메뉴 건너뛰기




Volumn 31, Issue , 2016, Pages 119-125

Lansoprazole and carbonic anhydrase IX inhibitors sinergize against human melanoma cells

Author keywords

Anti acid drugs; carbonic anhydrase IX inhibitors; lansoprazole; tumor acidity

Indexed keywords

CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; FC 9 399A; LANSOPRAZOLE; SULFAMATE S4; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CA9 PROTEIN, HUMAN; TUMOR ANTIGEN;

EID: 84965076162     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.1080/14756366.2016.1177525     Document Type: Article
Times cited : (57)

References (64)
  • 1
    • 0032904346 scopus 로고    scopus 로고
    • . Enhancement of chemotherapy by manipulation of tumour pH
    • Raghunand N, He X, van Sluis R, et al. Enhancement of chemotherapy by manipulation of tumour pH. Br J Cancer 1999;80:1005–11
    • (1999) Br J Cancer , vol.80 , pp. 1005-1011
    • Raghunand, N.1    He, X.2    van Sluis, R.3
  • 2
    • 0345389967 scopus 로고    scopus 로고
    • pH and drug resistance. II. Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs
    • Raghunand N, Martinez-Zaguilan R, Wright SH, Gillies RJ., pH and drug resistance. II. Turnover of acidic vesicles and resistance to weakly basic chemotherapeutic drugs. Biochem Pharmacol 1999;57:1047–58
    • (1999) Biochem Pharmacol , vol.57 , pp. 1047-1058
    • Raghunand, N.1    Martinez-Zaguilan, R.2    Wright, S.H.3    Gillies, R.J.4
  • 3
    • 0032543207 scopus 로고    scopus 로고
    • Defective acidification in human breast tumor cells and implications for chemotherapy
    • Altan N, Chen Y, Schindler M, Sanford SM., Defective acidification in human breast tumor cells and implications for chemotherapy. J Exp Med 1998;187:1583–98
    • (1998) J Exp Med , vol.187 , pp. 1583-1598
    • Altan, N.1    Chen, Y.2    Schindler, M.3    Sanford, S.M.4
  • 4
    • 0033043451 scopus 로고    scopus 로고
    • Mechanisms of altered sequestration and efflux of chemotherapeutic drugs by multidrug resistant cells
    • Ouar Z, Lacave R, Bens M, Vandewalle A., Mechanisms of altered sequestration and efflux of chemotherapeutic drugs by multidrug resistant cells. Cell Biol Toxicol 1999;15:91–100
    • (1999) Cell Biol Toxicol , vol.15 , pp. 91-100
    • Ouar, Z.1    Lacave, R.2    Bens, M.3    Vandewalle, A.4
  • 5
    • 0034104453 scopus 로고    scopus 로고
    • Resistance mechanisms associated with altered intracellular distribution of anticancer agents
    • Larsen AK, Escargueil AE, Skladanowski A., Resistance mechanisms associated with altered intracellular distribution of anticancer agents. Pharmacol Ther 2000;85:217–29
    • (2000) Pharmacol Ther , vol.85 , pp. 217-229
    • Larsen, A.K.1    Escargueil, A.E.2    Skladanowski, A.3
  • 6
    • 84895552868 scopus 로고    scopus 로고
    • Exosome release and low pH belong to a framework of resistance of human melanoma cells to cisplatin
    • Federici C, Petrucci F, Caimi S, et al. Exosome release and low pH belong to a framework of resistance of human melanoma cells to cisplatin. PLoS One 2014;9:e88193
    • (2014) PLoS One , vol.9 , pp. e88193
    • Federici, C.1    Petrucci, F.2    Caimi, S.3
  • 7
    • 20244388917 scopus 로고    scopus 로고
    • Cellular pH regulators: potentially promising molecular targets for cancer chemotherapy
    • Izumi H, Torigoe T, Ishiguchu H, et al. Cellular pH regulators:potentially promising molecular targets for cancer chemotherapy. Cancer Treat Rev 2003;29:541–9
    • (2003) Cancer Treat Rev , vol.29 , pp. 541-549
    • Izumi, H.1    Torigoe, T.2    Ishiguchu, H.3
  • 8
    • 84946795146 scopus 로고    scopus 로고
