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Volumn 4, Issue 4, 2012, Pages 505-524

Targeted cancer therapy: Giving histone deacetylase inhibitors all they need to succeed

Author keywords

[No Author keywords available]

Indexed keywords

ACY 1215; AZITHROMYCIN; BORTEZOMIB; CLARITHROMYCIN; HISTONE DEACETYLASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 3; HISTONE DEACETYLASE 6; HISTONE DEACETYLASE 8; HISTONE DEACETYLASE INHIBITOR; ROMIDEPSIN; UNCLASSIFIED DRUG; VORINOSTAT;

EID: 84858685501     PISSN: 17568919     EISSN: 17568927     Source Type: Journal    
DOI: 10.4155/fmc.12.3     Document Type: Review
Times cited : (333)

References (145)
  • 2
    • 54749102754 scopus 로고    scopus 로고
    • Cause and consequences of genetic and epigenetic alterations in human cancer
    • Sadikovic B, Al-Romaih K, Squire JA, Zielenska M. Cause and consequences of genetic and epigenetic alterations in human cancer. Curr. Genomics 9(6), 394-408 (2008).
    • (2008) Curr. Genomics , vol.9 , Issue.6 , pp. 394-408
    • Sadikovic, B.1    Al-Romaih, K.2    Squire, J.A.3    Zielenska, M.4
  • 4
    • 34249737896 scopus 로고    scopus 로고
    • Transcription factor networks in embryonic stem cells and testicular cancer and the definition of epigenetics
    • Schulz WA, Hoffmann MJ. Transcription factor networks in embryonic stem cells and testicular cancer and the definition of epigenetics. Epigenetics 2(1), 37-42 (2007). (Pubitemid 46824848)
    • (2007) Epigenetics , vol.2 , Issue.1 , pp. 37-42
    • Schulz, W.A.1    Hoffmann, M.J.2
  • 5
    • 79951679438 scopus 로고    scopus 로고
    • The challenge of modeling nuclear receptor regulatory networks in mammalian cells
    • Jagannathan V, Robinson-Rechavi M. The challenge of modeling nuclear receptor regulatory networks in mammalian cells. Mol. Cell. Endocrinol. 334(1-2), 91-97 (2011).
    • (2011) Mol. Cell. Endocrinol. , vol.334 , Issue.1-2 , pp. 91-97
    • Jagannathan, V.1    Robinson-Rechavi, M.2
  • 6
    • 79959359296 scopus 로고    scopus 로고
    • Long antisense non-coding RNAs function to direct epigenetic complexes that regulate transcription in human cells
    • Morris KV. Long antisense non-coding RNAs function to direct epigenetic complexes that regulate transcription in human cells. Epigenetics 4(5), 296-301 (2009).
    • (2009) Epigenetics , vol.4 , Issue.5 , pp. 296-301
    • Morris, K.V.1
  • 7
    • 33745286231 scopus 로고    scopus 로고
    • TUF love for 'junk' DNA
    • Willingham AT, Gingeras TR. TUF love for 'junk' DNA.Cell 125(7), 1215-1220 (2006).
    • (2006) Cell , vol.125 , Issue.7 , pp. 1215-1220
    • Willingham, A.T.1    Gingeras, T.R.2
  • 8
    • 34848857313 scopus 로고    scopus 로고
    • Gene silencing by double-stranded RNA (Nobel lecture
    • Fire AZ. Gene silencing by double-stranded RNA (Nobel lecture). Angew. Chem. Int. Ed. Engl. 46(37), 6967-6984 (2007).
    • (2007) Angew. Chem. Int. Ed. Engl. , vol.46 , Issue.37 , pp. 6967-6984
    • Fire, A.Z.1
  • 9
    • 79951500297 scopus 로고    scopus 로고
    • CpG island chromatin A platform for gene regulation
    • Blackledge NP, Klose RJ. CpG island chromatin A platform for gene regulation. Epigenetics 6(2), 147-152 (2011).
    • (2011) Epigenetics , vol.6 , Issue.2 , pp. 147-152
    • Blackledge, N.P.1    Klose, R.J.2
  • 10
    • 78751534193 scopus 로고    scopus 로고
    • A modified epigenetics toolbox to study histone modifications on the nucleosome core
    • Frederiks F, Stulemeijer IJE, Ovaa H, Van Leeuwen F. A modified epigenetics toolbox to study histone modifications on the nucleosome core. ChemBioChem 12(2), 308-313 (2011).
    • (2011) Chem. Bio. Chem. , vol.12 , Issue.2 , pp. 308-313
    • Frederiks, F.1    Stulemeijer, I.J.E.2    Ovaa, H.3    Van Leeuwen, F.4
  • 11
    • 77953428840 scopus 로고    scopus 로고
    • Epigenetic therapy: Targeting histones and their modifications in human disease
    • Gunjan A, Singh RK. Epigenetic therapy: targeting histones and their modifications in human disease. Future Med. Chem. 2(4), 543-548 (2010).
    • (2010) Future Med. Chem. , vol.2 , Issue.4 , pp. 543-548
    • Gunjan, A.1    Singh, R.K.2
  • 12
    • 70249121045 scopus 로고    scopus 로고
    • The logic of chromatin architecture and remodelling at promoters
    • Cairns BR. The logic of chromatin architecture and remodelling at promoters. Nature 461(7261), 193-198 (2009).
    • (2009) Nature , vol.461 , Issue.7261 , pp. 193-198
    • Cairns, B.R.1
  • 13
    • 78649902376 scopus 로고    scopus 로고
    • The role of transcription factories-mediated interchromosomal contacts in the organization of nuclear architecture
    • Dorier J, Stasiak A. The role of transcription factories-mediated interchromosomal contacts in the organization of nuclear architecture. Nucleic Acids Res. 38(21), 7410-7421 (2010).
    • (2010) Nucleic Acids Res. , vol.38 , Issue.21 , pp. 7410-7421
    • Dorier, J.1    Stasiak, A.2
  • 14
    • 33846283384 scopus 로고    scopus 로고
    • Dynamic genome architecture in the nuclear space: Regulation of gene expression in three dimensions
    • DOI 10.1038/nrg2041, PII NRG2041
    • Lanctot C, Cheutin T, Cremer M, Cavalli G, Cremer T. Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions. Nat. Rev. Genet. 8(2), 104-115 (2007). (Pubitemid 46122840)
    • (2007) Nature Reviews Genetics , vol.8 , Issue.2 , pp. 104-115
    • Lanctot, C.1    Cheutin, T.2    Cremer, M.3    Cavalli, G.4    Cremer, T.5
  • 15
    • 77953460884 scopus 로고    scopus 로고
    • Approaches to target the genome and its epigenome in cancer
    • Chapman-Rothe N, Brown R. Approaches to target the genome and its epigenome in cancer. Future Med. Chem. 1(8), 1481-1495 (2009).
    • (2009) Future Med. Chem. , vol.1 , Issue.8 , pp. 1481-1495
    • Chapman-Rothe, N.1    Brown, R.2
  • 16
    • 33846142183 scopus 로고    scopus 로고
    • HDAC inhibitors overcome first hurdle
    • DOI 10.1038/nbt0107-17, PII NBT010717
    • Garber K. HDAC inhibitors overcome first hurdle. Nat. Biotechnol. 25(1), 17-19 (2007). (Pubitemid 46087886)
    • (2007) Nature Biotechnology , vol.25 , Issue.1 , pp. 17-19
    • Garber, K.1
  • 17
    • 79955148265 scopus 로고    scopus 로고
    • Cancer cells' epigenetic composition and predisposition to histone deacetylase inhibitor sensitization
    • Nalabothula N, Carrier F. Cancer cells' epigenetic composition and predisposition to histone deacetylase inhibitor sensitization. Epigenomics 3(2), 145-155 (2011).
