Hypoxia induces VEGF-C expression in metastatic tumor cells via a HIF-1α-independent translation-mediated mechanism

Cell Reports

Volumn 6, Issue 1, 2014, Pages 155-167

  Morfoisse, Florent ^a,b   Kuchnio, Anna ^c   Frainay, Clement ^a,b   Gomez Brouchet, Anne ^a,b   Delisle, Marie Bernadette ^a,b   Marzi, Stefano ^d   Helfer, Anne Catherine ^d   Hantelys, Fransky ^e   Pujol, Francoise ^e   Guillermet Guibert, Julie ^a,b   Bousquet, Corinne ^a,b   Dewerchin, Mieke ^c   Pyronnet, Stephane ^a,b   Prats, Anne Catherine ^e   Carmeliet, Peter ^c   Garmy Susini, Barbara ^a,b  

^a INSERM   (France)

^b CANCER RESEARCH CENTER OF TOULOUSE   (France)

^c UNIVERSITY OF LEUVEN   (Belgium)

^d UNIVERSITÉ DE STRASBOURG   (France)

^e UNIVERSITÉ PAUL SABATIER   (France)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; INITIATION FACTOR 4E BINDING PROTEIN 1; MESSENGER RNA; VASCULOTROPIN C;

5' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BREAST CANCER; CELL HYPOXIA; CONTROLLED STUDY; HUMAN; HUMAN TISSUE; INTERNAL RIBOSOME ENTRY SITE; INTRACELLULAR SIGNALING; LYMPH NODE METASTASIS; LYMPHANGIOGENESIS; MOLECULAR PROBE; MOUSE; NONHUMAN; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RNA TRANSLATION; STRUCTURE ANALYSIS; TRANSLATION REGULATION; TUMOR CELL; UPREGULATION;

3' UNTRANSLATED REGIONS; ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BREAST NEOPLASMS; CARCINOMA; CELL HYPOXIA; CELL LINE, TUMOR; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LYMPHATIC METASTASIS; MICE; MICE, INBRED C57BL; MICE, NUDE; PHOSPHOPROTEINS; PROTEIN BIOSYNTHESIS; TRANSCRIPTION, GENETIC; VASCULAR ENDOTHELIAL GROWTH FACTOR C;

EID: 84892553285     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2013.12.011     Document Type: Article

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