Potential links between impaired one-carbon metabolism due to polymorphisms, inadequate B-vitamin status, and the development of Alzheimer’s disease

Nutrients

Volumn 8, Issue 12, 2016, Pages

  Troesch, Barbara ^a   Weber, Peter ^a   Mohajeri, M Hasan ^a  

^a DSM NUTRITIONAL PRODUCTS LTD   (Switzerland)

Author keywords

Alzheimer s disease; B vitamins; Dementia; Homocysteine; Nutrition; One carbon metabolism; Polymorphism; Prevention; Therapy

Indexed keywords

APOLIPOPROTEIN E; CYANOCOBALAMIN; CYSTATHIONINE BETA SYNTHASE; FOLIC ACID; GLYCINE HYDROXYMETHYLTRANSFERASE; HOMOCYSTEINE; METHIONINE SYNTHASE; METHYLENETETRAHYDROFOLIC ACID; MYELIN; NEUROTRANSMITTER; PHOSPHOLIPID; PYRIDOXINE; RIBOFLAVIN; VITAMIN B GROUP; 5 METHYLTETRAHYDROFOLATE HOMOCYSTEINE METHYLTRANSFERASE; FERREDOXIN NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE REDUCTASE; METHIONINE; METHIONINE SYNTHASE REDUCTASE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MTHFR PROTEIN, HUMAN; MTR PROTEIN, HUMAN; SHMT PROTEIN, HUMAN; VITAMIN B COMPLEX;

ALZHEIMER DISEASE; CARBON METABOLISM; DEMENTIA; DIETARY INTAKE; DNA METHYLATION; DNA SYNTHESIS; ENZYME ACTIVITY; GENE MUTATION; GENETIC ANALYSIS; GENOTYPE; HUMAN; HYPERHOMOCYSTEINEMIA; METABOLIC BALANCE; MORTALITY RATE; NUTRITIONAL STATUS; OBSERVATIONAL STUDY; OXIDATIVE STRESS; PREVALENCE; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; VITAMIN SUPPLEMENTATION; ANIMAL; BIOLOGICAL MODEL; DIET THERAPY; EVIDENCE BASED MEDICINE; GENE EXPRESSION REGULATION; GENETIC POLYMORPHISM; GENETIC PREDISPOSITION; GENETICS; METABOLISM; NUTRIGENOMICS; PATHOPHYSIOLOGY; PROCEDURES; TANDEM REPEAT; TRENDS; VITAMIN B DEFICIENCY;

5-METHYLTETRAHYDROFOLATE-HOMOCYSTEINE S-METHYLTRANSFERASE; ALZHEIMER DISEASE; ANIMALS; CYSTATHIONINE BETA-SYNTHASE; EVIDENCE-BASED MEDICINE; FERREDOXIN-NADP REDUCTASE; GENETIC PREDISPOSITION TO DISEASE; GLYCINE HYDROXYMETHYLTRANSFERASE; HUMANS; HYPERHOMOCYSTEINEMIA; METHIONINE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); MODELS, BIOLOGICAL; MUTAGENESIS, INSERTIONAL; NUTRIGENOMICS; NUTRITIONAL STATUS; POLYMORPHISM, GENETIC; POLYMORPHISM, SINGLE NUCLEOTIDE; TANDEM REPEAT SEQUENCES; VITAMIN B COMPLEX; VITAMIN B DEFICIENCY;

EID: 85016431203     PISSN: None     EISSN: 20726643     Source Type: Journal    
DOI: 10.3390/nu8120803     Document Type: Review

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