Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

Journal of Controlled Release

Volumn 164, Issue 2, 2012, Pages 192-204

  Mehta, Geeta ^a,b   Hsiao, Amy Y ^a   Ingram, Marylou ^c   Luker, Gary D ^d   Takayama, Shuichi ^a,e  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF MICHIGAN SCHOOL OF DENTISTRY   (United States)

^c HUNTINGTON MEDICAL RESEARCH INSTITUTES   (United States)

^d UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^e Ulsan National Institute of Science and Technology   (South Korea)

Author keywords

Drug delivery; Drug screening; High throughput; Imaging; Spheroids; Tissue engineering

Indexed keywords

COCULTURE; DRUG DELIVERY SYSTEM; DRUG PENETRATION; DRUG SCREENING; DRUG TESTING; EXTRACELLULAR MATRIX DEPOSITION; HIGH THROUGHPUT; IN-VITRO; IN-VIVO; MICRO-SCALES; MULTI-CELLULAR ARCHITECTURES; MULTICELLULAR SPHEROID; PATHOLOGICAL TISSUE; PHYSIOLOGIC PARAMETERS; SPHEROIDS; TARGET CELLS; TUMOR SPHEROID;

CELL CULTURE; ENZYME INHIBITION; IMAGING TECHNIQUES; TISSUE; TISSUE ENGINEERING;

DRUG DELIVERY;

GAMMA LINOLENIC ACID; METHOTREXATE;

ARTICLE; ASSAY; BLOOD BRAIN BARRIER; COCULTURE; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG PENETRATION; DRUG SCREENING; ENDOTHELIUM CELL; EPITHELIUM CELL; EXTRACELLULAR MATRIX; FIBROBLAST; GLIOBLASTOMA; GLIOMA; HUMAN; IMMUNOCOMPETENT CELL; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; MATHEMATICAL MODEL; MESENCHYMAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; TUMOR SPHEROID;

ANIMALS; ANTINEOPLASTIC AGENTS; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; HUMANS; NEOPLASMS; SPHEROIDS, CELLULAR; TREATMENT OUTCOME; TUMOR CELLS, CULTURED;

EID: 84869495994     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2012.04.045     Document Type: Article

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