    • Microenvironment acidity as a major determinant of tumor chemoresistance: proton pump inhibitors (PPIs) as a novel therapeutic approach
    • Taylor S, Spugnini EP, Assaraf YG, et al. Microenvironment acidity as a major determinant of tumor chemoresistance:proton pump inhibitors (PPIs) as a novel therapeutic approach. Drug Resist Updat 2015;23:69–78
    • (2015) Drug Resist Updat , vol.23 , pp. 69-78
    • Taylor, S.1    Spugnini, E.P.2    Assaraf, Y.G.3
  • 10
    • 33847377377 scopus 로고    scopus 로고
    • Tumor acidity, chemoresistance and proton pump inhibitors
    • De Milito A, Fais S., Tumor acidity, chemoresistance and proton pump inhibitors. Future Oncol 2005;1:779–86
    • (2005) Future Oncol , vol.1 , pp. 779-786
    • De Milito, A.1    Fais, S.2
  • 11
    • 0036481562 scopus 로고    scopus 로고
    • . The vacuolar (H+)-ATPases-nature's most versatile proton pumps
    • Nishi T, Forgac M. The vacuolar (H+)-ATPases-nature's most versatile proton pumps. Nat Rev Mol Cell Biol 2002;3:94–103
    • (2002) Nat Rev Mol Cell Biol , vol.3 , pp. 94-103
    • Nishi, T.1    Forgac, M.2
  • 12
    • 0027373117 scopus 로고
    • Vacuolar-type H(þ)-ATPases are functionally expressed in plasma membranes of human tumor cells
    • Martinez-Zaguilan R, Lynch RM, Martinez GM, Gillies RJ., Vacuolar-type H(þ)-ATPases are functionally expressed in plasma membranes of human tumor cells. Am J Physiol 1993;265:C1015–29
    • (1993) Am J Physiol , vol.265 , pp. C1015-C1029
    • Martinez-Zaguilan, R.1    Lynch, R.M.2    Martinez, G.M.3    Gillies, R.J.4
  • 13
    • 2442560191 scopus 로고    scopus 로고
    • Vacuolar H-ATPase in human breast cancer cells with distinct metastatic potential: distribution and functional activity
    • Sennoune SR, Bakunts K, Martinez GM, et al. Vacuolar H-ATPase in human breast cancer cells with distinct metastatic potential:distribution and functional activity. Am J Physiol Cell Physiol 2004;286:89–98
    • (2004) Am J Physiol Cell Physiol , vol.286 , pp. 89-98
    • Sennoune, S.R.1    Bakunts, K.2    Martinez, G.M.3
  • 15
    • 0027430285 scopus 로고
    • . Evidence for a common binding site for omeprazole and N-ethylmaleimide in subunit A of chromaffin granule vacuolar-type H(+)-ATPase
    • Moriyama Y, Patel V, Ueda I, Futai M. Evidence for a common binding site for omeprazole and N-ethylmaleimide in subunit A of chromaffin granule vacuolar-type H(+)-ATPase. Biochem Biophys Res Commun 1993;196:699–706
    • (1993) Biochem Biophys Res Commun , vol.196 , pp. 699-706
    • Moriyama, Y.1    Patel, V.2    Ueda, I.3    Futai, M.4
  • 16
    • 0034005344 scopus 로고    scopus 로고
    • The proton-pump inhibitors: similarities and differences
    • Horn J., The proton-pump inhibitors:similarities and differences. Clin Ther 2000;22:266–80
    • (2000) Clin Ther , vol.22 , pp. 266-280
    • Horn, J.1
  • 18
    • 0032765259 scopus 로고    scopus 로고
    • +-ATPase and gastric mucosa carbonic anhydrase enzyme in humans (in vitro and in vivo experiments)
    • +-ATPase and gastric mucosa carbonic anhydrase enzyme in humans (in vitro and in vivo experiments). J Pharmacol Exp Ther 1999;290:530–4
    • (1999) J Pharmacol Exp Ther , vol.290 , pp. 530-534
    • Puscas, I.1    Coltau, M.2    Baican, M.3    Domuta, G.4
  • 19
    • 0027207229 scopus 로고
    • . Effect of omeprazole, an inhibitor of H+, K(+)-ATPase, on bone resorption in humans
    • Mizunashi K, Furukawa Y, Katano K, Abe K. Effect of omeprazole, an inhibitor of H+, K(+)-ATPase, on bone resorption in humans. Calcif Tissue Int 1993;53:21–5
    • (1993) Calcif Tissue Int , vol.53 , pp. 21-25
    • Mizunashi, K.1    Furukawa, Y.2    Katano, K.3    Abe, K.4