    • (2011) Epigenomics , vol.3 , Issue.2 , pp. 145-155
    • Nalabothula, N.1    Carrier, F.2
  • 18
    • 69449102464 scopus 로고    scopus 로고
    • Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes
    • Wang Z, Zang C, Cui K et al. Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes. Cell 138(5), 1019-1031 (2009).
    • (2009) Cell , vol.138 , Issue.5 , pp. 1019-1031
    • Wang, Z.1    Zang, C.2    Cui, K.3
  • 19
    • 77249087051 scopus 로고    scopus 로고
    • Chemical phylogenetics of histone deacetylases
    • Bradner JE, West N, Grachan ML et al. Chemical phylogenetics of histone deacetylases. Nat. Chem. Biol. 6(3), 238-243 (2010).
    • (2010) Nat. Chem. Biol. , vol.6 , Issue.3 , pp. 238-243
    • Bradner, J.E.1    West, N.2    Grachan, M.L.3
  • 20
    • 1042302747 scopus 로고    scopus 로고
    • Histone Deacetylase Activity Is Required for Embryonic Stem Cell Differentiation
    • DOI 10.1002/gene.10250
    • Lee JH, Hart SRL, Skalnik DG. Histone deacetylase activity is required for embryonic stem cell differentiation. Genesis 38(1), 32-38 (2004). (Pubitemid 38197607)
    • (2004) Genesis , vol.38 , Issue.1 , pp. 32-38
    • Lee, J.-H.1    Hart, S.R.L.2    Skalnik, D.G.3
  • 21
    • 70349227061 scopus 로고    scopus 로고
    • Histone deacetylase 1 and 2-controlled embryonic development and cell differentiation
    • Brunmeir R, Lagger S, Seiser C. Histone deacetylase 1 and 2-controlled embryonic development and cell differentiation. Int. J. Dev. Biol. 53(2-3), 275-289 (2009).
    • (2009) Int. J. Dev. Biol. , vol.53 , Issue.2-3 , pp. 275-289
    • Brunmeir, R.1    Lagger, S.2    Seiser, C.3
  • 22
    • 79952384705 scopus 로고    scopus 로고
    • Cancer epigenetics reaches mainstream oncology
    • Rodriguez-Paredes M, Esteller M. Cancer epigenetics reaches mainstream oncology. Nat. Med. 17(3), 330-339 (2011).
    • (2011) Nat. Med. , vol.17 , Issue.3 , pp. 330-339
    • Rodriguez-Paredes, M.1    Esteller, M.2
  • 23
    • 53249130741 scopus 로고    scopus 로고
    • Therapeutic application of histone deacetylase inhibitors for central nervous system disorders
    • Kazantsev AG, Thompson LM. Therapeutic application of histone deacetylase inhibitors for central nervous system disorders. Nat. Rev. Drug Discov. 7(10), 854-868 (2008).
    • (2008) Nat. Rev. Drug Discov. , vol.7 , Issue.10 , pp. 854-868
    • Kazantsev, A.G.1    Thompson, L.M.2
  • 24
    • 57849154398 scopus 로고    scopus 로고
    • From immunity to tolerance through HDAC
    • Georgopoulos K. From immunity to tolerance through HDAC. Nat. Immunol. 10(1), 13-14 (2009).
    • (2009) Nat. Immunol. , vol.10 , Issue.1 , pp. 13-14
    • Georgopoulos, K.1
  • 25
    • 79955826710 scopus 로고    scopus 로고
    • Metabolic homeostasis: HDACs take center stage
    • Karpac J, Jasper H. Metabolic homeostasis: HDACs take center stage. Cell 145(4), 497-499 (2011).
    • (2011) Cell , vol.145 , Issue.4 , pp. 497-499
    • Karpac, J.1    Jasper, H.2
  • 26
    • 30344477367 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer
    • DOI 10.1038/nrc1779
    • Minucci S, Pelicci PG. Histone deacetylase inhibitors and the promise of epigenetic (and more) treatments for cancer. Nat. Rev. Cancer 6(1), 38-51 (2006). (Pubitemid 43054973)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.1 , pp. 38-51
    • Minucci, S.1    Pelicci, P.G.2
  • 27
    • 0037406061 scopus 로고    scopus 로고
    • Class II histone deacetylases: Versatile regulators
    • DOI 10.1016/S0168-9525(03)00073-8
    • Verdin E, Dequiedt F, Kasler HG. Class 2 histone deacetylases: versatile regulators. Trends Genet. 19(5), 286-293 (2003). (Pubitemid 36507011)
    • (2003) Trends in Genetics , vol.19 , Issue.5 , pp. 286-293
    • Verdin, E.1    Dequiedt, F.2    Kasler, H.G.3
  • 28
    • 45749142120 scopus 로고    scopus 로고
    • Isoform-selective histone deacetylase inhibitors
    • Bieliauskas AV, Pflum MKH. Isoform-selective histone deacetylase inhibitors. Chem. Soc. Rev. 37(7), 1402-1413 (2008).
    • (2008) Chem. Soc. Rev. , vol.37 , Issue.7 , pp. 1402-1413
    • Bieliauskas, A.V.1    Pflum, M.K.H.2
  • 29
    • 4644286941 scopus 로고    scopus 로고
    • Hydantoin-hydrolysing enzymes for the enantioselective production of amino acids: New insights and applications
    • DOI 10.1016/j.tetasy.2004.07.061, PII S0957416604006135, Integrating Biocatalysis into Organic Syntheses
    • Burton SG, Dorrington RA. Hydantoin-hydrolysing enzymes for the enantioselective production of amino acids: new insights and applications. Tetrahedron Asymmetry 15(18), 2737-2741 (2004). (Pubitemid 39277998)
    • (2004) Tetrahedron Asymmetry , vol.15 , Issue.18 , pp. 2737-2741
    • Burton, S.G.1    Dorrington, R.A.2
  • 30
    • 27444435580 scopus 로고    scopus 로고
    • Toward selective histone deacetylase inhibitor design: Homology modeling, docking studies, and molecular dynamics simulations of human class I histone deacetylases
    • DOI 10.1021/jm0505011
    • Wang DF, Helquist P, Wiech NL, Wiest O. Toward selective histone deacetylase inhibitor design: homology modeling, docking studies, and molecular dynamics simulations of human Class 1 histone deacetylases. J. Med. Chem. 48(22), 6936-6947 (2005). (Pubitemid 41533115)
    • (2005) Journal of Medicinal Chemistry , vol.48 , Issue.22 , pp. 6936-6947
    • Wang, D.-F.1    Helquist, P.2    Wiech, N.L.3    Wiest, O.4
  • 31
    • 77955355838 scopus 로고    scopus 로고
    • Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A
    • Butler KV, Kalin J, Brochier C, Vistoli G, Langley B, Kozikowski AP. Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, tubastatin A. J. Am. Chem. Soc. 132(31), 10842-10846 (2010).
    • (2010) J. Am. Chem. Soc. , vol.132 , Issue.31 , pp. 10842-10846
    • Butler, K.V.1    Kalin, J.2    Brochier, C.3    Vistoli, G.4    Langley, B.5    Kozikowski, A.P.6
  • 32
    • 33847258674 scopus 로고    scopus 로고
    • Discovery and development of SAHA as an anticancer agent
    • DOI 10.1038/sj.onc.1210204, PII 1210204
    • Marks PA. Discovery and development of SAHA as an anticancer agent. Oncogene 26(9), 1351-1356 (2007). (Pubitemid 46328465)
    • (2007) Oncogene , vol.26 , Issue.9 , pp. 1351-1356
    • Marks, P.A.1
  • 33
    • 77954884940 scopus 로고    scopus 로고
    • Romidepsin: A new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumors
    • Grant C, Rahman F, Piekarz R et al. Romidepsin: a new therapy for cutaneous T-cell lymphoma and a potential therapy for solid tumors. Expert Rev. Anticancer Ther. 10(7), 997-1008 (2010).
