40472-016-0089-6     Document Type: Article

References (34)

1. Services, U.S.D.o.H.H.S.U.S.D.o.H.H. Organ Procurement and Transplantation Network. OPTN [cited 2015 2015]; Available from: http://optn.transplant.hrsa.gov/.
2. Mulligan D. Disparity, liver demand, and access to transplants. Am J Transplant. 2015;15(7):1746–7. DOI: 10.1111/ajt.13302
3. Murphy SV, Atala A. 3D bioprinting of tissues and organs. Nat Biotechnol. 2014;32(8):773–85. This review provides a great overview of 3D bioprinting. The authors are pioneers in the field and Dr. Atala is considered among the worlwide 3D bioprinting experts. DOI: 10.1038/nbt.2958
4. Hull CW. In: Hull CW, editor. Apparatus for production of three-dimensional objects by stereolithography. United States: U.S.P.a.T. Office; 1986.
5. Atala A et al. Tissue-engineered autologous bladders for patients needing cystoplasty. Lancet. 2006;367(9518):1241–6. DOI: 10.1016/S0140-6736(06)68438-9
6. Zein NN et al. Three-dimensional print of a liver for preoperative planning in living donor liver transplantation. Liver Transpl. 2013;19(12):1304–10. DOI: 10.1002/lt.23729
7. University, Y. Dr Mark Michalski is ready to print a 3-D brain (maybe yours). 2013 [cited 2015; Available from: http://news.yale.edu/2013/07/15/dr-mark-michalski-ready-print-3-d-brain-maybe-yours.
8. Mironov V, Reis N, Derby B. Review: bioprinting: a beginning. Tissue Eng. 2006;12(4):631–4. DOI: 10.1089/ten.2006.12.631
9. Organovo. The Bioprinting Process. 2015 [cited 2015; Available from: http://www.organovo.com/science-technology/bioprinting-process.
10. Zhang, X. and Y. Zhang, Tissue Engineering Applications of Three-Dimensional Bioprinting. Cell Biochem Biophys, 2015.
11. Boland T et al. Application of inkjet printing to tissue engineering. Biotechnol J. 2006;1(9):910–7. DOI: 10.1002/biot.200600081
12. Guillemot F, Mironov V, Nakamura M. Bioprinting is coming of age: report from the International Conference on Bioprinting and Biofabrication in Bordeaux (3B'09). Biofabrication. 2010;2(1):010201. DOI: 10.1088/1758-5082/2/1/010201
13. Miller JS et al. Rapid casting of patterned vascular networks for perfusable engineered three-dimensional tissues. Nat Mater. 2012;11(9):768–74. DOI: 10.1038/nmat3357
14. Fedorovich NE et al. Organ printing: the future of bone regeneration? Trends Biotechnol. 2011;29(12):601–6. DOI: 10.1016/j.tibtech.2011.07.001
15. Cui X et al. Direct human cartilage repair using three-dimensional bioprinting technology. Tissue Eng Part A. 2012;18(11–12):1304–12. DOI: 10.1089/ten.tea.2011.0543
16. Mannoor MS et al. 3D printed bionic ears. Nano Lett. 2013;13(6):2634–9. DOI: 10.1021/nl4007744
17. Chang JW et al. Tissue-engineered tracheal reconstruction using three-dimensionally printed artificial tracheal graft: preliminary report. Artif Organs. 2014;38(6):E95–E105. DOI: 10.1111/aor.12310
18. Utrecht, U. 3D-Printed Skull Impanted In Patient. 2014 [cited 2015 2015]; Available from: http://www.umcutrecht.nl/en/Research/News/3D-printed-skull-implanted-in-patient.
19. Song JJ et al. Regeneration and experimental orthotopic transplantation of a bioengineered kidney. Nat Med. 2013;19(5):646–51. DOI: 10.1038/nm.3154
20. Yagi H et al. Human-scale whole-organ bioengineering for liver transplantation: a regenerative medicine approach. Cell Transplant. 2013;22(2):231–42. DOI: 10.3727/096368912X654939
21. Soto-Gutierrez A et al. Perspectives on whole-organ assembly: moving toward transplantation on demand. J Clin Invest. 2012;122(11):3817–23. Their perspectives on tissue engineering on how organ assembly should be approached is very interesting. Decellularization is a technique that might provide the answer for creating transplantable organs. DOI: 10.1172/JCI61974
22. Udelsman BV, Maxfield MW, Breuer CK. Tissue engineering of blood vessels in cardiovascular disease: moving towards clinical translation. Heart. 2013;99(7):454–60. DOI: 10.1136/heartjnl-2012-302984
23. Kurobe H et al. Concise review: tissue-engineered vascular grafts for cardiac surgery: past, present, and future. Stem Cells Transl Med. 2012;1(7):566–71. DOI: 10.5966/sctm.2012-0044
24. Norotte C et al. Scaffold-free vascular tissue engineering using bioprinting. Biomaterials. 2009;30(30):5910–7. DOI: 10.1016/j.biomaterials.2009.06.034
25. Visconti RP et al. Towards organ printing: engineering an intra-organ branched vascular tree. Expert Opin Biol Ther. 2010;10(3):409–20. DOI: 10.1517/14712590903563352
26. Robbins, J.G., V; Min, P; Shepherd, B; Presnell, S., A novel in vitro three-dimensional bioprinted liver tussue system for drug development. American Society of Experimental Biology, 2013.
27. Chang R et al. Biofabrication of a three-dimensional liver micro-organ as an in vitro drug metabolism model. Biofabrication. 2010;2(4):045004. DOI: 10.1088/1758-5082/2/4/045004
28. King, S.C., O; Presnell S; Nguyen D, Design and charactherization of a multicellular, three-dimensional tissue model of the human kidney proximal tubule. American Society of Experimental Biology, 2015.
29. Nakayama KH et al. Renal tissue engineering with decellularized rhesus monkey kidneys: age-related differences. Tissue Eng Part A. 2011;17(23–24):2891–901. DOI: 10.1089/ten.tea.2010.0714
30. Ott HC et al. Perfusion-decellularized matrix: using nature's platform to engineer a bioartificial heart. Nat Med. 2008;14(2):213–21. DOI: 10.1038/nm1684
31. Ott HC et al. Regeneration and orthotopic transplantation of a bioartificial lung. Nat Med. 2010;16(8):927–33. DOI: 10.1038/nm.2193
32. Lysaght MJ, Hazlehurst AL. Tissue engineering: the end of the beginning. Tissue Eng. 2004;10(1–2):309–20. DOI: 10.1089/107632704322791943
33. Bernhard JC, Isotani S, Matsugasumi T, et al.: Personalized 3D printed model of kidney and tumor anatomy: a useful tool for patient education. World Journal Urol 2015. DOI 10.1007/s00345-015-1632-2 DOI: 10.1007/s00345-015-1632-2
34. Seol YJ, Kang HW, Lee SJ, et al. Bioprinting technology and its applications. Eur J Cardiothorac Surg. 2014;46(3):342–8. DOI: 10.1093/ejcts/ezu148