  • 20
    • 0037313425 scopus 로고    scopus 로고
    • A proton-pump inhibitor expedition: the case histories of omeprazole and esomeprazole
    • Olbe L, Carlsson E, Lindberg P., A proton-pump inhibitor expedition:the case histories of omeprazole and esomeprazole. Nat Rev Drug Discov 2003;2:132–9
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 132-139
    • Olbe, L.1    Carlsson, E.2    Lindberg, P.3
  • 21
    • 77950501364 scopus 로고    scopus 로고
    • Proton pump inhibitor-induced tumour cell death by inhibition of a detoxification mechanism
    • Fais S., Proton pump inhibitor-induced tumour cell death by inhibition of a detoxification mechanism. J Intern Med 2010;267:515–25
    • (2010) J Intern Med , vol.267 , pp. 515-525
    • Fais, S.1
  • 22
    • 9744260934 scopus 로고    scopus 로고
    • Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs
    • Luciani F, Spada M, De Milito A, et al. Effect of proton pump inhibitor pretreatment on resistance of solid tumors to cytotoxic drugs. J Natl Cancer Inst 2004;96:1702–13
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1702-1713
    • Luciani, F.1    Spada, M.2    De Milito, A.3
  • 23
    • 69249211007 scopus 로고    scopus 로고
    • Effects and mechanisms of proton pump inhibitors as a novel chemosensitizer on human gastric adeno carcinoma (SGC7901) cells
    • Chen M, Zou X, Luo H, et al. Effects and mechanisms of proton pump inhibitors as a novel chemosensitizer on human gastric adeno carcinoma (SGC7901) cells. Cell Biol Int 2009;33:1008–19
    • (2009) Cell Biol Int , vol.33 , pp. 1008-1019
    • Chen, M.1    Zou, X.2    Luo, H.3
  • 24
    • 84861090758 scopus 로고    scopus 로고
    • . Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down-regulating the V-ATPases/mTOR/HIF-1α/P-gp and MRP1 signaling pathway in vitro and in vivo
    • Chen M, Huang SL, Zhang XQ, et al. Reversal effects of pantoprazole on multidrug resistance in human gastric adenocarcinoma cells by down-regulating the V-ATPases/mTOR/HIF-1α/P-gp and MRP1 signaling pathway in vitro and in vivo. J Cell Biochem 2012;113:2474–87
    • (2012) J Cell Biochem , vol.113 , pp. 2474-2487
    • Chen, M.1    Huang, S.L.2    Zhang, X.Q.3
  • 25
    • 79956342935 scopus 로고    scopus 로고
    • Omeprazole inhibits proliferation and modulates autophagy in pancreatic cancer cells
    • Udelnow A, Kreyes A, Ellinger S, et al. Omeprazole inhibits proliferation and modulates autophagy in pancreatic cancer cells. PLoS One 2011;6:e20143
    • (2011) PLoS One , vol.6 , pp. e20143
    • Udelnow, A.1    Kreyes, A.2    Ellinger, S.3
  • 26
    • 84939621452 scopus 로고    scopus 로고
    • Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer
    • Wang BY, Zhang J, Wang JL, et al. Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer. J Exp Clin Cancer Res 2015;34:2–12
    • (2015) J Exp Clin Cancer Res , vol.34 , pp. 2-12
    • Wang, B.Y.1    Zhang, J.2    Wang, J.L.3
  • 27
    • 84919430919 scopus 로고    scopus 로고
    • Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma
    • Azzarito T, Venturi G, Cesolini A, Fais S., Lansoprazole induces sensitivity to suboptimal doses of paclitaxel in human melanoma. Cancer Lett 2015;356:697–703
    • (2015) Cancer Lett , vol.356 , pp. 697-703
    • Azzarito, T.1    Venturi, G.2    Cesolini, A.3    Fais, S.4
  • 28
    • 67349286986 scopus 로고    scopus 로고
    • Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells
    • You H, Jin J, Shu H, et al. Small interfering RNA targeting the subunit ATP6L of proton pump V-ATPase overcomes chemoresistance of breast cancer cells. Cancer Lett 2009;18:110–19
