메뉴 건너뛰기




Volumn 8, Issue 23, 2017, Pages 38022-38043

Combination therapy in combating cancer

Author keywords

Carbonic anhydrase 9 (CAIX); Carbonic anhydrase inhibitor (CAI); HIF 1alpha; Histone deacetylase inhibitor (HDACi); Nrf2 Keap1

Indexed keywords

ANTINEOPLASTIC AGENT; AZACITIDINE; BENZAMIDE; BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; CARBONATE DEHYDRATASE INHIBITOR; CURCUMIN; DOCETAXEL; ENTINOSTAT; ERLOTINIB; FIGITUMUMAB; HISTONE DEACETYLASE INHIBITOR; IRINOTECAN; ITRACONAZOLE; KELCH LIKE ECH ASSOCIATED PROTEIN 1; LANSOPRAZOLE; METFORMIN; METHOTREXATE; MULTIDRUG RESISTANCE PROTEIN; PACLITAXEL; PAZOPANIB; PREDNISONE; ROMIDEPSIN; SALINOSPORAMIDE A; SULFORAPHANE; TOPOTECAN; TRANSCRIPTION FACTOR NRF2; UNINDEXED DRUG; VALPROIC ACID; VINCRISTINE; VORINOSTAT;

EID: 85018448054     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.16723     Document Type: Review
Times cited : (1692)

References (198)
  • 3
    • 85020163330 scopus 로고    scopus 로고
    • American Association for Cancer Research
    • AACR Releases AACR Cancer Progress Report 2015. American Association for Cancer Research; 2015. [Available from: http://cancerprogressreport.org/2015/Pages/cpr15release.aspx.]
    • (2015) AACR Releases AACR Cancer Progress Report 2015
  • 4
    • 0037674327 scopus 로고    scopus 로고
    • New approaches to cancer therapy
    • Garattini S. New approaches to cancer therapy. Ann Oncol. 2003;14:813-6
    • (2003) Ann Oncol , vol.14 , pp. 813-816
    • Garattini, S.1
  • 5
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: new estimates of drug development costs
    • DiMasi JA, Hansen RW, Grabowski HG. The price of innovation: new estimates of drug development costs. J Health Econ. 2003;22:151-85
    • (2003) J Health Econ , vol.22 , pp. 151-185
    • DiMasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3
  • 6
  • 8
    • 0033215191 scopus 로고    scopus 로고
    • Prevention of cancer in the next millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research
    • Prevention of cancer in the next millennium: Report of the Chemoprevention Working Group to the American Association for Cancer Research. Cancer Res. 1999;59:4743-58
    • (1999) Cancer Res , vol.59 , pp. 4743-4758
  • 9
    • 0035091343 scopus 로고    scopus 로고
    • Antibody-targeted immunotherapy for treatment of malignancy
    • White CA, Weaver RL, Grillo-Lopez AJ. Antibody-targeted immunotherapy for treatment of malignancy. Annu Rev Med. 2001;52:125-45
    • (2001) Annu Rev Med , vol.52 , pp. 125-145
    • White, C.A.1    Weaver, R.L.2    Grillo-Lopez, A.J.3
  • 10
    • 84876541026 scopus 로고    scopus 로고
    • Development of therapeutic combinations targeting major cancer signaling pathways
    • Yap TA, Omlin A, de Bono JS. Development of therapeutic combinations targeting major cancer signaling pathways. J Clin Oncol. 2013;31:1592-605
    • (2013) J Clin Oncol , vol.31 , pp. 1592-1605
    • Yap, T.A.1    Omlin, A.2    de Bono, J.S.3
  • 11
    • 12844281121 scopus 로고    scopus 로고
    • Analysis of FDA approved anticancer drugs reveals the future of cancer therapy
    • Blagosklonny MV. Analysis of FDA approved anticancer drugs reveals the future of cancer therapy. Cell Cycle. 2004;3:1035-42
    • (2004) Cell Cycle , vol.3 , pp. 1035-1042
    • Blagosklonny, M.V.1
  • 12
    • 0035752985 scopus 로고    scopus 로고
    • Side effects of chemotherapy and combined chemohormonal therapy in women with early-stage breast cancer
    • Partridge AH, Burstein HJ, Winer EP. Side effects of chemotherapy and combined chemohormonal therapy in women with early-stage breast cancer. J Natl Cancer Inst Monogr. 2001;30:135-42
    • (2001) J Natl Cancer Inst Monogr , vol.30 , pp. 135-142
    • Partridge, A.H.1    Burstein, H.J.2    Winer, E.P.3
  • 13
    • 0023716071 scopus 로고
    • Chemotherapy side effects in pediatric oncology patients: drugs, age, and sex as risk factors
    • LeBaron S, Zeltzer LK, LeBaron C, Scott SE, Zeltzer PM. Chemotherapy side effects in pediatric oncology patients: drugs, age, and sex as risk factors. Med Pediatr Oncol. 1988;16:263-8
    • (1988) Med Pediatr Oncol , vol.16 , pp. 263-268
    • LeBaron, S.1    Zeltzer, L.K.2    LeBaron, C.3    Scott, S.E.4    Zeltzer, P.M.5
  • 15
    • 84884588943 scopus 로고    scopus 로고
    • Combination of carbonic anhydrase inhibitor, acetazolamide, and sulforaphane, reduces the viability and growth of bronchial carcinoid cell lines
    • Mokhtari RB, Kumar S, Islam SS, Yazdanpanah M, Adeli K, Cutz E, Yeger H. Combination of carbonic anhydrase inhibitor, acetazolamide, and sulforaphane, reduces the viability and growth of bronchial carcinoid cell lines. BMC Cancer. 2013;13:378
    • (2013) BMC Cancer , vol.13 , pp. 378
    • Mokhtari, R.B.1    Kumar, S.2    Islam, S.S.3    Yazdanpanah, M.4    Adeli, K.5    Cutz, E.6    Yeger, H.7
  • 16
    • 12844255134 scopus 로고    scopus 로고
    • Overcoming limitations of natural anticancer drugs by combining with artificial agents
    • Blagosklonny MV. Overcoming limitations of natural anticancer drugs by combining with artificial agents. Trends Pharmacol Sci. 2005;26:77-81
    • (2005) Trends Pharmacol Sci , vol.26 , pp. 77-81
    • Blagosklonny, M.V.1
  • 17
    • 72149087697 scopus 로고    scopus 로고
    • Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance
    • Khdair A, Chen D, Patil Y, Ma L, Dou QP, Shekhar MP, Panyam J. Nanoparticle-mediated combination chemotherapy and photodynamic therapy overcomes tumor drug resistance. J Control Release. 2010;141:137-44
    • (2010) J Control Release , vol.141 , pp. 137-144
    • Khdair, A.1    Chen, D.2    Patil, Y.3    Ma, L.4    Dou, Q.P.5    Shekhar, M.P.6    Panyam, J.7
  • 18
    • 0036364467 scopus 로고    scopus 로고
    • Multidrug resistance in cancer: role of ATP-dependent transporters
    • Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: role of ATP-dependent transporters. Nat Rev Cancer. 2002;2:48-58
    • (2002) Nat Rev Cancer , vol.2 , pp. 48-58
    • Gottesman, M.M.1    Fojo, T.2    Bates, S.E.3
  • 19
    • 0034048358 scopus 로고    scopus 로고
    • Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice
    • Hanahan D, Bergers G, Bergsland E. Less is more, regularly: metronomic dosing of cytotoxic drugs can target tumor angiogenesis in mice. J Clin Invest. 2000;105:1045-7
    • (2000) J Clin Invest , vol.105 , pp. 1045-1047
    • Hanahan, D.1    Bergers, G.2    Bergsland, E.3
  • 21
    • 84881453720 scopus 로고    scopus 로고
    • Understanding and targeting cancer stem cells: therapeutic implications and challenges
    • Chen K, Huang YH, Chen JL. Understanding and targeting cancer stem cells: therapeutic implications and challenges. Acta Pharmacol Sin. 2013;34:732-40
    • (2013) Acta Pharmacol Sin , vol.34 , pp. 732-740
    • Chen, K.1    Huang, Y.H.2    Chen, J.L.3
  • 25
    • 45749117120 scopus 로고    scopus 로고
    • 'Targeting the absence' and therapeutic engineering for cancer therapy
    • Blagosklonny MV. 'Targeting the absence' and therapeutic engineering for cancer therapy. Cell Cycle. 2008;7:1307-12
    • (2008) Cell Cycle , vol.7 , pp. 1307-1312
    • Blagosklonny, M.V.1
  • 26
    • 34547770279 scopus 로고    scopus 로고
    • New uses for old drugs
    • Chong CR, Sullivan DJ Jr. New uses for old drugs. Nature. 2007;448:645-6
    • (2007) Nature , vol.448 , pp. 645-646
    • Chong, C.R.1    Sullivan, D.J.2
  • 27
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: identifying and developing new uses for existing drugs
