메뉴 건너뛰기




Volumn 6, Issue 4, 2013, Pages 493-503

Tumor dynamics in response to antiangiogenic therapy with oral metronomic topotecan and pazopanib in neuroblastoma xenografts

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE TRANSPORTER; PAZOPANIB; TOPOTECAN;

EID: 84881082484     PISSN: None     EISSN: 19365233     Source Type: Journal    
DOI: 10.1593/tlo.13286     Document Type: Article
Times cited : (20)

References (63)
  • 3
    • 77953396751 scopus 로고    scopus 로고
    • New anti-angiogenic strategies in pediatric solid malignancies: Agents and biomarkers of a near future
    • Taylor M, Rössler J, Geoerger B, Vassal G, and Farace F (2010). New anti-angiogenic strategies in pediatric solid malignancies: agents and biomarkers of a near future. Expert Opin Investig Drugs 19, 859-874.
    • (2010) Expert Opin Investig Drugs , vol.19 , pp. 859-874
    • Taylor, M.1    Rössler, J.2    Geoerger, B.3    Vassal, G.4    Farace, F.5
  • 4
    • 2942615257 scopus 로고    scopus 로고
    • The anti-angiogenic basis of metronomic chemotherapy
    • Kerbel RS and Kamen BA (2004). The anti-angiogenic basis of metronomic chemotherapy. Nat Rev Cancer 4, 423-436.
    • (2004) Nat Rev Cancer , vol.4 , pp. 423-436
    • Kerbel, R.S.1    Kamen, B.A.2
  • 5
    • 33745291938 scopus 로고    scopus 로고
    • Metronomic dosing of chemotherapy: Applications in pediatric oncology
    • Stempak D, Seely D, and Baruchel S (2006). Metronomic dosing of chemotherapy: applications in pediatric oncology. Cancer Invest 24, 432-443.
    • (2006) Cancer Invest , vol.24 , pp. 432-443
    • Stempak, D.1    Seely, D.2    Baruchel, S.3
  • 6
    • 84872084645 scopus 로고    scopus 로고
    • Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved pre-clinical orthotopic and adjuvant therapy colon cancer models
    • Hackl C, Man S, Francia G, Milsom C, Xu P, and Kerbel RS (2013). Metronomic oral topotecan prolongs survival and reduces liver metastasis in improved pre-clinical orthotopic and adjuvant therapy colon cancer models. Gut 62, 259-271.
    • (2013) Gut , vol.62 , pp. 259-271
    • Hackl, C.1    Man, S.2    Francia, G.3    Milsom, C.4    Xu, P.5    Kerbel, R.S.6
  • 7
    • 77955172181 scopus 로고    scopus 로고
    • Metronomic chemotherapy: New rationale for new directions
    • Pasquier E, Kavallaris M, and André N (2010). Metronomic chemotherapy: new rationale for new directions. Nat Rev Clin Oncol 7, 455-465.
    • (2010) Nat Rev Clin Oncol , vol.7 , pp. 455-465
    • Pasquier, E.1    Kavallaris, M.2    André, N.3
  • 10
    • 0034087691 scopus 로고    scopus 로고
    • Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity
    • Klement G, Baruchel S, Rak J, Man S, Clark K, Hicklin DJ, Bohlen P, and Kerbel RS (2000). Continuous low-dose therapy with vinblastine and VEGF receptor-2 antibody induces sustained tumor regression without overt toxicity. J Clin Invest 105, R15-R24.
    • (2000) J Clin Invest , vol.105
    • Klement, G.1    Baruchel, S.2    Rak, J.3    Man, S.4    Clark, K.5    Hicklin, D.J.6    Bohlen, P.7    Kerbel, R.S.8
  • 11
    • 84872425530 scopus 로고    scopus 로고
    • HIF-1α activation mediates resistance to anti-angiogenic therapy in neuro-blastoma xenografts
    • Hartwich J, Orr WS, Ng CY, Spence Y, Morton C, and Davidoff AM (2013). HIF-1α activation mediates resistance to anti-angiogenic therapy in neuro-blastoma xenografts. J Pediatr Surg 48, 39-46.
