Reconstituting organ-level lung functions on a chip

Science

Volumn 328, Issue 5986, 2010, Pages 1662-1668

  Huh, Dongeun ^a,b   Matthews, Benjamin D ^b   Mammoto, Akiko ^b   Montoya Zavala, Martin ^a,b   Yuan Hsin, Hong ^b   Ingber, Donald E ^a,b,c  

^a HARVARD UNIVERSITY   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; DIMETICONE; NANOPARTICLE;

ABSORPTION; BACTERIUM; BIOENGINEERING; DRUG; HOMINID; MEMBRANE; PARTICLE SIZE; PHYSIOLOGY; SILICA; TOXICOLOGY;

ARTICLE; BIOMIMETICS; BREATHING; CELL CULTURE; EXTRACELLULAR MATRIX; LUNG FUNCTION; MEDICAL TECHNOLOGY; NONHUMAN; PRIORITY JOURNAL;

AIR; ANIMALS; BIOMIMETIC MATERIALS; BLOOD-AIR BARRIER; CAPILLARIES; CAPILLARY PERMEABILITY; CELLS, CULTURED; ENDOTHELIAL CELLS; ESCHERICHIA COLI; HUMANS; IMMUNITY, INNATE; INFLAMMATION; LUNG; MICE; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROTECHNOLOGY; NANOPARTICLES; NEUTROPHIL INFILTRATION; OXIDATIVE STRESS; PNEUMOCYTES; PULMONARY ALVEOLI; RESPIRATION; SILICON DIOXIDE; STRESS, MECHANICAL;

ANIMALIA;

EID: 77954038080     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1188302     Document Type: Article

References (42)

1. J. C. Davila, R. J. Rodriguez, R. B. Melchert, D. Acosta Jr., Annu. Rev. Pharmacol. Toxicol. 38, 63 (1998).
2. F. Pampaloni, E. G. Reynaud, E. H. K. Stelzer, Nat. Rev. Mol. Cell Biol. 8, 839 (2007).
3. D. E. Ingber, FASEB J. 20, 811 (2006).
4. G. M. Whitesides, E. Ostuni, S. Takayama, X. Y. Jiang, D. E. Ingber, Annu. Rev. Biomed. Eng. 3, 335 (2001).
5. A. Khademhosseini, R. Langer, J. Borenstein, J. P. Vacanti, Proc. Natl. Acad. Sci. U.S.A. 103, 2480 (2006).
6. J. El-Ali, P. K. Sorger, K. F. Jensen, Nature 442, 403 (2006).
7. I. Meyvantsson, D. J. Beebe, Annu. Rev. Anal. Chem. 1, 423 (2008).
8. M. Shin et al., Biomed. Microdevices 6, 269 (2004).
9. J. W. Song et al., Anal. Chem. 77, 3993 (2005).
10. M. T. Lam, Y. C. Huang, R. K. Birla, S. Takayama, Biomaterials 30, 1150 (2009).
11. K. Jang, K. Sato, K. Igawa, U. I. Chung, T. Kitamori, Anal. Bioanal. Chem. 390, 825 (2008).
12. D. Huh et al., Proc. Natl. Acad. Sci. U.S.A. 104, 18886 (2007).
13. A. Carraro et al., Biomed. Microdevices 10, 795 (2008).
14. P. J. Lee, P. J. Hung, L. P. Lee, Biotechnol. Bioeng. 97, 1340 (2007).
15. M. J. Powers et al., Biotechnol. Bioeng. 78, 257 (2002).
16. S. R. Khetani, S. N. Bhatia, Nat. Biotechnol. 26, 120 (2008).
17. J. W. Park, B. Vahidi, A. M. Taylor, S. W. Rhee, N. L. Jeon, Nat. Protoc. 1, 2128 (2006).
18. S. G. Harris, M. L. Shuler, Biotechnol. Bioprocess Eng. 8, 246 (2003).
19. G. J. Mahler, M. B. Esch, R. P. Glahn, M. L. Shuler, Biotechnol. Bioeng. 104, 193 (2009).
20. R. Baudoin, L. Griscom, M. Monge, C. Legallais, E. Leclerc, Biotechnol. Prog. 23, 1245 (2007).
21. K. J. Jang, K. Y. Suh, Lab Chip 10, 36 (2010).
22. S. Takayama et al., Adv. Mater. 13, 570 (2001).
23. I. Frerking, A. Günther, W. Seeger, U. Pison, Intensive Care Med. 27, 1699 (2001).
24. K. J. Kim, A. B. Malik, Am. J. Physiol. Lung Cell. Mol. Physiol. 284, L247 (2003).
25. K. G. Birukov et al., Am. J. Physiol. Lung Cell. Mol. Physiol. 285, L785 (2003).
26. T. Iba, B. E. Sumpio, Microvasc. Res. 42, 245 (1991).
27. C. K. Thodeti et al., Circ. Res. 104, 1123 (2009).
28. J. G. Wagner, R. A. Roth, Pharmacol. Rev. 52, 349 (2000).
29. M. I. Hermanns et al., Cell Tissue Res. 336, 91 (2009).
30. D. Wong, K. Dorovini-Zis, J. Neuroimmunol. 39, 11 (1992).
31. A. Nel, T. Xia, L. Mädler, N. Li, Science 311, 622 (2006).
32. V. L. Colvin, Nat. Biotechnol. 21, 1166 (2003).
33. G. Oberdörster, E. Oberdörster, J. Oberdörster, Environ. Health Perspect. 113, 823 (2005).
34. W. S. Lin, Y. W. Huang, X. D. Zhou, Y. F. Ma, Toxicol. Appl. Pharmacol. 217, 252 (2006).
35. D. Napierska et al., Small 5, 846 (2009).
36. R. Merget et al., Arch. Toxicol. 75, 625 (2002).
37. N. L. Mills et al., Nat. Clin. Pract. Cardiovasc. Med. 6, 36 (2009).
38. A. M. Bilek, K. C. Dee, D. P. Gaver III, J. Appl. Physiol. 94, 770 (2003).
39. H. W. Sill et al., Am. J. Physiol. 268, H535 (1995).
40. A. Sin et al., Biotechnol. Prog. 20, 338 (2004).
41. C. Zhang, Z. Q. Zhao, N. A. Abdul Rahim, D. van Noort, H. Yu, Lab Chip 9, 3185 (2009).
42. We thank C. K. Thodeti for his help with ROS assays; G. M. Whitesides and P. Cherukuri for providing carbon nanotubes, gold nanoparticles, and helpful comments; N. Korin for helpful discussions; R. Ruch for providing alveolar epithelial cells; R. Mannix for his imaging assistance; and M. Butte for help with neutrophil isolation. This work was supported by grants from NIH (R01-ES016665), the American Heart Association (0835618D), the Department of Defense (W81XWH-051-0115), and the Wyss Institute for Biologically Inspired Engineering at Harvard University; D.H. is a recipient of a Wyss Technology Development Fellowship, and D.E.I. is a recipient of a Department of Defense Breast Cancer Innovator Award. A patent on the device described is pending.