    • Ashburn TT, Thor KB. Drug repositioning: identifying and developing new uses for existing drugs. Nat Rev Drug Discov. 2004;3:673-83
    • (2004) Nat Rev Drug Discov , vol.3 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 28
    • 84944710419 scopus 로고    scopus 로고
    • Simultaneous Targeting of Bladder Tumor Growth, Survival, and Epithelial-to-Mesenchymal Transition with a Novel Therapeutic Combination of Acetazolamide (AZ) and Sulforaphane (SFN)
    • Islam SS, Mokhtari RB, Akbari P, Hatina J, Yeger H, Farhat WA. Simultaneous Targeting of Bladder Tumor Growth, Survival, and Epithelial-to-Mesenchymal Transition with a Novel Therapeutic Combination of Acetazolamide (AZ) and Sulforaphane (SFN). Target Oncol. 2016;11:209-27
    • (2016) Target Oncol , vol.11 , pp. 209-227
    • Islam, S.S.1    Mokhtari, R.B.2    Akbari, P.3    Hatina, J.4    Yeger, H.5    Farhat, W.A.6
  • 29
    • 84894553603 scopus 로고    scopus 로고
    • Immunosuppressants in cancer prevention and therapy
    • Blagosklonny MV. Immunosuppressants in cancer prevention and therapy. Oncoimmunology. 2013;2:e26961
    • (2013) Oncoimmunology , vol.2
    • Blagosklonny, M.V.1
  • 30
    • 0037334306 scopus 로고    scopus 로고
    • A new science-business paradigm in anticancer drug development
    • Blagosklonny MV. A new science-business paradigm in anticancer drug development. Trends Biotechnol. 2003;21:103-6
    • (2003) Trends Biotechnol , vol.21 , pp. 103-106
    • Blagosklonny, M.V.1
  • 31
    • 84881082484 scopus 로고    scopus 로고
    • Tumor dynamics in response to antiangiogenic therapy with oral metronomic topotecan and pazopanib in neuroblastoma xenografts
    • Kumar S, Mokhtari RB, Oliveira ID, Islam S, Toledo SR, Yeger H, Baruchel S. Tumor dynamics in response to antiangiogenic therapy with oral metronomic topotecan and pazopanib in neuroblastoma xenografts. Transl Oncol. 2013;6:493-503
    • (2013) Transl Oncol , vol.6 , pp. 493-503
    • Kumar, S.1    Mokhtari, R.B.2    Oliveira, I.D.3    Islam, S.4    Toledo, S.R.5    Yeger, H.6    Baruchel, S.7
  • 32
    • 33847050801 scopus 로고    scopus 로고
    • Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway
    • Kensler TW, Wakabayashi N, Biswal S. Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathway. Annu Rev Pharmacol Toxicol. 2007;47:89-116
    • (2007) Annu Rev Pharmacol Toxicol , vol.47 , pp. 89-116
    • Kensler, T.W.1    Wakabayashi, N.2    Biswal, S.3
  • 33
    • 84874111758 scopus 로고    scopus 로고
    • The Nrf2 cell defence pathway: Keap1-dependent and-independent mechanisms of regulation
    • Bryan HK, Olayanju A, Goldring CE, Park BK. The Nrf2 cell defence pathway: Keap1-dependent and-independent mechanisms of regulation. Biochem Pharmacol. 2013;85:705-17
    • (2013) Biochem Pharmacol , vol.85 , pp. 705-717
    • Bryan, H.K.1    Olayanju, A.2    Goldring, C.E.3    Park, B.K.4
  • 34
    • 84870902532 scopus 로고    scopus 로고
    • Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection
    • Zhang M, An C, Gao Y, Leak RK, Chen J, Zhang F. Emerging roles of Nrf2 and phase II antioxidant enzymes in neuroprotection. Prog Neurobiol. 2013;100:30-47
    • (2013) Prog Neurobiol , vol.100 , pp. 30-47
    • Zhang, M.1    An, C.2    Gao, Y.3    Leak, R.K.4    Chen, J.5    Zhang, F.6
  • 35
    • 22544464124 scopus 로고    scopus 로고
    • Modifying specific cysteines of the electrophilesensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2
    • Eggler AL, Liu G, Pezzuto JM, van Breemen RB, Mesecar AD. Modifying specific cysteines of the electrophilesensing human Keap1 protein is insufficient to disrupt binding to the Nrf2 domain Neh2. Proc Natl Acad Sci U S A. 2005;102:10070-5
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 10070-10075
    • Eggler, A.L.1    Liu, G.2    Pezzuto, J.M.3    van Breemen, R.B.4    Mesecar, A.D.5
  • 37
    • 14044254798 scopus 로고    scopus 로고
    • Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation
    • Kobayashi M, Yamamoto M. Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation. Antioxid Redox Signal. 2005;7:385-94
    • (2005) Antioxid Redox Signal , vol.7 , pp. 385-394
    • Kobayashi, M.1    Yamamoto, M.2
  • 39
    • 0035965945 scopus 로고    scopus 로고
    • Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention
    • Hayes JD, McMahon M. Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention. Cancer Lett. 2001;174:103-13
    • (2001) Cancer Lett , vol.174 , pp. 103-113
    • Hayes, J.D.1    McMahon, M.2
  • 40
    • 5144232811 scopus 로고    scopus 로고
    • Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers
    • Kwak MK, Wakabayashi N, Kensler TW. Chemoprevention through the Keap1-Nrf2 signaling pathway by phase 2 enzyme inducers. Mutat Res. 2004;555:133-48
    • (2004) Mutat Res , vol.555 , pp. 133-148
    • Kwak, M.K.1    Wakabayashi, N.2    Kensler, T.W.3
  • 41
    • 53849145323 scopus 로고    scopus 로고
    • The antioxidant response element and oxidative stress modifiers in airway diseases
    • Reddy SP. The antioxidant response element and oxidative stress modifiers in airway diseases. Curr Mol Med. 2008;8:376-83
    • (2008) Curr Mol Med , vol.8 , pp. 376-383
    • Reddy, S.P.1
  • 43
    • 84958190953 scopus 로고    scopus 로고
    • Downregulation of Nrf2 by the combination of TRAIL and Valproic acid induces apoptotic cell death of TRAIL-resistant papillary thyroid cancer cells via suppression of Bcl-xL
    • Cha HY, Lee BS, Chang JW, Park JK, Han JH, Kim YS, Shin YS, Byeon HK, Kim CH. Downregulation of Nrf2 by the combination of TRAIL and Valproic acid induces apoptotic cell death of TRAIL-resistant papillary thyroid cancer cells via suppression of Bcl-xL. Cancer Lett. 2016;372:65-74
    • (2016) Cancer Lett , vol.372 , pp. 65-74
    • Cha, H.Y.1    Lee, B.S.2    Chang, J.W.3    Park, J.K.4    Han, J.H.5    Kim, Y.S.6    Shin, Y.S.7    Byeon, H.K.8    Kim, C.H.9
  • 44
    • 84919779530 scopus 로고    scopus 로고
    • The chemistry of curcumin: from extraction to therapeutic agent
    • Priyadarsini KI. The chemistry of curcumin: from extraction to therapeutic agent. Molecules. 2014;19:20091-112
    • (2014) Molecules , vol.19 , pp. 20091-20112
    • Priyadarsini, K.I.1
  • 45
  • 46
    • 84928911735 scopus 로고    scopus 로고
    • Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of inflammation in prevention of cancer
    • Das L, Vinayak M. Long term effect of curcumin in restoration of tumour suppressor p53 and phase-II antioxidant enzymes via activation of Nrf2 signalling and modulation of inflammation in prevention of cancer. PLoS One. 2015;10:e0124000
    • (2015) PLoS One , vol.10
    • Das, L.1    Vinayak, M.2
  • 47
    • 84895071276 scopus 로고    scopus 로고
    • Antioxidant effects of bioavailability-enhanced curcuminoids in patients with solid tumors: A randomized double-blind placebo-controlled trial
    • Panahi Y SA, Beiraghdar F, Nouzari SMH, Jalalian HR, Sahebkar A. Antioxidant effects of bioavailability-enhanced curcuminoids in patients with solid tumors: A randomized double-blind placebo-controlled trial. Journal of Functional Foods. 2014;6:615-22
    • (2014) Journal of Functional Foods , vol.6 , pp. 615-622
    • Panahi, Y.S.A.1    Beiraghdar, F.2    Nouzari, S.M.H.3    Jalalian, H.R.4    Sahebkar, A.5
  • 48
    • 84870943008 scopus 로고    scopus 로고
    • Role of antioxidants in cancer therapy
    • Fuchs-Tarlovsky V. Role of antioxidants in cancer therapy. Nutrition. 2013;29:15-21
    • (2013) Nutrition , vol.29 , pp. 15-21