    • (2013) J Pediatr Surg , vol.48 , pp. 39-46
    • Hartwich, J.1    Orr, W.S.2    Ng, C.Y.3    Spence, Y.4    Morton, C.5    Davidoff, A.M.6
  • 12
    • 77954595880 scopus 로고    scopus 로고
    • Metronomic gemcitabine in combination with sunitinib inhibits multisite metastasis and increases survival in an orthotopic model of pancreatic cancer
    • Tran Cao HS, Bouvet M, Kaushal S, Keleman A, Romney E, Kim G, Fruehauf J, Imagawa DK, Hoffman RM, and Katz MH (2010). Metronomic gemcitabine in combination with sunitinib inhibits multisite metastasis and increases survival in an orthotopic model of pancreatic cancer. Mol Cancer Ther 9, 2068-2078.
    • (2010) Mol Cancer Ther , vol.9 , pp. 2068-2078
    • Tran, C.H.S.1    Bouvet, M.2    Kaushal, S.3    Keleman, A.4    Romney, E.5    Kim, G.6    Fruehauf, J.7    Imagawa, D.K.8    Hoffman, R.M.9    Katz, M.H.10
  • 13
    • 84873080485 scopus 로고    scopus 로고
    • Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis
    • Jia L and Waxman DJ (2013). Thrombospondin-1 and pigment epithelium-derived factor enhance responsiveness of KM12 colon tumor to metronomic cyclophosphamide but have disparate effects on tumor metastasis. Cancer Lett 330, 241-249.
    • (2013) Cancer Lett , vol.330 , pp. 241-249
    • Jia, L.1    Waxman, D.J.2
  • 14
    • 84863445509 scopus 로고    scopus 로고
    • Enhanced anti-tumor and anti-angiogenic effects of metronomic cyclophosphamide combined with Endostar in a xenograft model of human lung cancer
    • Wang R, Qin S, Chen Y, Li Y, Chen C, Wang Z, Zheng R, and Wu Q (2012). Enhanced anti-tumor and anti-angiogenic effects of metronomic cyclophosphamide combined with Endostar in a xenograft model of human lung cancer. Oncol Rep 28, 439-445.
    • (2012) Oncol Rep , vol.28 , pp. 439-445
    • Wang, R.1    Qin, S.2    Chen, Y.3    Li, Y.4    Chen, C.5    Wang, Z.6    Zheng, R.7    Wu, Q.8
  • 15
    • 80054688412 scopus 로고    scopus 로고
    • The PACOVAR-trial: A phase I/II study of pazopanib (GW786034) and cyclophosphamide in patients with platinum-resistant recurrent, pre-treated ovarian cancer
    • Eichbaum M, Mayer C, Eickhoff R, Bischofs E, Gebauer G, Fehm T, Lenz F, Fricke HC, Solomayer E, Fersis N, et al. (2011). The PACOVAR-trial: a phase I/II study of pazopanib (GW786034) and cyclophosphamide in patients with platinum-resistant recurrent, pre-treated ovarian cancer. BMC Cancer 20, 453.
    • (2011) BMC Cancer , vol.20 , pp. 453
    • Eichbaum, M.1    Mayer, C.2    Eickhoff, R.3    Bischofs, E.4    Gebauer, G.5    Fehm, T.6    Lenz, F.7    Fricke, H.C.8    Solomayer, E.9    Fersis, N.10
  • 17
  • 18
    • 37849035249 scopus 로고    scopus 로고
    • Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: A trial of the California, Chicago, and Princess Margaret Hospital phase II consortia
    • Garcia AA, Hirte H, Fleming G, Yang D, Tsao-Wei DD, Roman L, Groshen S, Swenson S, Markland F, Gandara D, et al. (2008). Phase II clinical trial of bevacizumab and low-dose metronomic oral cyclophosphamide in recurrent ovarian cancer: a trial of the California, Chicago, and Princess Margaret Hospital phase II consortia. J Clin Oncol 26, 76-82.
