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Volumn 7, Issue 10, 2008, Pages 1307-1312

"Targeting the absence" and therapeutic engineering for cancer therapy

Author keywords

Cancer; Chemotherapy; Cure; Drug combinations; Drug resistance; Targets

Indexed keywords

3 [2 [(2 TERT BUTYLPHENYLAMINOOXALYL)AMINO]PROPIONYLAMINO] 4 OXO 5 (2,3,5,6 TETRAFLUOROPHENOXY)PENTANOIC ACID; BEVACIZUMAB; CISPLATIN; DOXORUBICIN; DOXYCYCLINE; EPOTHILONE A; ETOPOSIDE; FLAVOPIRIDOL; NAVELBINE; PACLITAXEL; PIFITHRIN ALPHA; PROTEIN P53; RAPAMYCIN; VINBLASTINE;

EID: 45749117120     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.10.6250     Document Type: Review
Times cited : (40)

References (59)
  • 1
    • 35448954854 scopus 로고    scopus 로고
    • Targeting the absence: Homozygous DNA deletions as immutable signposts for cancer therapy
    • Varshavsky A. Targeting the absence: homozygous DNA deletions as immutable signposts for cancer therapy. Proc Natl Acad Sci USA 2007; 104:14935-40.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 14935-14940
    • Varshavsky, A.1
  • 2
    • 0032478303 scopus 로고    scopus 로고
    • Codominant interference, antieffectors, and multitarget drugs
    • Varshavsky A. Codominant interference, antieffectors, and multitarget drugs. Proc Natl Acad Sci USA 1998; 95:2094-9.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 2094-2099
    • Varshavsky, A.1
  • 3
    • 0348008982 scopus 로고    scopus 로고
    • Angiogenesis inhibitors: A new class of drugs
    • Folkman. Angiogenesis inhibitors: A new class of drugs. Cancer Biol Ther 2003; 2:127-33.
    • (2003) Cancer Biol Ther , vol.2 , pp. 127-133
    • Folkman1
  • 4
    • 0031717905 scopus 로고    scopus 로고
    • Tumor-suppressor p53: Implications for tumor development and prognosis
    • Kirsch DG, Kastan MB. Tumor-suppressor p53: implications for tumor development and prognosis. J Clin Oncol 1998; 16:3158-68.
    • (1998) J Clin Oncol , vol.16 , pp. 3158-3168
    • Kirsch, D.G.1    Kastan, M.B.2
  • 5
    • 0034796595 scopus 로고    scopus 로고
    • Normalizing tumor vasculature with anti-angiogenic therapy: A new paradigm for combination therapy
    • Jain R. Normalizing tumor vasculature with anti-angiogenic therapy: a new paradigm for combination therapy. Nat Med 2001; 7:987-9.
    • (2001) Nat Med , vol.7 , pp. 987-989
    • Jain, R.1
  • 7
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B, Kinzler KW. Cancer genes and the pathways they control. Nat Med 2004; 10:789-99.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 8
    • 33846576538 scopus 로고    scopus 로고
    • Facultative or obligate anaerobic bacteria have the potential for multimodality therapy of solid tumours
    • Wei MQ, Ellem KA, Dunn P, West MJ, Bai CX, Vogelstein B. Facultative or obligate anaerobic bacteria have the potential for multimodality therapy of solid tumours. Eur J Cancer 2007; 43:490-6.
    • (2007) Eur J Cancer , vol.43 , pp. 490-496
    • Wei, M.Q.1    Ellem, K.A.2    Dunn, P.3    West, M.J.4    Bai, C.X.5    Vogelstein, B.6
  • 9
    • 0033721127 scopus 로고    scopus 로고
    • The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand
    • Ozoren N, Kim K, Burns TF, Dicker DT, Moscioni AD, El-Deiry WS. The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand. Cancer Res 2000; 60:6259-65.
    • (2000) Cancer Res , vol.60 , pp. 6259-6265
    • Ozoren, N.1    Kim, K.2    Burns, T.F.3    Dicker, D.T.4    Moscioni, A.D.5    El-Deiry, W.S.6
  • 10
    • 1542751704 scopus 로고    scopus 로고
    • Inhibiting tyrosine kinases: Successes and limitations
    • Arteaga CL. Inhibiting tyrosine kinases: successes and limitations. Cancer Biol Ther 2003; 2:79-83.