    • (2010) Expert Rev. Anticancer Ther. , vol.10 , Issue.7 , pp. 997-1008
    • Grant, C.1    Rahman, F.2    Piekarz, R.3
  • 36
    • 72049116798 scopus 로고    scopus 로고
    • Anti-malarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group
    • Patil V, Guerrant W, Chen PC et al. Anti-malarial and antileishmanial activities of histone deacetylase inhibitors with triazole-linked cap group. Bioorg. Med. Chem. 18(1), 415-425 (2010).
    • (2010) Bioorg. Med. Chem. , vol.18 , Issue.1 , pp. 415-425
    • Patil, V.1    Guerrant, W.2    Chen, P.C.3
  • 37
    • 70349128205 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors: Design, structure-activity relationships and therapeutic implications for cancer
    • Marson CM. Histone deacetylase inhibitors: design, structure-activity relationships and therapeutic implications for cancer. Anticancer Agents Med. Chem. 9(6), 661-692 (2009).
    • (2009) Anticancer Agents Med. Chem. , vol.9 , Issue.6 , pp. 661-692
    • Marson, C.M.1
  • 38
    • 80052555163 scopus 로고    scopus 로고
    • 2,5-Disubstituted-1, 3,4-oxadiazoles/thiadiazole as surface recognition moiety: Design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors
    • Rajak H, Agarawal A, Parmar P et al. 2,5-Disubstituted-1,3,4-oxadiazoles/ thiadiazole as surface recognition moiety: design and synthesis of novel hydroxamic acid based histone deacetylase inhibitors. Bioorg. Med. Chem. Lett. 21(19), 5735-5738 (2011).
    • (2011) Bioorg. Med. Chem. Lett. , vol.21 , Issue.19 , pp. 5735-5738
    • Rajak, H.1    Agarawal, A.2    Parmar, P.3
  • 39
    • 77249167010 scopus 로고    scopus 로고
    • Design, synthesis and preliminary activity assay of 1, 2, 3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as novel Histone deacetylases (HDACs) inhibitors
    • Zhang YJ, Feng JH, Liu CX et al. Design, synthesis and preliminary activity assay of 1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid derivatives as novel Histone deacetylases (HDACs) inhibitors. Bioorg. Med. Chem. Lett. 18(5), 1761-1772 (2010).
    • (2010) Bioorg. Med. Chem. Lett. , vol.18 , Issue.5 , pp. 1761-1772
    • Zhang, Y.J.1    Feng, J.H.2    Liu, C.X.3
  • 40
    • 71749084293 scopus 로고    scopus 로고
    • Design and synthesis of novel histone deacetylase inhibitor derived from nuclear localization signal peptide
    • Canzoneri JC, Chen PC, Oyelere AK. Design and synthesis of novel histone deacetylase inhibitor derived from nuclear localization signal peptide. Bioorg. Med. Chem. Lett. 19(23), 6588-6590 (2009).
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , Issue.23 , pp. 6588-6590
    • Canzoneri, J.C.1    Chen, P.C.2    Oyelere, A.K.3
  • 41
    • 42049096372 scopus 로고    scopus 로고
    • Chemical origins of isoform selectivity in histone deacetylase inhibitors
    • DOI 10.2174/138161208783885353
    • Butler KV, Kozikowski AP. Chemical origins of isoform selectivity in histone deacetylase inhibitors. Curr. Pharm. Design 14(6), 505-528 (2008). (Pubitemid 351516876)
    • (2008) Current Pharmaceutical Design , vol.14 , Issue.6 , pp. 505-528
    • Butler, K.V.1    Kozikowski, A.P.2
  • 42
    • 79960188498 scopus 로고    scopus 로고
    • Optimiz-ation of the in vitro cardiac safety of hydrox-amate-based histone deacetylase inhibitors
    • Shultz MD, Cao XY, Chen CH et al. Optimiz-ation of the in vitro cardiac safety of hydrox-amate-based histone deacetylase inhibitors. J. Med. Chem. 54(13), 4752-4772 (2011).
    • (2011) J. Med. Chem. , vol.54 , Issue.13 , pp. 4752-4772
    • Shultz, M.D.1    Cao, X.Y.2    Chen, C.H.3
  • 43
    • 77955866855 scopus 로고    scopus 로고
    • Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton
    • Mwakwari SC, Guerrant W, Patil V et al. Non-peptide macrocyclic histone deacetylase inhibitors derived from tricyclic ketolide skeleton. J. Med. Chem. 53(16), 6100-6111 (2010).
    • (2010) J. Med. Chem. , vol.53 , Issue.16 , pp. 6100-6111
    • Mwakwari, S.C.1    Guerrant, W.2    Patil, V.3
  • 44
    • 65449142086 scopus 로고    scopus 로고
    • Non-cancer uses of histone deacetylase inhibitors: Effects on infectious diseases and b-hemoglobinopathies
    • Rotili D, Simonetti G, Savarino A, Palamara AT, Migliaccio AR, Mai A. Non-cancer uses of histone deacetylase inhibitors: effects on infectious diseases and b-hemoglobinopathies. Curr. Top. Med. Chem. 9(3), 272-291 (2009).
    • (2009) Curr. Top. Med. Chem. , vol.9 , Issue.3 , pp. 272-291
    • Rotili, D.1    Simonetti, G.2    Savarino, A.3    Palamara, A.T.4    Migliaccio, A.R.5    Mai, A.6
  • 47
    • 72549086619 scopus 로고    scopus 로고
    • We should have a dream: Unlocking the workings of the genome in cutaneous T-cell lymphomas
    • Porcu P, Wong HK. We should have a dream: unlocking the workings of the genome in cutaneous T-cell lymphomas. Clin. Lymphoma Myeloma 9(6), 409-411 (2009).
    • (2009) Clin. Lymphoma Myeloma , vol.9 , Issue.6 , pp. 409-411
    • Porcu, P.1    Wong, H.K.2
  • 48
    • 36148950997 scopus 로고    scopus 로고
    • FDA approval summary: Vorinostat for treatment of advanced primary cutaneous T-cell lymphoma
    • DOI 10.1634/theoncologist.12-10-1247
    • Mann BS, Johnson JR, Cohen MH, Justice R, Pazdur R. FDA approval summary: vorinostat for treatment of advanced primary cutaneous T-cell lymphoma. Oncologist 12(10), 1247-1252 (2007). (Pubitemid 350106355)
    • (2007) Oncologist , vol.12 , Issue.10 , pp. 1247-1252
    • Mann, B.S.1    Johnson, J.R.2    Cohen, M.H.3    Justice, R.4    Pazdur, R.5
  • 50
    • 76349095566 scopus 로고    scopus 로고
    • Pruritus in cutaneous T-cell lymphomas: Frequent, often severe and difficult to treat
    • Meyer N, Paul C, Misery L. Pruritus in cutaneous T-cell lymphomas: frequent, often severe and difficult to treat. Acta Dermatol Venereologica 90(1), 12-17 (2010).