    • Fuchs-Tarlovsky, V.1
  • 49
    • 34547197625 scopus 로고    scopus 로고
    • Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trials
    • Block KI, Koch AC, Mead MN, Tothy PK, Newman RA, Gyllenhaal C. Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trials. Cancer Treat Rev. 2007;33:407-18
    • (2007) Cancer Treat Rev , vol.33 , pp. 407-418
    • Block, K.I.1    Koch, A.C.2    Mead, M.N.3    Tothy, P.K.4    Newman, R.A.5    Gyllenhaal, C.6
  • 50
    • 84968764917 scopus 로고    scopus 로고
    • A Novel Combinatorial Epigenetic Therapy Using Resveratrol and Pterostilbene for Restoring Estrogen Receptor-alpha (ERalpha) Expression in ERalpha-Negative Breast Cancer Cells
    • Kala R, Tollefsbol TO. A Novel Combinatorial Epigenetic Therapy Using Resveratrol and Pterostilbene for Restoring Estrogen Receptor-alpha (ERalpha) Expression in ERalpha-Negative Breast Cancer Cells. PLoS One. 2016;11:e0155057
    • (2016) PLoS One , vol.11
    • Kala, R.1    Tollefsbol, T.O.2
  • 51
    • 85001875325 scopus 로고    scopus 로고
    • [Study on the resveratrol and arsenic trioxide combination induced apoptosis and its mechanism on lung adenocarcinoma cells]. [Article in Chinese]
    • Gu S, Chen C, Jiang X, Zhang Z. [Study on the resveratrol and arsenic trioxide combination induced apoptosis and its mechanism on lung adenocarcinoma cells]. [Article in Chinese]. Wei Sheng Yan Jiu. 2016;45:87-92
    • (2016) Wei Sheng Yan Jiu , vol.45 , pp. 87-92
    • Gu, S.1    Chen, C.2    Jiang, X.3    Zhang, Z.4
  • 52
    • 84977657836 scopus 로고    scopus 로고
    • Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence
    • Kotecha R, Takami A, Espinoza JL. Dietary phytochemicals and cancer chemoprevention: a review of the clinical evidence. Oncotarget. 2016; 7:52517-52529. doi: 10.18632/oncotarget.9593
    • (2016) Oncotarget , vol.7 , pp. 52517-52529
    • Kotecha, R.1    Takami, A.2    Espinoza, J.L.3
  • 53
    • 2442521357 scopus 로고    scopus 로고
    • Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma
    • Liontas A, Yeger H. Curcumin and resveratrol induce apoptosis and nuclear translocation and activation of p53 in human neuroblastoma. Anticancer Res. 2004;24:987-98
    • (2004) Anticancer Res , vol.24 , pp. 987-998
    • Liontas, A.1    Yeger, H.2
  • 55
    • 54249135351 scopus 로고    scopus 로고
    • Squalene selectively protects mouse bone marrow progenitors against cisplatin and carboplatin-induced cytotoxicity in vivo without protecting tumor growth
    • Das B, Antoon R, Tsuchida R, Lotfi S, Morozova O, Farhat W, Malkin D, Koren G, Yeger H, Baruchel S. Squalene selectively protects mouse bone marrow progenitors against cisplatin and carboplatin-induced cytotoxicity in vivo without protecting tumor growth. Neoplasia. 2008;10:1105-19
    • (2008) Neoplasia , vol.10 , pp. 1105-1119
    • Das, B.1    Antoon, R.2    Tsuchida, R.3    Lotfi, S.4    Morozova, O.5    Farhat, W.6    Malkin, D.7    Koren, G.8    Yeger, H.9    Baruchel, S.10
  • 58
  • 61
    • 84904157844 scopus 로고    scopus 로고
    • Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1alpha/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents
    • Do MT, Kim HG, Choi JH, Jeong HG. Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1alpha/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents. Free Radic Biol Med. 2014;74:21-34
    • (2014) Free Radic Biol Med , vol.74 , pp. 21-34
    • Do, M.T.1    Kim, H.G.2    Choi, J.H.3    Jeong, H.G.4
  • 62
    • 10644270846 scopus 로고    scopus 로고
    • Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response
    • Vaupel P, Harrison L. Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response. Oncologist. 2004;9:4-9
    • (2004) Oncologist , vol.9 , pp. 4-9
    • Vaupel, P.1    Harrison, L.2
  • 63
    • 68349133231 scopus 로고    scopus 로고
    • Hypoxic tumor microenvironment and cancer cell differentiation
    • Kim Y, Lin Q, Glazer PM, Yun Z. Hypoxic tumor microenvironment and cancer cell differentiation. Curr Mol Med. 2009;9:425-34
    • (2009) Curr Mol Med , vol.9 , pp. 425-434
    • Kim, Y.1    Lin, Q.2    Glazer, P.M.3    Yun, Z.4
  • 64
    • 84899774937 scopus 로고    scopus 로고
    • Carbonic anhydrase IX: regulation and role in cancer
    • Benej M, Pastorekova S, Pastorek J. Carbonic anhydrase IX: regulation and role in cancer. Subcell Biochem. 2014;75:199-219
    • (2014) Subcell Biochem , vol.75 , pp. 199-219
    • Benej, M.1    Pastorekova, S.2    Pastorek, J.3
  • 65
    • 84978790892 scopus 로고    scopus 로고
    • The hypoxic microenvironment: A determinant of cancer stem cell evolution
    • Carnero A, Lleonart M. The hypoxic microenvironment: A determinant of cancer stem cell evolution. Bioessays. 2016;38:S65-74
    • (2016) Bioessays , vol.38 , pp. S65-S74
    • Carnero, A.1    Lleonart, M.2
  • 66
    • 80053563164 scopus 로고    scopus 로고
    • Interfering with pH regulation in tumors as a therapeutic strategy
    • Neri D SC. Interfering with pH regulation in tumors as a therapeutic strategy. Nat Rev Drug Discov. 2011;10:767-77
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 767-777
    • Neri, D.S.C.1
  • 72
    • 69949128698 scopus 로고    scopus 로고
    • Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model
    • Dubois L, Lieuwes NG, Maresca A, Thiry A, Supuran CT, Scozzafava A, Wouters BG, Lambin P. Imaging of CA IX with fluorescent labelled sulfonamides distinguishes hypoxic and (re)-oxygenated cells in a xenograft tumour model. Radiother Oncol. 2009;92:423-8
    • (2009) Radiother Oncol , vol.92 , pp. 423-428
    • Dubois, L.1    Lieuwes, N.G.2    Maresca, A.3    Thiry, A.4    Supuran, C.T.5    Scozzafava, A.6    Wouters, B.G.7    Lambin, P.8
  • 73
    • 84872293839 scopus 로고    scopus 로고
    • Targeting cancer stem cells: a new therapy to cure cancer patients
    • Hu Y, Fu L. Targeting cancer stem cells: a new therapy to cure cancer patients. Am J Cancer Res. 2012;2:340-56
    • (2012) Am J Cancer Res , vol.2 , pp. 340-356
    • Hu, Y.1    Fu, L.2
  • 74
    • 33847774266 scopus 로고    scopus 로고
    • Stochastic dynamics of hematopoietic tumor stem cells
    • Dingli D, Traulsen A, Pacheco JM. Stochastic dynamics of hematopoietic tumor stem cells. Cell Cycle. 2007;6:461-6
    • (2007) Cell Cycle , vol.6 , pp. 461-466
    • Dingli, D.1    Traulsen, A.2    Pacheco, J.M.3
  • 75
    • 33646045010 scopus 로고    scopus 로고
    • Stem cells and cancer: two faces of eve
    • Clarke MF, Fuller M. Stem cells and cancer: two faces of eve. Cell. 2006;124:1111-5
    • (2006) Cell , vol.124 , pp. 1111-1115
    • Clarke, M.F.1    Fuller, M.2
  • 77
    • 77954218410 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors
    • Supuran CT. Carbonic anhydrase inhibitors. Bioorg Med Chem Lett. 2010;20:3467-74
    • (2010) Bioorg Med Chem Lett , vol.20 , pp. 3467-3474
    • Supuran, C.T.1
  • 78
    • 38849143765 scopus 로고    scopus 로고
    • Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
    • Supuran CT. Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov. 2008;7:168-81
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 168-181
    • Supuran, C.T.1
  • 79
    • 84964614323 scopus 로고    scopus 로고
    • The history and rationale of using carbonic anhydrase inhibitors in the treatment of peptic ulcers. In memoriam Ioan Puscas (1932-2015)
    • Buzas GM, Supuran CT. The history and rationale of using carbonic anhydrase inhibitors in the treatment of peptic ulcers. In memoriam Ioan Puscas (1932-2015). J Enzyme Inhib Med Chem. 2016;31:527-33