    • (2008) J Clin Oncol , vol.26 , pp. 76-82
    • Garcia, A.A.1    Hirte, H.2    Fleming, G.3    Yang, D.4    Tsao-Wei, D.D.5    Roman, L.6    Groshen, S.7    Swenson, S.8    Markland, F.9    Gandara, D.10
  • 19
    • 33751218313 scopus 로고    scopus 로고
    • A pilot pharmacokinetic and antiangiogenic biomarker study of celecoxib and low-dose metronomic vinblastine or cyclophosphamide in pediatric recurrent solid tumors
    • Stempak D, Gammon J, Halton J, Moghrabi A, Koren G, and Baruchel S (2006). A pilot pharmacokinetic and antiangiogenic biomarker study of celecoxib and low-dose metronomic vinblastine or cyclophosphamide in pediatric recurrent solid tumors. J Pediatr Hematol Oncol 28, 720-728.
    • (2006) J Pediatr Hematol Oncol , vol.28 , pp. 720-728
    • Stempak, D.1    Gammon, J.2    Halton, J.3    Moghrabi, A.4    Koren, G.5    Baruchel, S.6
  • 20
    • 84872448128 scopus 로고    scopus 로고
    • A pilot study of low-dose anti-angiogenic chemotherapy in combination with standard multi-agent chemotherapy for patients with newly diagnosed metastatic Ewing sarcoma family of tumors: A Children's Oncology Group (COG) phase II study NCT00061893
    • Felgenhauer JL, Nieder ML, Krailo MD, Bernstein ML, Henry DW, Malkin D, Baruchel S, Chuba PJ, Sailer SL, Brown K, et al. (2013). A pilot study of low-dose anti-angiogenic chemotherapy in combination with standard multi-agent chemotherapy for patients with newly diagnosed metastatic Ewing sarcoma family of tumors: a Children's Oncology Group (COG) phase II study NCT00061893. Pediatr Blood Cancer 60, 409-414.
    • (2013) Pediatr Blood Cancer , vol.60 , pp. 409-414
    • Felgenhauer, J.L.1    Nieder, M.L.2    Krailo, M.D.3    Bernstein, M.L.4    Henry, D.W.5    Malkin, D.6    Baruchel, S.7    Chuba, P.J.8    Sailer, S.L.9    Brown, K.10
  • 21
    • 79960303699 scopus 로고    scopus 로고
    • Moving forward with metronomic chemotherapy: Meeting report of the 2nd International Workshop on Metronomic and Anti-Angiogenic Chemotherapy in Paediatric Oncology
    • Pasquier E, Kieran MW, Sterba J, Shaked Y, Baruchel S, Oberlin O, Kivivuori MS, Peyrl A, Diawarra M, Casanova M, et al. (2011). Moving forward with metronomic chemotherapy: meeting report of the 2nd International Workshop on Metronomic and Anti-Angiogenic Chemotherapy in Paediatric Oncology. Transl Oncol 4, 203-211.
    • (2011) Transl Oncol , vol.4 , pp. 203-211
    • Pasquier, E.1    Kieran, M.W.2    Sterba, J.3    Shaked, Y.4    Baruchel, S.5    Oberlin, O.6    Kivivuori, M.S.7    Peyrl, A.8    Diawarra, M.9    Casanova, M.10
  • 22
    • 77950815444 scopus 로고    scopus 로고
    • Potent preclinical impact of metronomic low-dose oral topotecan combined with the antiangiogenic drug pazopanib for the treatment of ovarian cancer
    • Hashimoto K, Man S, Xu P, Cruz-Munoz W, Tang T, Kumar R, and Kerbel RS (2010). Potent preclinical impact of metronomic low-dose oral topotecan combined with the antiangiogenic drug pazopanib for the treatment of ovarian cancer. Mol Cancer Ther 9, 996-1006.