    • (2009) Cancer Lett , vol.18 , pp. 110-119
    • You, H.1    Jin, J.2    Shu, H.3
  • 29
    • 34347207246 scopus 로고    scopus 로고
    • Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species
    • De Milito A, Iessi E, Logozzi M, et al. Proton pump inhibitors induce apoptosis of human B-cell tumors through a caspase-independent mechanism involving reactive oxygen species. Cancer Res 2007;67:5408–17
    • (2007) Cancer Res , vol.67 , pp. 5408-5417
    • De Milito, A.1    Iessi, E.2    Logozzi, M.3
  • 30
    • 77953463274 scopus 로고    scopus 로고
    • pH dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity
    • De Milito A, Canese R, Marino ML, et al. pH dependent antitumor activity of proton pump inhibitors against human melanoma is mediated by inhibition of tumor acidity. Int J Cancer 2010;127:207–19
    • (2010) Int J Cancer , vol.127 , pp. 207-219
    • De Milito, A.1    Canese, R.2    Marino, M.L.3
  • 31
    • 84906966131 scopus 로고    scopus 로고
    • Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance relevant miRNAs in esophageal cancer
    • Lindner K, Borchardt C, Schopp M, et al. Proton pump inhibitors (PPIs) impact on tumour cell survival, metastatic potential and chemotherapy resistance, and affect expression of resistance relevant miRNAs in esophageal cancer. J Exp Clin Cancer Res 2014;33:73–84
    • (2014) J Exp Clin Cancer Res , vol.33 , pp. 73-84
    • Lindner, K.1    Borchardt, C.2    Schopp, M.3
  • 32
    • 11144226693 scopus 로고    scopus 로고
    • Selective induction of apoptosis with proton pump inhibitor in gastric cancer cells
    • Yeo M, Kim DK, Kim YB, et al. Selective induction of apoptosis with proton pump inhibitor in gastric cancer cells. Clin Cancer Res 2004;10:8687–96
    • (2004) Clin Cancer Res , vol.10 , pp. 8687-8696
    • Yeo, M.1    Kim, D.K.2    Kim, Y.B.3
  • 33
    • 84877329980 scopus 로고    scopus 로고
    • V-ATPase is a candidate therapeutic target for Ewing sarcoma
    • Avnet S, Di Pompo G, Lemma S, et al. V-ATPase is a candidate therapeutic target for Ewing sarcoma. Biochim Biophys Acta 2013;1832:1105–16
    • (2013) Biochim Biophys Acta , vol.1832 , pp. 1105-1116
    • Avnet, S.1    Di Pompo, G.2    Lemma, S.3
  • 34
    • 84886035271 scopus 로고    scopus 로고
    • . Proton pump inhibitor chemosensitization in human osteosarcoma: from the bench to the patients' bed
    • Ferrari S, Perut F, Fagioli F, et al. Proton pump inhibitor chemosensitization in human osteosarcoma:from the bench to the patients' bed. J Transl Med 2013;11:268–74
    • (2013) J Transl Med , vol.11 , pp. 268-274
    • Ferrari, S.1    Perut, F.2    Fagioli, F.3
  • 35
    • 84888176031 scopus 로고    scopus 로고
    • V-ATPase as an effective therapeutic target for sarcomas
    • Perut F, Avnet S, Fotia C, et al. V-ATPase as an effective therapeutic target for sarcomas. Exp Cell Res 2013;320:21–32
    • (2013) Exp Cell Res , vol.320 , pp. 21-32
    • Perut, F.1    Avnet, S.2    Fotia, C.3
  • 36
    • 84455173776 scopus 로고    scopus 로고
    • Lansoprazole as a rescue agent in chemoresistant tumors: a phase I/II study in companion animals with spontaneously occurring tumors
    • Spugnini EP, Baldi A, Buglioni S, et al. Lansoprazole as a rescue agent in chemoresistant tumors:a phase I/II study in companion animals with spontaneously occurring tumors. J Transl Med 2011;9:221–32
    • (2011) J Transl Med , vol.9 , pp. 221-232
    • Spugnini, E.P.1    Baldi, A.2    Buglioni, S.3
  • 37
    • 84908135921 scopus 로고    scopus 로고
    • High dose lansoprazole combined with metronomic chemotherapy: a phase I/II study in companion animals with spontaneously occurring tumors