    • (2016) J Enzyme Inhib Med Chem , vol.31 , pp. 527-533
    • Buzas, G.M.1    Supuran, C.T.2
  • 80
    • 84955634237 scopus 로고    scopus 로고
    • Synthesis and inhibition potency of novel ureido benzenesulfonamides incorporating GABA as tumor-associated carbonic anhydrase IX and XII inhibitors
    • Ceruso M, Antel S, Scozzafava A, Supuran CT. Synthesis and inhibition potency of novel ureido benzenesulfonamides incorporating GABA as tumor-associated carbonic anhydrase IX and XII inhibitors. J Enzyme Inhib Med Chem. 2016;31:205-11
    • (2016) J Enzyme Inhib Med Chem , vol.31 , pp. 205-211
    • Ceruso, M.1    Antel, S.2    Scozzafava, A.3    Supuran, C.T.4
  • 82
    • 77956283843 scopus 로고    scopus 로고
    • Molecular targeting of carbonic anhydrase IX in mice with hypoxic HT29 colorectal tumor xenografts
    • Carlin S, Khan N, Ku T, Longo VA, Larson SM, Smith-Jones PM. Molecular targeting of carbonic anhydrase IX in mice with hypoxic HT29 colorectal tumor xenografts. PLoS One. 2010;5:e10857
    • (2010) PLoS One , vol.5
    • Carlin, S.1    Khan, N.2    Ku, T.3    Longo, V.A.4    Larson, S.M.5    Smith-Jones, P.M.6
  • 84
    • 84971634917 scopus 로고    scopus 로고
    • Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines
    • Abdel Gawad NM, Amin NH, Elsaadi MT, Mohamed FM, Angeli A, De Luca V, Capasso C, Supuran CT. Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines. Bioorg Med Chem. 2016;24:3043-51
    • (2016) Bioorg Med Chem , vol.24 , pp. 3043-3051
    • Abdel Gawad, N.M.1    Amin, N.H.2    Elsaadi, M.T.3    Mohamed, F.M.4    Angeli, A.5    De Luca, V.6    Capasso, C.7    Supuran, C.T.8
  • 85
    • 84907149054 scopus 로고    scopus 로고
    • Tumor microenvironmental changes induced by the sulfamate carbonic anhydrase IX inhibitor S4 in a laryngeal tumor model
    • Meijer TW, Bussink J, Zatovicova M, Span PN, Lok J, Supuran CT, Kaanders JH. Tumor microenvironmental changes induced by the sulfamate carbonic anhydrase IX inhibitor S4 in a laryngeal tumor model. PLoS One. 2014;9:e108068
    • (2014) PLoS One , vol.9
    • Meijer, T.W.1    Bussink, J.2    Zatovicova, M.3    Span, P.N.4    Lok, J.5    Supuran, C.T.6    Kaanders, J.H.7
  • 90
    • 85020190348 scopus 로고    scopus 로고
    • Comparative Oncology. Bucharest The Publishing House of the Romanian Academy;
    • Baba AI CC. The Tumor Cell. Comparative Oncology. Bucharest The Publishing House of the Romanian Academy; 2007
    • (2007) The Tumor Cell
    • Baba, A.I.C.C.1
  • 91
    • 33746091748 scopus 로고    scopus 로고
    • Epigenetics: the science of change
    • Weinhold B. Epigenetics: the science of change. Environ Health Perspect. 2006;114:A160-7
    • (2006) Environ Health Perspect , vol.114 , pp. A160-A167
    • Weinhold, B.1
  • 92
    • 84961218734 scopus 로고    scopus 로고
    • Epigenetic modulators, modifiers and mediators in cancer aetiology and progression
    • Feinberg AP, Koldobskiy MA, Gondor A. Epigenetic modulators, modifiers and mediators in cancer aetiology and progression. Nat Rev Genet. 2016;17:284-99
    • (2016) Nat Rev Genet , vol.17 , pp. 284-299
    • Feinberg, A.P.1    Koldobskiy, M.A.2    Gondor, A.3
  • 93
    • 84858685501 scopus 로고    scopus 로고
    • Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed
    • Gryder BE, Sodji QH, Oyelere AK. Targeted cancer therapy: giving histone deacetylase inhibitors all they need to succeed. Future Med Chem. 2012;4:505-24
    • (2012) Future Med Chem , vol.4 , pp. 505-524
    • Gryder, B.E.1    Sodji, Q.H.2    Oyelere, A.K.3
  • 94
    • 84892942381 scopus 로고    scopus 로고
    • New and emerging HDAC inhibitors for cancer treatment
    • West AC, Johnstone RW. New and emerging HDAC inhibitors for cancer treatment. J Clin Invest. 2014;124:30-9
    • (2014) J Clin Invest , vol.124 , pp. 30-39
    • West, A.C.1    Johnstone, R.W.2
  • 95
    • 36048958965 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: overview and perspectives
    • Dokmanovic M, Clarke C, Marks PA. Histone deacetylase inhibitors: overview and perspectives. Mol Cancer Res. 2007;5:981-9
    • (2007) Mol Cancer Res , vol.5 , pp. 981-989
    • Dokmanovic, M.1    Clarke, C.2    Marks, P.A.3
  • 96
    • 80053627793 scopus 로고    scopus 로고
    • Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung
    • Minamiya Y, Ono T, Saito H, Takahashi N, Ito M, Mitsui M, Motoyama S, Ogawa J. Expression of histone deacetylase 1 correlates with a poor prognosis in patients with adenocarcinoma of the lung. Lung Cancer. 2011;74:300-4
    • (2011) Lung Cancer , vol.74 , pp. 300-304
    • Minamiya, Y.1    Ono, T.2    Saito, H.3    Takahashi, N.4    Ito, M.5    Mitsui, M.6    Motoyama, S.7    Ogawa, J.8
  • 98
    • 84904070819 scopus 로고    scopus 로고
    • Chromatin modifiers and the promise of epigenetic therapy in acute leukemia
    • Greenblatt SM, Nimer SD. Chromatin modifiers and the promise of epigenetic therapy in acute leukemia. Leukemia. 2014;28:1396-406
    • (2014) Leukemia , vol.28 , pp. 1396-1406
    • Greenblatt, S.M.1    Nimer, S.D.2
  • 101
    • 85020213433 scopus 로고    scopus 로고
    • Romidepsin U.S. Food and Drug Administration
    • Romidepsin U.S. Food and Drug Administration; 2009
    • (2009)
  • 102
    • 85020204111 scopus 로고    scopus 로고
    • U.S. Food and Drug Administration (FDA)
    • Panobinostat. U.S. Food and Drug Administration (FDA)
  • 104
    • 0035965343 scopus 로고    scopus 로고
    • Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen
    • Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA, Klein PS. Histone deacetylase is a direct target of valproic acid, a potent anticonvulsant, mood stabilizer, and teratogen. J Biol Chem. 2001;276:36734-41
    • (2001) J Biol Chem , vol.276 , pp. 36734-36741
    • Phiel, C.J.1    Zhang, F.2    Huang, E.Y.3    Guenther, M.G.4    Lazar, M.A.5    Klein, P.S.6
  • 105
    • 84922513553 scopus 로고    scopus 로고
    • Results of phase 2 randomized study of low-dose decitabine with or without valproic acid in patients with myelodysplastic syndrome and acute myelogenous leukemia
    • Issa JP, Garcia-Manero G, Huang X, Cortes J, Ravandi F, Jabbour E, Borthakur G, Brandt M, Pierce S, Kantarjian HM. Results of phase 2 randomized study of low-dose decitabine with or without valproic acid in patients with myelodysplastic syndrome and acute myelogenous leukemia. Cancer. 2015;121:556-61
    • (2015) Cancer , vol.121 , pp. 556-561
    • Issa, J.P.1    Garcia-Manero, G.2    Huang, X.3    Cortes, J.4    Ravandi, F.5    Jabbour, E.6    Borthakur, G.7    Brandt, M.8    Pierce, S.9    Kantarjian, H.M.10
  • 108
    • 84871407100 scopus 로고    scopus 로고
    • Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination
    • Millward M, Price T, Townsend A, Sweeney C, Spencer A, Sukumaran S, Longenecker A, Lee L, Lay A, Sharma G, Gemmill RM, Drabkin HA, Lloyd GK, et al. Phase 1 clinical trial of the novel proteasome inhibitor marizomib with the histone deacetylase inhibitor vorinostat in patients with melanoma, pancreatic and lung cancer based on in vitro assessments of the combination. Invest New Drugs. 2012;30:2303-17
    • (2012) Invest New Drugs , vol.30 , pp. 2303-2317
    • Millward, M.1    Price, T.2    Townsend, A.3    Sweeney, C.4    Spencer, A.5    Sukumaran, S.6    Longenecker, A.7    Lee, L.8    Lay, A.9    Sharma, G.10    Gemmill, R.M.11    Drabkin, H.A.12    Lloyd, G.K.13
  • 111
    • 70449367075 scopus 로고    scopus 로고