    • (2003) Cancer Biol Ther , vol.2 , pp. 79-83
    • Arteaga, C.L.1
  • 12
    • 0347386407 scopus 로고    scopus 로고
    • Signal events: Cell signal transduction and its inhibition in cancer
    • Rowinsky EK. Signal events: Cell signal transduction and its inhibition in cancer. Oncologist 2003; 8:5-17.
    • (2003) Oncologist , vol.8 , pp. 5-17
    • Rowinsky, E.K.1
  • 13
    • 0344406759 scopus 로고    scopus 로고
    • Selective killing of cancer cells by beta -lapachone: Direct checkpoint activation as a strategy against cancer
    • Li Y, Sun X, LaMont JT, Pardee AB, Li CJ. Selective killing of cancer cells by beta -lapachone: direct checkpoint activation as a strategy against cancer. Proc Natl Acad Sci USA 2003; 100:2674-8.
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2674-2678
    • Li, Y.1    Sun, X.2    LaMont, J.T.3    Pardee, A.B.4    Li, C.J.5
  • 14
    • 1542298267 scopus 로고    scopus 로고
    • Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone
    • Workman P. Combinatorial attack on multistep oncogenesis by inhibiting the Hsp90 molecular chaperone. Cancer Lett 2004; 206:149-57.
    • (2004) Cancer Lett , vol.206 , pp. 149-157
    • Workman, P.1
  • 15
    • 4143066760 scopus 로고    scopus 로고
    • Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways
    • Sordella R, Bell DW, Haber DA, Settleman J. Gefitinib-sensitizing EGFR mutations in lung cancer activate anti-apoptotic pathways. Science 2004; 305:1163-7.
    • (2004) Science , vol.305 , pp. 1163-1167
    • Sordella, R.1    Bell, D.W.2    Haber, D.A.3    Settleman, J.4
  • 16
    • 17144395523 scopus 로고    scopus 로고
    • Inhibition of mutant EGF receptors by Gefitinib: Targeting an Achilles' heel of lung cancer
    • Settleman J. Inhibition of mutant EGF receptors by Gefitinib: Targeting an Achilles' heel of lung cancer. Cell Cycle 2004; 3:1496-7.
    • (2004) Cell Cycle , vol.3 , pp. 1496-1497
    • Settleman, J.1
  • 17
    • 9244251125 scopus 로고    scopus 로고
    • Cell-cycle checkpoints and cancer
    • Kastan MB, Bartek J. Cell-cycle checkpoints and cancer. Nature 2004; 432:316-23.
    • (2004) Nature , vol.432 , pp. 316-323
    • Kastan, M.B.1    Bartek, J.2
  • 18
    • 4344623889 scopus 로고    scopus 로고
    • Imatinib as a paradigm of targeted therapies
    • Druker BJ. Imatinib as a paradigm of targeted therapies. Adv Cancer Res 2004; 91:1-30.
    • (2004) Adv Cancer Res , vol.91 , pp. 1-30
    • Druker, B.J.1
  • 19
    • 9244222261 scopus 로고    scopus 로고
    • Targeted cancer therapy
    • Sawyers C. Targeted cancer therapy. Nature 2004; 432:294-7.
    • (2004) Nature , vol.432 , pp. 294-297
    • Sawyers, C.1
  • 20
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel RS, Kamen BA. The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 2004; 4:423-36.
    • (2004) Nat Rev Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 22
    • 2342431730 scopus 로고    scopus 로고
    • Intractable cancers: The many faces of multidrug resistance and the many targets it presents for therapeutic attack
    • Stein WD, Bates SE, Fojo T. Intractable cancers: the many faces of multidrug resistance and the many targets it presents for therapeutic attack. Curr Drug Targets 2004; 5:333-46.