    • (2010) Acta Dermatol Venereologica , vol.90 , Issue.1 , pp. 12-17
    • Meyer, N.1    Paul, C.2    Misery, L.3
  • 52
    • 73949149251 scopus 로고    scopus 로고
    • Phase 2 multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma
    • Piekarz RL, Frye R, Turner M et al. Phase 2 multi-institutional trial of the histone deacetylase inhibitor romidepsin as monotherapy for patients with cutaneous T-cell lymphoma. J. Clin. Oncol. 27(32), 5410-5417 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , Issue.32 , pp. 5410-5417
    • Piekarz, R.L.1    Frye, R.2    Turner, M.3
  • 53
    • 77954879663 scopus 로고    scopus 로고
    • Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma
    • Whittaker SJ, Demierre MF, Kim EJ et al. Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphoma. J. Clin. Oncol. 28(29), 4485-4491 (2010).
    • (2010) J. Clin. Oncol. , vol.28 , Issue.29 , pp. 4485-4491
    • Whittaker, S.J.1    Demierre, M.F.2    Kim, E.J.3
  • 54
    • 50249095068 scopus 로고    scopus 로고
    • Early Phase 2 trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer
    • Vansteenkiste J, Van Cutsem E, Dumez H et al. Early Phase 2 trial of oral vorinostat in relapsed or refractory breast, colorectal, or non-small cell lung cancer. Invest. N. Drugs 26(5), 483-488 (2008).
    • (2008) Invest. N. Drugs , vol.26 , Issue.5 , pp. 483-488
    • Vansteenkiste, J.1    Van Cutsem, E.2    Dumez, H.3
  • 55
    • 58149387609 scopus 로고    scopus 로고
    • Lack of therapeutic effect of the histone deacetylase inhibitor vorinostat in patients with metastatic radioiodine-refractory thyroid carcinoma
    • Woyach JA, Kloos RT, Ringel MD et al. Lack of therapeutic effect of the histone deacetylase inhibitor vorinostat in patients with metastatic radioiodine-refractory thyroid carcinoma. J. Clin. Endocrinol. Metab. 94(1), 164-170 (2009).
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , Issue.1 , pp. 164-170
    • Woyach, J.A.1    Kloos, R.T.2    Ringel, M.D.3
  • 57
    • 68649119641 scopus 로고    scopus 로고
    • Phase 2 trial of romidepsin (NSC-630176) in previously treated colorectal cancer patients with advanced disease: A Southwest oncology group study (S0336
    • Whitehead R, Rankin C, Hoff P et al. Phase 2 trial of romidepsin (NSC-630176) in previously treated colorectal cancer patients with advanced disease: a Southwest oncology group study (S0336). Invest. New Drugs 27(5), 469-475 (2009).
    • (2009) Invest. New Drugs , vol.27 , Issue.5 , pp. 469-475
    • Whitehead, R.1    Rankin, C.2    Hoff, P.3
  • 58
    • 79957839068 scopus 로고    scopus 로고
    • Interpreting clinical assays for histone deacetylase inhibitors
    • Martinet N, Bertrand P. Interpreting clinical assays for histone deacetylase inhibitors. Cancer Manage. Res. 3(1), 117-141 (2011).
    • (2011) Cancer Manage. Res. , vol.3 , Issue.1 , pp. 117-141
    • Martinet, N.1    Bertrand, P.2
  • 59
    • 34548276036 scopus 로고    scopus 로고
    • Molecularly targeted oncology therapeutics and prolongation of the QT interval
    • DOI 10.1200/JCO.2006.09.6925
    • Strevel EL, Ing DJ, Siu LL. Molecularly targeted oncology therapeutics and prolongation of the QT interval. J. Clin. Oncol. 25(22), 3362-3371 (2007). (Pubitemid 47325624)
    • (2007) Journal of Clinical Oncology , vol.25 , Issue.22 , pp. 3362-3371
    • Strevel, E.L.1    Ing, D.J.2    Siu, L.L.3
  • 61
    • 77649171884 scopus 로고    scopus 로고
    • Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents
    • Tan J, Cang S, Ma Y, Petrillo R, Liu D. Novel histone deacetylase inhibitors in clinical trials as anti-cancer agents. J. Hematol. Oncol. 3(1), 5 (2010).
    • (2010) J. Hematol. Oncol. , vol.3 , Issue.1 , pp. 5
    • Tan, J.1    Cang, S.2    Ma, Y.3    Petrillo, R.4    Liu, D.5
  • 62
    • 79251541733 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors in the treatment of hematological malignancies and solid tumors
    • Federico M, Bagella L. Histone deacetylase inhibitors in the treatment of hematological malignancies and solid tumors. J. Biomed. Biotechnol. (2011).
    • (2011) J. Biomed. Biotechnol.
    • Federico, M.1    Bagella, L.2
  • 63
    • 4544262570 scopus 로고    scopus 로고
    • Drugs that cause torsades de pointes and increase the risk of sudden cardiac death
    • Wolbrette D. Drugs that cause torsades de pointes and increase the risk of sudden cardiac death. Curr. Cardiol. Rep. 6(5), 379-384 (2004). (Pubitemid 39232727)
    • (2004) Current Cardiology Reports , vol.6 , Issue.5 , pp. 379-384
    • Wolbrette, D.L.1
  • 64
    • 33746080897 scopus 로고    scopus 로고
    • Challenges of evaluating the cardiac effects of anticancer agents
    • DOI 10.1158/1078-0432.CCR-06-1017
    • Bates SE, Rosing DR, Fojo T, Piekarz RL. Challenges of evaluating the cardiac effects of anticancer agents. Clin. Cancer Res. 12(13), 3871-3874 (2006). (Pubitemid 44078067)
    • (2006) Clinical Cancer Research , vol.12 , Issue.13 , pp. 3871-3874
    • Bates, S.E.1    Rosing, D.R.2    Fojo, T.3    Piekarz, R.L.4
  • 66
    • 77950855126 scopus 로고    scopus 로고
    • Mechanisms of drug induced QT interval prolongation
    • Ponte ML, Keller GA, Girolamo GD. Mechanisms of drug induced QT interval prolongation.Curr. Drug Saf. 5(1), 44-53 (2010).
    • (2010) Curr. Drug Saf. , vol.5 , Issue.1 , pp. 44-53
    • Ponte, M.L.1    Keller, G.A.2    Girolamo, G.D.3
  • 67
    • 33644524405 scopus 로고    scopus 로고
    • Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis a review of emerging trends
    • Hoffmann P, Warner B. Are hERG channel inhibition and QT interval prolongation all there is in drug-induced torsadogenesis? A review of emerging trends. J. Pharmacol. Toxicol. Methods 53(2), 87-105 (2006).
    • (2006) J. Pharmacol. Toxicol. Methods , vol.53 , Issue.2 , pp. 87-105
    • Hoffmann, P.1    Warner, B.2
  • 68
    • 79955047914 scopus 로고    scopus 로고
    • Involvement of caveolin in probucol-induced reduction in hERG plasma-membrane expression
    • Guo J, Li X, Shallow H et al. Involvement of caveolin in probucol-induced reduction in hERG plasma-membrane expression. Mol. Pharmacol. 79(5), 806-813 (2011).
    • (2011) Mol. Pharmacol. , vol.79 , Issue.5 , pp. 806-813
    • Guo, J.1    Li, X.2    Shallow, H.3
  • 69
    • 61849180389 scopus 로고    scopus 로고
    • Human ether-a-go-go related gene (hERG) K+ channels: Function and dysfunction
    • Perrin MJ, Subbiah RN, Vandenberg JI, Hill AP. Human ether-a-go-go related gene (hERG) K+ channels: function and dysfunction. Prog. Biophys. Mol. Biol. 98(2-3), 137-148. (2008).
