Homocysteine elicits a DNA damage response in neurons that promotes apoptosis and hypersensitivity to excitotoxicity

Journal of Neuroscience

Volumn 20, Issue 18, 2000, Pages 6920-6926

  Kruman, Inna I ^a   Culmsee, Carsten ^b   Chan, Sic L ^a   Kruman, Yuri ^a   Guo, Zhihong ^a   Penix, LaRoy ^b   Mattson, Mark P ^a,b,c  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

Calcium; Caspase; Mitochondrial transmembrane potential; NAD; PARP; Stroke

Indexed keywords

3 AMINOBENZAMIDE; AMINO ACID; CASPASE; DNA; HOMOCYSTEINE; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SULFUR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA DAMAGE; DNA STRAND BREAKAGE; EMBRYO; ENZYME ACTIVATION; ENZYME INHIBITION; MALE; MEMBRANE POTENTIAL; MOUSE; NERVE CELL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; TOXICITY;

EID: 0034666267     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.20-18-06920.2000     Document Type: Article

References (65)

1. DNA strand breaks in Alzheimer's disease
2. Plasma homocysteine before and after methionine loading with regard to age, gender, and menopausal status
3. An improved cycling assay for nicotinamide adenine dinucleotide
4. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: Implication for cancer and neuronal damage
5. Homocysteine mediated endothelial cell toxicity and its amelioration
6. Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization
7. The amyloid β protein induces oxidative damage of mitochondrial DNA
8. Homocysteine and cysteine: Determinants of plasma levels in middle aged and elderly subjects
9. Altered neuronal and microglial responses to brain injury in mice lacking TNF receptors
10. Tumor necrosis factors protect neurons against excitotoxic/metabolic insults and promote maintenance of calcium homeostasis
11. Folate, vitamin B12, and serum total homocysteine levels in confirmed Alzheimer disease
12. Bax-dependent caspase-3 activation is a key determinant in p53-induced apoptosis in neurons
13. P53- and CD95-associated apoptosis in neurodegenerative diseases
14. Pathobiology of ischaemic stroke: An integrated view
15. Stroke risk factors and stroke prevention
16. Methionine metabolism in mammals
17. The transcription factor NF-κB mediates increases in calcium currents and decreases in NMDA and AMPA/kainate-induced currents in response to TNFα in hippocampal neurons
18. Serum folate and risk for ischemic stroke. First National Health and Nutrition Examination Survey epidemiologic follow-up study
19. Synaptosomal plasma membrane transport of excitatory sulphur amino acid transmitter candidates: Kinetic characterisation and analysis of carrier specificity
20. Differential radiosensitivity of neurons and neuroglia of the hippocampus in the adult rabbit
21. Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation
22. Activation of poly[ADP-ribose]polymerase in endothelial cells and keratinocytes: Role in an in vitro model of sulfur mustard-mediated vesication
23. Increases in DNA lesions and the DNA damage indicator Gadd45 following transient cerebral ischemia
24. Neuronal loss and synaptic reorganization in temporal lobe epilepsy
25. A role for the tumour suppressor gene p53 in regulating neuronal apoptosis
26. Contribution of p53-dependent caspase activation to neuronal cell death declines with neuronal maturation
27. Mitochondrial MnSOD prevents neural apoptosis and reduces ischemic brain injury: Suppression of peroxynitrite production, lipid peroxidation and mitochondrial dysfunction
28. Mitochondrial depolarization is not required for neuronal apoptosis
29. Evidence that 4-hydroxy nonenal mediates oxidative stress-induced neuronal apoptosis
30. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE
31. Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats
32. Neurotoxicity associated with dual actions of homocysteine at the N-methyl-D-aspartate receptor
33. Apoptosis and expression of DNA repair proteins in ischaemic brain injury in man
34. Cellular actions of b-amyloid precursor protein and its soluble and fibrillogenic derivatives
35. Fibroblast growth factor and glutamate: Opposing actions in the generation and degeneration of hippocampal neuroarchitecture
36. Activation of NF-κB protects hippocampal neurons against oxidative stress-induced apoptosis: Evidence for induction of Mn-SOD and suppression of peroxynitrite production and protein tyrosine nitration
37. Evidence for synaptic apoptosis
38. Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases
39. Control of DNA repair linked to neuroblastoma differentiation
40. Hippocampal Myc and p53 expression following transient global ischemia
41. Homocysteine and vascular disease: Nature or nurture?
42. Homocysteine and Alzheimer's disease
43. Optimization of single-cell gel electrophoresis (SCGE) for quantitative analysis of neuronal DNA damage
44. Life and death of neurons in the aging brain
45. Neuronal necrosis and apoptosis: Two distinct events induced by exposure to glutamate or oxidative stress
46. Possible involvement of poly(ADP-ribosyl) polymerase in triggering stress-induced apoptosis
47. Characterization of the stress-inducing effects of homocysteine
48. Poly (ADP-ribose) polymerase, nitric oxide and cell death
49. Poly(ADP-ribosyl)ation basally activated by DNA strand breaks reflects glutamate-nitric oxide neurotransmission
50. Homocysteine and cardiovascular disease
51. Nuclear accumulation of p53 protein following kainic acid-induced seizures
52. Folic acid, homocysteine and one-carbon metabolism; a review of the essential biochemistry
53. B vitamins, homocysteine, and neurocognitive function in the elderly
54. Ischemic brain damage and memory impairment: A commentary
55. Endothelial cell injury due to copper-catalyzed hydrogen peroxide generation from homocysteine
56. A caspase-activated factor (CAF) induces mitochondrial membrane depolarization and cytochrome c release by a nonproteolytic mechanism
57. Immunocytochemical evidence for apoptosis in Alzheimer's disease
58. Cerebrospinal fluid and plasma total homocysteine and related metabolites in children with cystathionine β-synthase deficiency: The effect of treatment
59. GADD45 is induced in Alzheimer's disease, and protects against apoptosis in vitro
60. Hyperhomocysteinaemia; with reference to its neuroradiological aspects
61. Homocysteine-induced endothelial cell injury in vitro: A model for the study of vascular injury
62. Functional methionine synthase deficiency (cblE and cblG): Clinical and biochemical heterogeneity
63. Homocysteine and atherothrombosis
64. Mitochondrial depolarization in glutamate-stimulated neurons: An early signal specific to excitotoxin exposure
65. Bax involvement in p53-mediated neuronal cell death