    • Efficacy of MS-275, a selective inhibitor of class I histone deacetylases, in human colon cancer models
    • Bracker TU, Sommer A, Fichtner I, Faus H, Haendler B, Hess-Stumpp H. Efficacy of MS-275, a selective inhibitor of class I histone deacetylases, in human colon cancer models. Int J Oncol. 2009;35:909-20
    • (2009) Int J Oncol , vol.35 , pp. 909-920
    • Bracker, T.U.1    Sommer, A.2    Fichtner, I.3    Faus, H.4    Haendler, B.5    Hess-Stumpp, H.6
  • 112
    • 34248631385 scopus 로고    scopus 로고
    • The role of histone deacetylases (HDACs) in human cancer
    • Ropero S, Esteller M. The role of histone deacetylases (HDACs) in human cancer. Mol Oncol. 2007;1:19-25
    • (2007) Mol Oncol , vol.1 , pp. 19-25
    • Ropero, S.1    Esteller, M.2
  • 116
    • 79958075201 scopus 로고    scopus 로고
    • Survival by histologic subtype in stage IV nonsmall cell lung cancer based on data from the Surveillance, Epidemiology and End Results Program
    • Cetin K, Ettinger DS, Hei YJ, O'Malley CD. Survival by histologic subtype in stage IV nonsmall cell lung cancer based on data from the Surveillance, Epidemiology and End Results Program. Clin Epidemiol. 2011;3:139-48
    • (2011) Clin Epidemiol , vol.3 , pp. 139-148
    • Cetin, K.1    Ettinger, D.S.2    Hei, Y.J.3    O'Malley, C.D.4
  • 117
  • 118
    • 70350507208 scopus 로고    scopus 로고
    • Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines
    • Drozdov I, Kidd M, Gustafsson BI, Svejda B, Joseph R, Pfragner R, Modlin IM. Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines. Cancer. 2009;115:4934-45
    • (2009) Cancer , vol.115 , pp. 4934-4945
    • Drozdov, I.1    Kidd, M.2    Gustafsson, B.I.3    Svejda, B.4    Joseph, R.5    Pfragner, R.6    Modlin, I.M.7
  • 119
    • 84859445000 scopus 로고    scopus 로고
    • Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy
    • Semenza GL. Hypoxia-inducible factors: mediators of cancer progression and targets for cancer therapy. Trends Pharmacol Sci. 2012;33:207-14
    • (2012) Trends Pharmacol Sci , vol.33 , pp. 207-214
    • Semenza, G.L.1
  • 120
    • 0029913232 scopus 로고    scopus 로고
    • Autocrine growth loop of the epidermal growth factor receptor in normal and immortalized human bronchial epithelial cells
    • Tsao MS, Zhu H, Viallet J. Autocrine growth loop of the epidermal growth factor receptor in normal and immortalized human bronchial epithelial cells. Exp Cell Res. 1996;223:268-73
    • (1996) Exp Cell Res , vol.223 , pp. 268-273
    • Tsao, M.S.1    Zhu, H.2    Viallet, J.3
  • 121
    • 84890009448 scopus 로고    scopus 로고
    • Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer
    • Singh P, Alex JM, Bast F. Insulin receptor (IR) and insulin-like growth factor receptor 1 (IGF-1R) signaling systems: novel treatment strategies for cancer. Med Oncol. 2014;31:805
    • (2014) Med Oncol , vol.31 , pp. 805
    • Singh, P.1    Alex, J.M.2    Bast, F.3
  • 122
    • 3543072186 scopus 로고    scopus 로고
    • Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms
    • Calle EE, Kaaks R. Overweight, obesity and cancer: epidemiological evidence and proposed mechanisms. Nat Rev Cancer. 2004;4:579-91
    • (2004) Nat Rev Cancer , vol.4 , pp. 579-591
    • Calle, E.E.1    Kaaks, R.2
  • 123
    • 84886526901 scopus 로고    scopus 로고
    • Serotonin discovery and stepwise disclosure of 5-HT receptor complexity over four decade. Part I. General background and discovery of serotonin as a basis for 5-HT receptor identification
    • Gothert M. Serotonin discovery and stepwise disclosure of 5-HT receptor complexity over four decades. Part I. General background and discovery of serotonin as a basis for 5-HT receptor identification. Pharmacol Rep. 2013;65:771-86
    • (2013) Pharmacol Rep , vol.65 , pp. 771-786
    • Gothert, M.1
  • 126
    • 33644999651 scopus 로고    scopus 로고
    • The effect of serotonin and serotonin antagonists on bladder cancer cell proliferation
    • Siddiqui EJ, Shabbir MA, Mikhailidis DP, Mumtaz FH, Thompson CS. The effect of serotonin and serotonin antagonists on bladder cancer cell proliferation. BJU Int. 2006;97:634-9
    • (2006) BJU Int , vol.97 , pp. 634-639
    • Siddiqui, E.J.1    Shabbir, M.A.2    Mikhailidis, D.P.3    Mumtaz, F.H.4    Thompson, C.S.5
  • 127
  • 128
    • 33646045331 scopus 로고    scopus 로고
    • The 5-HT2A serotoninergic receptor is expressed in the MCF-7 human breast cancer cell line and reveals a mitogenic effect of serotonin
    • Sonier B, Arseneault M, Lavigne C, Ouellette RJ, Vaillancourt C. The 5-HT2A serotoninergic receptor is expressed in the MCF-7 human breast cancer cell line and reveals a mitogenic effect of serotonin. Biochem Biophys Res Commun. 2006;343:1053-9
    • (2006) Biochem Biophys Res Commun , vol.343 , pp. 1053-1059
    • Sonier, B.1    Arseneault, M.2    Lavigne, C.3    Ouellette, R.J.4    Vaillancourt, C.5
  • 129
    • 84864280209 scopus 로고    scopus 로고
    • Serotonin activates angiogenic phosphorylation signaling in human endothelial cells
    • Zamani A, Qu Z. Serotonin activates angiogenic phosphorylation signaling in human endothelial cells. FEBS Lett. 2012;586:2360-5
    • (2012) FEBS Lett , vol.586 , pp. 2360-2365
    • Zamani, A.1    Qu, Z.2
  • 130
    • 84918822217 scopus 로고    scopus 로고
    • Immunohistochemical characterization of the chemosensory pulmonary neuroepithelial bodies in the naked mole-rat reveals a unique adaptive phenotype
    • Pan J, Park TJ, Cutz E, Yeger H. Immunohistochemical characterization of the chemosensory pulmonary neuroepithelial bodies in the naked mole-rat reveals a unique adaptive phenotype. PLoS One. 2014;9:e112623
    • (2014) PLoS One , vol.9
    • Pan, J.1    Park, T.J.2    Cutz, E.3    Yeger, H.4
  • 131
    • 84940104767 scopus 로고    scopus 로고
    • Augmented 5-HT Secretion in Pulmonary Neuroepithelial Bodies from PHD1 Null Mice
    • Livermore S, Pan J, Yeger H, Ratcliffe P, Bishop T, Cutz E. Augmented 5-HT Secretion in Pulmonary Neuroepithelial Bodies from PHD1 Null Mice. Adv Exp Med Biol. 2015;860:309-13
    • (2015) Adv Exp Med Biol , vol.860 , pp. 309-313
    • Livermore, S.1    Pan, J.2    Yeger, H.3    Ratcliffe, P.4    Bishop, T.5    Cutz, E.6
  • 132
    • 84922235471 scopus 로고    scopus 로고
    • Carbonic anhydrase II mediates malignant behavior of pulmonary neuroendocrine tumors
    • Zhou Y, Mokhtari RB, Pan J, Cutz E, Yeger H. Carbonic anhydrase II mediates malignant behavior of pulmonary neuroendocrine tumors. Am J Respir Cell Mol Biol. 2015;52:183-92
    • (2015) Am J Respir Cell Mol Biol , vol.52 , pp. 183-192
    • Zhou, Y.1    Mokhtari, R.B.2    Pan, J.3    Cutz, E.4    Yeger, H.5
  • 133
    • 0036521963 scopus 로고    scopus 로고
    • Hypoxia-induced secretion of serotonin from intact pulmonary neuroepithelial bodies in neonatal rabbit
    • Fu XW, Nurse CA, Wong V, Cutz E. Hypoxia-induced secretion of serotonin from intact pulmonary neuroepithelial bodies in neonatal rabbit. J Physiol. 2002;539:503-10
    • (2002) J Physiol , vol.539 , pp. 503-510
    • Fu, X.W.1    Nurse, C.A.2    Wong, V.3    Cutz, E.4
  • 134
    • 77953964266 scopus 로고    scopus 로고
    • The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment
    • Svejda B, Kidd M, Giovinazzo F, Eltawil K, Gustafsson BI, Pfragner R, Modlin IM. The 5-HT(2B) receptor plays a key regulatory role in both neuroendocrine tumor cell proliferation and the modulation of the fibroblast component of the neoplastic microenvironment. Cancer. 2010;116:2902-12
    • (2010) Cancer , vol.116 , pp. 2902-2912
