Tumor hypoxia: Causative factors, compensatory mechanisms, and cellular response

Oncologist

Volumn 9, Issue SUPPL. 5, 2004, Pages 4-9

  Vaupel, Peter ^a   Harrison, Louis ^b  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

^b BETH ISRAEL MEDICAL CENTER   (United States)

Author keywords

Anemia; Biology; Causative factors; Cellular response; Hemoglobin; Malignant progression; Tumor hypoxia

Indexed keywords

CYTOTOXIC AGENT; EPIDERMAL GROWTH FACTOR; GLUCOSE TRANSPORTER; HEMOGLOBIN; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INDUCIBLE NITRIC OXIDE SYNTHASE; OXYGEN; PROTEOME; SOMATOMEDIN B; TRANSFORMING GROWTH FACTOR BETA; VASCULOTROPIN RECEPTOR; VASCULOTROPIN RECEPTOR 1;

ANEMIA; CONFERENCE PAPER; DISEASE COURSE; GENOME; HUMAN; HYPOXIA; OXYGEN TRANSPORT; OXYGENATION; PRIORITY JOURNAL; TREATMENT OUTCOME; TUMOR CELL; TUMOR GROWTH;

EID: 10644270846     PISSN: 10837159     EISSN: None     Source Type: Journal    
DOI: 10.1634/theoncologist.9-90005-4     Document Type: Conference Paper

References (29)

1. Schwarz G. Über Desensibilisierung gegen Röntgen- und Radiumstrahlen. Münchener Med Wochenschr 1909;24:1-2.
2. Mottram JC. A factor of importance in the radio-sensitivity of tumours. Br J Radiol 1931;9:606-614.
3. Gray LH, Conger AD, Ebert M et al. The concentration of oxygen dissolved in tissues at the time of irradiation as a factor in radiotherapy. Br J Radiol 1953;26:638-648.
4. Teicher BA, Holden SA, al-Achi A et al. Classification of antineoplastic treatments by their differential toxicity toward putative oxygenated and hypoxic tumor subpopulations in vivo in the FSa11C murine fibrosarcoma. Cancer Res 1990;50:3339-3344.
5. Littlewood TJ. The impact of hemoglobin levels on treatment outcomes in patients with cancer. Semin Oncol 2001;28(suppl 8):49-53.
6. 2 tension measurements. Cancer Res 1991;51:6098-6102.
7. 2 tension measurements. Cancer Res 1991;51:3316-3322.
8. Vaupel P, Thews O, Hoeckel M. Treatment resistance of solid tumors: role of hypoxia and anemia. Med Oncol 2001;18:243-259.
9. Vaupel P, Kelleher DK, Höckel M. Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy. Semin Oncol 2001;28(suppl 8):29-35.
10. Vaupel P, Briest S, Höckel M. Hypoxia in breast cancer: pathogenesis, characterization and biological/therapeutic implications. Wien Med Wochenschr 2002;152:334-342.
11. Höckel M, Vaupel P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J Natl Cancer Inst 2001;93:266-276.
12. Vaupel P, Thews O, Mayer A et al. Oxygenation status of gynecologic tumors: what is the optimal hemoglobin level? Strahlenther Onkol 2002;178:727-731.
13. Vaupel P, Mayer A, Briest S et al. Oxygenation gain factor: a novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers. Cancer Res 2003;63:7634-7637.
14. Zander R. [Oxygen supply and acid-base status in extreme anemia.] Anaesthesiol Intensivmed Notfallmed Schmerzther 1996;31:492-494. German.
15. Becker A, Stadler P, Lavey RS et al. Severe anemia is associated with poor tumor oxygenation in head and neck squamous cell carcinomas. Int J Radiat Oncol Biol Phys 2000;46:459-466.
16. Höckel M, Vaupel P. Biological consequences of tumor hypoxia. Semin Oncol 2001;28(suppl 8):36-41.
17. Moulder JE, Rockwell S. Tumor hypoxia: its impact on cancer therapy. Cancer Metastasis Rev 1987;5:313-341.
18. Durand RE. Keynote address: the influence of microenvironmental factors on the activity of radiation and drugs. Int J Radiat Oncol Biol Phys 1991;20:253-258.
19. Giaccia AJ. Hypoxic stress proteins: survival of the fittest. Semin Radiat Oncol 1996;6:46-58.
20. Riva C, Chauvin C, Pison C et al. Cellular physiology and molecular events in hypoxia-induced apoptosis. Anticancer Res 1998;18:4729-4736.
21. Haroon ZA, Raleigh JA, Greenberg CS et al. Early wound healing exhibits cytokine surge without evidence of hypoxia. Ann Surg 2000;231:137-147.
22. Goda N, Ryan HE, Khadivi B et al. Hypoxia-inducible factor 1 alpha is essential for cell cycle arrest during hypoxia. Mol Cell Biol 2003;23:359-369.
23. Koumenis C, Alarcon R, Hammond E et al. Regulation of p53 by hypoxia: dissociation of transcriptional repression and apoptosis from p53-dependent transactivation. Mol Cell Biol 2001;21:1297-1310.
24. Soengas MS, Alarcon RM, Yoshida H et al. Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition. Science 1999;284:156-159.
25. Prehn RT. The inhibition of tumor growth by tumor mass. Cancer Res 1991;51:2-4.
26. Demicheli R, Terenziani M, Valagussa P et al. Local recurrences following mastectomy: support for the concept of tumor dormancy. J Natl Cancer Inst 1994;86:45-48.
27. Holmgren L, O'Reilly MS, Folkman J. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression. Nat Med 1995;1:149-153.
28. Folkman J. Clinical applications of research on angiogenesis. N Engl J Med 1995;333:1757-1763.
29. Vaupel P. The role of hypoxia-induced factors in tumor progression. The Oncologist 2004;9(suppl 5):10-17.