    • (2010) Mol Cancer Ther , vol.9 , pp. 996-1006
    • Hashimoto, K.1    Man, S.2    Xu, P.3    Cruz-Munoz, W.4    Tang, T.5    Kumar, R.6    Kerbel, R.S.7
  • 24
    • 80052495441 scopus 로고    scopus 로고
    • Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor
    • Kumar S, Mokhtari RB, Sheikh R, Wu B, Zhang L, Xu P, Man S, Oliveira ID, Yeger H, Kerbel RS, et al. (2011). Metronomic oral topotecan with pazopanib is an active antiangiogenic regimen in mouse models of aggressive pediatric solid tumor. Clin Cancer Res 17, 5656-5667.
    • (2011) Clin Cancer Res , vol.17 , pp. 5656-5667
    • Kumar, S.1    Mokhtari, R.B.2    Sheikh, R.3    Wu, B.4    Zhang, L.5    Xu, P.6    Man, S.7    Oliveira, I.D.8    Yeger, H.9    Kerbel, R.S.10
  • 30
    • 84856297005 scopus 로고    scopus 로고
    • Resistance to angiogenesis inhibitors in renal cell carcinoma
    • Tamaskar I, Dhillon J, and Pili R (2011). Resistance to angiogenesis inhibitors in renal cell carcinoma. Clin Adv Hematol Oncol 9, 101-110.
    • (2011) Clin Adv Hematol Oncol , vol.9 , pp. 101-110
    • Tamaskar, I.1    Dhillon, J.2    Pili, R.3
  • 32
    • 79851509477 scopus 로고    scopus 로고
    • Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning
    • Milane L, Duan Z, and Amiji M (2011). Role of hypoxia and glycolysis in the development of multi-drug resistance in human tumor cells and the establishment of an orthotopic multi-drug resistant tumor model in nude mice using hypoxic pre-conditioning. Cancer Cell Int 11, 3.
    • (2011) Cancer Cell Int , vol.11 , pp. 3
    • Milane, L.1    Duan, Z.2    Amiji, M.3
  • 33
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G and Hanahan D (2008). Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 8, 592-603.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 34
    • 77952673621 scopus 로고    scopus 로고
    • Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates
    • Loges S, Schmidt T, and Carmeliet P (2010). Mechanisms of resistance to anti-angiogenic therapy and development of third-generation anti-angiogenic drug candidates. Genes Cancer 1, 12-25.
    • (2010) Genes Cancer , vol.1 , pp. 12-25
    • Loges, S.1    Schmidt, T.2    Carmeliet, P.3
  • 35
    • 0037154738 scopus 로고    scopus 로고
    • Effect of p53 status on tumor response to antiangiogenic therapy
    • Yu JL, Rak JW, Coomber BL, Hicklin DJ, and Kerbel RS (2002). Effect of p53 status on tumor response to antiangiogenic therapy. Science 295, 1526-1528.
    • (2002) Science , vol.295 , pp. 1526-1528
    • Yu, J.L.1    Rak, J.W.2    Coomber, B.L.3    Hicklin, D.J.4    Kerbel, R.S.5
  • 37
    • 84874753845 scopus 로고    scopus 로고
    • A comprehensive gene expression analysis of resistance formation upon metronomic cyclophosphamide therapy
    • Kubisch R, Meissner L, Krebs S, Blum H, Günther M, Roidl A, and Wagner E (2013). A comprehensive gene expression analysis of resistance formation upon metronomic cyclophosphamide therapy. Transl Oncol 6, 1-9.