    • Svejda, B.1    Kidd, M.2    Giovinazzo, F.3    Eltawil, K.4    Gustafsson, B.I.5    Pfragner, R.6    Modlin, I.M.7
  • 135
    • 2542601328 scopus 로고    scopus 로고
    • Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target
    • Potter C, Harris AL. Hypoxia inducible carbonic anhydrase IX, marker of tumour hypoxia, survival pathway and therapy target. Cell Cycle. 2004;3:164-7
    • (2004) Cell Cycle , vol.3 , pp. 164-167
    • Potter, C.1    Harris, A.L.2
  • 136
    • 0035000088 scopus 로고    scopus 로고
    • Serotonin-elicited inhibition of Cl(-) secretion in the rabbit conjunctival epithelium
    • Alvarez LJ, Turner HC, Zamudio AC, Candia OA. Serotonin-elicited inhibition of Cl(-) secretion in the rabbit conjunctival epithelium. Am J Physiol Cell Physiol. 2001;280:C581-92
    • (2001) Am J Physiol Cell Physiol , vol.280 , pp. C581-C592
    • Alvarez, L.J.1    Turner, H.C.2    Zamudio, A.C.3    Candia, O.A.4
  • 137
    • 48549088789 scopus 로고    scopus 로고
    • Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells
    • Mastrangelo L, Cassidy A, Mulholland F, Wang W, Bao Y. Serotonin receptors, novel targets of sulforaphane identified by proteomic analysis in Caco-2 cells. Cancer Res. 2008;68:5487-91
    • (2008) Cancer Res , vol.68 , pp. 5487-5491
    • Mastrangelo, L.1    Cassidy, A.2    Mulholland, F.3    Wang, W.4    Bao, Y.5
  • 138
    • 0029147358 scopus 로고
    • Carcinoid heart disease. Correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography
    • Robiolio PA, Rigolin VH, Wilson JS, Harrison JK, Sanders LL, Bashore TM, Feldman JM. Carcinoid heart disease. Correlation of high serotonin levels with valvular abnormalities detected by cardiac catheterization and echocardiography. Circulation. 1995;92:790-5
    • (1995) Circulation , vol.92 , pp. 790-795
    • Robiolio, P.A.1    Rigolin, V.H.2    Wilson, J.S.3    Harrison, J.K.4    Sanders, L.L.5    Bashore, T.M.6    Feldman, J.M.7
  • 139
    • 84938275519 scopus 로고    scopus 로고
    • Phase II trial of gefitinib in combination with bevacizumab as first-line therapy for advanced non-small cell lung cancer with activating EGFR gene mutations: the Okayama Lung Cancer Study Group Trial 1001
    • Ichihara E, Hotta K, Nogami N, Kuyama S, Kishino D, Fujii M, Kozuki T, Tabata M, Harada D, Chikamori K, Aoe K, Ueoka H, Hosokawa S, et al. Phase II trial of gefitinib in combination with bevacizumab as first-line therapy for advanced non-small cell lung cancer with activating EGFR gene mutations: the Okayama Lung Cancer Study Group Trial 1001. J Thorac Oncol. 2015;10:486-91
    • (2015) J Thorac Oncol , vol.10 , pp. 486-491
    • Ichihara, E.1    Hotta, K.2    Nogami, N.3    Kuyama, S.4    Kishino, D.5    Fujii, M.6    Kozuki, T.7    Tabata, M.8    Harada, D.9    Chikamori, K.10    Aoe, K.11    Ueoka, H.12    Hosokawa, S.13
  • 140
    • 77955049754 scopus 로고    scopus 로고
    • The insulinlike growth factor-I receptor inhibitor figitumumab (CP-751, 871) in combination with docetaxel in patients with advanced solid tumours: results of a phase Ib doseescalation, open-label study
    • Molife LR, Fong PC, Paccagnella L, Reid AH, Shaw HM, Vidal L, Arkenau HT, Karavasilis V, Yap TA, Olmos D, Spicer J, Postel-Vinay S, Yin D, et al. The insulinlike growth factor-I receptor inhibitor figitumumab (CP-751, 871) in combination with docetaxel in patients with advanced solid tumours: results of a phase Ib doseescalation, open-label study. Br J Cancer. 2010;103:332-9
    • (2010) Br J Cancer , vol.103 , pp. 332-339
    • Molife, L.R.1    Fong, P.C.2    Paccagnella, L.3    Reid, A.H.4    Shaw, H.M.5    Vidal, L.6    Arkenau, H.T.7    Karavasilis, V.8    Yap, T.A.9    Olmos, D.10    Spicer, J.11    Postel-Vinay, S.12    Yin, D.13
  • 142
    • 84929083437 scopus 로고    scopus 로고
    • A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: the GAMMA trial
    • Fuchs CS, Azevedo S, Okusaka T, Van Laethem JL, Lipton LR, Riess H, Szczylik C, Moore MJ, Peeters M, Bodoky G, Ikeda M, Melichar B, Nemecek R, et al. A phase 3 randomized, double-blind, placebo-controlled trial of ganitumab or placebo in combination with gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas: the GAMMA trial. Ann Oncol. 2015;26:921-7
    • (2015) Ann Oncol , vol.26 , pp. 921-927
    • Fuchs, C.S.1    Azevedo, S.2    Okusaka, T.3    Van Laethem, J.L.4    Lipton, L.R.5    Riess, H.6    Szczylik, C.7    Moore, M.J.8    Peeters, M.9    Bodoky, G.10    Ikeda, M.11    Melichar, B.12    Nemecek, R.13
  • 145
    • 0033588842 scopus 로고    scopus 로고
    • New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF
    • Holash J, Wiegand SJ, Yancopoulos GD. New model of tumor angiogenesis: dynamic balance between vessel regression and growth mediated by angiopoietins and VEGF. Oncogene. 1999;18:5356-62
    • (1999) Oncogene , vol.18 , pp. 5356-5362
    • Holash, J.1    Wiegand, S.J.2    Yancopoulos, G.D.3
  • 146
    • 0037699954 scopus 로고    scopus 로고
    • The biology of VEGF and its receptors
    • Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med. 2003;9:669-76
    • (2003) Nat Med , vol.9 , pp. 669-676
    • Ferrara, N.1    Gerber, H.P.2    LeCouter, J.3
  • 147
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol. 2002;20:4368-80
    • (2002) J Clin Oncol , vol.20 , pp. 4368-4380
    • Dvorak, H.F.1
  • 148
    • 84855343985 scopus 로고    scopus 로고
    • Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells
    • Cao X, Geradts J, Dewhirst MW, Lo HW. Upregulation of VEGF-A and CD24 gene expression by the tGLI1 transcription factor contributes to the aggressive behavior of breast cancer cells. Oncogene. 2012;31:104-15
    • (2012) Oncogene , vol.31 , pp. 104-115
    • Cao, X.1    Geradts, J.2    Dewhirst, M.W.3    Lo, H.W.4
  • 150
    • 84963502578 scopus 로고    scopus 로고
    • Integrin alpha4 Induces Lymphangiogenesis and Metastasis via Upregulation of VEGF-C in Human Colon Cancer
    • Lv XH, Liu BQ, Li XM, Wang XC, Li XL, Ahmed N, Zhang YF. Integrin alpha4 Induces Lymphangiogenesis and Metastasis via Upregulation of VEGF-C in Human Colon Cancer. Anat Rec (Hoboken). 2016;299:741-7
    • (2016) Anat Rec (Hoboken) , vol.299 , pp. 741-747
    • Lv, X.H.1    Liu, B.Q.2    Li, X.M.3    Wang, X.C.4    Li, X.L.5    Ahmed, N.6    Zhang, Y.F.7
  • 151
    • 78650182530 scopus 로고    scopus 로고
    • UVB-irradiation regulates VLA-4-mediated melanoma cell adhesion to endothelial VCAM-1 under flow conditions
    • Wang L, Shirure VS, Burdick MM, Wu S. UVB-irradiation regulates VLA-4-mediated melanoma cell adhesion to endothelial VCAM-1 under flow conditions. Mol Carcinog. 2011;50:58-65
    • (2011) Mol Carcinog , vol.50 , pp. 58-65
    • Wang, L.1    Shirure, V.S.2    Burdick, M.M.3    Wu, S.4
  • 152
    • 0034650802 scopus 로고    scopus 로고
    • Regulation of angiogenesis via vascular endothelial growth factor receptors
    • Veikkola T, Karkkainen M, Claesson-Welsh L, Alitalo K. Regulation of angiogenesis via vascular endothelial growth factor receptors. Cancer Res. 2000;60:203-12
    • (2000) Cancer Res , vol.60 , pp. 203-212
    • Veikkola, T.1    Karkkainen, M.2    Claesson-Welsh, L.3    Alitalo, K.4
  • 153
    • 84905716786 scopus 로고    scopus 로고
    • Metronomic chemotherapy
    • Maiti R. Metronomic chemotherapy. J Pharmacol Pharmacother. 2014;5:186-92
    • (2014) J Pharmacol Pharmacother , vol.5 , pp. 186-192
    • Maiti, R.1
  • 154
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer. 2004;4:423-36