    • (2008) Prog. Biophys. Mol. Biol. , vol.98 , Issue.2-3 , pp. 137-148
    • Perrin, M.J.1    Subbiah, R.N.2    Vandenberg, J.I.3    Hill, A.P.4
  • 71
    • 0033524661 scopus 로고    scopus 로고
    • Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system
    • Kupershmidt S, Yang T, Anderson ME et al. Replacement by homologous recombination of the minK gene with lacZ reveals restriction of minK expression to the mouse cardiac conduction system. Circulation Res. 84(2), 146-152 (1999). (Pubitemid 29070109)
    • (1999) Circulation Research , vol.84 , Issue.2 , pp. 146-152
    • Kupershmidt, S.1    Yang, T.2    Anderson, M.E.3    Wessels, A.4    Niswender, K.D.5    Magnuson, M.A.6    Roden, D.M.7
  • 72
    • 0033574273 scopus 로고    scopus 로고
    • MiRP1 forms IKr potassium channels withHERG and is associated with cardiac arrhythmia
    • Abbott GW, Sesti F, Splawski I et al. MiRP1 forms IKr potassium channels withHERG and is associated with cardiac arrhythmia. Cell 97(2), 175-187 (1999).
    • (1999) Cell , vol.97 , Issue.2 , pp. 175-187
    • Abbott, G.W.1    Sesti, F.2    Splawski, I.3
  • 73
    • 0030723260 scopus 로고    scopus 로고
    • Mutations in the hminK gene cause long QT syndrome and suppress I(Ks) function
    • DOI 10.1038/ng1197-338
    • Splawski I, Tristani-Firouzi M, Lehmann MH, Sanguinetti MC, Keating MT. Mutations in the hminK gene cause long QT syndrome and suppress lKs function. Nat. Genet. 17(3), 338-340 (1997). (Pubitemid 27476001)
    • (1997) Nature Genetics , vol.17 , Issue.3 , pp. 338-340
    • Splawski, I.1    Tristani-Firouzi, M.2    Lehmann, M.H.3    Sanguinetti, M.C.4    Keating, M.T.5
  • 74
    • 72549108593 scopus 로고    scopus 로고
    • A single supratherapeutic dose of vorinostat does not prolong the QTc interval in patients with advanced cancer
    • Munster PN, Rubin EH, Van Belle S et al. A single supratherapeutic dose of vorinostat does not prolong the QTc interval in patients with advanced cancer. Clin. Cancer Res. 15(22), 7077-7084 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.22 , pp. 7077-7084
    • Munster, P.N.1    Rubin, E.H.2    Van Belle, S.3
  • 76
    • 77949886046 scopus 로고    scopus 로고
    • Nonclinical safety assessment of the histone deacetylase inhibitor vorinostat
    • Kerr JS, Galloway S, Lagrutta A et al. Nonclinical safety assessment of the histone deacetylase inhibitor vorinostat. Int. J. Toxicol. 29(1), 3-19 (2010).
    • (2010) Int. J. Toxicol. , vol.29 , Issue.1 , pp. 3-19
    • Kerr, J.S.1    Galloway, S.2    Lagrutta, A.3
  • 77
    • 79952280909 scopus 로고    scopus 로고
    • Phase 1 clinical, pharmacokinetic and pharmacodynamic study of SB939, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumours
    • Razak ARA, Hotte SJ, Siu LL et al. Phase 1 clinical, pharmacokinetic and pharmacodynamic study of SB939, an oral histone deacetylase (HDAC) inhibitor, in patients with advanced solid tumours. Br. J. Cancer 104(5), 756-762 (2011).
    • (2011) Br. J. Cancer , vol.104 , Issue.5 , pp. 756-762
    • Razak, A.R.A.1    Hotte, S.J.2    Siu, L.L.3
  • 78
    • 79960163508 scopus 로고    scopus 로고
    • Discovery of (2E)-3-{2-Butyl-1-[2-(diethylamino)ethyl] - 1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile
    • Wang H, Yu N, Chen D et al. Discovery of (2E)-3-{2-Butyl-1-[2- (diethylamino)ethyl]- 1H-benzimidazol-5-yl}-N-hydroxyacrylamide (SB939), an orally active histone deacetylase inhibitor with a superior preclinical profile. J. Med. Chem. 54(13), 4694-4720 (2011).
    • (2011) J. Med. Chem. , vol.54 , Issue.13 , pp. 4694-4720
    • Wang, H.1    Yu, N.2    Chen, D.3
  • 79
    • 78649354620 scopus 로고    scopus 로고
    • Cardiotoxicity
    • Brana I, Tabernero J. Cardiotoxicity. Annu. Oncol. 21(Suppl. 7), vii173-vii179 (2010).
    • (2010) Annu. Oncol. , vol.21 , Issue.SUPPL. 7 , pp. 7173-7179
    • Brana, I.1    Tabernero, J.2
  • 80
    • 1442306232 scopus 로고    scopus 로고
    • Drug-Induced Prolongation of the QT Interval
    • DOI 10.1056/NEJMra032426
    • Roden DM. Drug-induced prolongation of the QT interval. N. Engl. J. Med. 350(10), 1013-1022 (2004). (Pubitemid 38269278)
    • (2004) New England Journal of Medicine , vol.350 , Issue.10 , pp. 1013-1022
    • Roden, D.M.1
  • 81
    • 0141939058 scopus 로고    scopus 로고
    • Effect of arsenic trioxide on QT interval in patients with advanced malignancies
    • DOI 10.1200/JCO.2003.10.009
    • Barbey JT, Pezzullo JC, Soignet SL. Effect of arsenic trioxide on QT interval in patients with advanced malignancies. J. Clin. Oncol. 21(19), 3609-3615 (2003). (Pubitemid 46594053)
    • (2003) Journal of Clinical Oncology , vol.21 , Issue.19 , pp. 3609-3615
    • Barbey, J.T.1    Pezzullo, J.C.2    Soignet, S.L.3
  • 82
    • 67349251502 scopus 로고    scopus 로고
    • QT interval prolongation among patients treated with angiogenesis inhibitors
    • Ederhy S, Cohen A, Dufaitre G et al. QT interval prolongation among patients treated with angiogenesis inhibitors. Targeted Oncol. 4(2), 89-97 (2009).
    • (2009) Targeted Oncol. , vol.4 , Issue.2 , pp. 89-97
    • Ederhy, S.1    Cohen, A.2    Dufaitre, G.3
  • 84
    • 0034917323 scopus 로고    scopus 로고
    • Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs: A call for consensus
    • DOI 10.1007/s002280100290
    • De Ponti F, Poluzzi E, Montanaro N. Organising evidence on QT prolongation and occurrence of Torsades de Pointes with non-antiarrhythmic drugs: a call for consensus. Eur. J. Clin. Pharmacol. 57(3), 185-209 (2001). (Pubitemid 32662464)
    • (2001) European Journal of Clinical Pharmacology , vol.57 , Issue.3 , pp. 185-209
    • De Ponti, F.1    Poluzzi, E.2    Montanaro, N.3
  • 85
    • 0033032481 scopus 로고    scopus 로고
    • Measurement of depressive symptoms in cancer patients: Evaluation of the center for epidemiological studies depression scale (CES-D)
    • DOI 10.1016/S0022-3999(99)00004-5, PII S0022399999000045
    • Hann D, Winter K, Jacobsen P. Measurement of depressive symptoms in cancer patients: Evaluation of the center for epidemiological studies depression scale (Ces-d). J. Psychosomatic Res. 46(5), 437-443 (1999). (Pubitemid 29277215)
    • (1999) Journal of Psychosomatic Research , vol.46 , Issue.5 , pp. 437-443
    • Hann, D.1    Winter, K.2    Jacobsen, P.3
  • 86
    • 0036155193 scopus 로고    scopus 로고
    • Clinical and therapeutic aspects of congenital and acquired long QT syndrome
    • Ijaz AK. Clinical and therapeutic aspects of congenital and acquired long QT syndrome. Am. J. Med. 112(1), 58-66 (2002).
