A novel combinatorial epigenetic therapy using resveratrol and pterostilbene for restoring estrogen receptor-α (ERα) expression in ERα-negative breast cancer cells

PLoS ONE

Volumn 11, Issue 5, 2016, Pages

  Kala, Rishabh ^a   Tollefsbol, Trygve O ^a,b,c  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^c UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCYTOSINE; AFIMOXIFENE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE; PROGESTERONE RECEPTOR; PTEROSTILBENE; RESVERATROL; STILBENE DERIVATIVE; TAMOXIFEN;

ADULT; ARTICLE; BREAST CANCER; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REACTIVATION; EPIGENETICS; ESTROGEN RECEPTOR ALPHA NEGATIVE BREAST CANCER; FEMALE; HUMAN; HUMAN CELL; LIMIT OF QUANTITATION; MIDDLE AGED; PGR GENE; PROMOTER REGION; PROTEIN EXPRESSION; ANALOGS AND DERIVATIVES; BREAST NEOPLASMS; DNA METHYLATION; GENETIC EPIGENESIS; GENETICS; METABOLISM; PATHOLOGY; TUMOR CELL LINE;

BREAST NEOPLASMS; CELL LINE, TUMOR; DNA METHYLATION; EPIGENESIS, GENETIC; ESTROGEN RECEPTOR ALPHA; FEMALE; HUMANS; PROMOTER REGIONS, GENETIC; STILBENES; TAMOXIFEN;

EID: 84968764917     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0155057     Document Type: Article

References (29)

