The relationship between riboflavin and plasma total homocysteine in the Framingham Offspring cohort is influenced by folate status and the C677T transition in the methylenetetrahydrofolate reductase gene

Journal of Nutrition

Volumn 132, Issue 2, 2002, Pages 283-288

  Jacques, Paul F ^a   Kalmbach, Renee ^a   Bagley, Pamela J ^a   Russo, Giuseppina T ^a   Rogers, Gail ^a   Wilson, Peter W F ^b   Rosenberg, Irwin H ^a   Selhub, Jacob ^a  

^a TUFTS UNIVERSITY   (United States)

^b FRAMINGHAM HEART STUDY   (United States)

Author keywords

Folate; Homocysteine; Humans; Methylenetetrahydrofolate reductase; Riboflavin

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); FLAVINE ADENINE NUCLEOTIDE; FLAVINE MONONUCLEOTIDE; FLAVINE NUCLEOTIDE; FOLIC ACID; HOMOCYSTEINE; RIBOFLAVIN;

ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID METABOLISM; ARTICLE; CARDIOVASCULAR DISEASE; COHORT ANALYSIS; FEMALE; GENE MUTATION; GENOTYPE; HUMAN; HYPERHOMOCYSTEINEMIA; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; NUTRITIONAL STATUS;

EID: 0036171590     PISSN: 00223166     EISSN: None     Source Type: Journal    
DOI: 10.1093/jn/132.2.283     Document Type: Article

References (27)

1. Intermediate homocysteinemia: A thermolabile variant of methylenetetrahydrofolate reductase
2. Human methylenetetrahydorfolate reductase: Isolation of cDNA, mapping and mutation identification
3. A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofotate reductase
4. Genetic predisposition to hyperhomcysteinemia: Deficiency of methylenetetrahydrofolate reductase (MTHFR) Thromb
5. The incidence of the gene for thermolabile methylene tetrahydrofolate reductase in African Americans
6. Prevalence of the mutation C677 → T in the methylene tetrahydrofolate reductase gene among distinct ethnic groups in Brazil
7. Thermolabile methylenetetrahydrofolate reductase: An inherited risk factor for coronary artery disease
8. Mutated methylenetetrahydrofotate reductase as a risk factor for spina bifida
9. Homocysteine and cardiovascular disease
10. Homocysteine and cardiovascular disease: Cause or effect?
11. Relation between folate status, a common mutation in methylenetetrahydrofolate reductase, and plasma homocysteine concentrations
12. Riboflavin as a determinant of plasma total homocysteine: Effect modification by the methylenetetrahydrofolate reductase C677T polymorphism
13. Coronary heart disease in the Framingham study
14. The Framingham offspring study. Design and preliminary data
15. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection
16. Lactobacillus casei assay of folic acid derivatives in 96-well microtiter plates
17. Inhibition of EDTA of growth of Lactobacillus casei in the folate microbiological assay and its reversal by added manganese or iron
18. A new enzymatic method for pyridoxal-5′-phosphate determination
19. The transport of thiamine, riboflavin and pyridoxal 5′-phosphate by human placenta
20. Impact of folic acid fortification on plasma folate and total homocysteine concentrations in middle-aged and older adults from the Framingham Study
21. A prospective study of plasma homocyst(e)ine and risk of myocardial infarction in US physicians
22. Vitamin intake: A possible determinant of plasma homocyst(e)ine among middle-aged adults
23. Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort
24. Food standards: Amendment of standards of identity for enriched grain products to require addition of folic acid
25. The structure and properties of methylenetetrahydrofolate reductase from Escherichia coli suggest how folate ameliorates human hyperhomocysteinemia
26. Folate status in women of child-bearing age - United States, 1999