    • Spugnini EP, Buglioni S, Carocci F, et al. High dose lansoprazole combined with metronomic chemotherapy:a phase I/II study in companion animals with spontaneously occurring tumors. J Transl Med 2014;12:225–35
    • (2014) J Transl Med , vol.12 , pp. 225-235
    • Spugnini, E.P.1    Buglioni, S.2    Carocci, F.3
  • 38
    • 84946795147 scopus 로고    scopus 로고
    • Enzyme proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect
    • Lugini L, Federici C, Borghi M, et al. Enzyme proton pump inhibitors while belonging to the same family of generic drugs show different anti-tumor effect. J Enzyme Inhib Med Chem 2015;28:1–8
    • (2015) J Enzyme Inhib Med Chem , vol.28 , pp. 1-8
    • Lugini, L.1    Federici, C.2    Borghi, M.3
  • 39
    • 44949190364 scopus 로고    scopus 로고
    • Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs
    • Thiry A, Supuran CT, Masereel JM, Dogné JM., Recent developments of carbonic anhydrase inhibitors as potential anticancer drugs. J Med Chem 2008;51:3051–6
    • (2008) J Med Chem , vol.51 , pp. 3051-3056
    • Thiry, A.1    Supuran, C.T.2    Masereel, J.M.3    Dogné, J.M.4
  • 40
    • 84857234280 scopus 로고    scopus 로고
    • Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI
    • Ekinci D, Cavdar H, Durdagi S, et al. Structure-activity relationships for the interaction of 5,10-dihydroindeno[1,2-b]indole derivatives with human and bovine carbonic anhydrase isoforms I, II, III, IV and VI. Eur J Med Chem 2012;49:68–73
    • (2012) Eur J Med Chem , vol.49 , pp. 68-73
    • Ekinci, D.1    Cavdar, H.2    Durdagi, S.3
  • 41
    • 55549090009 scopus 로고    scopus 로고
    • Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes
    • Hilvo M, Baranauskiene L, Salzano AM, et al. Biochemical characterization of CA IX, one of the most active carbonic anhydrase isozymes. J Biol Chem 2008;283:27799–809
    • (2008) J Biol Chem , vol.283 , pp. 27799-27809
    • Hilvo, M.1    Baranauskiene, L.2    Salzano, A.M.3
  • 42
    • 77953128631 scopus 로고    scopus 로고
    • NO-releasing esters show carbonic anhydrase inhibitory action against human isoforms I and II
    • Ekinci D, Cavdar H, Talaz O, et al. NO-releasing esters show carbonic anhydrase inhibitory action against human isoforms I and II. Bioorg Med Chem 2010;18:3559–63
    • (2010) Bioorg Med Chem , vol.18 , pp. 3559-3563
    • Ekinci, D.1    Cavdar, H.2    Talaz, O.3
  • 43
    • 40049101317 scopus 로고    scopus 로고
    • Carbonic anhydrase inhibitors: inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid
    • Innocenti A, Vullo D, Scozzafava A, Supuran CT., Carbonic anhydrase inhibitors:inhibition of mammalian isoforms I-XIV with a series of substituted phenols including paracetamol and salicylic acid. Bioorg Med Chem Lett 2008;18:1583–7
    • (2008) Bioorg Med Chem Lett , vol.18 , pp. 1583-1587
    • Innocenti, A.1    Vullo, D.2    Scozzafava, A.3    Supuran, C.T.4
  • 44
    • 84870560662 scopus 로고    scopus 로고
    • Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity
    • Akin Kazancioglu E, Guney M, Senturk M, Supuran CT., Simple methanesulfonates are hydrolyzed by the sulfatase carbonic anhydrase activity. J Enzyme Inhib Med Chem 2012;27:880–5
    • (2012) J Enzyme Inhib Med Chem , vol.27 , pp. 880-885
    • Akin Kazancioglu, E.1    Guney, M.2    Senturk, M.3    Supuran, C.T.4
  • 45
    • 81855199760 scopus 로고    scopus 로고
    • Salicylic acid derivatives: synthesis, features and usage as therapeutic tools
    • Ekinci D, Senturk M, Kufrevioglu OI., Salicylic acid derivatives:synthesis, features and usage as therapeutic tools. Expert Opin Ther Pat 2011;21:1831–41