    • (2013) Transl Oncol , vol.6 , pp. 1-9
    • Kubisch, R.1    Meissner, L.2    Krebs, S.3    Blum, H.4    Günther, M.5    Roidl, A.6    Wagner, E.7
  • 38
    • 84877872854 scopus 로고    scopus 로고
    • Concentration- and schedule-dependent effects of chemotherapy on the angiogenic potential and drug sensitivity of vascular endothelial cells
    • Pasquier E, Tuset MP, Street J, Sinnappan S, Mackenzie KL, Braguer D, Andre N, and Kavallaris M (2013). Concentration- and schedule-dependent effects of chemotherapy on the angiogenic potential and drug sensitivity of vascular endothelial cells. Angiogenesis 16, 373-386.
    • (2013) Angiogenesis , vol.16 , pp. 373-386
    • Pasquier, E.1    Tuset, M.P.2    Street, J.3    Sinnappan, S.4    Mackenzie, K.L.5    Braguer, D.6    Andre, N.7    Kavallaris, M.8
  • 40
    • 78650991789 scopus 로고    scopus 로고
    • Tumors that acquire resistance to low-dose metronomic cyclo-phosphamide retain sensitivity to maximum tolerated dose cyclophosphamide
    • Emmenegger U, Francia G, Chow A, Shaked Y, Kouri A, Man S, and Kerbel RS (2011). Tumors that acquire resistance to low-dose metronomic cyclo-phosphamide retain sensitivity to maximum tolerated dose cyclophosphamide. Neoplasia 13, 40-48.
    • (2011) Neoplasia , vol.13 , pp. 40-48
    • Emmenegger, U.1    Francia, G.2    Chow, A.3    Shaked, Y.4    Kouri, A.5    Man, S.6    Kerbel, R.S.7
  • 41
    • 77950935041 scopus 로고    scopus 로고
    • Human neuroblastoma cells with MYCN amplification are selectively resistant to oxidative stress by transcriptionally up-regulating glutamate cysteine ligase
    • Veas-Perez Tudela M, Delgado-Esteban M, Cuende J, Bolanos JP, and Almeida A (2010). Human neuroblastoma cells with MYCN amplification are selectively resistant to oxidative stress by transcriptionally up-regulating glutamate cysteine ligase. J Neurochem 113, 819-825.
    • (2010) J Neurochem , vol.113 , pp. 819-825
    • Veas-Perez, T.M.1    Delgado-Esteban, M.2    Cuende, J.3    Bolanos, J.P.4    Almeida, A.5
  • 42
    • 84863422466 scopus 로고    scopus 로고
    • Overcoming disappointing results with anti-angiogenic therapy by targeting hypoxia
    • Rapisarda A and Melillo G (2012). Overcoming disappointing results with anti-angiogenic therapy by targeting hypoxia. Nat Rev Clin Oncol 9, 378-390.
    • (2012) Nat Rev Clin Oncol , vol.9 , pp. 378-390
    • Rapisarda, A.1    Melillo, G.2
  • 43
    • 51049095933 scopus 로고    scopus 로고
    • Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuro-blastoma by targeting hypoxia-inducible factor-1α and -2α
    • Puppo M, Battaglia F, Ottaviano C, Delfino S, Ribatti D, Varesio L, and Bosco MC (2008). Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuro-blastoma by targeting hypoxia-inducible factor-1α and -2α. Mol Cancer Ther 7, 1974-1984.
    • (2008) Mol Cancer Ther , vol.7 , pp. 1974-1984
    • Puppo, M.1    Battaglia, F.2    Ottaviano, C.3    Delfino, S.4    Ribatti, D.5    Varesio, L.6    Bosco, M.C.7
  • 44
    • 19644376976 scopus 로고    scopus 로고
    • Topotecan blocks hypoxia-inducible factor-1α and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells
    • Beppu K, Nakamura K, Linehan WM, Rapisarda A, and Thiele CJ (2005). Topotecan blocks hypoxia-inducible factor-1α and vascular endothelial growth factor expression induced by insulin-like growth factor-I in neuroblastoma cells. Cancer Res 65, 4775-4781.
