Synthesis and inhibition potency of novel ureido benzenesulfonamides incorporating GABA as tumor-associated carbonic anhydrase IX and XII inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry

Volumn 31, Issue 2, 2016, Pages 205-211

  Ceruso, Mariangela ^a   Antel, Sabrina ^a   Scozzafava, Andrea ^a   Supuran, Claudiu T ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Anticancer agents; Carbonic anhydrase inhibitors; GABA linker; Transmembrane isoforms; Ureido benzenesulfonamide

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOETHYLBENZENSULFONAMIDE; 4 AMINOMETHYLBENZENESULFONAMIDE; ACETAZOLAMIDE; ANTINEOPLASTIC AGENT; BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE INHIBITOR; CARBONATE DEHYDRATASE IX; CARBONATE DEHYDRATASE XII; ETHYLBENZENSULFONAMIDE; HYPOXIA INDUCIBLE FACTOR 1; SULFANILAMIDE DERIVATIVE; UNCLASSIFIED DRUG; UREIDO BENZENESULFONAMIDE DERIVATIVE; BENZENESULFONAMIDE; CARBONATE DEHYDRATASE; ISOENZYME; SULFONAMIDE; UREA;

ANALYTIC METHOD; ARTICLE; CHEMICAL ANALYSIS; CLINICAL EFFECTIVENESS; COMPARATIVE STUDY; CONTROLLED STUDY; CYTOSOL; DRUG DETERMINATION; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; CHEMISTRY; DRUG EFFECTS; ENZYMOLOGY; METABOLISM; PRECLINICAL STUDY; PROCEDURES; SYNTHESIS;

ANTINEOPLASTIC AGENTS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASE IX; CARBONIC ANHYDRASES; CHEMISTRY TECHNIQUES, SYNTHETIC; CYTOSOL; DRUG EVALUATION, PRECLINICAL; GAMMA-AMINOBUTYRIC ACID; HUMANS; ISOENZYMES; SULFONAMIDES; UREA;

EID: 84955634237     PISSN: 14756366     EISSN: 14756374     Source Type: Journal    
DOI: 10.3109/14756366.2015.1014477     Document Type: Article

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