    • (2011) Expert Opin Ther Pat , vol.21 , pp. 1831-1841
    • Ekinci, D.1    Senturk, M.2    Kufrevioglu, O.I.3
  • 46
    • 0015239422 scopus 로고
    • The carbon dioxide hydration activity of carbonic anhydrase I. Stop-flow kinetic studies on the native human isoenzymes B and C
    • Khalifah RG., The carbon dioxide hydration activity of carbonic anhydrase I. Stop-flow kinetic studies on the native human isoenzymes B and C. J Biol Chem 1971;246:2561–73
    • (1971) J Biol Chem , vol.246 , pp. 2561-2573
    • Khalifah, R.G.1
  • 47
    • 33746149756 scopus 로고    scopus 로고
    • Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice
    • Rofstad EK, Mathiesen B, Kindem K, Galappathi K., Acidic extracellular pH promotes experimental metastasis of human melanoma cells in athymic nude mice. Cancer Res 2006;66:6699–707
    • (2006) Cancer Res , vol.66 , pp. 6699-6707
    • Rofstad, E.K.1    Mathiesen, B.2    Kindem, K.3    Galappathi, K.4
  • 48
    • 36349001899 scopus 로고    scopus 로고
    • Targeting vacuolar H+-ATPases as a new strategy against cancer
    • Fais S, De Milito A, You H, Qin W., Targeting vacuolar H+-ATPases as a new strategy against cancer. Cancer Res 2007;67:10627–30
    • (2007) Cancer Res , vol.67 , pp. 10627-10630
    • Fais, S.1    De Milito, A.2    You, H.3    Qin, W.4
  • 49
    • 84914105725 scopus 로고    scopus 로고
    • Microenvironmental acidosis in carcinogenesis and metastases: new strategies in prevention and therapy
    • Fais S, Venturi G, Gatenby B., Microenvironmental acidosis in carcinogenesis and metastases:new strategies in prevention and therapy. Cancer Metastasis Rev 2014;33:1095–108
    • (2014) Cancer Metastasis Rev , vol.33 , pp. 1095-1108
    • Fais, S.1    Venturi, G.2    Gatenby, B.3
  • 50
    • 84875881552 scopus 로고    scopus 로고
    • LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump
    • Fan S, Niu Y, Tan N, et al. LASS2 enhances chemosensitivity of breast cancer by counteracting acidic tumor microenvironment through inhibiting activity of V-ATPase proton pump. Oncogene 2013;28:1682–90
    • (2013) Oncogene , vol.28 , pp. 1682-1690
    • Fan, S.1    Niu, Y.2    Tan, N.3
  • 51
    • 0036166662 scopus 로고    scopus 로고
    • Applications of carbonic anhydrase inhibitors and activators in therapy
    • Supuran CT, Scozzafava A., Applications of carbonic anhydrase inhibitors and activators in therapy. Expert Opin Ther Patents 2002;12:217–42
    • (2002) Expert Opin Ther Patents , vol.12 , pp. 217-242
    • Supuran, C.T.1    Scozzafava, A.2
  • 52
    • 38849143765 scopus 로고    scopus 로고
    • Carbonic anhydrases: novel therapeutic applications for inhibitors and activators
    • Supuran CT., Carbonic anhydrases:novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 2008;7:168–81
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 168-181
    • Supuran, C.T.1
  • 53
    • 84944463700 scopus 로고    scopus 로고
    • Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models
    • Ward C, Meehan J, Mullen P, et al. Evaluation of carbonic anhydrase IX as a therapeutic target for inhibition of breast cancer invasion and metastasis using a series of in vitro breast cancer models. Oncotarget 2015;6:24856–70
    • (2015) Oncotarget , vol.6 , pp. 24856-24870
    • Ward, C.1    Meehan, J.2    Mullen, P.3
  • 54
    • 77956253534 scopus 로고    scopus 로고
    • Selective inhibition of carbonic anhydrase IX decreases cell proliferation and induces ceramide-mediated apoptosis in human cancer cells
    • Cianchi F, Vinci MC, Supuran CT, et al. Selective inhibition of carbonic anhydrase IX decreases cell proliferation and induces ceramide-mediated apoptosis in human cancer cells. J Pharmacol Exp Ther 2010;334:710–19