1. Cancer facts & statistics. 2016. Available: http://www.cancer.org/cancer/breastcancer/detailedguide/breast-cancer-key-statistics.
2. Saxena NK, Sharma D. Epigenetic Reactivation of Estrogen Receptor: Promising Tools for Restoring Response to Endocrine Therapy. Mol Cell Pharmacol. 2010; 2: 191-202. PMID: 21499573
3. Ni M, Chen Y, Lim E, Wimberly H, Bailey ST, Imai Y, et al. Targeting androgen receptor in estrogen receptor-negative breast cancer. Cancer Cell. 2011; 20: 119-131. doi: 10.1016/j.ccr.2011.05.026 PMID: 21741601
4. Kala R, Shah HN, Martin SL, Tollefsbol TO. Epigenetic-based combinatorial resveratrol and pterostilbene alters DNA damage response by affecting SIRT1 and DNMT enzyme expression, including SIRT1-dependent γ-H2AX and telomerase regulation in triple-negative breast cancer. BMC Cancer. 2015; 15:672. doi: 10.1186/s12885-015-1693-z PMID: 26459286
5. McDonnell D, Norris J. Connections and regulation of the human estrogen receptor. Science. 2002; 296:1642-1644. PMID: 12040178
6. Li Y, Yuan YY, Meeran SM, Tollefsbol TO. Synergistic epigenetic reactivation of estrogen receptor-α (ERα) by combined green tea polyphenol and histone deacetylase inhibitor in ERα-negative breast cancer cells. Molecular Cancer. 2010; 9:274. doi: 10.1186/1476-4598-9-274 PMID: 20946668
7. Meeran SM, Patel SN, Li Y, Shukla S, Tollefsbol TO. Bioactive Dietary Supplements Reactivate ER Expression in ER-Negative Breast Cancer Cells by Active Chromatin Modifications. PLoS ONE. 2012; 7(5): e37748. doi: 10.1371/journal.pone.0037748 PMID: 22662208
8. Sharma D, Blum J, Yang X, Beaulieu N, Macleod AR, Davidson NE. Release of methyl CpG binding proteins and histone deacetylase 1 from the Estrogen receptor alpha (ER) promoter upon reactivation in ER-negative human breast cancer cells. Mol Endocrinol. 2005; 19: 1740-1751. PMID: 15746193
9. Macaluso M, Cinti C, Russo G, Russo A, Giordano A. pRb2/p130- E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multimolecular complexes mediate the transcription of estrogen receptor-alpha in breast cancer. Oncogene. 2003; 22: 3511-3517. PMID: 12789259
10. Yang X, Ferguson A, Nass S, Phillips D, Butash K, Wang S, et al. Transcriptional activation of estrogen receptor alpha in human breast cancer cells by histone deacetylase inhibition. Cancer Res. 2000; 60:6890-6894. PMID: 11156387
11. Zhou Q, Atadja P, Davidson NE. Histone deacetylase inhibitor LBH589 reactivates silenced estrogen receptor alpha (ER) gene expression without loss of DNA hypermethylation. Cancer Biol Ther. 2007; 6: 64-69. PMID: 17172825
12. Kala R, Tollefsbol TO, Li Y. Potential of Resveratrol in Inhibiting Cancer and Slowing Aging. J Nutr Food Sci. 2012; S5:001.
13. Saldanha SN, Kala R, Tollefsbol TO. Molecular mechanisms for inhibition of colon cancer cells by combined epigenetic-modulating epigallocatechin gallate and sodium butyrate. Exp Cell Res. 2014; 324(1):40-53. doi: 10.1016/j.yexcr.2014.01.024 PMID: 24518414
14. Meeran SM, Patel SN, Tollefsbol TO. Sulforaphane causes epigenetic repression of hTERT expression in human breast cancer cell lines. PLoS One. 2010; 5: e11457. doi: 10.1371/journal.pone.0011457 PMID: 20625516
15. Macaluso M, Cinti C, Russo G, Russo A, Giordano A. pRb2/p130-E2F4/5-HDAC1-SUV39H1-p300 and pRb2/p130-E2F4/5-HDAC1-SUV39H1-DNMT1 multi molecular complexes mediate the transcription of estrogen receptor-a in breast cancer. Oncogene. 2003; 22, 3511-3517. PMID: 12789259
16. Li Y, Meeran SM, Patel SN, Chen H, Hardy TM, Tollefsbol TO. Epigenetic reactivation of estrogen receptor-α (ERα) by genistein enhances hormonal therapy sensitivity in ERα-negative breast cancer. Molecular Cancer 2013; 12:9. doi: 10.1186/1476-4598-12-9 PMID: 23379261
17. Clarke R, Liu M, Bouker K, Gu Z, Lee R, Zhu Y, et al. Antiestrogen resistance in breast cancer and the role of estrogen receptor signaling. Oncogene. 2003; 22:7316-7339. PMID: 14576841
18. Mandlekar S, Kong A. Mechanisms of tamoxifen-induced apoptosis. Apoptosis. 2001; 6:469-477. PMID: 11595837
19. Yang X, Phillips D, Ferguson A, Nelson W, Herman J, Davidson N. Synergistic activation of functional estrogen receptor (ER)-alpha by DNA methyltransferase and histone deacetylase inhibition in human ERalpha- negative breast cancer cells. Cancer Res 2001; 61:7025-7029. PMID: 11585728
20. Mirza S, Sharma G, Parshad R, Gupta SD, Pandya P, Ralhan R. Expression of DNA methyltransferases in breast cancer patients and to analyze the effect of natural compounds on DNA methyltransferases and associated proteins. J Breast Cancer. 2013; 16:23-31. doi: 10.4048/jbc.2013.16.1.23 PMID: 23593078
21. Gracia A, Elcoroaristizabal X, Quintela AF, Miranda J, Bediaga NG, de Pancorbo M, et al. Fatty acid synthase methylation levels in adipose tissue: effects of an obesogenic diet and phenol compounds. Genes & Nutrition. 2014; 9(4):411.
22. Liu T, Liu PY, Marshall GM. The Critical Role of the Class III Histone Deacetylase SIRT1 in Cancer. Cancer Res. 2009; 69: (5). 1702. doi: 10.1158/0008-5472.CAN-08-3365 PMID: 19244112
23. Vaquero A, Scher M, Lee D, Bromage HE, Tempst P, Reinberg D. Human SirT1 Interacts with Histone H1 and Promotes Formation of Facultative Heterochromatin, Molecular Cell. 2004; 16, 93-105. PMID: 15469825
24. Kong S, Kim SJ, Sandal B, Lee SM, Gao B, Zhang DD, et al. The Type III Histone Deacetylase Sirt1 Protein Suppresses p300-mediated Histone H3 Lysine 56 Acetylation at Bclaf1 Promoter to Inhibit T Cell Activation. The Journal of Biological Chemistry. 2011; 286,16967-16975. doi: 10.1074/jbc.M111.218206 PMID: 21454709
25. Zhang H, Liang F, Jia Z, Song S, Jiang Z. PTEN mutation, methylation and expression in breast cancer patients. Oncology Letters. 2013; 6, 161-168. PMID: 23946797
26. Laird P, Jaenisch R. The role of DNA methylation in cancer genetic and epigenetics. Annu Rev Genet 1996; 30:441-464. PMID: 8982461
27. Wang L, Tang L, Xie R, Nie W, Chen L, Guan X. p16 promoter hypermethylation is associated with increased breast cancer risk. Molecular Medicine Reports. 2012; 6, 904-908. doi: 10.3892/mmr.2012.1001 PMID: 22824969
28. Saxena NK, Sharma D. Epigenetic Reactivation of Estrogen Receptor: Promising Tools for Restoring Response to Endocrine Therapy. Molecular and cellular pharmacology. 2010; 2(5):191-202. PMID: 21499573
29. Sharma D, Saxena NK, Davidson NE, Vertino PM. Restoration of Tamoxifen Sensitivity in Estrogen Receptor-Negative Breast Cancer Cells: Tamoxifen-Bound Reactivated ER Recruits Distinctive Corepressor Complexes. Cancer Res. 2006; 66:(12): 6370-6378. PMID: 16778215