    • (2002) Am. J. Med. , vol.112 , Issue.1 , pp. 58-66
    • Ijaz, A.K.1
  • 87
    • 9244222261 scopus 로고    scopus 로고
    • Targeted cancer therapy
    • DOI 10.1038/nature03095
    • Sawyers C. Targeted cancer therapy. Nature 432(7015), 294-297 (2004). (Pubitemid 39551656)
    • (2004) Nature , vol.432 , Issue.7015 , pp. 294-297
    • Sawyers, C.1
  • 89
    • 67349227787 scopus 로고    scopus 로고
    • Isoform-specific histone deacetylase inhibitors: The next step
    • Balasubramanian S, Verner E, Buggy JJ. Isoform-specific histone deacetylase inhibitors: the next step? Cancer Lett. 280(2), 211-221 (2009).
    • (2009) Cancer Lett. , vol.280 , Issue.2 , pp. 211-221
    • Balasubramanian, S.1    Verner, E.2    Buggy, J.J.3
  • 91
    • 67349160499 scopus 로고    scopus 로고
    • HDAC expression and clinical prognosis in human malignancies
    • Weichert W. HDAC expression and clinical prognosis in human malignancies. Cancer Lett. 280(2), 168-176 (2009).
    • (2009) Cancer Lett. , vol.280 , Issue.2 , pp. 168-176
    • Weichert, W.1
  • 92
    • 1842631408 scopus 로고    scopus 로고
    • Upregulation and Nuclear Recruitment of HDACl in Hormone Refractory Prostate Cancer
    • DOI 10.1002/pros.20022
    • Halkidou K, Gaughan L, Cook S, Leung HY, Neal DE, Robson CN. Upregulation and nuclear recruitment of HDACI in hormone refractory prostate cancer. Prostate 59(2), 177-189 (2004). (Pubitemid 38481229)
    • (2004) Prostate , vol.59 , Issue.2 , pp. 177-189
    • Halkidou, K.1    Gaughan, L.2    Cook, S.3    Leung, H.Y.4    Neal, D.E.5    Robson, C.N.6
  • 96
    • 84994856253 scopus 로고    scopus 로고
    • Preclinical characterization of 4SC-202, a novel isotype specific HDAC inhibitor
    • Henning SW, Doblhofer R, Kohlhof H et al. Preclinical characterization of 4SC-202, a novel isotype specific HDAC inhibitor. Eur. J. Cancer Suppl. 8(7), 61 (2010).
    • (2010) Eur. J. Cancer Suppl. , vol.8 , Issue.7 , pp. 61
    • Henning, S.W.1    Doblhofer, R.2    Kohlhof, H.3
  • 99
    • 51649091668 scopus 로고    scopus 로고
    • A Phase 1 and pharmacokinetic study of the oral histone deacetylase inhibitor, MS-275, in patients with refractory solid tumors and lymphomas
    • Gore L, Rothenberg ML, O'Bryant CL et al. A Phase 1 and pharmacokinetic study of the oral histone deacetylase inhibitor, MS-275, in patients with refractory solid tumors and lymphomas. Clin. Cancer Res. 14(14), 4517-4525 (2008).
    • (2008) Clin. Cancer Res. , vol.14 , Issue.14 , pp. 4517-4525
    • Gore, L.1    Rothenberg, M.L.2    O'Bryant, C.L.3
  • 101
    • 58149377828 scopus 로고    scopus 로고
    • Multicenter Phase 2 trial of the histone deacetylase inhibitor pyridylmethyl-N-{4-[(2- aminophenyl)-carbamoyl]-benzyl}-carbamate in pretreated metastatic melanoma
    • Hauschild A, Trefzer U, Garbe C et al. Multicenter Phase 2 trial of the histone deacetylase inhibitor pyridylmethyl-N-{4-[(2- aminophenyl)-carbamoyl]- benzyl}-carbamate in pretreated metastatic melanoma. Melanoma Res. 18(4), 274-278 (2008).
    • (2008) Melanoma Res. , vol.18 , Issue.4 , pp. 274-278
    • Hauschild, A.1    Trefzer, U.2    Garbe, C.3
  • 102
    • 70350448445 scopus 로고    scopus 로고
    • Phase 2 study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia
    • Blum KA, Advani A, Fernandez L et al. Phase 2 study of the histone deacetylase inhibitor MGCD0103 in patients with previously treated chronic lymphocytic leukaemia. Br. J. Haematol. 147(4), 507-514 (2009).
    • (2009) Br. J. Haematol. , vol.147 , Issue.4 , pp. 507-514
    • Blum, K.A.1    Advani, A.2    Fernandez, L.3
  • 103
    • 42949154252 scopus 로고    scopus 로고
    • Phase 1 study of MGCD0103 given as a three-times-per-week oral dose in patients with advanced solid tumors
    • Siu LL, Pili R, Duran I et al. Phase 1 study of MGCD0103 given as a three-times-per-week oral dose in patients with advanced solid tumors. J. Clin. Oncol. 26(12), 1940-1947 (2008).
    • (2008) J. Clin. Oncol. , vol.26 , Issue.12 , pp. 1940-1947
    • Siu, L.L.1    Pili, R.2    Duran, I.3
  • 104
    • 80051599485 scopus 로고    scopus 로고
    • Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases
    • Cole KE, Dowling DP, Boone MA, Phillips AJ, Christianson DW. Structural basis of the antiproliferative activity of largazole, a depsipeptide inhibitor of the histone deacetylases. J. Am. Chem. Soc. 133(32), 12474-12477 (2011).
    • (2011) J. Am. Chem. Soc. , vol.133 , Issue.32 , pp. 12474-12477
    • Cole, K.E.1    Dowling, D.P.2    Boone, M.A.3    Phillips, A.J.4    Christianson, D.W.5
  • 105
    • 34547684065 scopus 로고    scopus 로고
    • HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination
    • DOI 10.1038/sj.onc.1210614, PII 1210614
    • Boyault C, Sadoul K, Pabion M, Khochbin S. HDAC6, at the crossroads between cytoskeleton and cell signaling by acetylation and ubiquitination. Oncogene 26(37), 5468-5476 (2007). (Pubitemid 47255928)
    • (2007) Oncogene , vol.26 , Issue.37 , pp. 5468-5476
    • Boyault, C.1    Sadoul, K.2    Pabion, M.3    Khochbin, S.4
  • 106
    • 61849144810 scopus 로고    scopus 로고
    • HDAC family: What are the cancer relevant targets
    • Witt O, Deubzer HE, Milde T, Oehme I. HDAC family: What are the cancer relevant targets? Cancer Lett. 277(1), 8-21 (2009).
    • (2009) Cancer Lett. , vol.277 , Issue.1 , pp. 8-21
    • Witt, O.1    Deubzer, H.E.2    Milde, T.3    Oehme, I.4
  • 109
    • 78649876797 scopus 로고    scopus 로고
    • Non-natural macrocyclic inhibitors of histone deacetylases: Design, syn thesis, and activity
    • Auzzas L, Larsson A, Matera R et al. Non-natural macrocyclic inhibitors of histone deacetylases: design, synthesis, and activity. J. Med. Chem. 53(23), 8387-8399 (2010).