    • (2004) Nat Rev Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 155
    • 0038118495 scopus 로고    scopus 로고
    • VEGF receptor expression and signaling in human bladder tumors
    • Wu W, Shu X, Hovsepyan H, Mosteller RD, Broek D. VEGF receptor expression and signaling in human bladder tumors. Oncogene. 2003;22:3361-70
    • (2003) Oncogene , vol.22 , pp. 3361-3370
    • Wu, W.1    Shu, X.2    Hovsepyan, H.3    Mosteller, R.D.4    Broek, D.5
  • 156
    • 84924259375 scopus 로고    scopus 로고
    • Refractory angiosarcoma of the breast with VEGFR2 upregulation successfully treated with sunitinib
    • Silva E, Gatalica Z, Vranic S, Basu G, Reddy SK, Voss A. Refractory angiosarcoma of the breast with VEGFR2 upregulation successfully treated with sunitinib. Breast J. 2015;21:205-7
    • (2015) Breast J , vol.21 , pp. 205-207
    • Silva, E.1    Gatalica, Z.2    Vranic, S.3    Basu, G.4    Reddy, S.K.5    Voss, A.6
  • 157
    • 80054888464 scopus 로고    scopus 로고
    • Itraconazole inhibits angiogenesis and tumor growth in nonsmall cell lung cancer
    • Aftab BT, Dobromilskaya I, Liu JO, Rudin CM. Itraconazole inhibits angiogenesis and tumor growth in nonsmall cell lung cancer. Cancer Res. 2011;71:6764-72
    • (2011) Cancer Res , vol.71 , pp. 6764-6772
    • Aftab, B.T.1    Dobromilskaya, I.2    Liu, J.O.3    Rudin, C.M.4
  • 159
    • 84937131279 scopus 로고    scopus 로고
    • Combination Chemotherapy with Itraconazole for Treating Metastatic Pancreatic Cancer in the Second-line or Additional Setting
    • Tsubamoto H, Sonoda T, Ikuta S, Tani S, Inoue K, Yamanaka N. Combination Chemotherapy with Itraconazole for Treating Metastatic Pancreatic Cancer in the Second-line or Additional Setting. Anticancer Res. 2015;35:4191-6
    • (2015) Anticancer Res , vol.35 , pp. 4191-4196
    • Tsubamoto, H.1    Sonoda, T.2    Ikuta, S.3    Tani, S.4    Inoue, K.5    Yamanaka, N.6
  • 161
    • 84908127948 scopus 로고    scopus 로고
    • Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study
    • Seto T, Kato T, Nishio M, Goto K, Atagi S, Hosomi Y, Yamamoto N, Hida T, Maemondo M, Nakagawa K, Nagase S, Okamoto I, Yamanaka T, et al. Erlotinib alone or with bevacizumab as first-line therapy in patients with advanced non-squamous non-small-cell lung cancer harbouring EGFR mutations (JO25567): an open-label, randomised, multicentre, phase 2 study. Lancet Oncol. 2014;15:1236-44
    • (2014) Lancet Oncol , vol.15 , pp. 1236-1244
    • Seto, T.1    Kato, T.2    Nishio, M.3    Goto, K.4    Atagi, S.5    Hosomi, Y.6    Yamamoto, N.7    Hida, T.8    Maemondo, M.9    Nakagawa, K.10    Nagase, S.11    Okamoto, I.12    Yamanaka, T.13
  • 162
    • 84926166792 scopus 로고    scopus 로고
    • Metabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentiality
    • McIntyre A, Harris AL. Metabolic and hypoxic adaptation to anti-angiogenic therapy: a target for induced essentiality. EMBO Mol Med. 2015;74:368-79
    • (2015) EMBO Mol Med , vol.74 , pp. 368-379
    • McIntyre, A.1    Harris, A.L.2
  • 163
    • 84872425530 scopus 로고    scopus 로고
    • HIF-1alpha activation mediates resistance to antiangiogenic therapy in neuroblastoma xenografts
    • Hartwich J, Orr WS, Ng CY, Spence Y, Morton C, Davidoff AM. HIF-1alpha activation mediates resistance to antiangiogenic therapy in neuroblastoma xenografts. J Pediatr Surg. 2013;48:39-46
    • (2013) J Pediatr Surg , vol.48 , pp. 39-46
    • Hartwich, J.1    Orr, W.S.2    Ng, C.Y.3    Spence, Y.4    Morton, C.5    Davidoff, A.M.6
  • 164
    • 31144458716 scopus 로고    scopus 로고
    • How Avastin potentiates chemotherapeutic drugs: action and reaction in antiangiogenic therapy
    • Blagosklonny MV. How Avastin potentiates chemotherapeutic drugs: action and reaction in antiangiogenic therapy. Cancer Biol Ther. 2005;4:1307-10
    • (2005) Cancer Biol Ther , vol.4 , pp. 1307-1310
    • Blagosklonny, M.V.1
  • 165
    • 33746886979 scopus 로고    scopus 로고
    • Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy
    • Fulda S, Debatin KM. Extrinsic versus intrinsic apoptosis pathways in anticancer chemotherapy. Oncogene. 2006;25:4798-811
    • (2006) Oncogene , vol.25 , pp. 4798-4811
    • Fulda, S.1    Debatin, K.M.2
  • 166
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: a review of programmed cell death
    • Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35:495-516
    • (2007) Toxicol Pathol , vol.35 , pp. 495-516
    • Elmore, S.1
  • 167
    • 0030656234 scopus 로고    scopus 로고
    • Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells
    • Friesen C, Fulda S, Debatin KM. Deficient activation of the CD95 (APO-1/Fas) system in drug-resistant cells. Leukemia. 1997;11:1833-41
    • (1997) Leukemia , vol.11 , pp. 1833-1841
    • Friesen, C.1    Fulda, S.2    Debatin, K.M.3
  • 168
    • 12844271542 scopus 로고    scopus 로고
    • Unraveling biologic therapy for Bcl-2-expressing malignancies
    • Cotter FE. Unraveling biologic therapy for Bcl-2-expressing malignancies. Semin Oncol. 2004;31:18-21
    • (2004) Semin Oncol , vol.31 , pp. 18-21
    • Cotter, F.E.1
  • 170
    • 9344259734 scopus 로고    scopus 로고
    • Antitumor efficacy of oblimersen Bcl-2 antisense oligonucleotide alone and in combination with vinorelbine in xenograft models of human non-small cell lung cancer
    • Hu Y, Bebb G, Tan S, Ng R, Yan H, Sartor JR, Mayer LD, Bally MB. Antitumor efficacy of oblimersen Bcl-2 antisense oligonucleotide alone and in combination with vinorelbine in xenograft models of human non-small cell lung cancer. Clin Cancer Res. 2004;10:7662-70
    • (2004) Clin Cancer Res , vol.10 , pp. 7662-7670
    • Hu, Y.1    Bebb, G.2    Tan, S.3    Ng, R.4    Yan, H.5    Sartor, J.R.6    Mayer, L.D.7    Bally, M.B.8
  • 171
    • 0027757091 scopus 로고
    • Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification
    • Castle VP, Heidelberger KP, Bromberg J, Ou X, Dole M, Nunez G. Expression of the apoptosis-suppressing protein bcl-2, in neuroblastoma is associated with unfavorable histology and N-myc amplification. Am J Pathol. 1993;143:1543-50
    • (1993) Am J Pathol , vol.143 , pp. 1543-1550
    • Castle, V.P.1    Heidelberger, K.P.2    Bromberg, J.3    Ou, X.4    Dole, M.5    Nunez, G.6
  • 172
    • 0029077281 scopus 로고
    • Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo
    • Raffo AJ, Perlman H, Chen MW, Day ML, Streitman JS, Buttyan R. Overexpression of bcl-2 protects prostate cancer cells from apoptosis in vitro and confers resistance to androgen depletion in vivo. Cancer Res. 1995;55:4438-45
    • (1995) Cancer Res , vol.55 , pp. 4438-4445
    • Raffo, A.J.1    Perlman, H.2    Chen, M.W.3    Day, M.L.4    Streitman, J.S.5    Buttyan, R.6
  • 173
    • 85020192703 scopus 로고    scopus 로고
    • Efficacy and safety of nitroglycerin combined with chemotherapy in the elderly patients with advanced non-small cell lung cancer complicated with coronary heart disease
    • Zhen H, Sun Q, Zhang M, Wu G, Chen X, Chen C, Li R, Wang L, Guo H, Wang Q, Wu Y, Wu G. Efficacy and safety of nitroglycerin combined with chemotherapy in the elderly patients with advanced non-small cell lung cancer complicated with coronary heart disease. J Clin Exp Med. 2016;9:1-7
    • (2016) J Clin Exp Med , vol.9 , pp. 1-7
    • Zhen, H.1    Sun, Q.2    Zhang, M.3    Wu, G.4    Chen, X.5    Chen, C.6    Li, R.7    Wang, L.8    Guo, H.9    Wang, Q.10    Wu, Y.11    Wu, G.12
  • 174
    • 77349118467 scopus 로고    scopus 로고