    • (2004) Curr Drug Targets , vol.5 , pp. 333-346
    • Stein, W.D.1    Bates, S.E.2    Fojo, T.3
  • 25
    • 34548202165 scopus 로고    scopus 로고
    • Vitamin D signalling pathways in cancer: Potential for anticancer therapeutics
    • Deeb KK, Trump DL, Johnson CS. Vitamin D signalling pathways in cancer: potential for anticancer therapeutics. Nat Rev Cancer 2007; 7:684-700.
    • (2007) Nat Rev Cancer , vol.7 , pp. 684-700
    • Deeb, K.K.1    Trump, D.L.2    Johnson, C.S.3
  • 26
    • 0033997563 scopus 로고    scopus 로고
    • Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs
    • Blagosklonny MV, Robey R, Bates S, Fojo T. Pretreatment with DNA-damaging agents permits selective killing of checkpoint-deficient cells by microtubule-active drugs. J Clin Invest 2000; 105:533-9.
    • (2000) J Clin Invest , vol.105 , pp. 533-539
    • Blagosklonny, M.V.1    Robey, R.2    Bates, S.3    Fojo, T.4
  • 27
    • 20144377122 scopus 로고    scopus 로고
    • Selective killing of adriamycin-resistant (G2 checkpoint-deficient and MRP1-expressing) cancer cells by docetaxel
    • Demidenko ZN, Halicka D, Kunicki J, McCubrey JA, Darzynkiewicz Z, Blagosklonny MV. Selective killing of adriamycin-resistant (G2 checkpoint-deficient and MRP1-expressing) cancer cells by docetaxel. Cancer Res 2005; 65:4401-7.
    • (2005) Cancer Res , vol.65 , pp. 4401-4407
    • Demidenko, Z.N.1    Halicka, D.2    Kunicki, J.3    McCubrey, J.A.4    Darzynkiewicz, Z.5    Blagosklonny, M.V.6
  • 28
    • 0037334306 scopus 로고    scopus 로고
    • A new science-business paradigm in anticancer drug development
    • Blagosklonny MV. A new science-business paradigm in anticancer drug development. Trends Biotechnol 2003; 21:103-6.
    • (2003) Trends Biotechnol , vol.21 , pp. 103-106
    • Blagosklonny, M.V.1
  • 29
    • 12844255134 scopus 로고    scopus 로고
    • Overcoming limitations of natural anticancer drugs by combining with designed agents
    • Blagosklonny MV. Overcoming limitations of natural anticancer drugs by combining with designed agents. Trends Pharm Sci 2005; 26:77-81
    • (2005) Trends Pharm Sci , vol.26 , pp. 77-81
    • Blagosklonny, M.V.1
  • 30
    • 16444380911 scopus 로고    scopus 로고
    • Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors
    • Carvajal D, Tovar C, Yang H, Vu BT, Heimbrook DC, Vassilev LT. Activation of p53 by MDM2 antagonists can protect proliferating cells from mitotic inhibitors. Cancer Res 2005; 65:1918-24.
    • (2005) Cancer Res , vol.65 , pp. 1918-1924
    • Carvajal, D.1    Tovar, C.2    Yang, H.3    Vu, B.T.4    Heimbrook, D.C.5    Vassilev, L.T.6
  • 31
    • 42449144748 scopus 로고    scopus 로고
    • Antagonistic Drug Combinations That Select Against Drug Resistance: From Bacteria to Cancer
    • Blagosklonny MV. Antagonistic Drug Combinations That Select Against Drug Resistance: From Bacteria to Cancer. Cancer Biol Ther 2007; 6:1013-4.
    • (2007) Cancer Biol Ther , vol.6 , pp. 1013-1014
    • Blagosklonny, M.V.1
  • 32
    • 0042887595 scopus 로고    scopus 로고
    • Dose-intense paclitaxel: Deja vu all over again?
    • Takimoto CH, Rowinsky EK. Dose-intense paclitaxel: deja vu all over again? J Clin Oncol 2003; 21:2810-4.
    • (2003) J Clin Oncol , vol.21 , pp. 2810-2814
    • Takimoto, C.H.1    Rowinsky, E.K.2
  • 34
    • 0037068773 scopus 로고    scopus 로고
    • Sequential activation and inactivation of G2 checkpoints for selective killing of p53-deficient cells by microtubule-active drugs
    • Blagosklonny MV. Sequential activation and inactivation of G2 checkpoints for selective killing of p53-deficient cells by microtubule-active drugs. Oncogene 2002; 21:6249-54.