    • (2010) J. Med. Chem. , vol.53 , Issue.23 , pp. 8387-8399
    • Auzzas, L.1    Larsson, A.2    Matera, R.3
  • 110
    • 80052925413 scopus 로고    scopus 로고
    • The structural requirements of histone deacetylase inhibitors: Suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity
    • Choi SE, Weerasinghe SVW, Pflum MKH. The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C3 position display isoform selectivity. Bioorg. Med. Chem. Lett. 21(20), 6139-6142 (2011).
    • (2011) Bioorg. Med. Chem. Lett. , vol.21 , Issue.20 , pp. 6139-6142
    • Choi, S.E.1    Weerasinghe, S.V.W.2    Pflum, M.K.H.3
  • 111
    • 80052555385 scopus 로고    scopus 로고
    • Selective inhibition of HDAC6 with a new prototype inhibitor (ACY-1215) overcomes bortezomib resistance in multiple myeloma (MM
    • Santo L, Hideshima T, Kung AL et al. Selective inhibition of HDAC6 with a new prototype inhibitor (ACY-1215) overcomes bortezomib resistance in multiple myeloma (MM). ASH Annu. Meet. Abstracts 116(21), 2997- (2010).
    • (2010) ASH Annu. Meet. Abstracts , vol.116 , Issue.21 , pp. 2997
    • Santo, L.1    Hideshima, T.2    Kung, A.L.3
  • 112
    • 20444487771 scopus 로고    scopus 로고
    • Histone deacetylase HDAC8 associates with smooth muscle α-actin and is essential for smooth muscle cell contractility
    • DOI 10.1096/fj.04-2303fje
    • Waltregny D, Glenisson W, Tran SL et al. Histone deacetylase HDAC8 associates with smooth muscle a-actin and is essential for smooth muscle cell contractility. FASEB J. 19(8), 966-968 (2005). (Pubitemid 40827719)
    • (2005) FASEB Journal , vol.19 , Issue.8 , pp. 966-968
    • Waltregny, D.1    Glenisson, W.2    Tran, S.L.3    North, B.J.4    Verdin, E.5    Colige, A.6    Castronovo, V.7
  • 113
    • 58849104486 scopus 로고    scopus 로고
    • Histone deacetylase 8 in neuroblastoma tumorigenesis
    • Oehme I, Deubzer HE, Wegener D et al. Histone deacetylase 8 in neuroblastoma tumorigenesis. Clin. Cancer Res. 15(1), 91-99 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.1 , pp. 91-99
    • Oehme, I.1    Deubzer, H.E.2    Wegener, D.3
  • 114
    • 43749109171 scopus 로고    scopus 로고
    • A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomas
    • DOI 10.1038/leu.2008.9, PII LEU20089
    • Balasubramanian S, Ramos J, Luo W, Sirisawad M, Verner E, Buggy JJ. A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI- 34051 induces apoptosis in T-cell lymphomas. Leukemia 22(5), 1026-1034 (2008). (Pubitemid 351689885)
    • (2008) Leukemia , vol.22 , Issue.5 , pp. 1026-1034
    • Balasubramanian, S.1    Ramos, J.2    Luo, W.3    Sirisawad, M.4    Verner, E.5    Buggy, J.J.6
  • 115
  • 117
    • 79960561626 scopus 로고    scopus 로고
    • Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors
    • Whitehead L, Dobler MR, Radetich B et al. Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors. Bioorg. Med. Chem. 19(15), 4626-4634 (2011).
    • (2011) Bioorg. Med. Chem. , vol.19 , Issue.15 , pp. 4626-4634
    • Whitehead, L.1    Dobler, M.R.2    Radetich, B.3
  • 120
    • 79960902512 scopus 로고    scopus 로고
    • The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors
    • Shultz M, Fan J, Chen C et al. The design, synthesis and structure-activity relationships of novel isoindoline-based histone deacetylase inhibitors. Bioorg. Med. Chem. Lett. 21(16), 4909-4912 (2011).
    • (2011) Bioorg. Med. Chem. Lett. , vol.21 , Issue.16 , pp. 4909-4912
    • Shultz, M.1    Fan, J.2    Chen, C.3
  • 121
    • 80052338033 scopus 로고    scopus 로고
    • Novel roles for hERG K(+) channels in cell proliferation and apoptosis
    • Jehle J, Schweizer PA, Katus HA, Thomas D. Novel roles for hERG K(+) channels in cell proliferation and apoptosis. Cell Death Dis. 2, e193 (2011).
    • (2011) Cell Death Dis. , vol.2
    • Jehle, J.1    Schweizer, P.A.2    Katus, H.A.3    Thomas, D.4
  • 123
    • 84858668183 scopus 로고    scopus 로고
    • Histone deacetylases as new therapeutical targets for the treatment of non-melanoma skin cancer: Results of Phase 1/2a trial with topical DAC060
    • Botti E, Mercurio C, Spallone G et al. Histone deacetylases as new therapeutical targets for the treatment of non-melanoma skin cancer: results of Phase 1/2a trial with topical DAC060. J. Invest. Dermatol. 131, S46-S46 (2011).
    • (2011) J. Invest. Dermatol. , vol.131
    • Botti, E.1    Mercurio, C.2    Spallone, G.3
  • 124
    • 77954249976 scopus 로고    scopus 로고
    • Polymeric drug delivery systems for localized cancer chemotherapy
    • De Souza R, Zahedi P, Allen CJ, Piquette- Miller M. Polymeric drug delivery systems for localized cancer chemotherapy. Drug Deliv. 17(6), 365-375 (2010).
    • (2010) Drug Deliv. , vol.17 , Issue.6 , pp. 365-375
    • De Souza, R.1    Zahedi, P.2    Allen, C.J.3    Piquette- Miller, M.4
  • 125
    • 84858643817 scopus 로고    scopus 로고
    • Government of the united states of america, represented by the secretary, department of health and human services, topical formulations of histone deacetylase inhibitors and methods using the same
    • Government of the United States of America, represented by the Secretary, Department of Health and Human Services, topical formulations of histone deacetylase inhibitors and methods using the same, US20080292616A1 (2008).
    • (2008) US20080292616A1
  • 126
    • 79955451248 scopus 로고    scopus 로고
    • Discovery, syn thesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors
    • Virasi M, Thaler F, Abate A et al. Discovery, synthesis, and pharmacological evaluation of spiropiperidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors. J. Med. Chem. 54(8), 3051-3064 (2011).
    • (2011) J. Med. Chem. , vol.54 , Issue.8 , pp. 3051-3064
    • Virasi, M.1    Thaler, F.2    Abate, A.3
  • 127
    • 77249133651 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors
    • Thaler F, Colombo A, Mai A et al. Synthesis and biological evaluation of N-hydroxyphenylacrylamides and N-hydroxypyridin-2-ylacrylamides as novel histone deacetylase inhibitors. J. Med. Chem. 53(2), 822-839 (2009).
    • (2009) J. Med. Chem. , vol.53 , Issue.2 , pp. 822-839
    • Thaler, F.1    Colombo, A.2    Mai, A.3
  • 128
    • 84858673947 scopus 로고    scopus 로고
    • A soft-drug histone deacetylase inhibitor for cutaneous T-cell lymphoma
    • Bradner J, Greenberg E, Ponduru S et al. A soft-drug histone deacetylase inhibitor for cutaneous T-cell lymphoma. ASH Annu. Meet. Abstracts 110(11), 800 (2007).
