Targeting anti-apoptotic Bcl-2 by AT-101 to increase radiation efficacy: Data from in vitro and clinical pharmacokinetic studies in head and neck cancer

Radiation Oncology

Volumn 10, Issue 1, 2015, Pages

  Zerp, Shuraila F ^a   Stoter, T Rianne ^b   Hoebers, Frank J P ^c   van den Brekel, Michiel W M ^a   Dubbelman, Ria ^a   Kuipers, Gitta K ^b   Lafleur, M Vincent M ^b   Slotman, Ben J ^b   Verheij, Marcel ^a  

^a NETHERLANDS CANCER INSTITUTE   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Apoptosis; Bcl 2; Head and neck cancer; Radiation

Indexed keywords

BISBENZIMIDE; CISPLATIN; ISOSORBIDE; PROPIDIUM IODIDE; PROTEIN BCL 2; ANTINEOPLASTIC AGENT; GOSSYPOL; GOSSYPOL ACETIC ACID; RADIOSENSITIZING AGENT;

ADVANCED CANCER; APOPTOSIS; ARTICLE; BLOOD SAMPLING; CANCER RADIOTHERAPY; CHEMORADIOTHERAPY; CLONOGENIC ASSAY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; DRUG EFFECT; DRUG MECHANISM; FLOW CYTOMETRY; HEAD AND NECK SQUAMOUS CELL CARCINOMA; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IN VITRO STUDY; PHASE 1 CLINICAL TRIAL; PHASE 2 CLINICAL TRIAL; PLASMA CONCENTRATION-TIME CURVE; PROTEIN EXPRESSION; RADIOSENSITIZATION; SQUAMOUS CELL CARCINOMA CELL; ANALOGS AND DERIVATIVES; ANTAGONISTS AND INHIBITORS; CLINICAL TRIAL; HEAD AND NECK TUMOR; PROCEDURES; RADIATION RESPONSE; SQUAMOUS CELL CARCINOMA; TUMOR CELL LINE; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CHEMORADIOTHERAPY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GOSSYPOL; HEAD AND NECK NEOPLASMS; HUMANS; PROTO-ONCOGENE PROTEINS C-BCL-2; RADIATION-SENSITIZING AGENTS; SQUAMOUS CELL CARCINOMA OF HEAD AND NECK;

EID: 84938086718     PISSN: None     EISSN: 1748717X     Source Type: Journal    
DOI: 10.1186/s13014-015-0474-9     Document Type: Article

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