    • (2002) Oncogene , vol.21 , pp. 6249-6254
    • Blagosklonny, M.V.1
  • 35
    • 0347480457 scopus 로고    scopus 로고
    • Matching targets for selective cancer therapy
    • Blagosklonny MV. Matching targets for selective cancer therapy. Drug Discov Today. 2003; 8:1104-7.
    • (2003) Drug Discov Today , vol.8 , pp. 1104-1107
    • Blagosklonny, M.V.1
  • 36
    • 0034988902 scopus 로고    scopus 로고
    • Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells
    • Blagosklonny MV. Treatment with inhibitors of caspases, that are substrates of drug transporters, selectively permits chemotherapy-induced apoptosis in multidrug-resistant cells but protects normal cells. Leukemia 2001;15:936-41.
    • (2001) Leukemia , vol.15 , pp. 936-941
    • Blagosklonny, M.V.1
  • 37
    • 0242298229 scopus 로고    scopus 로고
    • Tissue-selective therapy of cancer
    • Blagosklonny MV. Tissue-selective therapy of cancer. Br J Cancer 2003; 89:1147-51.
    • (2003) Br J Cancer , vol.89 , pp. 1147-1151
    • Blagosklonny, M.V.1
  • 38
    • 0032715399 scopus 로고    scopus 로고
    • Drug-resistance enables selective killing of resistant leukemia cells: Exploiting ofdrug resistance instead of reversal
    • Blagosklonny MV. Drug-resistance enables selective killing of resistant leukemia cells: exploiting ofdrug resistance instead of reversal. Leukemia 1999; 13:2031-5.
    • (1999) Leukemia , vol.13 , pp. 2031-2035
    • Blagosklonny, M.V.1
  • 39
    • 0042928366 scopus 로고    scopus 로고
    • Targeting cancer cells by exploiting their resistance
    • Blagosklonny MV. Targeting cancer cells by exploiting their resistance. Trends Mol Med 2003; 9:307-12.
    • (2003) Trends Mol Med , vol.9 , pp. 307-312
    • Blagosklonny, M.V.1
  • 40
    • 20044385140 scopus 로고    scopus 로고
    • Carcinogenesis, cancer therapy and chemoprevention
    • Blagosklonny MV. Carcinogenesis, cancer therapy and chemoprevention. Cell Death Differ 2005; 12:592-602.
    • (2005) Cell Death Differ , vol.12 , pp. 592-602
    • Blagosklonny, M.V.1
  • 41
    • 0035432151 scopus 로고    scopus 로고
    • Hypoxia-inducible factor: Achilles' heel of antiangiogenic cancer therapy
    • Blagosklonny MV. Hypoxia-inducible factor: Achilles' heel of antiangiogenic cancer therapy. Int J Oncol 2001; 19:257-62.
    • (2001) Int J Oncol , vol.19 , pp. 257-262
    • Blagosklonny, M.V.1
  • 42
    • 20544471876 scopus 로고    scopus 로고
    • Combined analysis of efficacy: The addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer
    • Kabbinavar FF, Hambleton J, Mass RD, Hurwitz HI, Bergsland E, Sarkar S. Combined analysis of efficacy: the addition of bevacizumab to fluorouracil/leucovorin improves survival for patients with metastatic colorectal cancer. J Clin Oncol 2005; 23:3706-12.
    • (2005) J Clin Oncol , vol.23 , pp. 3706-3712
    • Kabbinavar, F.F.1    Hambleton, J.2    Mass, R.D.3    Hurwitz, H.I.4    Bergsland, E.5    Sarkar, S.6
  • 44
    • 0036513029 scopus 로고    scopus 로고
    • Oncogenic resistance to growth-limiting conditions
    • Blagosklonny MV. Oncogenic resistance to growth-limiting conditions. Nature Rev Cancer 2002; 2:221-5.