    • (2010) J Pharmacol Exp Ther , vol.334 , pp. 710-719
    • Cianchi, F.1    Vinci, M.C.2    Supuran, C.T.3
  • 55
    • 84878067755 scopus 로고    scopus 로고
    • Anticancer carbonic anhydrase inhibitors: a patent review (2008-2013)
    • Monti SM, Supuran CT, De Simone G., Anticancer carbonic anhydrase inhibitors:a patent review (2008-2013). Expert Opin Ther Pat 2013;23:737–49
    • (2013) Expert Opin Ther Pat , vol.23 , pp. 737-749
    • Monti, S.M.1    Supuran, C.T.2    De Simone, G.3
  • 56
    • 84896360079 scopus 로고    scopus 로고
    • Novel coumarins and benzocoumarins acting as isoform-selective inhibitors against the tumor-associated carbonic anhydrase IX
    • Sharma A, Tiwari M, Supuran CT., Novel coumarins and benzocoumarins acting as isoform-selective inhibitors against the tumor-associated carbonic anhydrase IX. J Enzyme Inhib Med Chem 2014;29:292–6
    • (2014) J Enzyme Inhib Med Chem , vol.29 , pp. 292-296
    • Sharma, A.1    Tiwari, M.2    Supuran, C.T.3
  • 57
    • 84896355347 scopus 로고    scopus 로고
    • Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography
    • Pan J, Lau J, Mesak F, et al. Synthesis and evaluation of 18F-labeled carbonic anhydrase IX inhibitors for imaging with positron emission tomography. J Enzyme Inhib Med Chem 2014;2:249–55
    • (2014) J Enzyme Inhib Med Chem , vol.2 , pp. 249-255
    • Pan, J.1    Lau, J.2    Mesak, F.3
  • 58
    • 84865850354 scopus 로고    scopus 로고
    • Structure-based drug discovery of carbonic anhydrase inhibitors
    • Supuran CT., Structure-based drug discovery of carbonic anhydrase inhibitors. J Enzyme Inhib Med Chem 2012;6:759–72
    • (2012) J Enzyme Inhib Med Chem , vol.6 , pp. 759-772
    • Supuran, C.T.1
  • 59
    • 84950147999 scopus 로고    scopus 로고
    • 7-Aryl-triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrase IX and XII
    • Nocentini A, Ceruso M, Carta F, Supuran CT., 7-Aryl-triazolyl-substituted sulfocoumarins are potent, selective inhibitors of the tumor-associated carbonic anhydrase IX and XII. J Enzyme Inhib Med Chem 2015. [Epub ahead of print] doi:10.3109/14756366.2015.1115401
    • (2015) J Enzyme Inhib Med Chem
    • Nocentini, A.1    Ceruso, M.2    Carta, F.3    Supuran, C.T.4
  • 61
    • 67749145635 scopus 로고    scopus 로고
    • The role of carbonic anhydrase 9 in regulating extracellular and intracellular pH in three-dimensional tumor cell growths
    • Swietach P, Patiar S, Supuran CT, et al. The role of carbonic anhydrase 9 in regulating extracellular and intracellular pH in three-dimensional tumor cell growths. J Biol Chem 2009;284:20299–310
    • (2009) J Biol Chem , vol.284 , pp. 20299-20310
    • Swietach, P.1    Patiar, S.2    Supuran, C.T.3
  • 62
    • 80053563164 scopus 로고    scopus 로고
    • Interfering with pH regulation in tumours as a therapeutic strategy
    • Neri D, Supuran CT., Interfering with pH regulation in tumours as a therapeutic strategy. Nat Rev Drug Discov 2011;10:767–77
    • (2011) Nat Rev Drug Discov , vol.10 , pp. 767-777
    • Neri, D.1    Supuran, C.T.2
  • 63
    • 84863424129 scopus 로고    scopus 로고
    • Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines
    • Winum J-Y, Carta F, Ward C, et al. Ureido-substituted sulfamates show potent carbonic anhydrase IX inhibitory and antiproliferative activities against breast cancer cell lines. Bioorg Med Chem Lett 2012;22:4681–5
    • (2012) Bioorg Med Chem Lett , vol.22 , pp. 4681-4685
    • Winum, J.-Y.1    Carta, F.2    Ward, C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.