Histone Deacetylase is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen

Journal of Biological Chemistry

Volumn 276, Issue 39, 2001, Pages 36734-36741

  Phiel, Christopher J ^a   Zhang, Fang ^a   Huang, Eric Y ^a   Guenther, Matthew G ^a   Lazar, Mitchell A ^a   Klein, Peter S ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; GENES;

GENE EXPRESSION;

PROTEINS;

ANTICONVULSIVE AGENT; HISTONE DEACETYLASE; LITHIUM; TERATOGENIC AGENT; TRICHOSTATIN A; VALPROIC ACID; WNT PROTEIN; GLYCOGEN SYNTHASE KINASE 3; GREEN FLUORESCENT PROTEIN; HDAC1 PROTEIN, HUMAN; HISTONE; HYBRID PROTEIN; HYDROXAMIC ACID; ONCOPROTEIN; PHOTOPROTEIN; PROTEIN KINASE (CALCIUM,CALMODULIN); TRANQUILIZER; ZEBRAFISH PROTEIN;

ACETYLATION; ANIMAL CELL; ARTICLE; BIPOLAR DISORDER; BIRTH DEFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG TARGETING; EMBRYO; ENZYME INHIBITION; EPILEPSY; GENE EXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION INITIATION; ANIMAL; CELL LINE; DOSE RESPONSE; DRUG ANTAGONISM; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; IC 50; METABOLISM; PLASMID; PROMOTER REGION; SIGNAL TRANSDUCTION; TIME; XENOPUS;

ANIMALIA; VERTEBRATA;

ACETYLATION; ANIMALS; ANTICONVULSANTS; ANTIMANIC AGENTS; CA(2+)-CALMODULIN DEPENDENT PROTEIN KINASE; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GLYCOGEN SYNTHASE KINASE 3; GREEN FLUORESCENT PROTEINS; HISTONE DEACETYLASES; HISTONES; HUMANS; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; LITHIUM; LUMINESCENT PROTEINS; PLASMIDS; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; TERATOGENS; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; VALPROIC ACID; WNT PROTEINS; XENOPUS; ZEBRAFISH PROTEINS;

EID: 0035965343     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M101287200     Document Type: Article

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