    • (2002) Nature Rev Cancer , vol.2 , pp. 221-225
    • Blagosklonny, M.V.1
  • 45
    • 29244479554 scopus 로고    scopus 로고
    • Why therapeutic response may not prolong the life of a cancer patient: Selection for oncogenic resistance
    • Blagosklonny MV. Why therapeutic response may not prolong the life of a cancer patient: selection for oncogenic resistance. Cell Cycle 2005; 4:1693-8.
    • (2005) Cell Cycle , vol.4 , pp. 1693-1698
    • Blagosklonny, M.V.1
  • 46
    • 2442678063 scopus 로고    scopus 로고
    • Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor
    • Demidenko ZN, Blagosklonny MV. Flavopiridol induces p53 via initial inhibition of Mdm2 and p21 and, independently of p53, sensitizes apoptosis-reluctant cells to tumor necrosis factor. Cancer Res 2004; 64:3653-60.
    • (2004) Cancer Res , vol.64 , pp. 3653-3660
    • Demidenko, Z.N.1    Blagosklonny, M.V.2
  • 47
    • 33846584645 scopus 로고    scopus 로고
    • Mitotic arrest and cell fate: Why and how mitotic inhibition of transcription drives mutually exclusive events
    • Blagosklonny MV. Mitotic arrest and cell fate: why and how mitotic inhibition of transcription drives mutually exclusive events. Cell Cycle 2007; 6:70-4.
    • (2007) Cell Cycle , vol.6 , pp. 70-74
    • Blagosklonny, M.V.1
  • 48
    • 0037439820 scopus 로고    scopus 로고
    • Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer
    • Mueller T, Voigt W, Simon H, Fruehauf A, Bulankin A, Grothey A, Schmoll HJ. Failure of activation of caspase-9 induces a higher threshold for apoptosis and cisplatin resistance in testicular cancer. Cancer Res 2003; 63:513-21.
    • (2003) Cancer Res , vol.63 , pp. 513-521
    • Mueller, T.1    Voigt, W.2    Simon, H.3    Fruehauf, A.4    Bulankin, A.5    Grothey, A.6    Schmoll, H.J.7
  • 49
    • 12844281121 scopus 로고    scopus 로고
    • Analysis of FDA approved anticancer drugs reveals the future of cancer therapy
    • Blagosklonny MV. Analysis of FDA approved anticancer drugs reveals the future of cancer therapy. Cell Cycle 2004; 3:1035-42.
    • (2004) Cell Cycle , vol.3 , pp. 1035-1042
    • Blagosklonny, M.V.1
  • 50
    • 23644433384 scopus 로고    scopus 로고
    • How Cancer Could Be Cured by 2015
    • Blagosklonny MV. How Cancer Could Be Cured by 2015. Cell Cycle 2005; 4:269-78.
    • (2005) Cell Cycle , vol.4 , pp. 269-278
    • Blagosklonny, M.V.1
  • 55
    • 0000051538 scopus 로고    scopus 로고
    • Could p53 be a target for therapeutic suppression?
    • Komarova EA, Gudkov AV. Could p53 be a target for therapeutic suppression? Semin Cancer Biol 1998; 8:389-400.
    • (1998) Semin Cancer Biol , vol.8 , pp. 389-400
    • Komarova, E.A.1    Gudkov, A.V.2
  • 57
    • 0035884487 scopus 로고    scopus 로고
    • Chemoprotection from p53-dependent apoptosis: Potential clinical applications of the p53 inhibitors
    • Komarova EA, Gudkov AV. Chemoprotection from p53-dependent apoptosis: potential clinical applications of the p53 inhibitors. Biochem Pharmacol 2001; 62:657-67.
    • (2001) Biochem Pharmacol , vol.62 , pp. 657-667
    • Komarova, E.A.1    Gudkov, A.V.2
  • 59
    • 33847226657 scopus 로고    scopus 로고
    • An anti-aging drug today: From senescence-promoting genes to anti-aging pill
    • Blagosklonny MV. An anti-aging drug today: from senescence-promoting genes to anti-aging pill. Drug Discov Today 2007; 12:218-24.
    • (2007) Drug Discov Today , vol.12 , pp. 218-224
    • Blagosklonny, M.V.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.