    • (2007) ASH Annu. Meet. Abstracts , vol.110 , Issue.11 , pp. 800
    • Bradner, J.1    Greenberg, E.2    Ponduru, S.3
  • 129
    • 84858683737 scopus 로고    scopus 로고
    • In vitro and in vivo anti-leukemia activity of CHR- 2845, a cell-targeted HDAC inhibitor for use in monocytic leukemia
    • Tong W, Stevenson W, Cortes J et al. In vitro and in vivo anti-leukemia activity of CHR- 2845, a cell-targeted HDAC inhibitor for use in monocytic leukemia. ASCO Meet. Abstracts 27(15S), e14579 (2009).
    • (2009) ASCO Meet. Abstracts , vol.27 , Issue.S
    • Tong, W.1    Stevenson, W.2    Cortes, J.3
  • 130
    • 84858643816 scopus 로고    scopus 로고
    • CHR-2845, a monocyte/macrophage targeted histone deacetylase inhibitor in a first in man clinical trial in subjects with advanced haematological malignancies
    • Ossenkoppele G, Lowenberg B, Zachee P et al. CHR-2845, a monocyte/macrophage targeted histone deacetylase inhibitor in a first in man clinical trial in subjects with advanced haematological malignancies. ASH Annu. Meet. Abstracts 116(21), 3279 (2010).
    • (2010) ASH Annu. Meet. Abstracts , vol.116 , Issue.21 , pp. 3279
    • Ossenkoppele, G.1    Lowenberg, B.2    Zachee, P.3
  • 131
    • 0029020383 scopus 로고
    • Azithromycin - the first of the tissue-selective azalides
    • Hoepelman IM, Schneider MME. Azithromycin - the first of the tissue-selective azalides. Int. J. Antimicrob. Agents 5(3), 145-167 (1995).
    • (1995) Int. J. Antimicrob. Agents , vol.5 , Issue.3 , pp. 145-167
    • Hoepelman, I.M.1    Schneider, M.M.E.2
  • 133
    • 71449110365 scopus 로고    scopus 로고
    • Distribution characteristics of telithromycin, a novel ketolide antimicrobial agent applied for treatment of respiratory infection, in lung epithelial lining fluid and alveolar macrophages
    • Togami K, Chono S, Seki T, Morimoto K. Distribution characteristics of telithromycin, a novel ketolide antimicrobial agent applied for treatment of respiratory infection, in lung epithelial lining fluid and alveolar macrophages. Drug Metab. Pharmacokinet. 24(5), 411-417 (2009).
    • (2009) Drug Metab. Pharmacokinet. , vol.24 , Issue.5 , pp. 411-417
    • Togami, K.1    Chono, S.2    Seki, T.3    Morimoto, K.4
  • 134
    • 0036449979 scopus 로고    scopus 로고
    • Pharmacokinetics of azithromycin in lung tissue, bronchial washing, and plasma in patients given multiple oral doses of 500 and 1000 mg daily
    • DOI 10.1016/S1043661802002384
    • Di Paolo A, Barbara C, Chella A, Angeletti CA, Del Tacca M. Pharmacokinetics of azithromycin in lung tissue, bronchial washing, and plasma in patients given multiple oral doses of 500 and 1000 mg daily. Pharmacol. Res. 46(6), 545-550 (2002). (Pubitemid 35439167)
    • (2002) Pharmacological Research , vol.46 , Issue.6 , pp. 545-550
    • Di Paolo, A.1    Barbara, C.2    Chella, A.3    Angeletti, C.A.4    Del Tacca, M.5
  • 136
    • 0032737529 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of clarithromycin
    • Rodvold KA. Clinical pharmacokinetics of clarithromycin. Clin. Pharmacokinet. 37(5), 385-398 (1999).
    • (1999) Clin. Pharmacokinet. , vol.37 , Issue.5 , pp. 385-398
    • Rodvold, K.A.1
  • 137
    • 60549102514 scopus 로고    scopus 로고
    • Non-peptide macrocyclic histone deacetylase inhibitors
    • Oyelere AK, Chen PC, Guerrant W et al. Non-peptide macrocyclic histone deacetylase inhibitors. J. Med. Chem. 52(2), 456-468 (2009).
    • (2009) J. Med. Chem. , vol.52 , Issue.2 , pp. 456-468
    • Oyelere, A.K.1    Chen, P.C.2    Guerrant, W.3
  • 138
    • 55549094833 scopus 로고    scopus 로고
    • Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain
    • Bottomley MJ, Lo Surdo P, Di Giovine P et al. Structural and functional analysis of the human HDAC4 catalytic domain reveals a regulatory structural zinc-binding domain. J. Biol. Chem. 283(39), 26694-26704 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.39 , pp. 26694-26704
    • Bottomley, M.J.1    Lo Surdo, P.2    Di Giovine, P.3
  • 139
    • 45549095066 scopus 로고    scopus 로고
    • Human HDAC7 harbors a Class 2a histone deacetylase-specific zinc binding motif and cryptic deacetylase activity
    • Schuetz A, Min J, Allali-Hassani A et al. Human HDAC7 harbors a Class 2a histone deacetylase-specific zinc binding motif and cryptic deacetylase activity. J. Biol. Chem. 283(17), 11355-11363 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.17 , pp. 11355-11363
    • Schuetz, A.1    Min, J.2    Allali-Hassani, A.3
  • 140
    • 71449109387 scopus 로고    scopus 로고
    • New patented histone deacetylase inhibitors
    • Wang HS, Dymock BW. New patented histone deacetylase inhibitors. Expert Opin. Ther. Patents 19(12), 1727-1757 (2009).
    • (2009) Expert Opin. Ther. Patents , vol.19 , Issue.12 , pp. 1727-1757
    • Wang, H.S.1    Dymock, B.W.2
  • 141
    • 33644869283 scopus 로고    scopus 로고
    • Tissue distribution and pharmacodynamics: A complicated relationship
    • Lin JH. Tissue distribution and pharmacodynamics: a complicated relationship. Curr. Drug Metab. 7(1), 39-65 (2006).
    • (2006) Curr. Drug Metab. , vol.7 , Issue.1 , pp. 39-65
    • Lin, J.H.1
  • 142
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle therapeutics: An emerging treatment modality for cancer
    • Davis ME, Chen Z, Shin DM. Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat. Rev. Drug Discov. 7(9), 771-782 (2008).
    • (2008) Nat. Rev. Drug Discov. , vol.7 , Issue.9 , pp. 771-782
    • Davis, M.E.1    Chen, Z.2    Shin, D.M.3
  • 143
    • 77951778977 scopus 로고    scopus 로고
    • Personalized medicine in oncology: The future is now
    • Schilsky RL. Personalized medicine in oncology: the future is now. Nat. Rev. Drug Discov. 9(5), 363-366 (2010).
    • (2010) Nat. Rev. Drug Discov. , vol.9 , Issue.5 , pp. 363-366
    • Schilsky, R.L.1
  • 144
    • 42449102138 scopus 로고    scopus 로고
    • Epigenetics of cancer progression
    • DOI 10.2217/14622416.9.2.215
    • Vucic EA, Brown CJ, Lam WL. Epigenetics of cancer progression. Pharmacogenomics 9(2), 215-234 (2008). (Pubitemid 351575091)
    • (2008) Pharmacogenomics , vol.9 , Issue.2 , pp. 215-234
    • Vucic, E.A.1    Brown, C.J.2    Lam, W.L.3
  • 145
    • 79957537645 scopus 로고    scopus 로고
    • Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions
    • Ruthenburg AJ, Li HT, Milne TA et al. Recognition of a mononucleosomal histone modification pattern by BPTF via multivalent interactions. Cell 145(5), 692-706 (2011).
    • (2011) Cell , vol.145 , Issue.5 , pp. 692-706
    • Ruthenburg, A.J.1    Li, H.T.2    Milne, T.A.3


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