    • (2005) Cancer Res , vol.65 , pp. 4775-4781
    • Beppu, K.1    Nakamura, K.2    Linehan, W.M.3    Rapisarda, A.4    Thiele, C.J.5
  • 45
    • 65249183165 scopus 로고    scopus 로고
    • PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment
    • di Tomaso E, London N, Fuja D, Logie J, Tyrrell JA, Kamoun W, Munn LL, and Jain RK (2009). PDGF-C induces maturation of blood vessels in a model of glioblastoma and attenuates the response to anti-VEGF treatment. PLoS One 4, e5123.
    • (2009) PLoS One , vol.4
    • Di, T.E.1    London, N.2    Fuja, D.3    Logie, J.4    Tyrrell, J.A.5    Kamoun, W.6    Munn, L.L.7    Jain, R.K.8
  • 46
    • 0345798150 scopus 로고    scopus 로고
    • Endothelial and non-endothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors
    • Abramsson A, Lindblom P, and Betsholtz C (2003). Endothelial and non-endothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors. J Clin Invest 112, 1142-1151.
    • (2003) J Clin Invest , vol.112 , pp. 1142-1151
    • Abramsson, A.1    Lindblom, P.2    Betsholtz, C.3
  • 47
    • 79957571352 scopus 로고    scopus 로고
    • Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells
    • Liu CY, Chang HS, Chen IS, Chen CJ, Hsu ML, Fu SL, and Chen YJ (2011). Costunolide causes mitotic arrest and enhances radiosensitivity in human hepatocellular carcinoma cells. Radiat Oncol 6, 56.
    • (2011) Radiat Oncol , vol.6 , pp. 56
    • Liu, C.Y.1    Chang, H.S.2    Chen, I.S.3    Chen, C.J.4    Hsu, M.L.5    Fu, S.L.6    Chen, Y.J.7
  • 48
    • 79551688962 scopus 로고    scopus 로고
    • Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells
    • Lee CC, Lin YH, Chang WH, Lin PC, Wu YC, and Chang JG (2011). Squamocin modulates histone H3 phosphorylation levels and induces G1 phase arrest and apoptosis in cancer cells. BMC Cancer 11, 58.
    • (2011) BMC Cancer , vol.11 , pp. 58
    • Lee, C.C.1    Lin, Y.H.2    Chang, W.H.3    Lin, P.C.4    Wu, Y.C.5    Chang, J.G.6
  • 49
    • 10344240885 scopus 로고    scopus 로고
    • Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines
    • Box AH and Demetrick DJ (2004). Cell cycle kinase inhibitor expression and hypoxia-induced cell cycle arrest in human cancer cell lines. Carcinogenesis 25, 2325-2335.
    • (2004) Carcinogenesis , vol.25 , pp. 2325-2335
    • Box, A.H.1    Demetrick, D.J.2
  • 50
    • 84857040751 scopus 로고    scopus 로고
    • Cyclin-dependent kinase inhibitor, P276-00, inhibits HIF-1α and induces G2/M arrest under hypoxia in prostate cancer cells
    • Manohar SM, Padgaonkar AA, Jalota-Badhwar A, Rao SV, and Joshi KS (2012). Cyclin-dependent kinase inhibitor, P276-00, inhibits HIF-1α and induces G2/M arrest under hypoxia in prostate cancer cells. Prostate Cancer Prostatic Dis 15, 15-27.
    • (2012) Prostate Cancer Prostatic Dis , vol.15 , pp. 15-27
    • Manohar, S.M.1    Padgaonkar, A.A.2    Jalota-Badhwar, A.3    Rao, S.V.4    Joshi, K.S.5
  • 51
    • 77953982390 scopus 로고    scopus 로고
    • XQ2, a novel TPZ derivative, induced G2/M phase arrest and apoptosis under hypoxia in non-small cell lung cancer cells
    • Lou J, Zhou X, Weng Q, Wang DD, Xia Q, Hu Y, He Q, Yang B, and Luo P (2010). XQ2, a novel TPZ derivative, induced G2/M phase arrest and apoptosis under hypoxia in non-small cell lung cancer cells. Biosci Biotechnol Biochem 74, 1181-1187.
