ANTIANGIOGENIC ACTIVITY;
ANTINEOPLASTIC ACTIVITY;
CANCER PATIENT;
CHROMATIN STRUCTURE;
CLINICAL TRIAL;
CUTANEOUS T CELL LYMPHOMA;
DRUG APPROVAL;
DRUG EFFICACY;
DRUG POTENCY;
DRUG RESEARCH;
DRUG SAFETY;
DRUG TARGETING;
ENZYME INHIBITION;
FOOD AND DRUG ADMINISTRATION;
HEMATOLOGIC MALIGNANCY;
HUMAN;
NOTE;
PRIORITY JOURNAL;
TREATMENT INDICATION;
TREATMENT OUTCOME;
UNITED STATES;
ANTINEOPLASTIC AGENTS;
CLINICAL TRIALS;
CLINICAL TRIALS, PHASE I;
DRUG APPROVAL;
DRUG DESIGN;
ENZYME INHIBITORS;
HISTONE DEACETYLASES;
HUMANS;
HYDROXAMIC ACIDS;
LYMPHOMA, T-CELL, CUTANEOUS;
SKIN NEOPLASMS;
UNITED STATES;
UNITED STATES FOOD AND DRUG ADMINISTRATION;
Second generation hybrid polar compounds are potent inducers of transformed cell differentiation
Richon, V. M. et al. Second generation hybrid polar compounds are potent inducers of transformed cell differentiation. Proc. Natl Acad. Sci. USA 93, 5705-5708 (1996)
A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases
Richon, V. M. et al. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Proc. Natl Acad. Sci. USA 95, 3003-3007 (1998).
Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A
Yoshida, M. et al. Potent and specific inhibition of mammalian histone deacetylase both in vivo and in vitro by trichostatin A. J. Biol. Chem. 265, 17174-17179 (1990).
Drug insight: Histone deacetylase inhibitors - Development of the new targeted anticancer agent suberoylanilide hydroxamic acid
Kelly, W. K. & Marks, P. A. Drug insight: Histone deacetylase inhibitors - development of the new targeted anticancer agent suberoylanilide hydroxamic acid. Nature Clin. Pract. Oncol. 2, 150-157 (2005).
Richon, V. M. et al. Histone deacetylase inhibitor selectively induces p21WAF1 expression and gene-associated histone acetylation. Proc. Natl Acad. Sci. USA 97, 10014-10019 (2000).
Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: A novel basis for antileukemia activity of histone deacetylase inhibitors
Bali, P. et al. Inhibition of histone deacetylase 6 acetylates and disrupts the chaperone function of heat shock protein 90: A novel basis for antileukemia activity of histone deacetylase inhibitors. J. Biol. Chem. 280, 26729-26734 (2005).
Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate
Trachootham, D. et al. Selective killing of oncogenically transformed cells through a ROS-mediated mechanism by beta-phenylethyl isothiocyanate. Cancer Cell 10, 241-252 (2006).
Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors
Ungerstedt, J. S. et al. Role of thioredoxin in the response of normal and transformed cells to histone deacetylase inhibitors. Proc. Natl Acad. Sci. USA 102, 673-678 (2005).