Gene-environment and gene-gene interaction in the determination of plasma homocysteine levels in healthy middle-aged men

Thrombosis and Haemostasis

Volumn 85, Issue 1, 2001, Pages 67-74

  Dekou, V ^a   Gudnason, V ^a   Hawe, E ^a   Miller, G J ^a   Stansbie, D ^a   Humphries, S E ^a  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

CBS; Folate; Homocysteine; Methionine synthase; MTHFR

Indexed keywords

CYANOCOBALAMIN; CYSTATHIONINE BETA SYNTHASE; DNA; FOLIC ACID; HOMOCYSTEINE; METHIONINE SYNTHASE; METHYLENETETRAHYDROFOLIC ACID;

ADULT; AGE; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; BLOOD ANALYSIS; ENVIRONMENTAL FACTOR; GENE INSERTION; GENETIC POLYMORPHISM; GENETIC VARIABILITY; GENOTYPE; HOMOZYGOSITY; HUMAN; MALE; NORMAL HUMAN; NUTRITIONAL STATUS; PRIORITY JOURNAL; PROTEIN NUCLEIC ACID INTERACTION; SMOKING; VITAMIN BLOOD LEVEL;

EID: 0035159261     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-0037-1612906     Document Type: Article

References (48)

1. The metabolism of homocysteine: Pathways and regulation
2. Regulation of hepatic betaine-homocysteine methyltransferase by dietary methionine
3. Plasma homocyst(e)ine or homocysteine?
4. Methionine metabolism in mammals. Distribution of homocysteine between competing pathways
5. Bile methyl balances for normal humans on various dietary regimens
6. Mammalian methylenetetrahydrofolate reductase. Partial purification, properties, and inhibition by S-adenosylmethionine
7. Methionine metabolism in mammals: S-adenosyl-homocysteine hydrolase in rat intestinal mucosa
8. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Probable benefits of increasing folic acid intakes
9. Plasma homocysteine as a risk factor for vascular disease. The European Concerted Action Project
10. Homocyst(e)ine: An important risk factor for atherosclerotic vascular disease
11. Endothelial marker proteins in hyperhomocysteinemia
12. Stimulation of endothelial nitric oxide production by homocyst(e)ine
13. Hyperhomocyst(e)inemia and a common methylenetetrahydrofolate reductase mutation (Ala223Val MTHFR) in patients with inherited thrombophilic coagulation defects
14. Interrelation of hyperhomocysteinemia, factor V Leiden and risk of future venous thromboembolism
15. Meta analysis of hyperhomocysteinemia as a risk factor for venous thrombosis disease
16. Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase
17. A candidate genetic risk factor for vascular disease: A common mutation in methylene-tetrahydrofolate reductase
18. Common Methylenetetrahudrofolate reductase gene mutation leads to hyperhomocysteinaemia but not to vascular disease: The result of a meta-analysis
19. C677T (thermolabile alanine/valine) polymorphism in methylenetetrahydrofolate reductase (MTHFR): Its frequency and impact on plasma homocysteine concentration in different European populations. EARS group
20. MTHFR association with arteriosclerotic vascular disease?
21. The molecular basis of homocystinuria due to cystathionine beta-synthase deficiency in Italian families, and report of four novel mutations
22. High prevalence of a mutation in the cystathionine beta-synthase gene
23. Homocysteine response to methionine challenge in four obligate heterozygotes for homocystinuria and relationship with cystathionine beta-synthase mutations
24. Human methionine synthase: cDNA cloning and identification of mutations in patients of the cblG complementation group of folate/cobalamin disorders
25. Sequence analysis of the coding region of human methionine synthase: Relevance to hyperhomocysteinaemia in neural-tube defects and vascular disease
26. Susceptibility to spina bifida: An association study of five candidate genes
27. Polymorphism of the Methionine Synthase Gene. Association with homocysteine metabolism and late onset vascular diseases in the Japanese population
28. Increased activation of the haemostatic system in men at high risk of fatal coronary heart disease
29. Homocysteine and other thiols in plasma and urine: Automated determination and sample stability
30. A simple salting out procedure for extracting DNA from human nucleated cells
31. Linkage disequilibrium at the cystathionine B synthase (CBS) locus and the association between genetic variation at the CBS locus and plasma levels of homocysteine
32. Electrophoresis for genotyping: Microtiter array diagonal gel electrophoresis on horizontal polyacrylamide gels, hydrolink, or agarose
33. Total plasma homocysteine and cardiovascular risk profile. The Hordaland Homocysteine Study
34. Dietary differences in smokers and nonsmokers from two southeastern New England communities
35. The effects of folic acid supplementation on plasma total homocysteine are modulated by multivitamin use and methylenetetrahydrofolate reductase genotypes
36. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
37. Methylenetetrahydrofolate reductase polymorphism affects the change in homocysteine and folate concentrations resulting from low dose folic acid supplementation in women with unexplained recurrent miscarriages
38. Myocardial infarction in young women in relation to plasma total homocysteine, folate, and a common variant in the methylenetetrahydrofolate reductase gene
39. Thermolabile variant of 5,10-methylenetetrahydrofolate reductase associated with low red-cell folates: Implications for folate intake recommendations
40. Hyperhomocysteinemia in premature arterial disease: Examination of cystathionine beta-synthase alleles at the molecular level
41. Relationship between total plasma homocysteine, polymorphisms of homocysteine metabolism related enzymes, risk factors and coronary artery disease in the Australian hospital-based population
42. Relation between plasma homocysteine concentration, the 844ins68 variant of the cystathionine β-synthase gene, and pyridoxal-5′-phosphate concentration
43. Disordered methionine/homocysteine metabolism in premature vascular disease. Its occurrence, cofactor therapy, and enzymology
44. Low whole-blood S-adenosylmethionine and correlation between 5-methyltetrahydrofolate and homocysteine in coronary artery disease
45. Methionine synthase D919G mutation in type 2 diabetes and its relation to vascular events
46. Determinants and vitamin responsiveness of intermediate hyperhomocysteinemia (> or = 40 micromol/liter). The Hordaland Homocysteine Study Kinetics of total plasma homocysteine in subjects with hyperhomocysteinemia due to folate or cobalamin deficiency
47. Methylenetetrahydrofolate reductase polymorphism, plasma folate, homocysteine, and risk of myocardial infarction in US physicians
48. The common 'thermolabile' variant of methylene tetrahydrofolate reductase is a major determinant of mild hyperhomocysteinaemia