Folate depletion and elevated plasma homocysteine promote oxidative stress in rat livers

Journal of Nutrition

Volumn 131, Issue 1, 2001, Pages 33-38

  Huang, R F S ^a   Hsu, Y C ^a   Lin, H L ^a   Yang, F L ^a  

^a FU JEN CATHOLIC UNIVERSITY   (Taiwan)

Author keywords

Folate depletion; Oxidative stress; Plasma homocysteine; Rats

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; GLUTATHIONE; GLUTATHIONE PEROXIDASE; HOMOCYSTEINE; HYDROGEN PEROXIDE; IRON; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; DIET; DIETARY INTAKE; ENZYME ACTIVITY; FOLIC ACID DEFICIENCY; LIPID PEROXIDATION; LIVER; MALE; NONHUMAN; OXIDATIVE STRESS; RAT;

ANIMALIA; RATTUS NORVEGICUS;

EID: 0035182406     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/131.1.33     Document Type: Article

References (44)

1. Catalase in vitro
2. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection
3. Hepatic one-carbon metabolism in early folate deficiency in rats
4. Folate deficiency inhibits pancreatic amylase secretion in rats
5. Homocysteine mediated endothelial cell toxicity and its amelioration
6. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease
7. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
8. Tissue distribution and prediction of total body folate of rats
9. Folate deficiency enhances the development of colonic neoplasia in dimethylhydrazine-treated rats
10. Hyperhomocysteinemia induced by folio acid deficiency and methionine load: Applications of a modified HPLC method
11. Pro-thrombotic effects of a folio acid deficient diet in rat platelets and macrophages related to elevated homocysteine and decreased n-3 polyunsaturated fatty acids
12. Lipid peroxidation measured as thiobarbituric-reactive substances in tissue slices: Characterization and comparison with homogenates and microsomes
13. Homocysteine and vascular disease
14. Hepatic content of S-adenosylmethione, S-adenosylhomocysteine and glutathione in rats receiving treatments modulating methyl donor availability
15. Vitamins C, E, and A and heme oxygenase in rats fed methyl/folate-deficient diets
16. A fluorometric method for determination of oxidized and reduced glutathione in tissues
17. Lactobacillus casei microbiological assay of folic acid derivatives in 96-well microtiter plates
18. Tissue vitamin E status is compromised by dietary protein insufficiency in young growing rats
19. The cell-damaging effects of low amounts of homocysteine and copper ions in human cell line cultures are caused by oxidative stress
20. The effects of homocysteine and copper ions on the concentration and redox status of thiols in cell line cultures
21. Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women
22. Homocysteine increases as folate decreases in plasma of healthy men during short-term dietary folate and methyl group restriction
23. Lipid peroxidation and homocysteine induced toxicity
24. Homocysteinemia in rats induced by folic acid deficiency
25. The oxidant stress of hyperhomocyst(e)inemia
26. Involvement of the superoxide anion radical in the autoxidation of paragallol and a convenient assay for superoxide dismutase
27. Folate-deficiency-induced homocysteinaemia in rats: Disruption of S-adenosylmethionine's co-ordinate regulation of homocysteine metabolism
28. Homocysteine as a modulator of platelet-derived growth factor action in vascular smooth muscle cells: A possible role for hydrogen peroxide
29. Homocysteine metabolism and the oxidative modification of proteins and lipids
30. Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells
31. Changes in activity of the Cu-Zn superoxide dismutase enzyme in tissues of the rat with changes in dietary copper
32. Folate in preventive medicine: A new role in cardiovascular disease, neural tube defects and cancer
33. Relationship between plasma homocysteine, vitamin status and extracranial carotid-artery stenosis in the Frarningham study population
34. Vitamin intake: A possible determinant of plasma homocyst(e)ine among middle-aged adults
35. Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine
36. Glutathione peroxidase and hydroperoxides
37. Homocyst(e)ine decreases bioavailable nitric oxide by a mechanism involving glutathione perozidase
38. Long-term folate deficiency alters folate content and distributiorT differentially in rat tissues
39. Folate deficiency in rats fed diets containing free amino acid or intact proteins
40. Homocysteine and atherothrombosis
41. Homocysteine, oxidative stress, and vascular disease
42. Activities of antioxidant enzymes in various tissues of male Fisher 344 rats are altered by food restriction
43. Lipid peroxidation induced in vivo by hyperhomocysteinemia in pigs