Synthesis of 4-(thiazol-2-ylamino)-benzenesulfonamides with carbonic anhydrase I, II and IX inhibitory activity and cytotoxic effects against breast cancer cell lines

Bioorganic and Medicinal Chemistry

Volumn 24, Issue 13, 2016, Pages 3043-3051

  Abdel Gawad, Nagwa M ^a   Amin, Noha H ^b   Elsaadi, Mohammed T ^b   Mohamed, Fatma M M ^b   Angeli, Andrea ^c   De Luca, Viviana ^d   Capasso, Clemente ^d   Supuran, Claudiu T ^c  

^a CAIRO UNIVERSITY   (Egypt)

^b Beni Suef University   (Egypt)

^c UNIVERSITY OF FLORENCE   (Italy)

^d CNR   (Italy)

Author keywords

Antitumor; Carbonic anhydrase; Cytotoxic agent; Inhibitor; Sulfonamide

Indexed keywords

4 [2 [4 OXO 2 [(4 SULFAMOYLPHENYL)AMINO]THIAZOL 5(4H)YLIDENE]HYDRAZINYL]BENZENESULFONAMIDE; 4 [2 [4 OXO 2 [(4 SULFAMOYLPHENYL)AMINO]THIAZOL 5(4H)YLIDENE]HYDRAZINYL]BENZOIC ACID; 4 [[2 [(4 SULFAMOYLPHENYL)AMINO]THIAZOL 4 YL]AMINO]BENZOIC ACID; 4 [[4 (PIPERIDIN 1 YL)THIAZOL 2 YL]AMINO]BENZENESULFONAMIDE; 4 [[4 [(4 BENZYLIDENE 5 OXO 2 PHENYL 4,5 DIHYDRO 1H IMIDAZOL 1 YL)AMINO]THIAZOL 2 YL]AMINO]BENZENESULFONAMIDE; 4 [[4 [(4 FLUOROPHENYL)AMINO]THIAZOL 2 YL]AMINO]BENZENESULFONAMIDE; 4 [[4 [[2 (4 CHLOROPHENYL) 4 [4 (DIMETHYLAMINO)BENZYLIDENE] 5 OXO 4,5 DIHYDRO 1H IMIDAZOL 1 YL]AMINO]THIAZOL 2 YL]AMINO]BENZENESULFONAMIDE; 4 [[4 [[4 (4 CHLOROBENZYLIDENE) 2 (4 CHLOROPHENYL) 5 OXO 4,5 DIHYDRO 1H IMIDAZOL 1 YL]AMINO]THIAZOL 2 YL]AMINO]BENZENESULFONAMIDE; 4 [[4 [[4 (CHLOROBENZYLIDENE) 5 OXO 2 PHENYL 4,5 DIHYDRO 1H IMIDAZOL 1 YL]AMINO]THIAZOL 2 YL]AMINO]BENZENESULFONAMIDE; 4 [[4 [[4 BENZYLIDENE 2 (4 CHLOROPHENYL) 5 OXO 4,5 DIHYDRO 1H IMIDAZOL 1 YL]AMINO]THIAZOL 2 YL]AMINO]BENZENESULFONAMIDE; 4 [[4 [[4 [4 (DIMETHYLAMINO)BENZYLIDENE] 5 OXO 2 PHENYL 4,5 DIHYDRO 1H IMIDAZOL 1 YL]AMINO]THIAZOL 2 YL]AMINO]BENZENESULFONAMIDE; 4 [[5 [2 (4 CHLOROPHENYL)HYDRAZONO] 4 OXO 4,5 DIHYDROTHIAZOL 2 YL]AMINO]BENZENESULFONAMIDE; 4,4' [THIAZOLE 2,4 DIYLBIS(AZANEDIYL)]DIBENZENESULFONAMIDE; ACETAZOLAMIDE; ANTINEOPLASTIC AGENT; BENZENESULFONAMIDE DERIVATIVE; CARBONATE DEHYDRATASE I; CARBONATE DEHYDRATASE II; CARBONATE DEHYDRATASE IX; FLUOROURACIL; N (DIAMINOMETHYLENE) 4 [2 [4 OXO 2 [(4 SULFAMOYLPHENYL)AMINO]THIAZOL 5(4H)YLIDENE]HYDRAZINYL]BENZENESULFONAMIDE; SLC 0111; UNCLASSIFIED DRUG; BENZENESULFONAMIDE; CARBONATE DEHYDRATASE; CARBONATE DEHYDRATASE INHIBITOR; SULFONAMIDE; THIAZOLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; MCF 7 CELL LINE; BREAST NEOPLASMS; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; FEMALE; IC50; MCF-7 CELL LINE; METABOLISM; SYNTHESIS;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CARBONIC ANHYDRASE INHIBITORS; CARBONIC ANHYDRASES; CELL PROLIFERATION; CELL SURVIVAL; DRUG DELIVERY SYSTEMS; FEMALE; HUMANS; INHIBITORY CONCENTRATION 50; MCF-7 CELLS; MOLECULAR STRUCTURE; SULFONAMIDES; THIAZOLES;

EID: 84971634917     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2016.05.016     Document Type: Article

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