    • (2010) Biosci Biotechnol Biochem , vol.74 , pp. 1181-1187
    • Lou, J.1    Zhou, X.2    Weng, Q.3    Wang, D.D.4    Xia, Q.5    Hu, Y.6    He, Q.7    Yang, B.8    Luo, P.9
  • 53
    • 0034900493 scopus 로고    scopus 로고
    • Glucose transporter Glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix
    • Airley R, Loncaster J, Davidson S, Bromley M, Roberts S, Patterson A, Hunter R, Stratford I, and West C (2001). Glucose transporter Glut-1 expression correlates with tumor hypoxia and predicts metastasis-free survival in advanced carcinoma of the cervix. Clin Cancer Res 7, 928-934.
    • (2001) Clin Cancer Res , vol.7 , pp. 928-934
    • Airley, R.1    Loncaster, J.2    Davidson, S.3    Bromley, M.4    Roberts, S.5    Patterson, A.6    Hunter, R.7    Stratford, I.8    West, C.9
  • 54
    • 66249108601 scopus 로고    scopus 로고
    • Understanding the Warburg effect: The metabolic requirements of cell proliferation
    • Vander Heiden MG, Cantley LC, and Thompson CB (2009). Understanding the Warburg effect: the metabolic requirements of cell proliferation. Science 324, 1029-1033.
    • (2009) Science , vol.324 , pp. 1029-1033
    • Vander, H.M.G.1    Cantley, L.C.2    Thompson, C.B.3
  • 55
    • 78650403118 scopus 로고    scopus 로고
    • Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1α
    • Qing G, Skuli N, Mayes PA, Pawel B, Martinez D, Maris JM, and Simon MC (2010). Combinatorial regulation of neuroblastoma tumor progression by N-Myc and hypoxia inducible factor HIF-1α. Cancer Res 70, 10351-10361.
    • (2010) Cancer Res , vol.70 , pp. 10351-10361
    • Qing, G.1    Skuli, N.2    Mayes, P.A.3    Pawel, B.4    Martinez, D.5    Maris, J.M.6    Simon, M.C.7
  • 59
    • 79955837932 scopus 로고    scopus 로고
    • Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4
    • Rademakers SE, Lok J, van der Kogel AJ, Bussink J, and Kaanders JH (2011). Metabolic markers in relation to hypoxia; staining patterns and colocalization of pimonidazole, HIF-1α, CAIX, LDH-5, GLUT-1, MCT1 and MCT4. BMC Cancer 11, 167.
    • (2011) BMC Cancer , vol.11 , pp. 167
    • Rademakers, S.E.1    Lok, J.2    Van der, K.A.J.3    Bussink, J.4    Kaanders, J.H.5
  • 60
    • 33746924468 scopus 로고    scopus 로고
    • Hexokinase II: Cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria
    • Mathupala SP, Ko YH, and Pedersen PL (2006). Hexokinase II: cancer's double-edged sword acting as both facilitator and gatekeeper of malignancy when bound to mitochondria. Oncogene 25, 4777-4786.
    • (2006) Oncogene , vol.25 , pp. 4777-4786
    • Mathupala, S.P.1    Ko, Y.H.2    Pedersen, P.L.3
  • 62
    • 70350220872 scopus 로고    scopus 로고
    • Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanism
    • Shulga N, Wilson-Smith R, and Pastorino JG (2009). Hexokinase II detachment from the mitochondria potentiates cisplatin induced cytotoxicity through a caspase-2 dependent mechanism. Cell Cycle 8, 3355-3364.
    • (2009) Cell Cycle , vol.8 , pp. 3355-3364
    • Shulga, N.1    Wilson-Smith, R.2    Pastorino, J.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.