    • Nitroglycerin enhances vascular blood flow and drug delivery in hypoxic tumor tissues: analogy between angina pectoris and solid tumors and enhancement of the EPR effect
    • Maeda H. Nitroglycerin enhances vascular blood flow and drug delivery in hypoxic tumor tissues: analogy between angina pectoris and solid tumors and enhancement of the EPR effect. J Control Release. 2010;142:296-8
    • (2010) J Control Release , vol.142 , pp. 296-298
    • Maeda, H.1
  • 176
    • 0026675249 scopus 로고
    • New macrolide antibiotics: clarithromycin and azithromycin
    • Stott GA. New macrolide antibiotics: clarithromycin and azithromycin. Am Fam Physician. 1992;46:863-9
    • (1992) Am Fam Physician , vol.46 , pp. 863-869
    • Stott, G.A.1
  • 177
    • 84875985028 scopus 로고    scopus 로고
    • Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells
    • Moriya S, Che XF, Komatsu S, Abe A, Kawaguchi T, Gotoh A, Inazu M, Tomoda A, Miyazawa K. Macrolide antibiotics block autophagy flux and sensitize to bortezomib via endoplasmic reticulum stress-mediated CHOP induction in myeloma cells. Int J Oncol. 2013;42:1541-50
    • (2013) Int J Oncol , vol.42 , pp. 1541-1550
    • Moriya, S.1    Che, X.F.2    Komatsu, S.3    Abe, A.4    Kawaguchi, T.5    Gotoh, A.6    Inazu, M.7    Tomoda, A.8    Miyazawa, K.9
  • 178
    • 84858683912 scopus 로고    scopus 로고
    • Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells
    • Komatsu S, Miyazawa K, Moriya S, Takase A, Naito M, Inazu M, Kohno N, Itoh M, Tomoda A. Clarithromycin enhances bortezomib-induced cytotoxicity via endoplasmic reticulum stress-mediated CHOP (GADD153) induction and autophagy in breast cancer cells. Int J Oncol. 2012;40:1029-39
    • (2012) Int J Oncol , vol.40 , pp. 1029-1039
    • Komatsu, S.1    Miyazawa, K.2    Moriya, S.3    Takase, A.4    Naito, M.5    Inazu, M.6    Kohno, N.7    Itoh, M.8    Tomoda, A.9
  • 179
    • 84880512254 scopus 로고    scopus 로고
    • Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells
    • Komatsu S, Moriya S, Che XF, Yokoyama T, Kohno N, Miyazawa K. Combined treatment with SAHA, bortezomib, and clarithromycin for concomitant targeting of aggresome formation and intracellular proteolytic pathways enhances ER stress-mediated cell death in breast cancer cells. Biochem Biophys Res Commun. 2013;437:41-7
    • (2013) Biochem Biophys Res Commun , vol.437 , pp. 41-47
    • Komatsu, S.1    Moriya, S.2    Che, X.F.3    Yokoyama, T.4    Kohno, N.5    Miyazawa, K.6
  • 180
    • 84942990748 scopus 로고    scopus 로고
    • A phase II trial of tamoxifen and bortezomib in patients with recurrent malignant gliomas
    • Odia Y, Kreisl TN, Aregawi D, Innis EK, Fine HA. A phase II trial of tamoxifen and bortezomib in patients with recurrent malignant gliomas. J Neurooncol. 2015;125:191-5
    • (2015) J Neurooncol , vol.125 , pp. 191-195
    • Odia, Y.1    Kreisl, T.N.2    Aregawi, D.3    Innis, E.K.4    Fine, H.A.5
  • 182
    • 84937520417 scopus 로고    scopus 로고
    • Oral Debio1143 (AT406), an antagonist of inhibitor of apoptosis proteins, combined with daunorubicin and cytarabine in patients with poor-risk acute myeloid leukemia-results of a phase I dose-escalation study
    • DiPersio JF, Erba HP, Larson RA, Luger SM, Tallman MS, Brill JM, Vuagniaux G, Rouits E, Sorensen JM, Zanna C. Oral Debio1143 (AT406), an antagonist of inhibitor of apoptosis proteins, combined with daunorubicin and cytarabine in patients with poor-risk acute myeloid leukemia-results of a phase I dose-escalation study. Clin Lymphoma Myeloma Leuk. 2015;15:443-9
    • (2015) Clin Lymphoma Myeloma Leuk , vol.15 , pp. 443-449
    • DiPersio, J.F.1    Erba, H.P.2    Larson, R.A.3    Luger, S.M.4    Tallman, M.S.5    Brill, J.M.6    Vuagniaux, G.7    Rouits, E.8    Sorensen, J.M.9    Zanna, C.10
  • 184
    • 33845762340 scopus 로고    scopus 로고
    • Multi-target therapeutics: when the whole is greater than the sum of the parts
    • Zimmermann GR, Lehar J, Keith CT. Multi-target therapeutics: when the whole is greater than the sum of the parts. Drug Discov Today. 2007;12:34-42
    • (2007) Drug Discov Today , vol.12 , pp. 34-42
    • Zimmermann, G.R.1    Lehar, J.2    Keith, C.T.3
  • 188
    • 84981717364 scopus 로고    scopus 로고
    • Overexpression of VEGF-C correlates with a poor prognosis in esophageal cancer patients
    • Xia H, Shen J, Chen S, Huang H, Xu Y, Ma H. Overexpression of VEGF-C correlates with a poor prognosis in esophageal cancer patients. Cancer Biomark. 2016;17:165-70
    • (2016) Cancer Biomark , vol.17 , pp. 165-170
    • Xia, H.1    Shen, J.2    Chen, S.3    Huang, H.4    Xu, Y.5    Ma, H.6
  • 190
    • 84865480687 scopus 로고    scopus 로고
    • Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy
    • Parhi P, Mohanty C, Sahoo SK. Nanotechnology-based combinational drug delivery: an emerging approach for cancer therapy. Drug Discov Today. 2012;17:1044-52
    • (2012) Drug Discov Today , vol.17 , pp. 1044-1052
    • Parhi, P.1    Mohanty, C.2    Sahoo, S.K.3
  • 191
    • 3242803674 scopus 로고    scopus 로고
    • Benefits of adding a drug to a single-agent or a 2-agent chemotherapy regimen in advanced non-small-cell lung cancer: a meta-analysis
    • Delbaldo C, Michiels S, Syz N, Soria JC, Le Chevalier T, Pignon JP. Benefits of adding a drug to a single-agent or a 2-agent chemotherapy regimen in advanced non-small-cell lung cancer: a meta-analysis. JAMA. 2004;292:470-84
    • (2004) JAMA , vol.292 , pp. 470-484
    • Delbaldo, C.1    Michiels, S.2    Syz, N.3    Soria, J.C.4    Le Chevalier, T.5    Pignon, J.P.6
  • 192
    • 84977653541 scopus 로고    scopus 로고
    • Combination therapy targeting both cancer stem-like cells and bulk tumor cells for improved efficacy of breast cancer treatment
    • Wang T, Narayanaswamy R, Ren H, Torchilin VP. Combination therapy targeting both cancer stem-like cells and bulk tumor cells for improved efficacy of breast cancer treatment. Cancer Biol Ther. 2016;17:698-707
    • (2016) Cancer Biol Ther , vol.17 , pp. 698-707
    • Wang, T.1    Narayanaswamy, R.2    Ren, H.3    Torchilin, V.P.4
  • 194
    • 45549093647 scopus 로고    scopus 로고
    • Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis
    • Eyler CE, Rich JN. Survival of the fittest: cancer stem cells in therapeutic resistance and angiogenesis. J Clin Oncol. 2008;26:2839-45
    • (2008) J Clin Oncol , vol.26 , pp. 2839-2845
    • Eyler, C.E.1    Rich, J.N.2
  • 197
    • 77955747734 scopus 로고    scopus 로고
    • A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression
    • Geretti E, van Meeteren LA, Shimizu A, Dudley AC, Claesson-Welsh L, Klagsbrun M. A mutated soluble neuropilin-2 B domain antagonizes vascular endothelial growth factor bioactivity and inhibits tumor progression. Mol Cancer Res. 2010;8:1063-73
    • (2010) Mol Cancer Res , vol.8 , pp. 1063-1073
    • Geretti, E.1    van Meeteren, L.A.2    Shimizu, A.3    Dudley, A.C.4    Claesson-Welsh, L.5    Klagsbrun, M.6
  • 198
    • 0035422178 scopus 로고    scopus 로고
    • Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells
    • Bachelder RE, Crago A, Chung J, Wendt MA, Shaw LM, Robinson G, Mercurio AM. Vascular endothelial growth factor is an autocrine survival factor for neuropilin-expressing breast carcinoma cells. Cancer Res. 2001;61:5736-40
    • (2001) Cancer Res , vol.61 , pp. 5736-5740
    • Bachelder, R.E.1    Crago, A.2    Chung, J.3    Wendt, M.A.4    Shaw, L.M.5    Robinson, G.6    Mercurio, A.M.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.